Following the 2011 Fukushima Daiichi nuclear catastrophe, there has been a significant surge in interest towards innovative materials capable of enhancing the safety, performance, and efficiency of nuclear reactors. T...
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Following the 2011 Fukushima Daiichi nuclear catastrophe, there has been a significant surge in interest towards innovative materials capable of enhancing the safety, performance, and efficiency of nuclear reactors. This study introduces a new class of layered ternary compounds, specifically (UC) n Si 3 C 2 (n = 1,2), and derived two-dimensional (2D) U 2 C, discovered through first-principles calculations. We predict the electronic, mechanical, and thermodynamic properties of these compounds within the PBE and PBE + U frameworks, with a comparative analysis of the (UC) n Al 3 C 2 (n = 1,2) series. Our findings reveal that the USi 3 C 3 and U 2 Si 3 C 4 compounds exhibit mechanical and dynamic stabilities, suggesting their potential for experimental synthesis under specific conditions. These compounds demonstrate superior mechanical and thermal properties as nuclear fuels, including higher elastic moduli and improved ductility compared to (UC) n Al 3 C 2 compounds. The mechanical and dynamical stabilities of 2D U 2 C are confirmed, and the calculated thermal conductivity and mechanical properties position it as a promising candidate for high-performance nuclear fuel applications. We anticipate that the present work will bolster future experimental endeavors and help explore the practical applications of these novel materials in future nuclear systems.
Concentrating optical field in an eigenmode with a tiny volume is vitally important for light-matter interactions at the fundamental level and underpins new technologies. In the past decades, researchers have investig...
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Gas bubbles widely exist in nature and numerous industrial processes. The physicochemical characteristics of bubbles such as large specific surface area, low density, and hydrophobicity make them an ideal platform for...
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Gas bubbles widely exist in nature and numerous industrial processes. The physicochemical characteristics of bubbles such as large specific surface area, low density, and hydrophobicity make them an ideal platform for developing colloidal and interfacial technologies. Over the past few decades, much effort has been devoted to investigating the properties and behaviors of bubbles and their applications. A series of bubble-based technologies (BBTs) have been developed, which have attracted increasing attention and shown great importance in a wide range of engineering, material, and biological fields. These BBTs, such as bubble flotation and the bubble-liposome system, provide feasible and promising solutions to mineral separation, material assembling, medical diagnosis, and drug delivery. In this work, we have systematically reviewed the physicochemical characteristics of bubbles and how to modulate their behaviors in complex fluid systems, as well as the underlying fundamental interaction mechanisms of bubbles in related BBTs. Advanced nanomechanical techniques such as atomic force microscopy, which are used to quantify the interaction mechanisms in bubble-containing systems, have been introduced. The effects of various influential factors on the bubble behaviors are discussed, which provide potential approaches to improve the controllability and performance of BBTs. The recent advances in the applications of selected BBTs in engineering, biomedical, and material areas are presented. Some remaining challenging issues and perspectives for future studies have also been discussed. This review improves the fundamental understanding of characteristics and surface interaction mechanisms of bubbles, with useful implications for developing advanced BBTs.
Nanoparticles stabilized Pickering emulsions have been widely applied in various fields. The size and morphology of nanoparticles are regarded as crucial factors for the emulsion stability. In this study, the dendriti...
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Nanoparticles stabilized Pickering emulsions have been widely applied in various fields. The size and morphology of nanoparticles are regarded as crucial factors for the emulsion stability. In this study, the dendritic mesoporous silica nanoparticles (DMSNs) and two kinds of hybrid dendritic mesoporous silica titanium nanoparticles (DMSTNs-0.01 and DMSTNs-0.03) have been successfully prepared and investigated for their potential application to stabilize Pickering emulsions. Scanning electron microscopy, transmission electron microscopy, Fourier transform infrared spectroscopy, and UV-Vis diffuse reflectance spectra are employed to confirm the successful fabrication of the nanoparticles. The stability of DMSNs and DMSTNs stabilized emulsions are systematically evaluated via the optical microscopy and static multiple light scattering. The DMSTNs-0.01 displays the greatest ability to stabilize emulsions. N-2 physisorption and atomic force microscopy demonstrate the stability of Pickering emulsions is closely related to the specific surface area and surface roughness of nanoparticles. Moreover, DMSTNs-0.01 stabilized O/W Pickering emulsions show satisfactory displacement performance (tertiary oil recovery of 14.05%) in core flooding experiments. Microscopic visualization tests further indicate the emulsions can effectively block the high permeability channels generated by initial water flooding to increase the flowing resistance and then cause the flow diversion of the repellent fluid to enlarge the sweep area.
This paper presents the participation of the Image Semantics group (ImageSem) of the Institute of Medical Information at the ImageCLEFmed Caption task, which was launched by ImageCLEF 2019. The Concept Detection sub-t...
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The compact extracellular matrix (ECM) of pancreatic ductal adenocarcinoma (PDAC) is the major physical barrier that hinders the delivery of anti-tumor drugs, leading to strong inherent chemotherapy resistance as well...
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The compact extracellular matrix (ECM) of pancreatic ductal adenocarcinoma (PDAC) is the major physical barrier that hinders the delivery of anti-tumor drugs, leading to strong inherent chemotherapy resistance as well as establishing an immunosuppressive tumor microenvironment (TME). However, forcibly destroying the stroma barrier would break the balance of delicate signal transduction and dependence between tumor cells and matrix components. Uncontrollable growth and metastasis would occur, making PDAC more difficult to control. Hence, we design and construct an aptamer-decorated hypoxia-responsive nanoparticle s(DGL)(n)@Apt co-loading gemcitabine monophosphate and STAT3 inhibitor HJC0152. This nanoparticle can reverse its surficial charge in the TME, and reduce the size triggered by hypoxia. The released ultra-small DGL particles loading gemcitabine monophosphate exhibit excellent deep-tumor penetration, chemotherapy drugs endocytosis promotion, and autophagy induction ability. Meanwhile, HJC0152 inhibits overactivated STAT3 in both tumor cells and tumor stroma, softens the stroma barrier, and reeducates the TME into an immune-activated state. This smart code -livery strategy provides an inspiring opportunity in PDAC treatment.
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