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应用激光 2022年第5期42卷 109-119页

作者：崔缙郭华玲郑宾刘辉张钰龙邓祎昕贺旭文中北大学电气与控制工程学院山西太原030051

小口径金属圆柱体的缺陷检测是无损检测领域的一个难题。通过有限元方法对金属圆柱中横波传播特性以及与缺陷作用机理进行数值模拟。探究了横波的方向性变化、圆孔缺陷半径对横波传播影响、不同位置和不同长度的缺陷对横波传播的影响。... 详细信息

小口径金属圆柱体的缺陷检测是无损检测领域的一个难题。通过有限元方法对金属圆柱中横波传播特性以及与缺陷作用机理进行数值模拟。探究了横波的方向性变化、圆孔缺陷半径对横波传播影响、不同位置和不同长度的缺陷对横波传播的影响。研究表明横波在传播过程中主要能量范围由15°~36°变为20°~35°,提出了近似正三角形的传播路径并进行验证,发现横波到达表面后发生模态转换,一部分声波以略面纵波的速度沿表面传播;对于圆孔缺陷,圆孔半径在3.4~4.6mm范围内可通过幅值变化判断孔径信息,半径在4.6~5.8mm范围内可通过接收时间判断孔径信息;对于不同位置的矩形缺陷,当缺陷进入到横波主要能量范围内,C扫图中出现近似线性的高能量区域,探测角度随着缺陷位置增加而增大,此范围内的缺陷可通过反射信号的探测角度判断位置信息;对于不同长度的矩形缺陷,随着缺陷长度增加,透射波能量减弱并且探测角度减小,呈现出近似线性的能量分布,通过探测透射波到达外表面的角度可判断缺陷长度信息。提出了相应的传播路径和长度计算公式,计算结果得到的误差百分比控制在6.5%以内,验证了该缺陷长度检测方法的有效性。

关键词：横波柱状材料激光超声内部缺陷数值模拟

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Synthesis of Composite Carbon-Based Nano-Zero-Valent Iron Micro-Electrolytic Material and Removal of Dichloromethanesulfonic Acid in Drinking Water

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NANO 2019年第5期14卷

作者： Liu, Kai Shangguan, Zhonghua zhang, Xiaohang Shi, Yali Wang, Hao Yang, Shipeng He, xuwen China Univ Min & Technol Sch Chem & Environm Engn 11 Xueyuan Rd Beijing 100083 Peoples R China Xian Zhongdi Environm Technol Co Ltd Xian Geol Survey Ctr China Geol Survey Youyi East Rd Xian 710054 Shanxi Peoples R China Chinese Acad Sci Res Ctr Ecoenvironm Sci 18 Shuangqing Rd Beijing 100085 Peoples R China Tsinghua Univ Sch Environm 30 Shuangqing Rd Beijing 100084 Peoples R China

Composite carbon-based nano-zero-valent iron materials not only have excellent characteristics of nano materials, but also solve the difficulty of recycling nano materials after use, and overcome the shortcomings of the nano materials. The introduction of copper increases the redox reaction activity of the micro-electrolytic material and expands the applicable pH range of the reaction environment. In the range of pH = 3-9, the removal efficiency of dichloromethanesulfonic acid (Cl-2-MSA) was maintained at 95.5-99.7% after 30 min. Continuous dynamic simulation experiments verified that the composite carbon-based nano zero-valent iron material has a stable removal effect on the target pollutants.

关键词： Nano-zero-valent iron micro-electrolytic dichloromethanesulfonic acid

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高转速低功耗非晶定子永磁无刷直流电机优化设计研究

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佛山科学技术学院学报（自然科学版） 2023年第5期41卷 1-10页

作者：孙海波朱锋张志臻庞雷宇黄旭文佛山科学技术学院材料科学与氢能学院广东佛山528000 佛山中研磁电科技股份有限公司广东佛山528241

结合多目标优化设计和有限元模拟方法,对24槽28极非晶定子永磁无刷直流电机拓扑结构优化设计进行了系统研究,以期进一步提高电机效率和降低质量。结果表明,与粒子群优化算法(PSO)和自适应多目标算法(AMO)相比,多目标遗传算法(MOGA)具有... 详细信息

结合多目标优化设计和有限元模拟方法,对24槽28极非晶定子永磁无刷直流电机拓扑结构优化设计进行了系统研究,以期进一步提高电机效率和降低质量。结果表明,与粒子群优化算法(PSO)和自适应多目标算法(AMO)相比,多目标遗传算法(MOGA)具有帕累托解连续性最强及精度高等优势,更加适合于非晶电机优化设计。其中,经有限元分析验证和计算,MOGA算法优化的电机效率为93.79%、质量为1.33kg。对该MOGA方案拓扑结构做进一步的优化,与优化前相比,非晶电机效率提升了1.02%,可达94.81%,相应定子和转子轭铁重量分别减少了2.0%和5.6%。由此可知,采用多目标设计和有限元模拟相结合方法是提升电机效率、降低电机质量的有效途径之一。

关键词：永磁无刷直流电机非晶定子多目标优化设计拓扑结构优化

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Red-shifted electrochemiluminescence of CdTe nanocrystals via Co²⁺-Doping and its spectral sensing application in near-infrared region

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BIOSENSORS & BIOELECTRONICS 2020年第0期150卷 111880-000页

作者： Gao, xuwen Fu, Kena Fu, Li Wang, Huaisheng zhang, Bin Zou, Guizheng Shandong Univ Sch Chem & Chem Engn Jinan 250100 Peoples R China Liaocheng Univ Dept Chem Liaocheng 252059 Shandong Peoples R China

Novel optical labels for biosensing in near-infrared (NIR) region (especially between 800 and 900 nm) are arousing much attention for higher penetrating capability, less scattering and lowered autofluorescent background. Herein, a water-soluble electrochemiluminophore with effective electrochemiluminescence (ECL) around 815 nm is developed via doping dual-stabilizers-capped CdTe nanocrystals (NCs) with Co2+ species in a growth-doping way. The Co2+-doped CdTe NCs not only can preserve the highly-passivated surface states of dual-stabilizers-capped CdTe NCs, but also exhibit efficient red-shifted photoluminescence (PL) and ECL into the promising optical NIR window of 800-900 nm. A spectrum-based ultrasensitive NIR ECL immunosensor is consequently fabricated with the Co2+-doped CdTe NCs as tags for the first time, which can selectively and sensitively determine human carcinoembryonic antigen with a wide linearity range from 1 fg/mL to 10 pg/mL and a low limit of detection at 0.2 fg/mL (S/N = 3). This work opens a way to screen novel NIR electrochemiluminophore as well as to modulate the ECL performance of NCs via surface doping and engineering.

关键词： Electrochemiluminescence Near-infrared Co2+-doped CdTe NCs Immunosensor Human carcinoembryonic antigen

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The characteristics and analysis of the complete chloroplast genome ofHemerocalliscultivar Small orange lamp 2019 (Asphodelaceae)

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Mitochondrial DNA Part B 2024年第12期9卷

作者： Xiaofei zhang Jiaming Yang xuwen Shang Shengyue Chai Lanling Jiang Xiaolei Hou Zhenting Wang Lixin Lang a Liaoning Academy of Agricultural Sciences Institute of Flowers Shenyang China b Shenyang Agricultural University Shenyang China c China State Construction Corporation Limited Shenyang China

Hemerocalliscultivar Small orange lamp is a hybrid variety. Its whole chloroplast genome was 156,053 bp in size, consisting of 135 genes in total, including 89 mRNA genes, 38 tRNA genes, and 8 rRNA genes. The chloroplast genome contained a large single copy region (LSC 84,805 bp), a small single copy region (SSC 18,510 bp) and a pair of inverted repeats (IRa and IRb 26,369 bp). The overall GC content was 37.34%. Phylogenetic analysis showed thatHemerocallis lilioasphodelusandH. cultivar Small orange lamp are most closely related. This will provide valuable reference for further research on the genetic information of plants in theHemerocallis.

关键词： Chloroplast genome Asphodelaceae Hemerocallis cultivar Small orange lamp phylogenetic analysis

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Discovery of Novel GR Ligands toward Druggable GR Antagonist Conformations Identified by MD Simulations and Markov State Model Analysis

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ADVANCED SCIENCE 2022年第3期9卷 e2102435页

作者： Hu, Xueping Pang, Jinping zhang, Jintu Shen, Chao Chai, Xin Wang, Ercheng Chen, Haiyi Wang, xuwen Duan, Mojie Fu, Weitao Xu, Lei Kang, Yu Li, Dan Xia, Hongguang Hou, Tingjun Zhejiang Univ Coll Pharmaceut Sci Innovat Inst Artificial Intelligence Med Hangzhou 310058 Zhejiang Peoples R China Zhejiang Univ State Key Lab CAD&CG Hangzhou 310058 Zhejiang Peoples R China Chinese Acad Sci Key Lab magnet Resonance Biol Syst State Key Lab Magnet Resonance & Atom & Mol Phys Natl Ctr Magnet Resonance WuhanWuhan Inst Phys & Wuhan 430071 Hubei Peoples R China Jiangsu Univ Technol Inst Bioinformat & Med Engn Sch Elect & Informat Engn Changzhou 213001 Jiangsu Peoples R China Zhejiang Univ Sch Med Affiliated Hosp 1 Dept Biochem Hangzhou 310058 Zhejiang Peoples R China Zhejiang Univ Sch Med Affiliated Hosp 1 Res Ctr Clin Pharm Hangzhou 310058 Zhejiang Peoples R China

Binding of different ligands to glucocorticoid receptor (GR) may induce different conformational changes and even trigger completely opposite biological functions. To understand the allosteric communication within the GR ligand binding domain, the folding pathway of helix 12 (H12) induced by the binding of the agonist dexamethasone (DEX), antagonist RU486, and modulator AZD9567 are explored by molecular dynamics simulations and Markov state model analysis. The ligands can regulate the volume of the activation function-2 through the residues Phe737 and Gln738. Without ligand or with agonist binding, H12 swings from inward to outward to visit different folding positions. However, the binding of RU486 or AZD9567 perturbs the structural state, and the passive antagonist state appears more stable. Structure-based virtual screening and in vitro bioassays are used to discover novel GR ligands that bias the conformation equilibria toward the passive antagonist state. HP-19 exhibits the best anti-inflammatory activity (IC50 = 0.041 +/- 0.011 mu m) in nuclear factor-kappa B signaling pathway, which is comparable to that of DEX. HP-19 also does not induce adverse effect-related transactivation functions of GR. The novel ligands discovered here may serve as promising starting points for the development of GR modulators.

关键词： glucocorticoid ligand binding domain Markov state model nuclear receptor virtual screening

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猪XCR1/FMDV双特异纳米抗体融合蛋白的制备与鉴定

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中国农业大学学报 2025年第1期30卷 131-141页

作者：杨利杜露平侯立婷张浩明于晓明李兰乔绪稳张元鹏秦竹王义伟郑其升陈瑾程海卫江苏省农业科学院动物免疫工程研究所/国家兽用生物制品工程技术研究中心/江苏省食品质量与安全重点实验室南京210014 兽用生物制品(泰州)国泰技术创新中心江苏泰州225300

为通过将FMDV抗原靶向提呈至猪DC细胞进而提高疫苗免疫效力,本研究利用原核系统表达了猪XCR1目的蛋白,以该蛋白为免疫原免疫羊驼,提取其外周血淋巴细胞的总mRNA并反转录为cDNA,构建噬菌体展示纳米抗体文库,经过3轮亲和筛选获得猪XCR1特... 详细信息

为通过将FMDV抗原靶向提呈至猪DC细胞进而提高疫苗免疫效力,本研究利用原核系统表达了猪XCR1目的蛋白,以该蛋白为免疫原免疫羊驼,提取其外周血淋巴细胞的总mRNA并反转录为cDNA,构建噬菌体展示纳米抗体文库,经过3轮亲和筛选获得猪XCR1特异性纳米抗体;利用SOE-PCR技术将该纳米抗体和猪O型FMDV特异性纳米抗体Nb205连接,构建XCR1/FMDV双特异纳米抗体融合蛋白。结果表明:1)成功原核表达猪XCR1目的蛋白,SDS-PAGE和Western blot结果显示,其相对分子量大小约35 ku,符合预期。2)羊驼血清效价为1∶64000,满足建库要求;构建的噬菌体展示文库库容量约为1.91×10^(8)CFU/mL,插入率为91.3%,多样性好;经3轮亲和筛选成功获得了纳米抗体Nb75,间接ELISA结果显示该纳米抗体能特异性与XCR1结合。3)利用SOE-PCR技术成功构建XCR1/FMDV双特异纳米抗体融合蛋白Nb75-205;SDS-PAGE和Western blot显示,该蛋白在大肠杆菌中可溶性表达,且呈现二聚体结构,间接ELISA结果显示Nb75-205能同时与XCR1目的蛋白和FMDV抗原结合。综上,本研究采用噬菌体展示技术成功获得猪XCR1特异性纳米抗体,并构建XCR1/FMDV双特异纳米抗体融合蛋白Nb75-205,且该蛋白为天然二聚体结构,与XCR1目的蛋白和FMDV抗原均具有较好的结合活性,为进一步开展FMDV抗原的猪XCR1靶向提呈研究奠定基础。

关键词：趋化因子受体1 双特异纳米抗体二聚体 FMDV

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南海东部次海盆南侧基底结构与沉积特征及其控制因素

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大地构造与成矿学 2022年第5期46卷 884-897页

作者：赵斌王利杰张宝金耿明会秦绪文张如伟杨振陈玺吕文超张旭东中国地质调查局广州海洋地质调查局广东广州510760 南方海洋科学与工程广东省实验室(广州) 广东广州511458 中国地质调查局北京100037

南海东部次海盆经历了完整的海底扩张过程,对其进行从北至南、从东到西系统的研究有助于进一步认识南海的演化过程。通过南海东部次海盆3条多道地震剖面的解析,对其基底形态、沉积充填和岩浆活动特征进行研究,首次揭露了南海东部次海盆... 详细信息

南海东部次海盆经历了完整的海底扩张过程,对其进行从北至南、从东到西系统的研究有助于进一步认识南海的演化过程。通过南海东部次海盆3条多道地震剖面的解析,对其基底形态、沉积充填和岩浆活动特征进行研究,首次揭露了南海东部次海盆南侧东西向的沉积-构造特征。结果表明,南海东部次海盆南侧基底主要分为两种类型:一种为崎岖不平、深海丘陵和海山发育,且基底隆起表现为“东高西低”;另一种基底相对平坦,局部有岩浆侵入。两种基底形态受海底扩张速率、板片俯冲挠曲和扩张后岩浆活动等因素综合控制。东部次海盆南部的沉积充填类型主要有3种,受构造、沉积作用和物源供给共同控制,总体上呈现出邻近扩张脊一侧沉积薄、靠南部陆缘一侧沉积厚;东部边缘因构造挠曲等因素,基底构造隆起更强,形成较薄沉积,厚度最小处约160 m。基于沉积-构造-岩浆特征,构建东部次海盆南部海底扩张末期以来(16 Ma至今)的沉积-构造演化模型,对南海形成演化研究具有重要意义。

关键词：基底形态海盆沉积岩浆供应沉积-构造演化南海东部次海盆

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Electrochemical determination of methyl parathion based on pillararene@AuNPs@reduced graphene oxide hybrid nanomaterials

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NEW JOURNAL OF CHEMISTRY 2019年第33期43卷 13048-13057页

作者： Hou, Xiaoqian Liu, xuwen Li, Zhi zhang, Jun Dua, Guanben Ran, Xin Yang, Long Southwest Forestry Univ Minist Educ Key Lab Forest Resources Conservat & Utilizat Sou Kunming 650224 Yunnan Peoples R China Southwest Forestry Univ Sch Mat Sci & Engn Sch Chem Engn Kunming 650224 Yunnan Peoples R China Southwest Forestry Univ Yunnan Prov Key Lab Wood Adhes & Glued Prod Kunming 650224 Yunnan Peoples R China

The detection of pesticides has become a very important and critical research area because of the rapid development of agriculture and strict environmental protection regulations. In this paper, a fast and sensitive non-enzymatic electrochemical sensor for methyl parathion (MP) on a glassy carbon electrode (GCE) modified with hydroxylatopillar[5]arene@gold nanoparticles and electrochemical reduced graphene oxide (HCP5@AuNPs-ERGO) hybrid nanomaterials was proposed. The properties of the modified electrode were characterized by cyclic voltammetry (CV), differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS). The experimental parameters such as preconcentration time, preconcentration potential and pH value were optimized. It was found that the improved electrode showed a high detection sensitivity to MP, with a detection range of 0.005 mu M to 30 mu M and a detection limit (LOD) of 0.001 mu M, and other interfering substances had no effect on the detection of MP. In addition, the modified electrode is also used for the detection of MP in actual water samples, showing an efficient sensing capability. The results show that the electrochemical sensor provides a new idea for the trace analysis of MP in agricultural and environmental samples.

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Comparison and analysis of fecal components in Blaptica dubia and Blatta lateralis

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分子科学学报 2024年第6期40卷 546-551页

作者： ZHOU Jie LIU xuwen YE Dongyan LI Qianhui YIN Shuren zhang Suyi ZHOU Zhihan WANG Jing LIU Lijuan BAI Helong College of Chemistry Changchun Normal UniversityChangchun 130032China Technical Innovation Laboratory for Research and Development of Economic Plants and Edible Mushroomsand Medicinal Mushrooms in Cold Regions of Jilin ProvinceChangchun 130032China Changchun Guoxin Modern Agricultural Science and Technology Development Co. Ltd.Changchun 130600China

The fecal components of Blaptica dubia and Blatta lateralis were analyzed and characterized using solid-phase microextraction-gas chromatography-mass spectrometry(SPME-GC-MS)to explore can-didate compounds mediating their aggregation *** results revealed that hydrocarbons and alde-hydes accounted for the majority of the 85 components detected in the fecula of ***,with hexadecane(6.721%)and tetradecanal(6.555%)as the most *** the fecula of ***,esters and hy-drocarbons accounted for the majority of the 93 identified components,with 3-phenylpropionic acid methyl ester(10.020%)and 2,7-dioxa-tricyclo[4.4.0.0(3,8)]deca-4,9-diene(3.604%)hexadecane(2.504%)*** fecal compositions of the two cockroach species exhibited similarities,with seven common substances identified out of a total of *** relative percentages of these common components in the fecula were 68.516%for *** and 53.541%for ***.

关键词： Blaptica dubia Blatta lateralis fecal component SPME-GC-MS aggregation pheromone

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