BACKGROUND: Disruption of dopamine neurotransmis-sion is associated with functional impairment after severe traumatic brain injury (sTBI). This has prompted the study of dopamine agonists, such as amantadine, to assis...
详细信息
BACKGROUND: Disruption of dopamine neurotransmis-sion is associated with functional impairment after severe traumatic brain injury (sTBI). This has prompted the study of dopamine agonists, such as amantadine, to assist re-covery of consciousness. Randomized trials have mostly addressed the posthospital setting, with inconsistent findings. Therefore, we evaluated the efficacy of early amantadine administration on recovery of consciousness after ***: We searched the medical records of all pa-tients with sTBI admitted to our hospital between 2010 and 2021 who survived 10 days postinjury. We identified all patients receiving amantadine and compared them with all patients not receiving amantadine and a propensity score-matched nonamantadine group. Primary outcome measures included discharge Glasgow Coma Scale, Glasgow Outcome Scale-Extended score, length of stay, mortality, recovery of command-following (CF), and days to CF. -RESULTS: In our study population, 60 patients received amantadine and 344 did not. Compared with the propensity score-matched nonamantadine group, the amantadine group had no difference in mortality (86.67% vs. 88.33%, P = 0.783), rates of CF (73.33% vs. 76.67%, P = 0.673), or percentage of patients with severe (3-8) discharge Glas-gow Coma Scale scores (11.11% vs. 12.28%, P = 0.434). In addition, the amantadine group was less likely to have a favorable recovery (discharge Glasgow Outcome Scale-Extended score 5-8) (14.53% vs. 16.67%, P < 0.001), had a longer length of stay (40.5 vs. 21.0 days, P < 0.001), and had a longer time to CF (11.5 vs. 6.0 days, P = 0.011). No dif-ference in adverse events existed between ***: Our findings do not support the early administration of amantadine for sTBI. Larger inpatient randomized trials are necessary to further investigate amantadine treatment for sTBI.
Abiotic stresses, including cold and drought, negatively affect maize (Zea mays L.) seed field emergence and later yield and quality. In order to reveal the molecular mechanism of maize seed resistance to abiotic stre...
Abiotic stresses, including cold and drought, negatively affect maize (Zea mays L.) seed field emergence and later yield and quality. In order to reveal the molecular mechanism of maize seed resistance to abiotic stress at seed germination, the global transcriptome of high- vigour variety Zhongdi175 exposed to cold- and drought- stress was analyzed by RNA-seq. In the comparison between the control and different stressed sample, 12,299 differentially expressed genes (DEGs) were detected, of which 9605 and 7837 DEGs were identified under cold- and drought- stress, respectively. Functional annotation analysis suggested that stress response mediated by the pathways involving ribosome, phenylpropanoid biosynthesis and biosynthesis of secondary metabolites, among others. Of the obtained DEGs (12,299), 5,143 genes are common to cold- and drought- stress, at least 2248 TFs in 56 TF families were identified that are involved in cold and/or drought treatments during seed germination, including bHLH, NAC, MYB and WRKY families, which suggested that common mechanisms may be originated during maize seed germination in response to different abiotic stresses. This study will provide a better understanding of the molecular mechanism of response to abiotic stress during maize seed germination, and could be useful for cultivar improvement and breeding of high vigour maize cultivars.
In recent years, pregnant women in China generally face problems such as unbalanced and excessive nutrition, lack of proper exercise during pregnancy, which shows a significant increase in weight during pregnancy, lea...
详细信息
In recent years, pregnant women in China generally face problems such as unbalanced and excessive nutrition, lack of proper exercise during pregnancy, which shows a significant increase in weight during pregnancy, leading to an increasing trend of perinatal complications. At present, there is less sports health management system for pregnant women throughout pregnancy. In view of this, based on the existing research in related fields, this study deeply explores the appropriate monitoring methods of pregnant women's sports in China. In this study, effective and convenient testing methods and evaluation criteria were proposed for pregnant women's sports and psychology. The research idea was a method based on the pulse wave to detect pregnant women's cardiac reserve capacity, and grading the Diastolic/Systolic value of pregnant women as a reference for grading individualized target heart rate range of moderate intensity exercise. The effective time and energy expenditure of pregnant women were assessed by monitoring the exercise process. The purpose is to help and guide pregnant women in the whole process of pregnancy self-movement management, and thus improve the quality of maternal health care services in China.
Amorphous materials have recently received much attention as catalysts for electrochemical reactions. However, there are relatively few reports focused on the structure change of amorphous catalysts during the catalys...
详细信息
Amorphous materials have recently received much attention as catalysts for electrochemical reactions. However, there are relatively few reports focused on the structure change of amorphous catalysts during the catalysis process, although this is quite important to the identification of active species and in revealing the reaction mechanism. Herein, amorphous Co-Ni sulfide in the form of a nanoplate and nanowire hybrid on the surface of nickel foam is prepared as the electrode for the hydrogen evolution reaction (HER). During the hydrogen evolution process, the amorphous Co-Ni sulfide is in-situ transformed into crystalline Ni, S-co-doped CoO which is actually responsible for the catalysis of HER The transformation process is studied in detail by high-resolution transmission electron microscopy (HRTEM), X-ray photoelectron spectroscopy (XPS), and theoretical calculations. The in-situ formed electrode presents a high activity and durability toward HER in alkaline media. The Ni and S dopants, sulfurization temperature, and electrode substrate are revealed to be important factors that affect the activity. The present work will not only give more insights in the structure evolution of the electrocatalyst during HER but also provides a new strategy to the fabrication of new electrocatalysts.
暂无评论