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半导体技术 2019年第6期44卷 410-414,420页

作者：刘召军李坤李云超胡旭文闫树斌张彦军中北大学电子测试技术国防科技重点实验室太原030051 中北大学仪器科学与动态测试教育部重点实验室太原030051 北京动力机械研究所北京100074

芯片原子钟(CSAC)可以提供精准的时间基准,具有较好的应用前景。利用微型PIC~?单片机和增量式比例-微分-积分(PID)算法设计了一种CSAC微电子机械系统(MEMS)原子气室数字温控系统,并通过磁控溅射方法制作了MEMS原子气室专用的氧化铟锡(I... 详细信息

芯片原子钟(CSAC)可以提供精准的时间基准,具有较好的应用前景。利用微型PIC~?单片机和增量式比例-微分-积分(PID)算法设计了一种CSAC微电子机械系统(MEMS)原子气室数字温控系统,并通过磁控溅射方法制作了MEMS原子气室专用的氧化铟锡(ITO)加热玻璃。温度是影响CSAC稳定度的一个重要因素,解决了CSAC系统气室温控的加热不均匀问题,温控精度达到了0.10℃,达到了CSAC温控精度优于0.15℃的要求。通过饱和吸收光谱实验,获得了明显的饱和吸收谱线。实验结果为高性能CSAC的研究提供了参考。

关键词：芯片原子钟(CSAC) 数字温控饱和吸收微电子机械系统(MEMS)原子气室氧化铟锡(ITO)加热玻璃

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热带海洋大气环境下道岔扣件关键零部件锈蚀机理研究

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高速铁路新材料 2025年第1期4卷 7-13页

作者：徐超王晨阳胡莲俊刘甜甜王玉婷张倩孙旭文冯博宇杨其全中国铁道科学研究院集团有限公司金属及化学研究所北京100081 海南铁路有限公司海口综合维修段海口570300 北京中铁科新材料技术有限公司北京100081

为分析热带海洋气候下道岔弹条和T型螺栓的锈蚀机理及影响因素,对海南岛某高铁线路上现场抽取的锈蚀扣件进行了宏观形貌观察,光学显微镜和扫描电子显微镜微观组织、锈蚀层的化学成分能谱和XRD物相检测分析。结果表明:高湿热、高盐雾气... 详细信息

为分析热带海洋气候下道岔弹条和T型螺栓的锈蚀机理及影响因素,对海南岛某高铁线路上现场抽取的锈蚀扣件进行了宏观形貌观察,光学显微镜和扫描电子显微镜微观组织、锈蚀层的化学成分能谱和XRD物相检测分析。结果表明:高湿热、高盐雾气候条件与微动磨损致防锈涂层脱落、缝隙腐蚀等服役条件综合作用于扣件表面,使某些部位发生了较快的电化学腐蚀,生成α-FeOOH、γ-FeOOH和Fe_(3)O_(4)等锈蚀产物,锈层为存在孔洞和缝隙的疏松组织,难以为基体提供有效保护。对于已经没有有效防腐涂层的服役扣件,应及时替换为具有更强结合力及抗腐蚀性能的涂覆工艺的扣件;在铁路巡检中应对扣件朝向地面及与垫板接触的隐蔽位置进行重点观测。

关键词：弹条 T型螺栓锈蚀机理影响因素热带海洋气候

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Development of a Cell-Based High-Throughput Screening Assay to Identify Porcine Host Defense Peptide-Inducing Compounds

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JOURNAL OF IMMUNOLOGY RESEARCH 2018年第1期2018卷 1-13页

作者： Deng, Zhuo Wang, Jing Lyu, Wentao Wieneke, xuwen Matts, Robert Ma, Xi zhang, Guolong Oklahoma State Univ Dept Anim & Food Sci Stillwater OK 74078 USA Beijing Acad Agr & Forestry Sci Inst Anim Husb & Vet Med Beijing 100097 Peoples R China Oklahoma State Univ Dept Biochem & Mol Biol Stillwater OK 74078 USA China Agr Univ State Key Lab Anim Nutr Beijing 100193 Peoples R China Oklahoma State Univ Ctr Vet Hlth Sci Dept Physiol Sci Stillwater OK 74078 USA

Novel alternatives to antibiotics are needed for the swine industry, given increasing restrictions on subtherapeutic use of antibiotics. Augmenting the synthesis of endogenous host defense peptides (HDPs) has emerged as a promising antibiotic-alternative approach to disease control and prevention. To facilitate the identification of HDP inducers for swine use, we developed a stable luciferase reporter cell line, IPEC-J2/PBD3-luc, through permanent integration of a luciferase reporter gene driven by a 1.1 kb porcine beta-defensin 3 (PBD3) gene promoter in porcine IPEC-J2 intestinal epithelial cells. Such a stable reporter cell line was employed in a high-throughput screening of 148 epigenetic compounds and 584 natural products, resulting in the identification of 41 unique hits with a minimum strictly standardized mean difference (SSMD) value of 3.0. Among them, 13 compounds were further confirmed to give at least a 5-fold increase in the luciferase activity in the stable reporter cell line, with 12 being histone deacetylase (HDAC) inhibitors. Eight compounds were subsequently observed to be comparable to sodium butyrate in inducing PBD3 mRNA expression in parental IPEC-J2 cells in the low micromolar range. Six HDAC inhibitors including suberoylanilide hydroxamine (SAHA), HC toxin, apicidin, panobinostat, SB939, and LAQ824 were additionally found to be highly effective HDP inducers in a porcine 3D4/31 macrophage cell line. Besides PBD3, other HDP genes such as PBD2 and cathelicidins (PG1-5) were concentration-dependently induced by those compounds in both IPEC-J2 and 3D4/31 cells. Furthermore, the antibacterial activities of 3D4/31 cells were augmented following 24 h exposure to HDAC inhibitors. In conclusion, a cell-based high-throughput screening assay was developed for the discovery of porcine HDP inducers, and newly identified HDP-inducing compounds may have potential to be developed as alternatives to antibiotics for applications in swine and possibly other anima

关键词： ANTIBIOTICS PEPTIDES LUCIFERASES DEFENSINS EPITHELIAL cells HISTONE deacetylase inhibitors HIGH throughput screening (Drug development)

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改良Burks-Schaffer入路切开复位空心钉固定与关节镜下Endobutton带袢钢板固定治疗后交叉韧带胫骨止点撕脱骨折的疗效比较

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中华创伤骨科杂志 2019年第5期21卷 378-383页

作者：刘炜洁陈峰叶发刚戚超宫海峰张成栋王开钱源李绪文青岛大学附属医院创伤外科 266000

目的通过分析比较改良Burks-Schaffer入路切开复位空心钉固定与关节镜下Endobutton带袢钢板固定治疗后交叉韧带(PCL)胫骨止点撕脱骨折的临床疗效。方法回顾性分析2013年2月至2017年8月青岛大学附属医院创伤外科收治的41例PCL胫骨止点撕... 详细信息

目的通过分析比较改良Burks-Schaffer入路切开复位空心钉固定与关节镜下Endobutton带袢钢板固定治疗后交叉韧带(PCL)胫骨止点撕脱骨折的临床疗效。方法回顾性分析2013年2月至2017年8月青岛大学附属医院创伤外科收治的41例PCL胫骨止点撕脱骨折患者资料。男24例,女17例;年龄18~65岁,平均39岁;左膝22例,右膝19例;根据固定方式不同将患者分为2组:改良切开组23例(行改良Burks-Schaffer入路切开复位空心钉固定),关节镜组18例(行关节镜下Endobutton带袢钢板固定)。术后比较两组患者的手术时间、出血量、膝关节各项客观评分及膝关节活动度(ROM)等情况。结果41例患者术后获23~40个月(平均27.2个月)随访。所有患者均未出现切口感染、骨折畸形愈合或不愈合、固定装置松动等并发症。末次随访时膝关节X线片示撕脱骨折均已达到骨性愈合标准。改良切开组与关节镜组手术时间分别为(52.6±7.3)、(86.8±9.2)min,出血量分别为(63.9±12.7)、(19.7±10.2)mL,以上项目两组间比较差异均有统计学意义(P<0.05)。而两组患者在膝关节各项客观评分及ROM方面差异均无统计学意义(P>0.05)。结论改良Burks-Schaffer入路切开复位空心钉固定与关节镜下Endobutton带袢钢板固定治疗PCL胫骨止点撕脱骨折均能获得满意效果,后者出血少,但前者在手术时间方面更具优势。

关键词：膝关节关节镜检查骨折固定术,内后交叉韧带胫骨止点撕脱骨折改良Burks-Schaffer入路

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溶剂型氯丁橡胶胶粘剂研究进展

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材料开发与应用 2019年第5期34卷 83-87页

作者：李景瑞李煜张玲王绪文中国船舶重工集团公司第七二五研究所河南洛阳471023 河南省减振降噪材料工程技术中心河南洛阳471023

介绍了氯丁橡胶(CR)胶粘剂特点和溶剂型CR胶粘剂溶剂研究情况,并对溶剂型CR胶粘剂发展方向进行了展望。

关键词：氯丁橡胶胶粘剂混配型接枝型

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Correction: CEPC Technical Design Report: Accelerator

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Radiation Detection Technology and Methods 2024年第1期9卷 184-192页

作者： Abdallah, Waleed de Freitas, Tiago CarlosAdorno Afanaciev, Konstantin Ahmad, Shakeel Ahmed, Ijaz Ai, Xiaocong Aleem, Abid Altmannshofer, Wolfgang Alves, Fabio An, Weiming An, Rui Anderle, Daniele Paolo Antusch, Stefan Arai, Yasuo Arbuzov, Andrej Arhrib, Abdesslam Ashry, Mustafa Bai, Sha Bai, Yu Bai, Yang Bairathi, Vipul Balazs, Csaba Bambade, Philip Ban, Yong Bandyopadhyay, Triparno Bao, Shou-Shan Barber, Desmond P. Bat, Ays¸e Batozskaya, Varvara Behera, Subash Chandra Belyaev, Alexander Bertucci, Michele Bi, Xiao-Jun Bi, Yuanjie Bian, Tianjian Bianchi, Fabrizio Bieko¨tter, Thomas Biglietti, Michela Bilanishvili, Shalva Binglin, Deng Bodrov, Denis Bogomyagkov, Anton Bondarenko, Serge Boogert, Stewart Boonekamp, Maarten Borri, Marcello Bosotti, Angelo Boudry, Vincent Boukidi, Mohammed Boyko, Igor Bozovic, Ivanka Bozzi, Giuseppe Brient, Jean-Claude Budzinskaya, Anastasiia Bukhari, Masroor Bytev, Vladimir Cacciapaglia, Giacomo Cai, Hua Cai, Wenyong Cai, Wujun Cai, Yijian Cai, Yizhou Cai, Yuchen Cai, Haiying Cai, Huacheng Calibbi, Lorenzo Cang, Junsong Cao, Guofu Cao, Jianshe Chance, Antoine Chang, Xuejun Chang, Yue Chang, Zhe Chang, Xinyuan Chao, Wei Chatrabhuti, Auttakit Che, Yimin Che, Yuzhi Chen, Bin Chen, Danping Chen, Fuqing Chen, Fusan Chen, Gang Chen, Guoming Chen, Hua-Xing Chen, Huirun Chen, Jinhui Chen, Ji-Yuan Chen, Kai Chen, Mali Chen, Mingjun Chen, Mingshui Chen, Ning Chen, Shanhong Chen, Shanzhen Chen, Shao-Long Chen, Shaomin Chen, Shiqiang Chen, Tianlu Chen, Wei Chen, Xiang Chen, Xiaoyu Chen, Xin Chen, Xun Chen, Xurong Chen, Ye Chen, Ying Chen, Yukai Chen, Zelin Chen, Zilin Chen, Boping Chen, Chunhui Cheng, Hok Chuen Cheng, Huajie Cheng, Shan Cheng, Tongguang Chi, Yunlong Chimenti, Pietro Chiu, Wen Han Cho, Guk Chu, Ming-Chung Chu, Xiaotong Chu, Ziliang Coloretti, Guglielmo Crivellin, Andreas Cui, Hanhua Cui, Xiaohao Cui, Zhaoyuan D’Anzi, Brunella Dai, Ling-Yun Dai, Xinchen Dai, xuwen De Maria, Antonio De Filippis, Nicola De La Taille, Christophe De Mori, Francesca De Sio, Chiara Del Core, Elisa Deng, Cairo University Giza Egypt Xi’an Jiaotong-Liverpool University Suzhou China Institute of Power Engineering of National Academy of Sciences of Belarus Minsk Belarus Pakistan Institute of Nuclear Science and Technology (PINSTECH) Islamabad Pakistan Applied Physics Department Science and Technology Federal Urdu University of Arts Islamabad Pakistan Zhengzhou University Zhengzhou China Institute of High Energy Physics Chinese Academy of Sciences Beijing China University of California Santa Cruz Santa Cruz USA Nanjing University Nanjing China Beijing Normal University Beijing China Harvard University Cambridge USA South China Normal University Guangzhou China University of Basel Basel Switzerland High Energy Accelerator Research Organization (KEK) Tsukuba Japan Joint Institute for Nuclear Research Dubna Russia Faculty of Sciences and Techniques Université Abdelmalek Essaadi Tangier Morocco Southeast University Nanjing China Department of Physics University of Wisconsin–Madison Madison USA Instituto de Alta Investigación Universidad de Tarapacá Arica Chile Monash University Melbourne Australia Laboratoire de Physique des 2 infinis Irène Joliot-Curie – IJCLab Orsay France Peking University Beijing China Department of Physics and Nanotechnology SRM Institute of Science and Technology Kattankulathur India Shandong University Jinan China University of New Mexico Albuquerque USA Bandirma Onyedi Eylul University Bandırma Turkey National Centre for Nuclear Research Warsaw Poland Indian Institute of Technology Madras (IN) Chennai India University of Southampton Southampton UK INFN Milano - LASA Segrate Italy Sun Yat-Sen University Guangzhou China China Institute of Atomic Energy Beijing China INFN-University of Torino Turin Italy Karlsruhe Institute of Technology Institute for Theoretical Physics Karlsruhe Germany INFN-Sezione di Roma Tre Rome Italy Kutaisi International University Kutaisi Georgia Soochow University Suzhou China Budker Institute

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Chemical compositions of mussels and clams from the Tangyin and Yonaguni Knoll IV hydrothermal fields in the southwestern Okinawa Trough

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ORE GEOLOGY REVIEWS 2017年 87卷 172-191页

作者： Zeng, Zhigang Chen, Shuai Ma, Yao Yin, Xuebo Wang, Xiaoyuan zhang, Suping zhang, Junlong Wu, xuwen Li, Yang Dong, Dong Xiao, Ning Chinese Acad Sci Inst Oceanol Key Lab Marine Geol & Environm Seafloor Hydrothermal Act Lab 7 Nanhai Rd Qingdao 266071 Peoples R China Qingdao Natl Lab Marine Sci & Technol Lab Marine Mineral Resources Qingdao 266071 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China Qingdao Collaborat Innovat Ctr Marine Sci & Techn Qingdao 266061 Peoples R China Chinese Acad Sci Inst Oceanol Marine Biol Museum Qingdao 266071 Peoples R China

Studies of the chemical characteristics of mussels and clams in seafloor hydrothermal fields are important for understanding mass fluxes and elemental partitioning from hydrothermal vents into the biosphere, metal bioaccumulation of seafloor hydrothermal ecosystems, and the sources and sinks of biogeochemical and fluid cycles. We are the first to measure the mineral, major, trace and rare earth element, and carbon and oxygen isotope compositions of mussels (Bathymodiolus platifrons) and clams (Conchocele bisecta) from the Tangyin and Yonaguni Knoll IV hydrothermal fields in the southwestern Okinawa Trough. Mineralogical analysis shows that the carbonate shells of the mussel and clam samples are mainly composed of calcite and aragonite. Metal elements exhibit linear correlations in the shells (e.g., V and U) and tissues (e.g., Li and Rb) of the mussels and clams, suggesting that not all positive correlations of elements in tissues are inherited by the shells. V/As, Ca/Sr, and Fe/Cr ratios in the mussels and clams are close to those in the seawater, indicating that element ratios of seawater might be inherited by the mussels and clams. In addition, the Fe/Cr ratio of the shells of both mussels and clams can be used to trace the local seawater composition. The total LREE concentrations of mussel and clam tissue samples are higher than those of the mussel and clam shell samples, are similar to the hydrothermal fluids, exhibit LREE enrichment (La-CN/Nd-CN ratios = 1.86-32.1), and no or only slightly negative Eu anomalies, indicating that benthic animals are a sink of LREEs from hydrothermal fluids, and that the Eu/Eu* ratios of fluids change when fluids are incorporated into the tissues of the mussels and clams. In addition, the delta C-13 values of mussel shell samples are heavier than those of the clam shell samples in the hydrothermal field, indicating that more than one carbon source may be involved in defining the delta C-13 compositions of the shells. The majority

关键词： Mussel Clam C hemical composition Tangyin and Yonaguni Knoll IV hydrothermal fields

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Enhanced soluble production of cholera toxin B subunit in Escherichia coil by co-expression of SKP chaperones

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PROTEIN EXPRESSION AND PURIFICATION 2017年 138卷 1-6页

作者： zhang, Yuanpeng Qiao, xuwen Yu, Xiaoming Chen, Jin Hou, Liting Bi, Zhixiang Zheng, Qisheng Hou, Jibo Jiangsu Acad Agr Sci Natl Res Ctr Engn & Technol Vet Biol 50 Zhong Ling St Nanjing 210014 Jiangsu Peoples R China Jiangsu Co Innovat Ctr Prevent & Control Importan Nanjing Jiangsu Peoples R China

The cholera toxin B subunit (CTB) is a nontoxic portion of the cholera toxin that retains mucosal adjuvant properties. Expression of CTB in Escherichia coli is difficult as CTB aggregates and accumulates as insoluble inclusion bodies. To remedy this problem, the periplasmic chaperone, SKP, was investigated as possible co-expression partner to increase the solubility of recombinant CTB (rCTB) in E. coil. The result showed co-expression of SKP enhanced the soluble expression of rCTB in E. coli. Moreover, soluble rCTB was successfully expressed and secreted into the periplasmic space through the direction of the LTB leader signal. rCTB in periplasm was purified using an immobilized D-galactose resin;GM1-ELISA ex-periments showed that rCTB retains strong GM1 ganglioside-binding activity. Intranasal administration of ovalbumin (OVA) with rCTB significantly induced both mucosal and humoral immune responses specific to OVA. These data indicate that co-expression of the molecular chaperone SKP with CTB increased the solubility of rCTB while maintaining its function. (c) 2017 Elsevier Inc. All rights reserved.

关键词： Recombinant cholera toxin B subunit SKP Chaperones Co-expression

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煤矿矿井水资源化综合利用体系与技术创新

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煤炭科学技术 2018年第9期46卷 4-11页

作者：何绪文张晓航李福勤张春晖中国矿业大学(北京)化学与环境工程学院北京100083 河北工程大学能源与环境工程学院河北邯郸056038

为了更好地指导煤矿矿井水处理的工程实践,以"两山论"、"生命共同体"、"治水十六字方针"等新理念为指导,总结了分质供水梯级利用、井下处理就地复用、高品质按需供水以及零排放4种矿井水资源化利用的新模... 详细信息

为了更好地指导煤矿矿井水处理的工程实践,以"两山论"、"生命共同体"、"治水十六字方针"等新理念为指导,总结了分质供水梯级利用、井下处理就地复用、高品质按需供水以及零排放4种矿井水资源化利用的新模式;介绍了矿井水资源化生态化利用技术体系、酸性矿井水处理技术、相互冲洗滤池、溶解性总固体TDS处理工艺中反渗透RO浓水利用技术以及人工湿地与生态塘等矿井水资源化利用的新技术;指出了现有矿井水处理技术中存在涌水量预测不精准、井下高效处理设备参数与"三化"研发不足,以及含特殊污染物矿井水处理领域成套可行性技术较少等短板,并提出涌水量要从开发准确有效,具有动态性、综合性的预测方法来考虑;井下高效处理设备要注重相关工艺设备参数、运行参数与工艺控制条件等基础数据的积累,并加强矿井水处理设备的"三化"研发与相关标准的订立;含特殊污染物矿井水处理要协调好不同矿区、不同矿井及时间尺度上的共性与个性的统一问题,在相关领域加强研究与应用,以形成最佳可行技术。

关键词：矿井水分质利用水资源涌水量预测

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Tree diversity promotes generalist herbivore community patterns in a young subtropical forest experiment

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OECOLOGIA 2017年第2期183卷 455-467页

作者： zhang, Jiayong Bruelheide, Helge Chen, Xufei Eichenberg, David Kroeber, Wenzel Xu, xuwen Xu, Liting Schuldt, Andreas Zhejiang Normal Univ Inst Ecol Jinhua 321004 Peoples R China Martin Luther Univ Halle Wittenberg Inst Biol Geobot & Bot Garden Kirchtor 1 D-06108 Halle Germany German Ctr Integrat Biodivers Res iDiv Deutsch Pl 5e Deutsch Pl 5e D-04103 Leipzig Germany Leuphana Univ Luneburg Inst Ecol Scharnhorststr 1 D-21335 Luneburg Germany

Stand diversification is considered a promising management approach to increasing the multifunctionality and ecological stability of forests. However, how tree diversity affects higher trophic levels and their role in regulating forest functioning is not well explored particularly for (sub)tropical regions. We analyzed the effects of tree species richness, community composition, and functional diversity on the abundance, species richness, and beta diversity of important functional groups of herbivores and predators in a large-scale forest biodiversity experiment in south-east China. Tree species richness promoted the abundance, but not the species richness, of the dominant, generalist herbivores (especially, adult leaf chewers), probably through diet mixing effects. In contrast, tree richness did not affect the abundance of more specialized herbivores (larval leaf chewers, sap suckers) or predators (web and hunting spiders), and only increased the species richness of larval chewers. Leaf chemical diversity was unrelated to the arthropod data, and leaf morphological diversity only positively affected oligophagous herbivore and hunting spider abundance. However, richness and abundance of all arthropods showed relationships with community-weighted leaf trait means (CWM). The effects of trait diversity and CWMs probably reflect specific nutritional or habitat requirements. This is supported by the strong effects of tree species composition and CWMs on herbivore and spider beta diversity. Although specialized herbivores are generally assumed to determine herbivore effects in species-rich forests, our study suggests that generalist herbivores can be crucial for trophic interactions. Our results indicate that promoting pest control through stand diversification might require a stronger focus on identifying the best-performing tree species mixtures.

关键词： Biodiversity and ecosystem function Host specialization Plant species richness Sustainable forest management Trophic interactions

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