Provided are a series of BTK inhibitors, and specifically disclosed are a compound, pharmaceutically acceptable salt thereof, tautomer thereof or prodrug thereof represented by formula (I), (II), (III) or (IV).
标准号:
US2017313683(A1)
Provided are a series of BTK inhibitors, and specifically disclosed are a compound, pharmaceutically acceptable salt thereof, tautomer thereof or prodrug thereof represented by formula (I), (II), (III) or (IV).
Vitamin D supplementation is regarded as a novel approach to treat Alzheimer's disease, but the underlying mechanism remains elusive. The cytokine IL-34 provides strong neuroprotective and survival signals in brai...
详细信息
Vitamin D supplementation is regarded as a novel approach to treat Alzheimer's disease, but the underlying mechanism remains elusive. The cytokine IL-34 provides strong neuroprotective and survival signals in brain injury and neurodegeneration and could be an immunological mediator for the vitamin D-induced protection. The aim of this study was to investigate whether human IL-34 is up-regulated in neuronal cells by the hormonally active form of vitamin D, 1,25-dihydroxyvitamin D3 [1,25(OH)(2)D-3]. We found that IL-34 was detectable in a variety of cell lines and its expression was strongly induced in SH-SY5Y neural cells in a dose- and time-dependent manner by 1,25(OH)(2)D-3 through the vitamin D receptor (VDR). Furthermore, we identified the core promoter of IL-34 gene and a VDR binding site (CGCCCT) that was required for 1,25(OH)(2)D-3-induced IL-34 expression. These findings suggest that the induction of IL-34 expression by 1,25(OH)(2)D-3 may constitute a mechanism that explains the protective function of vitamin D in Alzheimer's disease.
In this letter, we investigate the problem of feedforward timing estimation for burst-mode satellite communications. By analyzing the correlation property of frame header (FH) acquisition in the presence of sampling o...
详细信息
In this letter, we investigate the problem of feedforward timing estimation for burst-mode satellite communications. By analyzing the correlation property of frame header (FH) acquisition in the presence of sampling offset, a novel data-aided feedforward timing estimator that utilizes the correlation peaks for interpolating the fractional timing offset is proposed. Numerical results show that even under low signal-to-noise ratio (SNR) and small rolloff factor conditions, the proposed estimator can approach the modified Cramer-Rao bound (MCRB) closely. Furthermore, this estimator only requires two samples per symbol and can be implemented with low complexity with respect to conventional data-aided estimators.
暂无评论