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Improving the stability of wheat gliadin nanoparticles - Effect of gum arabic addition

FOOD HYDROCOLLOIDS 2018年 80卷 78-87页

作者： Wu, Weihao Kong, Xiangzhen Zhang, Caimeng Hua, Yufei Chen, Yeming Jiangnan Univ Sch Food Sci & Technol State Key Lab Food Sci & Technol 1800 Lihu Ave Wuxi 214122 Jiangsu Peoples R China

Wheat gliadin nanoparticles were prepared by antisolvent precipitation, and gum arabic (GA) was added to improve the stability of the nanoparticles. Effect of pH, gliadin/GA ratio and gliadin concentration on the gliadin-GA particles were studied by turbidimetric measurement. Spinodal lines for the GA-gliadin-solvent system were built under different pH. The influences of gliadin/GA ratio and their concentrations were represented in the diagram, thus the conditions for preparing stable composite were defined. The stability of GA-coated gliadin nanoparticles (Gliadin/GA = 1:3) was further studied compared with un-coated gliadin particles. GA-coated nanoparticles had a relatively good stability at pH 4.0-7.0 and remained a relatively low particle size with the elevated ionic strengths. They also had good thermal stability at 80 degrees C. Moreover, the interactions between gliadin particles and GA under different pH were further investigated. Hydrogen bonding was found to be the predominant force at pH 5.0, while hydrophobic force took charge of the formation of complex at pH 7.0. The findings are of great importance for extending the current knowledge about gliadin nanoparticles coupled with polysaccharides, thus providing valuable information for the development of gliadin-polysaccharide nanoparticles as potential nano-delivery systems. (C) 2018 Elsevier Ltd. All rights reserved.

关键词： Gliadin Gum arabic Nanoparticles Stability

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Power allocation in small cell networks with full-duplex self-backhauls and massive MIMO

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WIRELESS NETWORKS 2018年第4期24卷 1083-1098页

作者： Chen, Lei Yu, F. Richard Ji, Hong Rong, Bo Leung, Victor C. M. Beijing Univ Posts & Telecommun Key Lab Universal Wireless Commun Beijing Peoples R China Carleton Univ Dept Syst & Comp Engn Ottawa ON Canada Commun Res Ctr Ottawa ON Canada Univ British Columbia Dept Elect & Comp Engn Vancouver BC Canada

With the dense deployment of small cell networks, low-cost backhaul schemes for small cell base stations (SBSs) have attracted great attentions. Self-backhaul using cellular communication technology is considered as a promising solution. Although some excellent works have been done on self-backhaul in small cell networks, most of them do not consider the recent advances of full-duplex (FD) and massive multiple-input and multiple-output (MIMO) technologies. In this paper, we propose a self-backhaul scheme for small cell networks by combining FD and massive MIMO technologies. In our proposed scheme, the macro base station (MBS) is equipped with massive MIMO antennas, and the SBSs have the FD communication ability. By treating the SBSs as special macro users, we can achieve the simultaneous transmissions of the access link of users and the backhaul link of SBSs in the same frequency. Furthermore, considering the existence of inter-tier and intra-tier interference, we formulate the power allocation problem of the MBS and SBSs as an optimization problem. Because the formulated power allocation problem is a non-convex problem, we transform the original problem into a difference of convex program by successive convex approximation method and variable transformation, and then solve it using a constrained concave convex procedure based iterative algorithm. Finally, extensive simulations are conducted with different system configurations to verify the effectiveness of the proposed scheme.

关键词： Small cell networks Self-backhaul Full duplex Massive MIMO

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Physiological cyclic stretch up-regulates angiotensin-converting enzyme 2 expression to reduce proliferation and migration of vascular smooth muscle cells

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BIOSCIENCE REPORTS 2020年第6期40卷 BSR20192012页

作者： Song, Jiantao Qu, Haiyan Hu, Bo Bi, Chenglong Li, Mengmeng Wang, Lin Huang, Xiaozhen Zhang, Mei Shandong First Med Univ Shandong Prov Hosp Dept Emergency Jinan Peoples R China Chinese Natl Hlth Commiss Chinese Minist Educ Key Lab Cardiovasc Remodeling & Funct Res 107 Wenhuaxi Rd Jinan 250012 Peoples R China Chinese Acad Med Sci State & Shandong Prov Joint Key Lab Translat Card Qilu Hosp Shandong Univ 107 Wenhuaxi Rd Jinan 250012 Peoples R China Shandong First Med Univ Affiliated Hosp 1 Dept Cardiol Jinan Peoples R China

Angiotensin-converting enzyme 2 (ACE2) is considered as an endogenous negative regulator of renin-angiotensin system (RAS), exerting multiple cardiovascular protective roles. Whether mechanical stretch modulates ACE2 expression remains unknown. The present study aimed at investigating whether ACE2 is involved in physiological stretch (10% elongation, 1 Hz) mediated cellular functions and the underlying mechanism. Cultured human aortic smooth muscle cells (HASMCs) were exposed to 10% stretch for indicated time, and real-time PCR and Western blot analysis showed 10% stretch increased ACE2 expression and activity significantly compared with static conditions and increased Ang-(1-7) level, but decreased Ang II level;Brdu incorporation assay and Scratch test showed that ACE2 was involved in the inhibition of HASMCs proliferation and migration by 10% stretch;the Dual-Luciferase Reporter Assay demonstrated that 10% increased ACE2 promoter activity, but had no effect on ACE2 mRNA stability;kinase inhibition study and Electrophoretic mobility shift assay (EMSA) showed that JNK1/2 and PKC beta II pathway, as well as their downstream transcription factors, AP-1 and NF-kappa B, were involved in 10% stretch induced ACE2 expression. In conclusion, our study indicates ACE2 is a mechanosensitive gene, and may represent a potential therapeutic target for mechanical forces related vascular diseases.

关键词： ACE2 HASMCs cyclic stretch migration proliferation

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On the method of multidimensional Q-factor and velocity inversion with VSP data 83

On the method of multidimensional Q-factor and velocity inve...

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Society of Exploration Geophysicists International Exposition and 83rd Annual Meeting: Expanding Geophysical Frontiers, SEG 2013

作者： Zhao, Jing Gao, Jinghuai Li, Qiang Institute of Wave and Information Xi'an Jiaotong University National Engineering Laboratory for Offshore Oil Exploration Xi'an710049 China

ISBN: (纸本)9781629931883

Based on the theory of one-way wave propagation in a 1-D viscoelastic medium, we propose an inversion method to estimate the Q-factor and velocity using the Gauss-Newton method. To speed up the computation, we derive an analytic expression of the Jacobi matrix. As the forward simulation is one of the base steps of the inversion problem, we derived the transfer matrix to simulate the forward model with direct downgoing wave and primary reflection (upgoing wave) of zero-offset VSP data. We give the workflow of both the forward and inversion method, and discuss the optimum initial value determination. Test on synthetic VSP data shows that the proposed method doesn't need a priori information of interfaces positions and can eliminates the influence of upgoing wave at the interfaces. By applying to field VSP data, we obtained Q and velocity curves which have almost the same distribution as that obtained from a known well. It's a powerful tool to predict potential high productivity gas well. © 2013 SEG SEG Houston 2013 Annual Meeting.

关键词： Wave propagation

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Genetic and population analyses of Vibrio parahaemolyticus isolates from three major coastal regions in china

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FUTURE MICROBIOLOGY 2018年第11期13卷 1261-1269页

作者： Li, Ping Xin, Wenwen Kang, Lin Chen, Zhongwen Guo, Chenyi Gao, Shan Yang, Hao Ji, Bin Yan, Yong Wang, Henghui Zhou, Dongsheng Yang, Wenhui Wang, Jinglin Jiaxing Ctr Dis Control & Prevent Jiaxing Key Lab Pathogen Microbiol Jiaxing 314050 Peoples R China Anhui Med Univ Grad Coll Hefei 230032 Anhui Peoples R China Beijing Inst Microbiol & Epidemiol State Key Lab Pathogen & Biosecur Beijing 100071 Peoples R China

Aim: This study aims to evaluate the genetic and population structure of Vibrio parahaemolyticus in the major coastal regions of china. Materials & methods: Multilocus sequence typing was performed. Results: Insertion of large sequence into recA happened in nearly 30 strains, which were untypeable by multilocus sequence typing. A collection of 307V. parahaemolyticus isolates were typed into 160 sequence types, including 117 novel ones. eBURST analysis revealed five clonal complexes, 11 doublets, and 108 singletons. The 160 sequence types formed two main lineages in the phylogenetic analysis. Conclusion:V. parahaemolyticus along the Chinese coastal regions exhibits high levels of genetic diversity and has undergone significant purifying selection and frequent recombination. A deeper understanding of V. parahaemolyticus genetic diversity could be obtained at the level of genome sequences.

关键词： china genetic diversity MLST population structure Vibrio parahaemolyticus

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Novel 7-formyl-naphthyridyl-ureas derivatives as potential selective FGFR4 inhibitors: Design, synthesis, and biological activity studies

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BIOORGANIC & MEDICINAL CHEMISTRY 2019年第10期27卷 1932-1941页

作者： Sun, Chang'an Fang, Lei Zhang, Xiaobing Gao, Peng Gou, Shaohua Southeast Univ Jiangsu Prov Hitech Key Lab Biomed Res Nanjing 211189 Jiangsu Peoples R China Southeast Univ Sch Chem & Chem Engn Nanjing 211189 Jiangsu Peoples R China Guangxi Normal Univ State Key Lab Chem & Mol Engn Med Resources Guilin 541004 Peoples R China Jiangsu Hansoh Pharmaceut Grp CO LTD Lianyungang 222000 Peoples R China

Total twenty-five 7-formyl-naphthyridyl-urea derivatives were designed, synthesized and evaluated for their inhibition of FGFR4 kinase and antitumor activity. The pharmacological data indicated that most of the tested compounds showed high selectivity towards FGFR4 kinase and could significantly inhibit FGFR4 and the tumor cells lines with the high expression of FGFR4. In particular, compounds 6f, 6g, 6h, 6l, 6m and 6s showed a good performance in pharmacokinetic tests. When tested in mice, the representative compound 6f was found to have good pharmacokinetic parameters, low toxicity, and better tumor inhibiting activity in vivo.

关键词： FGFR4 Selectivity Antitumor Pharmacokinetic profile

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Effect of high-speed shearing treatment on dehulled walnut proteins

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LWT-FOOD SCIENCE AND techNOLOGY 2019年 116卷

作者： Kong, Xiangzhen Zhang, Lina Lu, Xu Zhang, Caimeng Hua, Yufei Chen, Yeming Jiangnan Univ Sch Food Sci & Technol State Key Lab Food Sci & Technol Wuxi Jiangsu Peoples R China

To understand more clearly about true characteristics of walnut protein, dehulled walnut kernels were used to prepare proteins, thus influences of polyphenols on proteins were minimized. Based on solubility, glutelin was found to be the predominant walnut protein (67.64% of total walnut proteins), meanwhile albumin and globulin accounted for 32.29%. SDS-PAGE and two-dimensional electrophoresis results showed that polypeptide profiles for albumin, globulin and glutelin exhibited significant differences. Walnut protein contained major polypeptides of MWs 30-35 kDa (pI 5.5-7.5) and 17-22 kDa (pI 9.0-10.0), along with minor polypeptides of MWs 50-73 kDa (pI 6.0-7.5) and 11-13 kDa (pI about 6.3). Disulfide bonds-linked polypeptides in walnut protein were determined with diagonal electrophoresis, and intermolecular disulfide bonds among polypeptides with MWs 30-34 kDa and 17-22 kDa were dominant. Further analysis by MALDI-TOF/TOF-MS showed that main components of walnut proteins were vicilin and legumin-like proteins. Through high-speed shearing (15,000 rpm) treatment at 60 degrees C for 5 min, walnut protein solubility were greatly increased from 24.33% to 62.81% at pH 8.0 and from 50.93% to 76.65% at pH 9.0. high-speed shearing treatment, especially at basic pH, could be a better way to improve protein solubility, with decreased particle sizes and more globulin and glutelin solubilized.

关键词： Walnut protein Electrophoresis high-speed shearing Solubility Structure

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A silver catalyzed domino reaction of N-cyanamide alkenes and 1,3-dicarbonyls for the synthesis of quinazolinones

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ORGANIC & BIOMOLECULAR CHEMISTRY 2018年第32期16卷 5899-5906页

作者： Xu, Gang Tong, Chaodi Cui, Sunliang Dai, Liyan Zhejiang Univ Coll Chem & Biol Engn Hangzhou 310027 Zhejiang Peoples R China Zhejiang Univ Coll Pharmaceut Sci Inst Drug Discovery & Design Hangzhou 310058 Zhejiang Peoples R China

A silver catalyzed domino reaction of N-cyanamide alkenes and 1,3-dicarbonyls including 1,3-diketones and ethyl acetoacetate has been developed for the facile synthesis of quinazolinones. In the presence of AgNO3/K2S2O8, the diketones could be converted to radicals and coupled with N-cyanamide alkenes to undergo a cyclization cascade for accessing quinazolinones. This method features mild reaction conditions, readily available starting materials, and valuable synthetic utility. Moreover, the products could be further transformed into various heterocycles.

关键词： Hydrocarbons

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Photon efficiency of computational ghost aging with single-photon detection

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JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION 2018年第10期35卷 1741-1748页

作者： Liu, Xialin Sun, Yiwei Shi, Jianhong Zeng, Guihua Shanghai Jiao Tong Univ State Key Lab Adv Opt Commun Syst & Networks Shanghai 200240 Peoples R China Shanghai Jiao Tong Univ Ctr Quantum Sensing & Informat Proc QSIP Shanghai 200240 Peoples R China

Photon-limited imaging has significant application under extreme environments, in which the photon efficiency is an important parameter. In this paper, we investigate the photon efficiency of computational ghost imaging with single-photon detection. By exploiting the Poisson statistical characteristics of single-photon counting, the relationships between the photon efficiency and the signal-to-noise ratio of the retrieved image are theoretically obtained, and both are closely related to the distribution characteristics of target and spatial modulation in the ghost imaging framework. To verify the availability of the built theoretical model for the photon efficiency, a specific computational ghost imaging with a binary object and the first-photon imaging algorithm is rigorously demonstrated in theory and in experiment. Our investigation paves the way for optimization of photon-limited ghost imaging. (C) 2018 Optical Society of America

关键词： Computational imaging Ghost imaging Image quality Imaging systems Imaging techniques Low light level techniques

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Photon-limited face image super-resolution based on deep learning

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OPTICS EXPRESS 2018年第18期26卷 22773-22782页

作者： Niu, Zhouzhou Shi, Jianhong Sun, Lei Zhu, Yan Fan, Jianping Zeng, Guihua Shanghai Jiao Tong Univ Ctr Quantum Sensing & Informat Proc State Key Lab Adv Opt Commun Syst & Networks Shanghai 200240 Peoples R China Univ North Carolina Charlotte Dept Comp Sci Charlotte NC 28223 USA

With one single photon camera (SPC), imaging under ultra weak-lighting conditions may have wide-ranging applications ranging from remote sensing to night vision, but it may seriously suffer from the problem of under-sampled inherent in SPC detection. Some approaches have been proposed to solve the under-sampled problem by detecting the objects many times to generate high-resolution images and performing noise reduction to suppress the Poission noise inherent in low-flux operation. To address the under-sampled problem more effectively, a new approach is developed in this paper to reconstruct high-resolution images with lower-noise by seamlessly integrating low-light-level imaging with deep learning. In our new approach, all the objects are detected only once by SPC, where a deep network is learned to reduce noise and reconstruct high-resolution images from the detected noisy under-sampled images. In order to demonstrate our proposal is feasible, we first select a special category to verify by experiment, which are human faces. Such deep network is able to recover high-resolution and lower-noise face images from new noisy under-sampled face images and the resolution can achieve 4x up-scaling factor. Our experimental results have demonstrated that our proposed method can generate high-quality images from only similar to 0.2 detected signal photon per pixel. (C) 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

关键词： Image processing Image quality Imaging noise Imaging systems Imaging techniques Noise reduction

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