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high-frequency rTMS treatment increases left prefrontal myo-inositol in young patients with treatment-resistant depression

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PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYChiATRY 2010年第7期34卷 1189-1195页

作者： Zheng, Huirong Zhang, Li Li, Lingjiang Liu, Peng Gao, Junling Liu, Xiaoyun Zou, Juan Zhang, Yan Liu, Jun Zhang, Zhijun Li, Zexuan Men, Weiwei Cent South Univ Xiangya Hosp 2 Mental Hlth Inst Changsha 410011 Hunan Peoples R China Hunan Gen Hosp Dept Radiol Changsha Hunan Peoples R China Cent South Univ Xiangya Hosp 2 Dept Radiol Changsha 410011 Hunan Peoples R China Chinese Univ Hong Kong Hong Kong Hong Kong Peoples R China Univ Hong Kong Div Neurol Dept Med Hong Kong Hong Kong Peoples R China Southeast Univ Dept Neuropsychiat Affiliated ZhongDa Hosp Nanjing Peoples R China Southeast Univ Inst Neuropsychiat Res Affiliated ZhongDa Hosp Nanjing Peoples R China Xinjiang Normal Univ Coll Math Phys & Informat Sci Urumqi Peoples R China

Background. Neuroimaging studies suggest that the prefrontal coltex (PFC) is involved in the pathophysiology of major depression Repetitive transcranial magnetic stimulation (rTMS) as an antidepressant intervention has increasingly been investigated in the last two decades In this study metabolic changes within PFC of severely depressed patients before and after rTMS were evaluated by proton magnetic resonance spectroscopy (1H-MRS) Method Thirty-four young depressed patients with treatment-resistant unipolar depression were enrolled in a double-blind, randomized study active ((n = 19) vs sham(n = 15)). and the PFC was investigated before and after high-frequency (15 Hz) rTMS using 3-tesla proton magnetic resonance spectroscopy Response was defined as a 50% reduction of the Hamilton depression rating scale. The results were compared with 28 age- and gender-matched healthy controls. Results In depressive patients a significant reduction in myo-inositol (m-Ino) was observed pre-rTMS (p<0.001) After successful treatment, m-Ino increased significantly in left PFC and the levels no longer differed from those of age-matched controls In addition to a positive correlation between clinical improvement and an increment in m-Ino ratio, a correlation between clinical improvement and early age onset was observed Conclusions. Our results support the notion that major depressive disorder is accompanied by state-dependent metabolic alterations, especially in myo-inositol metabolism, which can be partly reversed by successful rTMS. (C) 2010 Elsevier Inc All rights reserved.

关键词： Depression Magnetic resonance spectroscopy Myo-inositol rTMS

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Seismic facies response of tectonics and direction of block movement in the northeastern South china Sea

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Applied Geophysics 2010年第4期7卷 306-314,399页

作者：陈洁钟广见刘少华广州海洋地质调查局广州510760 中科院地质地球物理所北京100029

The close relationship between the structure,evolution,and resources environment of the South china Sea is a current research focus and also a focal point of our *** this paper,we use regional seismic sections to analyze the relationship between seismic facies and the structure and tectonic evolution of the northeastern South china Sea and propose new points about the structure and the direction of block（land mass） ***,the tectonic features are clear and can be divided into five different structural units which are both linked and independent of each ***,it doesn＇t matter if the South china Sea basin pattern is extensional,weakly compressive,or strongly compressive,the regional tectonic stress field is *** the first time we find that two shallow subduction zones are recognized in the seismic *** the tectonic blocks have accordion-fold-style structures,converging in the east,and the South china Sea exhibits different stages of basin development：growth, maturity,end,and *** block subduction and regional block dip directions are all aligned with the regional stress field.

关键词： Sea-floor spreading SCS shallow subduction one way drifting extrusion metamorphism accordion-style seismic facies

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Game-theoretic spectrum sharing for cognitive radio based on the expectation of primary users

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The Journal of china Universities of Posts and Telecommunications 2010年第3期17卷 6-12页

作者： MA Liang ZHU Qi Jiangsu Key Laboratory of Wireless Communications Nanjing University of Posts and Telecommunications Nanjing 210003 China National Mobile Communications Research Laboratory Southeast University Nanjing 210003 China

Cognitive radio is a new intelligent wireless communication technique for remedying the shortage of spectrum resource in recent years. Secondary users have to pay when they share available spectrum with primary users while price is an important factor in the spectrum allocation. Based on the game theory, an improved pricing function is proposed by considering the expectation of primary users. In this article, expectation represents the positivity of sharing spectrum with primary users. By introducing the positivity, price not only becomes different for different secondary users, but also can be adjusted according to the positivity. It is proved that the Nash Equilibrium of the new utility function exists. The simulation results show that spectrum sharing can not only be determined by the channel quality of secondary users, but also can be adapted according to the expectation of primary users. Besides, the proposed algorithm improves the fairness of sharing.

关键词： cognitive radio game theory spectrum allocation pricing function

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The cotton dehydration-responsive element binding protein GhDBP1 contains an EAR-motif and is involved in the defense response of Arabidopsis to salinity stress

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FUNCTIONAL PLANT BIOLOGY 2010年第1期37卷 64-73页

作者： Dong, Chun-Juan Huang, Bo Liu, Jin-Yuan Tsinghua Univ Lab Mol Biol & MOE Lab Prot Sci Dept Biol Sci & Biotechnol Beijing 100084 Peoples R China

Our previous work reported that cotton dehydration-responsive element (DRE) binding protein 1 (GhDBP1) could function as an active transcriptional repressor for DRE-mediated gene expression. However, the repression mechanism utilised by GhDBP1 was unclear. In this report, we demonstrate that GhDBP1's transcriptional repression domain is located at the C-terminus, and is known as an ERF-associated amphiphilic repression (EAR)-motif. Furthermore, the amino acid residues aspartic acid (D), leucine (L), asparagine (N) and proline (P) are conserved in the EAR-motif, and were found to be necessary for repression through mutational analysis. In addition, our promoter assays demonstrated a dehydration-induced and rehydration-repressed expression pattern of GhDBP1. Transgenic Arabidopsis plants overexpressing GhDBP1 were more sensitive to high salinity stress and appeared to downregulate the expression levels of the stress-induced effecter genes. Taken together, our findings provide an important insight into GhDBP1's potential molecular repression mechanism and how it is involved in plant stress responses.

关键词： DRE-binding protein Gossypium hirsutum high salinity transcriptional repressor transgenic Arabidopsis

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Chordal Graph Based Channel Assignment for Multicast and Unicast Traffic in Wireless Mesh Networks

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IEICE TRANSACTIONS ON COMMUNICATIONS 2010年第12期E93B卷 3409-3416页

作者： Jin, Junfeng Ji, Yusheng Zhao, Baohua Zhou, Hao Univ Sci & Technol China Sch Comp Sci Hefei 230027 Anhui Peoples R China State Key Lab Networking & Switching Technol Beij Beijing 100876 Peoples R China Prov Key Lab Software Comp & Commun Hefei 230027 Anhui Peoples R China Natl Inst Informat Tokyo 1018430 Japan

With the increasing popularity of multicast and real time streaming service applications efficient channel assignment algorithms that handle both multicast and unicast traffic in wireless mesh networks are needed One of the most effective approaches to enhance the capacity of wireless networks is to use systems with multiple channels and multiple radio interfaces However most of the past works focus on vertex coloring of a general contention graph which is NP Complete and use the greedy algorithm to achieve a suboptimal result In this piper we combine unicast and multicast with a transmission set and propose a framework named Chordal Graph Based Channel Assignment (CGCA) that performs channel assignment for multicast and unicast traffic in multi channel multi radio wireless mesh networks The proposed framework based on chordal graph coloring minimizes the interference of the network and prevents unicast traffic from starvation Simulation results show that our framework provides high throughput and low end to end delay for both multicast and unicast traffic Furthermore our framework significantly outperforms other well known schemes that have a similar objective in various scenarios

关键词： channel assignment minimal triangulation multiple radios wireless mesh networks

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Laboratory investigation on the strength characteristic of frozen sand considering effect of confining pressure

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COLD REGIONS SCIENCE AND techNOLOGY 2010年第3期60卷 245-250页

作者： Yang, Yugui Lai, Yuanming Li, Jingbo Chinese Acad Sci State Key Lab Frozen Soil Engn Cold & Arid Reg Environm & Engn Res Inst Lanzhou 730000 Peoples R China

This paper presents the experimental investigations on the strength of frozen sand by conducting the triaxial compressive tests under confining pressures varying from 0.0 to 18.0 MPa at a temperature of - 4 degrees C. The results demonstrated that the strength of frozen sand increases with increasing in confining pressure at first, and then decreases with a further increasing in confining pressure for pressure melting and crushing phenomena. A strength criterion is presented to describe the failure mechanism of frozen sand under general stress state by the combination of strength function F-1(p) in p-q plane and F-2(q,theta(upsilon)) in pi plane. In this study, the strength function F-1(p) was well fitted by cubic polynomial equation, considering the pressure melting and crushing phenomena of frozen sand under high confining pressures. The strength function F-2(q,theta(sigma)) derived from the extended Matsuoka-Nakai model. considering the influence of hydrostatic pressure, was used. All the parameters of this failure criterion can be easily determined using the conventional triaxial compression tests. (C) 2009 Elsevier B.V. All rights reserved.

关键词： Frozen sand Strength criterion Pressure melting Stress-strain curve

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Expression and Hormonal Regulation of E-Cadherin in Canine Uterus During Early Pregnancy

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REPRODUCTION IN DOMESTIC ANIMALS 2010年第6期45卷 e255-e259页

作者： Guo, B. Han, B-C Tian, Z. Zhang, X-M Jiang, L-X Liu, J-X Yue, Z-P Jilin Univ Coll Anim Sci & Vet Med Changchun 130062 Peoples R China Xiamen Univ Coll Life Sci Xiamen Peoples R China Jilin Univ Clin Hosp 2 Changchun 130062 Peoples R China

Contents E-cadherin, a Ca2 + -dependent cell adhesion molecule, is necessary for endometrial receptivity to blastocyst implantation. The aim of this study was to investigate the differential expression of E-cadherin in canine uterus during early pregnancy and its regulation under different conditions by in situ hybridization. E-cadherin mRNA expression was at a low level in the glandular epithelium on days 6, 12 and 17 of pregnancy. On days 20 and 23 of pregnancy, E-cadherin mRNA was highly expressed in the glandular epithelium surrounding the embryo, but not in the luminal epithelium and declined in villi and placenta on day 28 of pregnancy. During oestrous cycle, a moderate level of E-cadherin mRNA expression was found in the luminal and glandular epithelium of canine uteri at oestrus stage. The same expression was also found at anoestrus stage. Progesterone slightly induced the expression of E-cadherin mRNA in the luminal and glandular epithelium of ovariectomized canine uterus. These results suggest that E-cadherin expression is closely related to canine implantation and can be up-regulated by progesterone.

关键词： PREGNANCY in animals CADHERINS BLASTOCYST IN situ hybridization GENE expression PROGESTERONE ESTRUS

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Control Models and Control Strategies on Hot Strip Mill's Laminar Cooling System

Control Models and Control Strategies on Hot Strip Mill's La...

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2nd International Asia Conference on Informatics in Control, Automation and Robotics (CAR)

作者： Liu, Wenhong Xie, Zhi Northeastern Univ Minist Educ Key Lab Integrated Automat Proc Ind Shenyang Peoples R China Northeastern Univ Coll Informat Sci & Engn Shenyang Peoples R China

ISBN: (纸本)9781424451944

Control models and control strategies on hot strip mill's laminar cooling system, including water level control, feedforward control and feedback control of coiling temperature with smith predictor, is introduced. Steady water level can be got by water level control model, which is very important for water flux stabilization and the setup precision of process computer. Feedforward control strategy and feedback control strategy are necessary for the control precision of coiling temperature. The Control models and control strategies have been used on site and good performance has been got, which testifies that this system may be applied on the other hot strip mill's laminar cooling system.

关键词： laminar cooling PID control feedback control feedforward control Smith predictor

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Biosynthesis of fluorescent cyanobacterial allophycocyanin trimer in Escherichia coli

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PHotOSYNTHESIS research 2010年第2期105卷 135-142页

作者： Liu, Shaofang Chen, Yingjie Lu, Yandu Chen, Huaxin Li, Fuchao Qin, Song Chinese Acad Sci Key Lab Expt Marine Biol Inst Oceanol Qingdao 266071 Peoples R China Chinese Acad Sci Grad Sch Beijing 100049 Peoples R China Chinese Acad Sci Yantai Inst Coastal Zone Res Yantai 264003 Peoples R China

Allophycocyanin (APC), a cyanobacterial photosynthetic phycobiliprotein, functions in energy transfer as a light-harvesting protein. One of the prominent spectroscopic characteristics of APC is a strong red-shift in the absorption and emission maxima when monomers are assembled into a trimer. Previously, holo-APC alpha and beta subunits (holo-ApcA and ApcB) were successfully synthesized in Escherichia coli. In this study, both holo-subunits from Synechocystis sp. PCC 6803 were co-expressed in E. coli, and found to self-assemble into trimers. The recombinant APC trimer was purified by metal affinity and size-exclusion chromatography, and had a native structure identical to native APC, as determined by characteristic spectroscopic measurements, fluorescence quantum yield, tryptic digestion analysis, and molecular weight measurements. Combined with results from a study in which only the monomer was formed, our results indicate that bilin synthesis and the subsequent attachment to apo-subunits are important for the successful assembly of APC trimers. This is the first study to report on the assembly of recombinant ApcA and ApcB into a trimer with native structure. Our study provides a promising method for producing better fluorescent tags, as well as a method to facilitate the genetic analysis of APC trimer assembly and biological function.

关键词： Allophycocyanin Trimer assembly Recombinant protein Allophycocyanin monomer Fluorescence Escherichia coli

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Combined energy detection and one-order cyclostationary feature detection techniques in cognitive radio systems

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The Journal of china Universities of Posts and Telecommunications 2010年第4期17卷 18-25页

作者： YUE Wen-jing ZHENG Bao-yu MENG Qing-min YUE Wen-jie Institute of Signal Processing and Transmission Nanjing University of Posts and Telecommunications Nanjing 210003 China Department of Electronic Engineering Shanghai Jiaotong University Shanghai 200240 China Shanxi Institute of Educational Science Taiyuan 030009 China

One of the main requirements of cognitive radio systems is the ability to detect the presence of the primary user with fast speed and precise accuracy. To achieve that, a possible two-stage spectrum sensing scheme is suggested in this paper. More specifically, a fast spectrum sensing algorithm based on the energy detection is introduced focusing on the coarse detection. A complementary fine spectrum sensing algorithm adopts one-order cyclostationary properties of primary user＇s signals in time domain. Since the one-order feature detection is performed in time domain, the real-time operation and low-computational complexity can be achieved. Also, it drastically reduces hardware burdens and power consumption as opposed to two-order feature detection. The sensing performance of the proposed method is studied and the analytical performance results are given. The results indicate that better performance can be achieved in proposed two-stage sensing detection compared to the conventional energy detector.

关键词： cognitive radio （CR） spectrum sensing energy detector cyclostationary feature detector

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