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Recent advances in tenuazonic acid as a potential herbicide

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY 2017年第Nov.期143卷 252-257页

作者： Chen, Shiguo Qiang, Sheng Nanjing Agr Univ Weed Res Lab Nanjing 210095 Jiangsu Peoples R China

Tenuazonic acid (TeA), belonging to tetramic acids that are the largest family of natural products, is a mycotoxin produced by members of the genus Alternaria and other phytopathogenic fungi. TeA has many desirable bioactivities. In the past two decades, several studies have addressed its phytotoxic activity. Because it can cause brown leaf spot and kill seedlings of mono- and dicotyledonous plants, TeA is regarded as a potential herbicidal agent. TeA blocks electron transport beyond Q(A) by interacting with D1 protein and is a PSII inhibitor. The chloroplast-derived oxidative burst is responsible for TeA-induced cell death and plant necrosis. Based on the model of molecular interaction between TeA and D1 protein, a series of its derivatives with stable herbicidal activity have been designed, evaluated and patented. Recently, some chemical synthetic approaches of TeA and its derivatives have been successfully developed. This paper will mainly focus on new developments regarding TeA's herbicidal activity, mode of action, biosynthesis and chemical synthesis, and characterization of new derivatives. (C) 2017 Elsevier Inc. All rights reserved.

关键词： Mycotoxin Tetramic acid Mode of action Bioherbicide

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A new hand-eye calibration approach for fracture reduction robot

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COMPUTER ASSISTED SURGERY 2017年第sup1期22卷 113-119页

作者： Wang, Lifeng Wang, Tianmiao Tang, Peifu Hu, Lei Liu, Wenyong Han, Zhonghao Hao, Ming Liu, Hongpeng Wang, Kun Zhao, Yanpeng Guo, Na Cao, Yanxiang Li, Changsheng Beihang Univ Sch Mech Engn & Automat Beijing Peoples R China Chinese Peoples Liberat Army Gen Hosp Dept Orthopaed Beijing Peoples R China Beihang Univ Sch Biol Sci & Med Engn Beijing Peoples R China Natl Univ Singapore Dept Biomed Engn Singapore Singapore

Objective: The hand-eye calibration is used to determine the transformation between the end-effector and the camera marker of the robot. But the robot movement in traditional method would be time-consuming, inaccurate and even unavailable in some conditions. The method presented in this article can complete the calibration without any movement and is more suitable in clinical applications. Methods: Instead of solving the classic non-linear equation AX = XB, we collected the points on X and Y axes of the tool coordinate system (TCS) with the visual probe and fitted them using the singular value decomposition algorithm (SVD). Then, the transformation was obtained with the data of the tool center point (TCP). A comparison test was conducted to verify the performance of the method. Results: The average translation error and orientation error of the new method are 0.12 +/- 0.122 mm and 0.18 +/- 0.112 degrees respectively, while they are 0.357 +/- 0.347 mm and 0.416 +/- 0.234 degrees correspondingly in the traditional method. Conclusions: The high accuracy of the method indicates that it is a good candidate for medical robots, which usually need to work in a sterile environment.

关键词： Hand-Eye Calibration singular value decomposition fracture reduction robot

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Biocompatible aggregation-induced emission nanoparticles with red emission for in vivo three-photon brain vascular imaging

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JOURNAL OF MATERIALS CHEMISTRY B 2017年第15期5卷 2757-2762页

作者： Zhang, Hequn Alifu, Nuernisha Jiang, Tao Zhu, Zhenggang Wang, Yalun Hua, Jianli Qian, Jun Zhejiang Univ Coll Opt Sci & Engn Ctr Opt & Electromagnet Res State Key Lab Modern Opt Instrumentat Hangzhou 310058 Zhejiang Peoples R China East China Univ Sci & Technol Inst Fine Chem Dept Chem Key Lab Adv Mat Shanghai 200237 Peoples R China Zhejiang Univ Interdisciplinary Inst Neurosci & Technol ZIINT Hangzhou 310020 Zhejiang Peoples R China

Three-photon luminescence (3PL) imaging with near-infrared (NIR) excitation is quite promising for its deep penetration, high resolution, and good signal-to-noise ratio (SNR). In this report, a type of red emissive fluorophore TPEPT with aggregation-induced emission (AIE) properties was synthesized, and it was found to possess a large three-photon absorption (3PA) cross-section of 6.33 x 10 (-78) cm(6) s(2) under 1550 nm femtosecond laser excitation. TPEPT was then encapsulated with mPEG(5000)-DSPE to form AIE nanoparticles, and the chemical stability, optical properties and toxicity were studied afterwards. TPEPT nanoparticles were then applied for 3PL in vivo vascular imaging of mouse brain under 1550 nm fs laser excitation, and a fine three-dimensional (3D) reconstruction with a depth of 500 mu m was achieved.

关键词： Nanoparticles

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Revealing intra-urban travel patterns and service ranges from taxi trajectories

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JOURNAL OF TRANSPORT GEOGRAPHY 2017年 61卷 72-86页

作者： Zhang, Shen Tang, Jinjun Wang, Haixiao Wang, Yinhai An, Shi Harbin Inst Technol Sch Transportat Sci & Engn 73 Huang He St Harbin 150090 Heilongjiang Peoples R China Cent South Univ Sch Traff & Transportat Engn Changsha 410075 Hunan Peoples R China Inner Mongolia Agr Univ Sch Energy & Transportat Engn Hohhot 010018 Peoples R China Univ Washington Dept Civil & Environm Engn Seattle WA 98195 USA

As an important transport tool, taxi plays a significant role to meet travel demand in urban city. Understanding the travel patterns of taxis is important for addressing many urban sustainability challenges. Previous research has primarily focused on examining the statistical properties of taxi trips to characterize travel patterns, while it may be more appropriate to explore taxi service strategies on seasonal, weekly or daily time scale. Therefore, intra-urban taxi mobility is investigated by examining taxi trajectory data that were collected in Harbin, china, while 12-week corresponding to 12-month is chosen as the sampling period in our study. The multivariate spatial point pattern analysis is firstly adopted to characterize and model the spatial dependence, and infer significant positive spatial relationships between the picked up points (PUPs) and the dropped off points (DOPs). Secondly, the points of interest (POIs) are identified from DOPs using the emerging hot spot detection technique, then the taxi services and movement patterns surrounding POIs are further examined in details. Moreover, our study builds on and extends the existing work to examine the statistical regularities of trip distances, and we also validate and quantify the impacts posed by airport trips on the distance distributions. Finally, the movement based kernel density estimation (MKDE) method is proposed to estimate taxis' service ranges within three isopleth levels (50, 75 and 95%) between summer/weekday and winter/weekend from taxi driver's perspective, and season as well as temperature factors are identified as the significant effect within certain service range levels. These results are expected to enhance current urban mobility research and suggest some interesting avenues for future research.

关键词： Taxi trajectory Spatial point pattern Utilization distribution Movement-based kernel density estimation

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Identification of novel regulatory GRE-binding elements in the porcine IP3R1 gene promoter and their transcriptional activation under glucocorticoid stimulation

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GENERAL AND COMPARATIVE ENDOCRINOLOGY 2017年 249卷 71-81页

作者： Chai, Jin Xiong, Qi Wang, Dan Wan, Xuebing Niu, Hongdan Xiang, Hong Li, Huanan Wang, Hongshuai Zheng, Rong Peng, Jian Jiang, Siwen Huazhong Agr Univ Agr Minist Key Lab Swine Breeding & Genet Wuhan Peoples R China Huazhong Agr Univ Minist Educ Key Lab Agr Anim Genet Breeding & Reprod Wuhan Peoples R China Cooperat Innovat Ctr Sustainable Pig Prod Wuhan Peoples R China Huazhong Agr Univ Dept Anim Nutr Wuhan Peoples R China Hubei Acad Agr Sci Inst Anim Husb & Vet Hubei Key Lab Anim Embryo Engn & Mol Breeding Wuhan Peoples R China

Inositol 1,4,5-trisphosphate receptor 1 (IP3R1) is a type of ligand-gated calcium channel that is expressed predominantly in mammalian skeletal muscle, where it acts as a key regulator of calcium homeostasis. In meat, calcium disequilibrium is accompanied by the deterioration of meat quality. Here we show that serum cortisol concentration was higher and the IP3R1 gene expression level increased markedly in pigs exposed to high stress. In porcine primary muscle cells, dexamethasone (DEX, a synthetic glucocorticoid) increased the protein levels of porcine IP3R1 and GR alpha, and cell apoptosis, and the specific GRa inhibitor RU486 attenuated these effects. DEX also increased the expression of IP3R1 at both the gene and protein levels, and this expression was attenuated by RU486, siRNA against GRa, and the transcriptional inhibitor actinomycin D. DEX significantly reduced cell viability and increased the intracellular calcium concentration, and these effects were attenuated by siRNA against GRa. Bioinformatics analyses predicted a potential glucocorticoid response element (GRE) located in the region -326 to -309 upstream of the IP3R1 promoter and highly conserved in pigs and other mammalian species. Promoter analysis showed that this region containing the GRE was critical for transcriptional activity of porcine IP3R1 under DEX stimulation. This was confirmed by deletion and site-mutation methods. EMSA and ChiP assays showed that this potential GRE bound specifically to GRa, and this complex activated the transcription of the IP3R1 gene. Taken together, these data suggest that DEX-mediated induction of IP3R1 influences porcine muscle cells through the transcriptional activation of a mechanism involving interactions between GRa and a GRE present in the proximal IP3R1 promoter. This process can lead to an imbalance in intracellular calcium concentration, which may subsequently activate the apoptosis signal and decrease cell activity, and cause deterioration of meat qualit

关键词： Porcine IP3R1 gene Glucocorticoid Glucocorticoid receptor element Promoter Transcriptional regulation

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Imaging Lysosomal pH Alteration in Stressed Cells with a Sensitive Ratiometric Fluorescence Sensor

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ACS SENSORS 2017年第3期2卷 436-442页

作者： Xue, Zhongwei Zhao, Hu Liu, Jian Han, Jiahuai Han, Shoufa Xiamen Univ Dept Chem Biol Xiamen 361005 Peoples R China Xiamen Univ Coll Chem & Chem Engn Xiamen 361005 Peoples R China Xiamen Univ State Key Lab Phys Chem Solid Surfaces Xiamen 361005 Peoples R China Xiamen Univ Key Lab Chem Biol Fujian Prov Xiamen 361005 Peoples R China Xiamen Univ MOE Key Lab Spectrochem Anal & Instrumentat Xiamen 361005 Peoples R China Xiamen Univ Innovat Ctr Cell Signaling Network Xiamen 361005 Peoples R China Xiamen Univ State Key Lab Cellular Stress Biol Xiamen 361005 Peoples R China Xiamen Univ Sch Life Sci Xiamen 361005 Peoples R China

The organelle-specific pH is crucial for cell homeostasis. Aberrant pH of lysosomes has been manifested in myriad diseases. To probe lysosome responses to cell stress, we herein report the detection of lysosomal pH changes with a dual colored probe (CM-ROX), featuring a coumarin domain with '' always-on '' blue fluorescence and a rhodamine lactam domain activatable to lysosomal acidity to give red fluorescence. With sensitive ratiometric signals upon subtle pH changes, CM-ROX enables discernment of lysosomal pH changes in cells undergoing autophagy, cell death, and viral infection.

关键词： lysosome pH changes ratiometric fluorescence imaging autophagy cell death viral infection

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Regulation of the Docosapentaenoic Acid/Docosahexaenoic Acid Ratio (DPA/DHA Ratio) in Schizochytrium limacinum B4D1

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APPLIED BIOCHEMISTRY AND BIOtechNOLOGY 2017年第1期182卷 67-81页

作者： Zhang, Ke Li, Huidong Chen, Wuxi Zhao, Minli Cui, Haiyang Min, Qingsong Wang, Haijun Chen, Shulin Li, Demao Chinese Acad Sci Tianjin Inst Ind Biotechnol Tianjin Key Lab Ind BioSyst & Bioproc Engn Tianjin 300308 Peoples R China Tianjin Cent Hosp Gynecol & Obstet Tianjin 300100 Peoples R China

Docosapentaenoic acid/docosahexaenoic acid ratio (DPA/DHA ratio) in Schizochytrium was relatively stable. But ideally the ratio of DPA/DHA will vary according to the desired end use. This study reports several ways of modulating the DPA/DHA ratio. Incubation times changed the DPA/DHA ratio, and changes in this ratio were associated with the variations in the saturated fatty acid (SFAs) content. Propionic acid sharply increased the SFAs content in lipids, dramatically decreased the even-chain SFAs content, and reduced the DPA/DHA ratio. Pentanoic acid (C5:0) and heptanoic acid (C7:0) had similar effects as propionic acid, whereas butyric acid (C4:0), hexanoic acid (C6:0), and octanoic acid (C8:0) did not change the fatty acid profile and the DPA/DHA ratio. Transcription analyses show that beta-oxidation might be responsible for this phenomenon. Iodoacetamide upregulated polyunsaturated fatty acid (PUFA) synthase genes, reduced the DHA content, and improved the DPA content, causing the DPA/DHA ratio to increase. These results present new insights into the regulation of the DPA/DHA ratio.

关键词： Schizochytrium Docosapentaenoic acid Docosapentaenoic acid/docosahexaenoic acid ratio Polyunsaturated fatty acid synthase Docosapentaenoic acid biosynthesis

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改进共沉淀法以提高三效催化剂中铈锆复合氧化物的热稳定性(英文)

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无机材料学报 2017年第3期32卷 331-336页

作者：伍青峰崔亚娟张海龙周怡兰丽王健礼陈耀强四川大学化学学院成都610064 四川大学化学学院绿色化学与技术教育部重点实验室成都610064 四川大学化工学院成都610064

采用共沉淀法制备了铈锆材料(铈锆比为3/2)。通过改进反应器装置(图1),延长了初始晶粒生长的时间,提高了铈锆材料的热稳定性。采用X射线衍射(XRD)、氮气吸脱附和透射电镜(TEM)对制备的材料进行了表征。结果表明,延长初始晶粒生长的时间... 详细信息

采用共沉淀法制备了铈锆材料(铈锆比为3/2)。通过改进反应器装置(图1),延长了初始晶粒生长的时间,提高了铈锆材料的热稳定性。采用X射线衍射(XRD)、氮气吸脱附和透射电镜(TEM)对制备的材料进行了表征。结果表明,延长初始晶粒生长的时间可以得到较大尺寸的晶粒,这有利于提高材料的织构和结构性能,从而提高热稳定性。本研究将该材料应用于单Pd三效催化剂,表现出了优异的活性和热稳定性,具有良好的应用前景。

关键词：铈锆材料初始晶粒共沉淀法热稳定性

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dbDEPC 3.0: the database of differentially expressed proteins in human cancer with multi-level annotation and drug indication

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DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION 2018年第2018期2018卷 1-N.PAG页

作者： Yang, Qingmin Zhang, Yuqi Cui, Hui Chen, Lanming Zhao, Yong Lin, Yong Zhang, Menghuan Xie, Lu Shanghai Ocean Univ Coll Food Sci & Technol Shanghai 201306 Peoples R China Shanghai Acad Sci & Technol Shanghai Ctr Bioinformat Technol Shanghai 201203 Peoples R China Univ Shanghai Sci & Technol Sch Med Instrument & Food Engn Shanghai 201210 Peoples R China ShanghaiTech Univ Sch Life Sci & Technol Shanghai 201210 Peoples R China Univ Chinese Acad Sci Shanghai Inst Biol Sci Inst Nutr Sci Shanghai 200031 Peoples R China Minist Agr Lab Qual & Safety Risk Assessment Aquat Prod Stor Shanghai 201306 Peoples R China Shanghai Engn Res Ctr Aquat Prod Proc & Preservat Shanghai 201306 Peoples R China

Proteins are major effectors of biological functions, and differentially expressed proteins (DEPs) are widely reported as biomarkers in pathological mechanism, prognosis prediction as well as treatment targeting in cancer research. high-throughput technology of mass spectrometry (MS) has identified large amounts of DEPs in human cancers. Through mining published researches with detailed experiment information, dbDEPC was the first database aimed to provide a systematic resource for the storage and query of the DEPs generated by MS in cancer research. It was updated to dbDEPC 2.0 in 2012. Here, we provide another updated version of dbDEPC, with improvement of database contents and enhanced web interface. The current version of dbDEPC 3.0 contains 11 669 unique DEPs in 26 different cancer types. Multi-level annotations of DEPs have been firstly introduced this time, including cancer-related peptide amino acid variations, post-translational modifications and drug information. Moreover, these multi-level annotations can be displayed in the biological networks, which can benefit integrative analysis. Finally, an online enrichment analysis tool has been developed, to support a KEGG enrichment analysis and to browse the relationship among interested protein list and known DEPs in KEGG pathways. In summary, dbDEPC 3.0 provides a comprehensive resource for accessing integrated and highly annotated DEPs in human cancer.

关键词： PRotEIN expression BIOCHEMICAL markers CANCER research

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ShareRender: Bypassing GPU Virtualization to Enable Fine-grained Resource Sharing for Cloud Gaming 17

ShareRender: Bypassing GPU Virtualization to Enable Fine-gra...

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25th ACM International Conference on Multimedia (MM)

作者： Zhang, Wei Liao, Xiaofei Li, Peng Jin, Hai Lin, Li Huazhong Univ Sci & Technol Sch Comp Sci & Technol Cluster & Grid Comp Lab Serv Comp Technol & Syst Lab Wuhan Hubei Peoples R China Univ Aizu Sch Comp Sci & Engn Aizu Wakamatsu Fukushima Japan

ISBN: (纸本)9781450349062

Cloud gaming is promising to provide high-quality game services by outsourcing game execution to cloud so that users can access games via thin clients (e.g., smartphones or tablets). However, existing cloud gaming systems suffer from low GPU utilization in the virtualized environment. Moreover, GPU resources are scheduled in units of virtual machines (VMs) and this kind of coarse-grained scheduling at the VM-level fails to fully exploit GPU processing capacity. In this paper, we present ShareRender, a cloud gaming system that offloads graphics workloads within VMs directly to GPUs, bypassing GPU virtualization. For each game running in a VM, ShareRender starts a graphics wrapper to intercept frame rendering requests and assign them to render agents responsible for frame rendering on GPUs. Thanks to the flexible workload assignment among multiple render agents, ShareRender enables fine-grained resource sharing at the frame-level to significantly improve GPU utilization. Furthermore, we design an online algorithm to determine workload assignment and migration of render agents, which considers the tradeoff between minimizing the number of active server and low agent migration cost. We conduct experiments on real deployment and trace-driven simulations to evaluate the performance of ShareRender under different system settings. The results show that ShareRender outperforms the existing video-streaming-based cloud gaming system by over 4 times.

关键词： cloud gaming GPU fine-grained scheduling

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