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A High Precision Direction-Finding Algorithm for Low-Noise Target Based on Single Vector Hydrophone

ACOUSTICS AUSTRALIA 2025年 1-18页

作者： Wang, Chao Zhang, Qi Zhang, Yanhou Yuan, Meng Li, Qiang Naval Submarine Acad Qingdao 266199 Shandong Peoples R China Lao Shan Lab Qingdao 266237 Shandong Peoples R China Qingdao Inst Collaborat Innovat Qingdao 266071 Shandong Peoples R China

Given the energy and size constraints of small and micro underwater unmanned platforms, along with the limited space gain available for acoustic systems and the challenge of detecting low-noise targets autonomously, this study introduces an improved histogram algorithm that relies on a single vector hydrophone. Additionally, a novel azimuth-based constant false alarm rate target autonomous detection method is developed to enhance the performance of target direction-finding and autonomous detection in scenarios characterized by low signal-to-noise ratio (SNR). Simulation results demonstrate that the modified histogram algorithm exhibits a narrower beamwidth and improved direction-finding accuracy. The SNR of -10 dB corresponds to a -3 dB beamwidth of 14 degrees and direction-finding errors of 2.3 degrees. Achieving a target autonomous detection probability of 100% simply requires an SNR of -16 dB. Experimental results in an anechoic pool show that the ameliorative histogram algorithm can effectively perform direction-finding and independent detection of sound sources at an SNR of -13 dB, with an average direction-finding error of approximately 4.8 degrees. Sea testing data processing indicates that the improved histogram algorithm outperforms its predecessor in target direction-finding performance and enhances detection distance by approximately 2 times, validating the efficacy of the enhancement.

关键词： Low-noise target Single vector hydrophone Improved histogram Autonomous detection Direction-finding performance

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A Secure and Efficient Blockchain Sharding Scheme via Hybrid Consensus and Dynamic Management

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IEEE TRANSACTIONS ON INFORMATION FORENSICS AND SECURITY 2024年 19卷 5911-5924页

作者： Li, Meiqi Luo, Xinyi Xue, Kaiping Xue, Yingjie Sun, Wentuo Li, Jian Univ Sci & Technol China Sch Cyber Sci & Technol Hefei 230027 Anhui Peoples R China Hong Kong Univ Sci & Technol Guangzhou Guangzhou Municipal Key Lab Financial Technol Cutt Guangzhou Guangdong Peoples R China

Sharding significantly enhances blockchain scalability by dividing the entire network into smaller shards that reach consensus and process transactions in parallel. Nevertheless, two new issues emerge with the adoption of sharding. One issue involves the shrinking size of consensus groups, which leads to vulnerability in consensus. Most existing works introduce periodic shuffle mechanisms to mitigate this problem. Nevertheless, these measures necessitate stronger security assumptions and can only offer a probabilistic assurance of consensus security. Another issue is the challenge in processing cross-shard transactions posed by the isolation of shards. Existing approaches utilize two-phase commit (2PC) or relay transaction mechanisms to handle cross-shard transactions. However, these approaches are vulnerable to double cross-shard attacks from malicious shards and are unable to achieve immediate atomicity. In this paper, to address the vulnerable consensus issue and achieve instant atomicity in cross-shard transactions, we design a hybrid consensus mechanism that embeds a lightweight global consensus into parallel intra-shard consensus processes. The global consensus allows all consensus nodes to jointly process cross-shard transactions, achieving cross-shard transaction instant atomicity. It also records shard snapshots to facilitate shard auditing to defend against malicious shards. Furthermore, we consider the performance of the proposed mechanism, and design a dynamic shard management mechanism. The dynamic shard management mechanism reduces transaction congestion and maintains an appropriate number of shards based on the system's state. We conduct analyses of potential attacks and prove that our approach ensures safety and liveness even in the presence of malicious shards. We also evaluate the performance of our system and compare it with both non-sharded and classic blockchain-sharding systems. The evaluation results demonstrate the efficacy of our approach in

关键词： Blockchain sharding distributed consensus

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Hierarchical reinforcement learning for kinematic control tasks with parameterized action spaces

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NEURAL COMPUTING & APPLICATIONS 2024年第1期36卷 323-336页

作者： Cao, Jingyu Dong, Lu Sun, Changyin Southeast Univ Sch Automat Nanjing 210096 Peoples R China Southeast Univ Sch Cyber Sci & Engn Nanjing 211189 Peoples R China

Most existing reinforcement learning (RL) algorithms are solely applied to scenarios with pure discrete action space or pure continuous action space. However, in certain real-world kinematic control tasks that involve robot control based on kinematic properties, the action space is parameterized, wherein actions are represented by a fusion of discrete actions and continuous parameters. In this paper, we propose a hierarchical RL architecture designed specifically for handling parameterized action spaces. Our architecture consists of two levels, the higher level (discrete actor network) selects the discrete action and the lower level (continuous actor networks) determines the corresponding continuous parameters. These components work in tandem to generate an action-parameters vector to interact with the environment. Both the higher and lower levels share the rewards of environmental feedback and the critic networks to update the network weights. The soft actor critic and deep deterministic policy gradient algorithms are adopted to update higher-level and lower-level policies, respectively. Through simulation experiments conducted on different kinematic control tasks with parameterized action spaces, we demonstrate the effectiveness of our proposed algorithm.

关键词： Hierarchical architecture Reinforcement learning Kinematic control tasks Parameterized action spaces

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Hollowing integration engineering to construct MOF-derived carbon composites for lightweight and efficient microwave absorption materials

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JOURNAL OF MATERIALS CHEMISTRY C 2025年第13期13卷 6556-6568页

作者： Zhang, Zhe Cui, Jiewu Yu, Dongbo Zhang, Pengjie Sun, Wei Zhang, Yong Ma, Song Liang, Xiaohui Wu, Yucheng Hefei Univ Technol Sch Mat Sci & Engn Key Lab Adv Funct Mat & Devices Anhui Prov Hefei 230009 Peoples R China Hefei Univ Technol Instrumental Anal Ctr Hefei 230009 Peoples R China BGRIMM Technol Grp Co Ltd Beijing 102600 Peoples R China Chinese Acad Sci Inst Met Res Shenyang Natl Lab Mat Sci Shenyang 110016 Peoples R China Hangzhou Dianzi Univ Hangzhou 310018 Peoples R China

The rational and precise preparation of metal-organic framework (MOF)-derived carbon-based absorbers with a fine hollow structure and the tuning of their electromagnetic properties at low loading for synergistic optimization of impedance matching and high attenuation capacity for efficient utilization have become important challenges for lightweight electromagnetic wave absorption (EMWA). Herein, a hollow particle-assembled one-dimensional (1D) nanotube carbon matrix composite loaded with dispersed Co nanoparticles is fabricated by a two-step hollowing strategy of solvent-assisted ligand exchange (SALE) and a protected etching process, combined with a subsequently optimized pyrolysis. This novel hollow structure promotes multiple reflections and scattering of incident electromagnetic waves, optimizes impedance matching, and also greatly enhances the synergistic effect of multiple loss mechanisms, remarkably improving the electromagnetic characteristics. The results indicate that Co-ZIF-HPT-700 achieves a minimum reflection loss (RLmin) of -76.93 dB at 8.96 GHz with a fill rate of only 10 wt%. At the matched thicknesses of 2.12 and 2.96 mm, it realizes full-band absorption in Ku and X bands, respectively. This work provides novel ideas for the design of a new generation of ultra-lightweight EMWA materials.

关键词： Carbon carbon composites

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Drosophila modeling to identify causative genes and reveal the underlying molecular mechanisms for primary ovarian insufficiency

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JOURNAL OF MOLECULAR MEDICINE-JMM 2025年第2期103卷 239-253页

作者： Ma, Yanbin Liu, Yuxin Xu, Man Yin, Xinhuan Hu, Chenyu Yang, Xiaohang Ge, Wanzhong Zhejiang Univ Sch Med Womens Hosp Div Human Reprod & Dev Genet Hangzhou 310058 Zhejiang Peoples R China Zhejiang Univ Sch Med Inst Genet Hangzhou 310058 Zhejiang Peoples R China Zhejiang Univ Womens Hosp Zhejiang Key Lab Precis Diag & Therapy Major Gynec Sch Med Hangzhou 310006 Zhejiang Peoples R China Zhejiang Univ Zhejiang Univ Univ Edinburgh Inst Sch Med Haining 314400 Peoples R China Zhejiang Univ Womens Hosp Zhejiang Prov Clin Res Ctr Child Hlth Sch Med Hangzhou 310006 Zhejiang Peoples R China Zhejiang Univ Canc Ctr Hangzhou 310058 Zhejiang Peoples R China

Primary ovarian insufficiency (POI) is a disease defined as a reduction in ovarian function under the age of 40 and represents the main cause of female infertility. In recent years, many genetic mutations associated with POI have been identified using high-throughput sequencing technology. However, one big challenge today is to determine the disease-causing gene associations through functional assessment. Here, we develop a Drosophila model to study the POI-associated genes and provide in vivo functional evidence to validate the POI-causing genes. We use two different Gal4 drivers, in combination with RNAi transgene, and systematically knockdown 51 genes associated with POI. We show that 22 and 17 genes are required for female fertility and ovarian development in somatic and germline cells, respectively. Moreover, we also focus on AlaRS-m, the Drosophila ortholog of the human AARS2 gene, for further functional characterization. Depletion of AlaRS-m in ovarian somatic cells leads to decreased female fertility and a reduction in ovary size, as well as egg chamber degeneration. We also provide evidence that AlaRS-m deficiency causes mitochondrial dysfunction, overproduction of ROS, and apoptotic cell death. Our findings demonstrate that Drosophila can be used as a platform to assess the functional significance of POI-associated genes identified in genomic studies and illustrate the molecular mechanism underlying the pathogenesis of POI.

关键词： Primary ovarian insufficiency Drosophila RNAi Female fertility Ovary

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Cytokine profile in first-episode drug-naive major depressive disorder patients with or without anxiety

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BMC PSYCHIATRY 2024年第1期24卷 93-93页

作者： Liang, Jun Xu, Yayun Gao, Wenfan Sun, Yanhong Zhang, Yuanyuan Shan, Feng Xia, Qingrong Anhui Med Univ Affiliated Psychol Hosp Hefei Peoples R China Hefei Fourth Peoples Hosp Dept Pharm Hefei Peoples R China Anhui Mental Hlth Ctr Psychopharmacol Res Lab Hefei Peoples R China Anhui Clin Res Ctr Mental Disorders Hefei Peoples R China Anhui Med Univ Sch Publ Hlth Dept Epidemiol & Biostat Hefei Peoples R China Anhui Med Univ Anhui Inst Innovat Drugs Inflammat & Immune Mediated Dis Lab Anhui Prov Hefei Peoples R China Minist Educ Key Lab Antiinflammatory & Immune Med Hefei Peoples R China Hosp Anhui Med Univ Hefei Peoples Hosp 4 Anhui Mental Hlth Ctr Dept Sci & EducAffiliated Psychol 316 Huangshan Rd Hefei 230000 Peoples R China

Objective It is known that cytokines play a role in both depression and anxiety. This study aimed to compare the levels of multiple cytokines in patients with first-episode drug-naive major depressive disorder (MDD) with or without anxiety and analyze the correlation between the level of depression or anxiety and the serum cytokine levels. MethodsThe study involved 55 patients with first-episode drug-naive MDD. To assess anxiety symptoms, the 14-item HAMA was used. MDD patients were divided into two groups: 23 MDD patients without anxiety and 32 MDD patients with anxiety. The measurement of 37 cytokines was conducted. Serum cytokine levels between patients with MDD without anxiety and anxiety were compared. In multiple linear regression models, the relationship between the group and abnormal cytokines was explored. The receiver operating characteristic (ROC) curve analysis was performed to estimate diagnostic performance of serum cytokines in discriminating MDD patients with anxiety from MDD patients without anxiety. A correlation was evaluated between the scores of HAMD or HAMA and the serum cytokine levels. Results In MDD patients with anxiety, IL-17 C and CCL17 levels were significantly lower than in MDD patients without anxiety (all P < 0.05). Multiple measurements were corrected with Benjamini-Hochberger corrections, but none of these differences persisted (all P > 0.05). The results of multiple linear regression models revealed that after controlling for other independent variables, group was not a significant independent predictor of serum IL-17 C or CCL17 (all P > 0.05). The AUC values of IL-17 C and CCL17 were 0.643 and 0.637, respectively, in discriminating MDD patients with anxiety from MDD patients without anxiety. The results of partial correlation analyses showed the scores of HAMD were negatively correlated with the IL-17 C (r = -0.314, P = 0.021) levels with sex as a covariate. Conclusions The findings suggest that there is a potential absence of dis

关键词： Cytokines Serum Major depressive disorder Anxiety Correlation

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CAV3 alleviates diabetic cardiomyopathy via inhibiting NDUFA10-mediated mitochondrial dysfunction

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JOURNAL OF TRANSLATIONAL MEDICINE 2024年第1期22卷 390页

作者： Guo, Ping Hu, Shuiqing Liu, Xiaohui He, Miaomiao Li, Jie Ma, Tingqiong Huang, Man Fang, Qin Wang, Yan Huazhong Univ Sci & Technol Div Cardiol Wuhan 430030 Peoples R China Huazhong Univ Sci & Technol Tongji Hosp Tongji Med Coll Dept Internal Med Wuhan 430030 Peoples R China Hubei Key Lab Genet & Mol Mech Cardiol Disorders Wuhan 430030 Peoples R China

BackgroundThe progression of diabetic cardiomyopathy (DCM) is noticeably influenced by mitochondrial dysfunction. Variants of caveolin 3 (CAV3) play important roles in cardiovascular diseases. However, the potential roles of CAV3 in mitochondrial function in DCM and the related mechanisms have not yet been *** were cultured under high-glucose and high-fat (HGHF) conditions in vitro, and db/db mice were employed as a diabetes model in vivo. To investigate the role of CAV3 in DCM and to elucidate the molecular mechanisms underlying its involvement in mitochondrial function, we conducted Liquid chromatography tandem mass spectrometry (LC-MS/MS) analysis and functional *** findings demonstrated significant downregulation of CAV3 in the cardiac tissue of db/db mice, which was found to be associated with cardiomyocyte apoptosis in DCM. Importantly, cardiac-specific overexpression of CAV3 effectively inhibited the progression of DCM, as it protected against cardiac dysfunction and cardiac remodeling associated by alleviating cardiomyocyte mitochondrial dysfunction. Furthermore, mass spectrometry analysis and immunoprecipitation assays indicated that CAV3 interacted with NDUFA10, a subunit of mitochondrial complex I. CAV3 overexpression reduced the degradation of lysosomal pathway in NDUFA10, restored the activity of mitochondrial complex I and improved mitochondrial function. Finally, our study demonstrated that CAV3 overexpression restored mitochondrial function and subsequently alleviated DCM partially through *** current study provides evidence that CAV3 expression is significantly downregulated in DCM. Upregulation of CAV3 interacts with NDUFA10, inhibits the degradation of lysosomal pathway in NDUFA10, a subunit of mitochondrial complex I, restores the activity of mitochondrial complex I, ameliorates mitochondrial dysfunction, and thereby protects against DCM. These findings indicate that targeting CAV

关键词： CAV3 Diabetic cardiomyopathy Apoptosis NDUFA10 Mitochondrial dysfunction

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Biological characteristics of two pathogens causing brown blotch in Agaricus Bisporus and the toxin identification of Cedecea neteri

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PHYTOPATHOLOGY research 2024年第1期6卷 1-13页

作者： Huang, Zaixing Huang, Yiyun Nie, Yulu Liu, Bin Guangxi Univ Inst Appl Microbiol Coll Agr Nanning 530005 Peoples R China Guangxi Key Lab Agroenvironm & Agroprod Safety Nanning 530004 Peoples R China

Brown blotch disease in Agaricus bisporus reduces its commercial value, resulting in significant economic losses. The pathogens of brown blotch disease are diverse. Current research on the biological characteristics and toxins has been limited to Pseudomonas tolaasii but lacks understanding of other pathogens. Understanding the biological characteristics of the pathogens and identifying their toxins are essential prerequisites for disease prevention and control. This study isolated two pathogens from brown discoloration in A. bisporus in Guangxi, China, and identified them as Pseudomonas tolaasii and Cedecea neteri. C. neteri exhibited stronger resistance to sodium dodecyl sulfate (SDS) and H2O2 and a broader pH adaptation range than P. tolaasii. P. tolaasii showed higher swimming motility than C. neteri. C. neteri produces two toxins identified as phenylacetic acid and p-hydroxybenzoic acid, causing browning symptoms in A. bisporus at 20 mu g and 10 mu g, respectively. The present study compared various biological characteristics between P. tolaasii and C. neteri. The toxins produced by C. neteri were extracted and identified, and their toxicity to A. bisporus was evaluated, which is the first report on C. neteri toxins. These discoveries have enhanced our understanding of the biological characteristics and biotoxins of C. neteri. The research findings offer new insights for developing novel disease prevention and control strategies.

关键词： Agaricus bisporus Bacterial disease Pseudomonas tolaasii Cedecea neteri Toxin Biological characteristics

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Analysis of tumor abnormal protein expression and epidermal growth factor receptor mutation status in non-small cell lung cancer

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DISCOVER ONCOLOGY 2024年第1期15卷 274页

作者： Cheng, Yuanjun Chen, Bin Fang, Qianru Zang, Guohui Yao, Jie Peoples Hosp Chizhou Dept Cardiothorac Surg 3 Baiya Rd Chizhou 247000 Peoples R China Peoples Hosp Chizhou Dept Obstet Chizhou 247000 Peoples R China

Background The level of tumor abnormal protein (TAP) level has a significant impact on tumor growth, recurrence, and metastasis. Previous studies have highlighted the influence of the mutations in exons 19 and 21 of the epidermal growth factor receptor (EGFR), particularly the sensitivity displayed by tumor cells to epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) therapy. Our study is centered on exploring the clinical relevance of TAP and EGFR mutations in patients with non-small cell lung cancer (NSCLC). Material and methods In this study, tissue samples were collected from a total of 176 patients diagnosed with non-small cell lung cancer (NSCLC). Real-time PCR technology was utilized to detect mutations within exons 19 and 21 of the epidermal growth factor receptor (EGFR) gene in these samples. This approach enables precise identification of EGFR mutations associated with NSCLC. Furthermore, the study investigated the impact of various tumor markers, including tumor abnormal protein (TAP) and carcinoembryonic antigen (CEA), on EGFR mutation status. Established assays were employed to evaluate TAP and CEA levels, aiming to ascertain their potential correlation with EGFR mutation in NSCLC patients. Results EGFR exhibited mutation rates of 23.86% and 12.50% in exons 19 and 21, respectively. EGFR mutations were more prevalent in younger women (< 60 years old) and in cases with pleural invasion, vessel invasion, CEA > 6.5 ng/mL, and TAP > 228 mu m2 for both genders. Increased TAP levels independently predicted EGFR mutations (P = 0.001 for males;P = 0.000 for females). An area under the curve (AUC) of 0.833 indecated EGFR mutation prediction with sensitivity and specificity of 79.7% and 87.0%, respectively. For females, the sensitivity increased to 89.7% and specificity increased to 93.8%. Conclusions TAP effectively predicts EGFR mutations in NSCLC patients with moderate accuracy, particularly benefiting diagnosis in females with high sensitivit

关键词： EGFR mutation EGFR-TKI Lung cancer Prognosis TAP

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Safety and Efficacy of Inactivated SARS-CoV-2 Vaccine in Patients with Rheumatic Diseases and Serum Antibody Changes Post-Omicron Variant Infection

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RHEUMATOLOGY AND THERAPY 2024年第1期11卷 191-200页

作者： Zhang, Xiaowei Li, Yifei Dai, Chunqing Chu, Yaya Luan, Chaoqi Wang, Guihong Anhui Med Univ Sch Clin Med 5 Anqing Med Ctr 352 Renmin Rd Anqing Anhui Peoples R China Wannan Med Coll 22 Wenchang West Rd Wuhu Anhui Peoples R China Anhui Med Univ Anqing Med Ctr Dept Rheumatol & Immunol Anqing Anhui Peoples R China Anhui Med Univ Anqing Med Ctr Dept Lab Anqing Anhui Peoples R China

Introduction: The purpose of this study was to investigate whether the inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine has a similar effectiveness and safety profile in patients with rheumatic and musculoskeletal diseases (RMDs) and healthy controls (HCs).Methods: Between August 10, 2021 and September 30, 2021, 134 HCs and 269 patients with RMDs were recruited. All participants who tested negative for COVID-19 were vaccinated with SARS-CoV-2 inactivated vaccine. Next, 150 patients with RMDs and 30 HCs infected with the SARS-CoV-2 Omicron variant within the previous 12 weeks were recruited between February 20, 2023 and March 1, 2023. Serum samples were collected from each participant, and the serum immunoglobulin G (IgG) and immunoglobulin M (IgM) antibody titers against SARS-CoV-2 were determined using a chemiluminescence ***: No statistically significant difference was found in the titer of anti-SARS-CoV-2 IgG and IgM antibodies, or in the incidence of vaccination-related adverse events between the RMD and HC groups (P = 0.183, P = 0.903, and P = 0.27, respectively). Serum IgG titers of SARS-CoV-2 neutralizing antibodies were significantly higher in patients who received two or more doses of inactivated vaccine than in patients who were unvaccinated or had received one dose of vaccine (244.36 +/- 109.79 vs. 66.20 +/- 82.50;P < 0.001).Conclusions: SARS-CoV-2 inactivated vaccines have similar protective effects in HCs and patients with RMDs, with an appreciable safety profile. Fully vaccinated patients with RMDs infected with the Omicron variant were able to produce effective neutralizing antibody concentrations.

关键词： Rheumatic diseases Musculoskeletal diseases SARS-CoV-2 vaccine Serum antibodies Adverse events Omicron variant

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