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Establishment and external validation of an early warning model of diabetic peripheral neuropathy based on random forest and logistic regression

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BMC ENDOCRINE DISORDERS 2024年第1期24卷 1页

作者： Wang, Lujie Li, Jiajie Lin, Yixuan Yuan, Huilun Fang, Zhaohui Fei, Aihua Shen, Guoming Jiang, Aijuan Anhui Univ Chinese Med Sch Integrated Tradit Chinese & Western Med 350 Longzihu Rd Hefei 230012 Anhui Peoples R China Anhui Univ Chinese Med Affiliated Hosp 1 Hefei 230031 Peoples R China Anhui Univ Chinese Med Affiliated Hosp 2 Hefei 230031 Peoples R China Yunnan Univ Chinese Med Kunming 650500 Peoples R China

Objective The primary objective of this study was to investigate the risk factors for diabetic peripheral neuropathy (DPN) and to establish an early diagnostic prediction model for its onset, based on clinical data and biochemical indices. Methods Retrospective data were collected from 1,446 diabetic patients at the First Affiliated Hospital of anhui University of Chinese Medicine and were split into training and internal validation sets in a 7:3 ratio. Additionally, 360 diabetic patients from the Second Affiliated Hospital were used as an external validation cohort. Feature selection was conducted within the training set, where univariate logistic regression identified variables with a p-value < 0.05, followed by backward elimination to construct the logistic regression model. Concurrently, the random forest algorithm was applied to the training set to identify the top 10 most important features, with hyperparameter optimization performed via grid search combined with cross-validation. Model performance was evaluated using ROC curves, decision curve analysis, and calibration curves. Model fit was assessed using the Hosmer-Lemeshow test, followed by Brier Score evaluation for the random forest model. Ten-fold cross-validation was employed for further validation, and SHAP analysis was conducted to enhance model interpretability. Results A nomogram model was developed using logistic regression with key features: limb numbness, limb pain, diabetic retinopathy, diabetic kidney disease, urinary protein, diastolic blood pressure, white blood cell count, HbA1c, and high-density lipoprotein cholesterol. The model achieved AUCs of 0.91, 0.88, and 0.88 for the training, validation, and test sets, respectively, with a mean AUC of 0.902 across 10-fold cross-validation. Hosmer-Lemeshow test results showed p-values of 0.595, 0.418, and 0.126 for the training, validation, and test sets, respectively. The random forest model demonstrated AUCs of 0.95, 0.88, and 0.88 for the trainin

关键词： Diabetic peripheral neuropathy Nomogram model Risk factors Predictive model

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Comparative Metabolome and Transcriptome Analysis Revealed the Accumulative Mechanism of Rubusoside in Chinese Sweet Tea

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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2024年第44期72卷 24539-24551页

作者： Huang, Jun Lei, Ting Zhou, Qi Fang, Zhou Ruan, Haixiang Wang, Lei Qian, Wei Lu, Yeyang Wang, Qi Gao, Liping Wang, Zhenhong Wang, Yunsheng Anhui Agr Univ Sch Life Sci Hefei 230036 Anhui Peoples R China Anhui Agr Univ State Key Lab Tea Plant Biol & Utilizat Hefei 230036 Anhui Peoples R China South China Univ Technol Sch Biol & Biol Engn Guangzhou 510641 Guangdong Peoples R China Tibet Agr & Anim Husb Univ Resources & Environm Coll Nyingchi 860000 Xizang Peoples R China

Terpenoids are important secondary metabolites in Rubus. Rubusoside is a relatively specific diterpenoid bioactive component in the leaves of Chinese Sweet Tea (Rubus suavissimus). However, the terpenoid anabolic pathway of Rubus and the molecular mechanism underlying the specific accumulation of rubusoside in R. suavissimus remain unclear. Here, metabolomics and transcriptomics analyses were performed on differences in terpenoid metabolism levels between R. suavissimus (sweet leaves) and Rubus chingii (bitter leaves). Steviol glycosides and goshonosides primarily accumulated in R. suavissimus and R. chingii, respectively. Three pairs of highly homologous glycosyltransferase genes (UGT85A57, UGT75L20, and UGT75T4) associated with rubusoside biosynthesis in the two Rubus species were identified. The three pairs of UGT proteins in both species could glycosylate steviol. Thus, the transcriptional regulation of UGTs in R. suavissimus appears to play a pivotal role in rubusoside accumulation. Our findings provide insights into the differences in terpenoid metabolism between R. suavissimus and R. chingii and reveal the molecular mechanism of rubusoside accumulation in R. suavissimus.

关键词： R. suavissimus R. chingii metabolomics transcriptomics rubusoside uridine diphosphateglycosyltransferases

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Progress of research on the bonding-strength improvement of two-layer adhesive-free flexible copper-clad laminates

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RSC ADVANCES 2024年第18期14卷 12372-12385页

作者： Tang, Wanqi Liu, Yuxi Jing, Xianghai Hou, Jinsong Zhang, Qianfeng Jian, Chongguang Anhui Univ Technol Inst Mol Engn & Appl Chem Maanshan 243002 Anhui Peoples R China Chuzhou Univ Coll Mat & Chem Engn Chuzhou 239000 Peoples R China Chuzhou HKC Optoelect Co Ltd Chuzhou 239000 Peoples R China

The arrival of the 5G era has placed high demands on the electronic products. Developing thin, light, and portable electronic products capable of simultaneously improving the transmission rate and reducing the signal delay and transmission loss is necessary to meet such demands. The traditional three-layer, adhesive, flexible copper-clad laminate (3L-FCCL) cannot satisfy these demands because of its adhesive component. The large thickness and poor heat resistance disadvantages of 3L-FCCL can be avoided with a two-layer, adhesive-free, flexible copper-clad laminate (2L-FCCL). However, 2L-FCCL has low bonding strength. This work introduces the selection of conductor materials and insulating base films for flexible copper-clad laminates. Modification studies aimed at increasing the bonding performance of 2L-FCCL are summarized based on three aspects. These modification techniques include the surface treatment of copper foils, modification and surface treatment of polyimide films, and surface treatment of liquid-crystal polymers. Prospects are further provided. Bond strength of two-layer adhesive-free flexible copper-clad laminate is an important factor that directly affects the stability and reliability of electronic devices.

关键词： Adhesives

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Ultrawideband Horizontally Polarized Omnidirectional Antenna by Using Multiple Feeds

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IEEE ANTENNAS AND WIRELESS PROPAGATION LETTERS 2025年第1期24卷 108-112页

作者： Ding, Dawei Chen, Junfeng Fan, Guangwei Zhang, Xiu Yin Anhui Univ Sch Elect & Informat Engn Hefei 230093 Peoples R China Anhui Univ Informat Mat & Intelligent Sensing Lab Anhui Prov Anhui 230093 Peoples R China South China Univ Technol Sch Elect & Informat Engn Guangzhou 511370 Peoples R China

In this letter, an ultrawideband horizontally polarized omnidirectional antenna (HPOA) covering 1.47 GHz to 6.07 GHz (122%) is designed to behave stable main beam directions in vertical plane. In order to stabilize its radiation patterns, three measures are made through reassigning electric field distribution in slotline structures by using multiple feeds: decrease the spacing of each pair of monopolar modes, decrease the number of monopolar modes, and eliminate the anti-phase current loop. As seen from measured results, the designed HPOA has gain variations of less than 2 dB in horizontal plane and variations of main beam directions of less than 4 degrees in vertical plane within working band. Therefore, the designed antenna is promising for LTE/5G/WiFi indoor communication systems especially in data-intensive regions.

关键词： Feeds Slot lines Antenna measurements Antenna radiation patterns Gain Ultra wideband technology Bandwidth Antenna arrays Magnetic resonance Electric fields Base station antenna indoor base station omnidirectional antenna ultrawideband antenna

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Role of oxygen in enhancing magnetism of Fe-doped MoSi2N4 monolayer from first-principles study

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SOLID STATE COMMUNICATIONS 2024年 394卷

作者： Wang, Yueqin Cao, Huan Chen, Fuzhang Liu, Yin Anhui Univ Sci & Technol Sch Mech & Optoelect Phys Huainan 232001 Anhui Peoples R China South China Univ Technol Sch Mat Sci & Engn Guangzhou 510641 Guangdong Peoples R China Anhui Univ Sci & Technol Sch Mat Sci & Engn Huainan 232001 Anhui Peoples R China Anhui Univ Sci & Technol Anhui Int Joint Res Ctr Nano Carbon based Mat & En Huainan 232001 Peoples R China

MoSi2N4 is a new type of two-dimensional layered material, which is semiconducting with novel valley-physics properties and excellent stability, suggesting its great applications in the field of valleytronics and spintronics. In present work, the spin-polarized electronic structure and magnetic properties of different doping models of MoSi2N4 are investigated based on first principles. The results show that Fe doping presents a semi-metallic band structure, inducing a total magnetic moment of 4.01 mu B. For Fe + O co-doping configuration, further introduction of the O atom increases the total magnetic moment to 5.0 mu B. The magnetic moments mainly originate from the coupling of Fe-3d and O-2p and Mo-4d and O-2p. Then, the calculations show that the stability of Fe + O + Fe codoping configuration is enhanced and exhibits antiferromagnetic order with a total magnetic moment of about 0.98 mu B. Due to the antiferromagnetic interaction, the magnetic moment is mainly derived from the hybridization of Mo-4d and O-2p states, and a transition from semi-metallic to metallic band structure is observed.

关键词： Electronics structure Magnetism First-principles calculations

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Preparation and Performance of Ternary Early Strength Agent and Quercetin Composite Cement Sealing Material

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 130-140页

作者： LIU Jian CHEN Meiting JI Xiaoli XU Chao WANG Chunmei Department of Safety Science and Engineering Anhui University of Science and TechnologyHuainan 232001China Key Laboratory of Mine Safety and High Efficient Mining Jointly Built by Province and Education Ministry Anhui University of Science and TechnologyHuainan 232001China Department of Chemical Engineering and Explosives Anhui University of Science and TechnologyHuainan 232001China

A ternary early-strengthening agent consisting of calcium formate+triethanolamine+lithium sulfate was compounded with quercetin to shorten the setting time of cementitious materials while ensuring their early *** optimum ratio of the three early-strengthening agents was determined as 0.5%calcium formate+0.04%triethanolamine+0.4%lithium sulfate by response surface *** effects of the ternary early-strengthening agent composed of calcium formate+triethanolamine(TEA)+lithium sulfate on cementitious pore sealing materials under the synergistic effect of quercetin were studied by means of the performance tests of compressive strength,fluidity,and setting time,and the microstructural characterizations of X-ray powder diffractometer(XRD),thermogravimetry(TG-DSC)and scanning electron microscopy(SEM).The study shows that the synergistic effect of ternary early-strengthening agent and quercetin forms a multi-performance composite admixture for cementitious *** best performance was obtained with the compounding scheme of 0.5%calcium formate+0.04%triethanolamine+0.4%lithium sulfate ternary early-strengthening agent and 0.05%*** compressive strength of 1,3,7,and 28 d are 94.8%,39.8%,42%,and 28%higher than those of the blank group,*** initial time and final setting time are 41 and 57 minutes,*** to the microscopic analysis,the network and fibrous C-S-H gels generated by ternary early-strengthening agents are attached to the surface promoted by quercetin,which forms skeleton support while thickening and solidifying the cement slurry,which enhances the early compressive strength of the cement-based materials.

关键词： sealing material ternary early-strengthening agent quercetin synergetic effect response surface methodology

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Tetracycline degradation in the Fe3O4@HKUST-1/persulfate system: properties, activation mechanism, and degradation pathways

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REACTION CHEMISTRY & ENGINEERING 2024年第3期9卷 728-739页

作者： Wu, Tongtong Gao, Weili Zhang, Jiehe Hao, Mingxu Zhang, Shiyu Tao, Haisheng Anhui Normal Univ Collaborat Innovat Ctr Recovery & Reconstruct Degr Sch Ecol & Environm Anhui Prov Engn Lab Water & Soil Pollut Control & Wuhu 241000 Peoples R China Anhui Normal Univ Coll Chem & Mat Sci Anhui Lab Mol Based Mat Wuhu 241000 Peoples R China

As a typical antibiotic, tetracycline is ecotoxic and prone to bacterial resistance, producing superbugs and causing a public ecological crisis, thus raising the need to eliminate tetracycline from the aqueous environment. In this work, magnetic catalyst Fe3O4@HKUST-1 was prepared for catalyzing the degradation of tetracycline by persulfate. X-ray diffraction, scanning electron microscopy, and vibrating sample magnetometry were used to characterize the catalyst, and the results show that the catalyst had good crystallinity and magnetic properties. Tetracycline removal in the Fe3O4@HKUST-1/persulfate system reached84.80%, and the catalyst was easily recovered from the solution due to its good magnetic properties. Mechanism analysis revealed that the non-radical pathway was the main degradation channel in the Fe-3-O-4@HKUST-1/persulfate system, and(1)O(2)was the main reactive oxygen species generated from O-v on the surface of the Fe3O4@HKUST-1 catalyst. Tetracycline degradation was achieved by hydroxylation, demethylation, decarbonylation, dehydroxylation and the cleavage of C-N bonds. This finding holds significant value in further comprehension of the catalytic activation mechanism of metal-organic frameworks derivatives on persulfate and provides novel ideas for efficient water treatment technology development.

关键词： Magnetite

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RBS-YOLO: A Lightweight YOLOv5-Based Surface Defect Detection Model for Castings

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IET IMAGE PROCESSING 2025年第1期19卷

作者： Wu, Kezhu Sun, Shaoming Sun, Yining Wang, Cunyi Wei, Yifan Chinese Acad Sci Hefei Inst Phys Sci Hefei Peoples R China Univ Sci & Technol China Hefei Peoples R China Anhui Univ Sch Elect & Informat Engn Hefei Peoples R China Anhui Univ Sci & Technol Sch Mech & Elect Engn Huainan Peoples R China

To ensure precise and rapid identification of casting surface defects and to support the subsequent realisation of high-precision grinding, this study introduces a method for detecting casting surface defects using a lightweight YOLOv5 framework. The enhanced model integrates the ShuffleNetV2 high-efficiency CNN architecture into the YOLOv5 foundation, substantially reducing network parameters to achieve a lightweight model. Additionally, the Convolutional Block Attention Module (CBAM) attention mechanism is incorporated to enhance the model's capability to detect defects. The ReLU activation function replaces the SiLU function in the convolutional layer, decreasing the computational load and boosting efficiency. Subsequently, the optimised model is quantised and implemented on the RV1126 embedded development board, successfully performing image inference. To validate the effectiveness of the proposed method, a dataset of casting surface defects was designed and constructed. The optimised model has a file size of 7.6 MB, representing 55.4% of the original model, with about 50.6% of the original model's parameters. The onboard inference speed of the improved model is 50 ms per image, which is 9.1% faster than the traditional YOLOv5 model. These results offer valuable insights for future casting surface defect detection technologies.

关键词： CBAM attention mechanism embedded deployment lightweight RV1126 YOLOv5

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Study on preparation and early strength property of modified nano-MgO complexed TEA composite cement materials

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INTERNATIONAL JOURNAL OF APPLIED CERAMIC TECHNOLOGY 2025年第3期22卷

作者： Liu, Jian Chen, Meiting Ji, Xiaoli Wang, Chunmei Xie, Xinyuan Dong, Ziyuan Anhui Univ Sci & Technol Dept safety sci & engn Huainan Peoples R China Anhui Univ Sci & Technol Key Lab Mine Safety & High Efficient Min Jointly b Huainan Peoples R China Anhui Univ Sci & Technol Dept Chem Engn & Explos Huainan Peoples R China

In this study, nano-magnesium oxide (MgO) was modified with surfactants sodium polyacrylate, polyvinyl alcohol (PVA) and polyethylene glycol (PEG) based on the agglomeration problem of nano-MgO in cement. The surfactant PEG with the best modification effect was selected to modify nano-MgO and synergize with the dispersing effect and early-strengthening effect of triethanolamine (TEA) to prepare a new type of composite cementitious sealing material with high early compressive strength and good fluidity. The optimal ratio of the mass fraction of the composite early-strengthening agent was determined by the response surface method: 0.02% PEG + 2% nano-MgO + 0.04% TEA. The effects of the composite early-strengthening agent on the cementitious sealing material were investigated by the compressive strength, fluidity, setting time, X-ray diffraction experiments (XRD), thermogravimetric (TG-DSC), scanning electron microscopy (SEM), etc. The effect of the composite early-strengthening agent on the cementitious sealing material was also investigated by the response surface method. The compressive strength of the composite cement specimens at 1d, 3d, and 7d was increased by 92.59%, 35.50%, and 47.73% respectively compared to the blank group. In comparison to the control group, the flowability increased by 31.96%, and the initial and final setting time was shortened to 377 min and 394 min, respectively.

关键词： dispersion response surface methodology modification effect nano-magnesium oxide sealing materials

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A Survey on Computational Solutions for Reconstructing Complete Objects by Reassembling Their Fractured Parts

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COMPUTER GRAPHICS FORUM 2025年

作者： Lu, Jiaxin Liang, Yongqing Han, Huijun Hua, Jiacheng Jiang, Junfeng Li, Xin Huang, Qixing Univ Texas Austin Comp Sci Dept Austin TX 78712 USA Texas A&M Univ Dept Comp Sci & Engn College Stn TX 77840 USA Tsinghua Univ Dept Comp Sci & Technol Beijing Peoples R China Hohai Univ Coll Artificial Intelligence & Automa Nanjing Peoples R China Texas A&M Univ Sect Visual Comp & Computat Media College Stn TX 77840 USA

Reconstructing a complete object from its parts is a fundamental problem in many scientific domains. The purpose of this article is to provide a systematic survey on this topic. This reassembly problem requires understanding the attributes of individual pieces and establishing matches between different pieces. Many approaches also model priors of the underlying complete object. Existing approaches are tightly connected problems of shape segmentation, shape matching, and learning shape priors. We provide existing algorithms in this context and emphasize their similarities and differences to general-purpose approaches. We also survey the trends from early procedural approaches to more recent deep learning approaches. In addition to algorithms, this survey will also describe existing datasets, open-source software packages, and applications. To the best of our knowledge, this is the first comprehensive survey on this topic in computer graphics.

关键词： CCS Concepts • Computing methodologies → Shape analysis

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