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Multiscale engineered artificial compact bone via bidirectional freeze-driven lamellated organization of mineralized collagen microfibrils

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Bioactive Materials 2024年第10期40卷 168-181页

作者： Lingwenyao Kong Yonggang Zhao Yang Xiong Junlin Chen Shuo Wang Ziming Yan Huibin Shi Zhanli Liu Xiumei Wang State Key Laboratory of New Ceramics and Fine Processing Key Laboratory of Advanced Materials of Ministry of EducationSchool of Materials Science and EngineeringTsinghua UniversityBeijing100084China State Key Laboratory for Performance and Structure Safety of Petroleum Tubular Goods and Equipment Materials Tubular Goods Research Institute of CNPCXi’an710077China Department of Orthopedics Dongzhimen HospitalBeijing University of Chinese MedicineBeijingChina School of Aerospace Engineering Tsinghua UniversityBeijing100084China

Bone,renowned for its elegant hierarchical structure and unique mechanical properties,serves as a constant source of inspiration for the development of synthetic ***,achieving accurate replication of bone features in artificial materials with remarkable structural and mechanical similarity remains a significant *** this study,we employed a cascade of continuous fabrication processes,including biomimetic mineralization of collagen,bidirectional freeze-casting,and pressure-driven fusion,to successfully fabricate a macroscopic bulk material known as artificial compact bone(ACB).The ACB material closely replicates the composition,hierarchical structures,and mechanical properties of natural *** demonstrates a lamellated alignment of mineralized collagen(MC)microfibrils,similar to those found in natural ***,the ACB exhibits a similar high mineral content(70.9%)and density(2.2 g/cm^(3))as natural cortical bone,leading to exceptional mechanical properties such as high stiffness,hardness,and flexural strength that are comparable to those of natural ***,the ACB also demonstrates excellent mechanical properties in wet,outstanding biocompatibility,and osteogenic properties in vivo,rendering it suitable for a broad spectrum of biomedical applications,including orthopedic,stomatological,and craniofacial surgeries.

关键词： Artificial compact bone Bidirectional freeze-casting Mineralized collagen microfibril Hierarchical structures

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A review of the technology and applications of methods for evaluating the transport of air pollutants

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Journal of Environmental Sciences 2023年第1期123卷 341-349页

作者： Xiaoqi Wang Shuiyuan Cheng Ying Zhou Hanyu Zhang Panbo Guan Zhida Zhang Weichao Bai Wujun dai Key Laboratory of Beijing on Regional Air Pollution Control Beijing University of TechnologyBeijing 100124China School of Ecology and Environment Beijing Technology and Business UniversityBeijing 100048China State Environmental Protection Key Laboratory of Food Chain Pollution Control Beijing Technology and Business UniversityBeijing 100048China

A variety of methods based on air quality models,including tracer methods,the bruteforce method(BFM),decoupled direct method(ddM),high-order decoupled direct method(HddM),response surface models(rSMs)and so on forth,have been widely used to study the transport of air *** methods have good applicability for the transport of air pollutants with simple formation ***,differences in research conclusions on secondary pollutants with obvious nonlinear characteristics have been *** example,the tracer method is suitable for the study of simpli?ed scenarios,while HddM and rSMs are more suitable for the study for nonlinear *** observation techniques,including conventional air pollutant observation,lidar observation,air sounding balloons,vehicle-mounted and ship-borne technology,aerial surveys,and remote sensing observations,have been utilized to investigate air pollutant transport characteristics with time resolution as high as 1 *** addition,based on a multi-regional input-output model combined with emission inventories,the transfer of air pollutant emissions can be evaluated and applied to study the air pollutant transport *** technologies have advantages in temporal resolution and accuracy,while modeling technologies are more?exible in spatial resolution and research plan *** order to accurately quantify the transport characteristics of pollutants,it is necessary to develop a research method for interactive veri?cation of observation and *** evaluation of the transport of air pollutants from different angles can provide a scienti?c basis for regional joint prevention and control.

关键词： Air pollutant transport Simulation technology Observation technology Transport matrix Transport?ux

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Combining genome-wide association study and transcriptome analysis to identify molecular markers and genetic basis of population-asynchronous ovarian development in Coilia nasus

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Zoological research 2024年第3期45卷 491-505页

作者： Yue Yu Shi-Ming Wan Cheng-You Huang Shuang-Meng Zhang Ai-Li Sun Jun-Qi Liu Shun-Yao Li Yong-Fu Zhu Shu-Xin Gu Ze-Xia Gao College of Fisheries Hubei Hongshan Laboratory/Key Lab of Freshwater Animal BreedingMinistry of Agriculture and Rural Affairs/Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic BeltMinistry of EducationHuazhong Agricultural UniversityWuhanHubei 430070China Laboratory for Marine Biology and Biotechnology Qingdao Marine Science and Technology CenterQingdaoShandong 266237China Wuhan Hengyuxin Technology Breeding Professional Cooperative WuhanHubei 430117China Hubei Provincial Aquatic Science Research Institute WuhanHubei 430208China Zhenjiang Jiangzhiyuan Fishery Technology Co. Ltd.ZhenjiangJiangsu 212213China

Coilia nasus,a migratory fish species found in the middle and lower reaches of the Yangtze river and along offshore areas of China,possesses considerable aquacultural and economic ***,the species faces challenges due to significant variation in the gonadal development rate among females,resulting in inconsistent ovarian maturation times at the population level,an extended reproductive period,and limitations on fish growth rate due to ovarian *** the present study,we combined genome-wide association study(GWAS)and comparative transcriptome analysis to investigate the potential single nucleotide polymorphisms(SNPs)and candidate genes associated with population-asynchronous ovarian development in *** of the female population based on whole-genome resequencing yielded 2120695 high-quality SNPs,39 of which were suggestively associated with ovarian *** note,a significant SNP peak on LG21 containing 30 suggestively associated SNPs was identified,with cpne5a determined as the causal gene of the ***,single-marker and haplotype association analyses were performed on cpne5a,revealing four genetic markers(P<0.05)and seven haplotypes(r2>0.9)significantly associated with the *** transcriptome analysis of precociously and normally maturing individuals screened out 29 and 426 overlapping differentially expressed genes in the brain and ovary,respectively,between individuals of different body *** the GWAS and transcriptome analysis results,this study identified genes and pathways related to hypothalamic-pituitary-gonadal axis hormone secretion,extracellular matrix,angiogenesis,and gap junctions involved in population-asynchronous ovarian *** insights gained from this study provide a basis for a deeper understanding of the molecular mechanisms underlying ovarian development in fish and may facilitate the genetic breeding of *** strains exhibiting population-synchronous ovarian

关键词： Coilia nasus GWAS Transcriptome Ovarian development SNP

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data-driven Transient Stability Assessment Using Sparse PMU Sampling and Online Self-check Function

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CSEE Journal of Power and Energy Systems 2023年第3期9卷 910-920页

作者： Guozheng Wang Jianbo Guo Shicong Ma Xi Zhang Qinglai Guo Shixiong Fan Haotian Xu Department of Electrical Engineering Tsinghua UniversityBeijing 100084China Department of Power System China Electric Power Research InstituteBeijing 100192China School of Automation Beijing Institute of TechnologyBeijing 100192China

Artificial intelligence technologies provide a newapproach for the real-time transient stability assessment (TSA)of large-scale power systems. In this paper, we propose a datadriven transient stability assessment model (dTSA) that combinesdifferent AI algorithms. A pre-AI based on the time-delay neuralnetwork is designed to locate the dominant buses for installingthe phase measurement units (PMUs) and reducing the datadimension. A post-AI is designed based on the bidirectionallong-short-term memory network to generate an accurate TSAwith sparse PUM sampling. An online self-check function of theonline TSA’s validity when the power system changes is furtheradded by comparing the results of the pre-AI and the *** IEEE 39-bus system and the 300-bus AC/dC hybrid systemestablished by referring to China’s existing power system areadopted to verify the proposed method. results indicate that theproposed method can effectively reduce the computation costswith ensured TSA accuracy as well as provide feedback forits applicability. The dTSA provides new insights for properlyintegrating varied AI algorithms to solve practical problems inmodern power systems.

关键词： Artificial intelligence phasor measurement units recurrent neural networks transient stability assessment

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Interruption Characteristics of High-speed Switches in 500 kV Fault Current Limiter with High Coupled Split reactance

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CSEE Journal of Power and Energy Systems 2023年第4期9卷 1577-1584页

作者： Yanzhe Zhang Shixin Xiu Qiang Tang Shenli Jia Bo Chu Wenxiong Mo Yong Wang Haibo Su State Key Laboratory of Electrical Insulation and Power Equipment the School of Electrical EngineeringXi'an Jiaotong UniversityXi'an 710049China. Test and Research Institute of Guangzhou Power Supply Company Ltd. Guangzhou 510410China.

A 500 kV high-voltage AC fault current limiter(FCL)based on a high coupled split reactor(HCSr)is pro-posed by the national key r&d project *** impedance under normal conditions and high impedance under short-circuit conditions are accomplished by the cooperation of HCSr and high-speed ***-speed switches play an important role in current limiting processes,thus interruption characteristics of the high-speed switch in the 500 kV FCL are studied in this *** simulation model of the FCL and the external equivalent power grid are *** short-circuit current and recovery voltage characteristics of the high-speed switch in FCL are *** results show that maximum dC component of the short-circuit current of the high-speed switch reaches 91%,the maximum peak value is 118 kA,and the longest arcing time is 14.8 *** is a discontinuity in the curve of the short-circuit current peak and arcing time as a function of the short-circuit occurrence time;the peak recovery voltage of a single break of the high-speed switch has a maximum value of 87.5 kV under a three-phase ungrounded short-circuit condition,and the rate of rise of recovery voltage is o.22 kV/*** recovery voltage peak shows a period change with the short-circuit occurrence time,and the period is 10 *** effects of the shunt capacitor value and short-circuit ground resistance on the recovery voltage of high-speed switching are also *** research can be used for reference by r&d personnel and *** Terms-Fault current limiter(FCL),high coupled split reactor(HCSr),high-speed switch,interruption characteristics,short circuit current.

关键词： Fault current limiter(FCL) high coupled split reactor(HCSr) high-speed switch interruption characteristics short circuit current.

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Investigation of spatiotemporal distribution and formation mechanisms of ozone pollution in eastern Chinese cities applying convolutional neural network

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Journal of Environmental Sciences 2025年第2期148卷 126-138页

作者： Qiaoli Wang dongping Sheng Chengzhi Wu Xiaojie Ou Shengdong Yao Jingkai Zhao Feili Li Wei Li Jianmeng Chen 无 College of Environment Zhejiang University of TechnologyHangzhou 310032China Key Laboratory of Biomass Chemical Engineering of the Ministry of Education Institute of Industrial Ecology and EnvironmentCollege of Chemical and Biological EngineeringZhejiang University(Zijingang Campus)Hangzhou 310027China Trinity Consultants Inc.(China office)Hangzhou 310012China Zhejiang University of Science&Technology Hangzhou 310023China

Severe ground-level ozone(O_(3))pollution over major Chinese cities has become one of the most challenging problems,which have deleterious effects on human health and the sustainability of *** study explored the spatiotemporal distribution characteristics of ground-level O_(3) and its precursors based on conventional pollutant and meteorological monitoring data in Zhejiang Province from 2016 to ***,a high-performance convolutional neural network(CNN)model was established by expanding the moment and the concentration variations to general ***,the response mechanism of O_(3) to the variation with crucial influencing factors is explored by controlling variables and interpolating target *** results indicated that the annual average MdA8-90th concentrations in Zhejiang Province are higher in the northern and lower in the *** the wind direction(Wd)ranges from east to southwest and the wind speed(WS)ranges between 2 and 3 m/sec,higher O_(3) concentration prone to *** different temperatures(T),the O_(3) concentration showed a trend of first increasing and subsequently decreasing with increasing NO_(2) concentration,peaks at the NO_(2) concentration around 0.02mg/m^(3).The sensitivity of NO_(2) to O_(3) formation is not easily affected by temperature,barometric pressure and dew point ***,there is a minimum IrNO_(2) at each temperature when the NO_(2) concentration is 0.03 mg/m^(3),and this minimum IrNO_(2) decreases with increasing *** study explores the response mechanism of O_(3) with the change of driving variables,which can provide a scientific foundation and methodological support for the targeted management of O_(3) pollution.

关键词： Ozone Spatiotemporal distribution Convolutional neural network Ozone formation rules Incremental reactivity

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Study on the mass transfer characteristics of hydrogen in heavy oil by a modified dynamic pressure step method

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Petroleum Science 2025年第3期22卷 1360-1369页

作者： Tao Jiang Fei Yu Qian-Min Jiang Yan-Xin Song Qing-Feng Tan Wu Su Xu Yang Zhen-Tao Chen Chun-Ming Xu State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing102249China Petrochemical Research Institute PetroChina Company LimitedBeijing102206China

The dissolved hydrogen, rather than gaseous hydrogen, plays a crucial role in the hydrogenation process. A thorough understanding of hydrogen dissolution is essential for optimizing the hydrogenation process. In this paper, the dynamic pressure step method was modified to reduce the temperature difference between the hydrogen and solution, from which the hydrogen solubility and volumetric liquid-side mass transfer coefficient (k_(L)a) of the vacuum residue were obtained. It was discovered that temperature was the most critical factor in hydrogen dissolution, simultaneously enhancing both the hydrogen solubility and k_(L)a. Pressure played a significant role in promoting hydrogen solubility, but had a relatively small impact on kLa. Stirring speed, although it enhanced k_(L)a, did not affect hydrogen solubility. By normalizing the dissolution parameter, the results showed that the gas-liquid mass transfer rate decreased continuously during hydrogen dissolution and that the Sd-td curves after normalization were almost the same in all experimental conditions.

关键词： Hydrogenation Heavy oil Hydrogen solubility Gas-liquid mass transfer

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Effect of Sodium Alginate and Calcium Chloride on the Physicochemical Characteristics of Shrimp(Penaeus Vannamei)Surimi Gels

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Journal of Ocean University of China 2024年第6期23卷 1645-1654页

作者： WANG Ziyan FENG Jiehui LI Qianqian JIA ru HUANG Tao WEI Huamao YANG Wenge College of Food and Pharmaceutical Sciences Ningbo UniversityNingbo 315211China Key Laboratory of Animal Protein Food Deep Processing Technology of Zhejiang Province Ningbo 315211China

The object of this study is to investigate the effects of sodium alginate(SA)and CaCl_(2) on the physicochemical characteristics of shrimp surimi by studying gel strength,water holding capacity(WHC),as well as by texture profile analysis(TPA).In addition,the mechanism was analyzed through chemical interactions,protein secondary structure,and *** results showed that with the addition of different concentrations of SA and CaCl_(2) to the shrimp surimi,the gel quality firstly increased and then decreased with the increase of SA and CaCl_(2) *** highest values of WHC,breaking force and gel strength were obtained with the addition of 1.2%SA or 0.1%CaCl_(2).When SA and CaCl_(2) were used in concert,the group containing 1.2%SA and 0.15%CaCl_(2) had the highest gel strength with the densest three-dimensional network structure of the *** addition,the results of chemical interaction analyses showed that hydrogen and ionic bonds were the main chemical bonds of shrimp surimi sol,while shrimp surimi gel mainly consisted of hydrophobic and disulfide *** incorporation of SA and CaCl_(2) resulted in a significant increase in hydrophobic interactions and disulfide bonding,which could effectively improve the gel properties of shrimp surimi.

关键词： Penaeus vannamei sodium alginate calcium chloride shrimp surimi gels microstructure

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Interpretation of the Standards of Basic dataset of Chronic diseases Behavior risk Factor Surveillance in Adults

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Biomedical and Environmental Sciences 2024年第5期37卷 551-556页

作者： ZHAO Yan Fang ZHANG Mei WEI Wen Qiang SUN Ke Xin LI Xin Hua WANG Li Min National Center for Chronic and Noncommunicable Disease Control and Prevention(NCNCD) Chinese Center for Disease Control and PreventionBeijing 100050China Cancer Hospital Chinese Academy of Medical SciencesBeijing 100021China Chinese Center for Disease Control and Prevention Beijing 102206China People's Medical Publishing House Beijing 100021China

BACKGrOUNd China’s Behavioral risk Factor Surveillance System(BrFSS)originated from the World Bankfunded HealthⅦLoan project in the 1990s,which conducted behavioral risk factor surveillance in seven cities and one province^([1]).drawing on the World Health Organization’s(WHO)STEPwise approach to surveillance(STEPs)and the *** risk Factor Surveillance System(BrFSS)^([2,3]).

关键词： funded Basic originated

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The high-quality genome of Grona styracifolia uncovers the genomic mechanism of high levels of schaftoside,a promising drug candidate for treatment of COVId-19

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园艺研究（英文） 2024年第12期11卷 40-49页

作者： Shaohua Zeng Zhiqiang Wang dingding Shi Fangqin Yu Ting Liu Ting Peng Guiqi Bi Jianbin Yan Ying Wang Guangdong Provincial Key Laboratory of Applied Botany Key Laboratory of National Forestry and Grassland Administration on Plant Conservation and Utilization in Southern ChinaSouth China National Botanical GardenState Key Laboratory of Plant Diversity and Specialty CropsSouth China Botanical GardenChinese Academy of SciencesGuangzhou 510650China College of Life Sciences Gannan Normal UniversityGanzhou 341000China University of Chinese Academy of Sciences Beijing 100049China Guangdong Provincial Key Laboratory of Applied Botany Key Laboratory of National Forestry and Grassland Administration on Plant Conservation and Utilization in Southern ChinaSouth China National Botanical GardenState Key Laboratory of Plant Diversity and Specialty CropsSouth China Botanical GardenChinese Academy of SciencesGuangzhou 510650China University of Chinese Academy of Sciences Beijing 100049China Guangdong Provincial Key Laboratory of Applied Botany Key Laboratory of National Forestry and Grassland Administration on Plant Conservation and Utilization in Southern ChinaSouth China National Botanical GardenState Key Laboratory of Plant Diversity and Specialty CropsSouth China Botanical GardenChinese Academy of SciencesGuangzhou 510650China College of Life Sciences Gannan Normal UniversityGanzhou 341000China College of Life Sciences Gannan Normal UniversityGanzhou 341000China Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureKey Laboratory of Synthetic BiologyMinistry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518124China

recent study has evidenced that traditional Chinese medicinal(TCM)plant-derived schaftoside shows promise as a potential drug candidate for COVId-19 ***,the biosynthetic pathway of schaftoside in TCM plants remains *** this study,the genome of the TCM herb Grona styracifolia(Osbeck)*** & ***(GSO),which is rich in schaftoside,was sequenced,and a high-quality assembly of GSO genome was *** findings revealed that GSO did not undergo recent whole genome duplication(WGd)but shared an ancestral papilionoid polyploidy event,leading to the gene expansion of chalcone synthase(CHS)and isoflavone 2'-hydroxylase(HIdH).Furthermore,GSO-specific tandem gene duplication resulted in the gene expansion of C-glucosyltransferase(CGT).Integrative analysis of the metabolome and transcriptome identified 13 CGTs and eight HIdHs involved in the biosynthetic pathway of *** studies indicated that CGTs and HIdHs identified here are bona fide responsible for the biosynthesis of schaftoside in GSO,as confirmed through hairy root transgenic system and in vitro enzyme activity *** together,the ancestral papilionoid polyploidy event expanding CHSs and HIdHs,along with the GSO-specific tandem duplication of CGT,contributes,partially if not completely,to the robust biosynthesis of schaftoside in *** findings provide insights into the genomic mechanisms underlying the abundant biosynthesis of schaftoside in GSO,highlighting the potential of GSO as a source of bioactive compounds for pharmaceutical development.

关键词： schaftoside mechanism covid-19 genomic levels genome candidate drug grona high-quality

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