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Aqueous humor adipokine profile of primary open angle glaucoma patients and cataract patients with or without metabolic disorders

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International Journal of Ophthalmology(English edition) 2025年第4期18卷 615-626页

作者： Zi-Yao Xia Ke Xu Wei-Jia Zhang de-Fu Wu Zhe Pan Hao-Cheng Xian Xue-Min Li Huai-Zhou Wang Chun Zhang Department of Ophthalmology Peking University Third HospitalBeijing 100191China Beijing Key Laboratory of Restoration of Damaged Ocular Nerve Peking University Third HospitalBeijing 100191China Department of Ophthalmology Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Beijing Tsinghua Changgung Hospital Eye Center Beijing Tsinghua Changgung HospitalTsinghua MedicineTsinghua UniversityBeijing 102218China Beijing Visual Science and Translational Eye Research Institute(BERI) Beijing 102218China

AIM:To investigate the role of adipokines in primary open angle glaucoma(POAG)by comparing the levels of these molecules in the aqueous humor among POAG patients and cataract patients with or without metabolic ***:In this cross-sectional study,aqueous humor samples of 22 eyes of POAG patients(POAG group),24 eyes of cataract patients without metabolic disorders(cataract group),and 24 eyes of cataract patients with metabolic disorders(cataract+metabolic disorders group)were assessed for 15 adipokines by Luminex bead-based multiplex *** correlation between aqueous humor adipokines and clinical indicators of POAG was analyzed and compared across the ***:The analysis revealed that the levels of adiponectin,leptin,adipsin,retinol-binding protein 4(rBP4),angiopoietin-2,angiopoietin-like protein 4(ANGPTL4),chemokine(C-C motif)ligand 2(CCL2),interleukin-8(IL-8),and interleukin-18(IL-18)in the aqueous humor of the POAG group were significantly higher than those in the cataract ***,the level of angiopoietin-2 in the POAG group was higher than in the cataract+metabolic disorders ***,no significant correlation was found between the levels of adipokines in the POAG group and intraocular pressure(IOP),severity of POAG,or the use of glaucoma ***:This study demonstrates significant differences in aqueous humor adipokine levels between POAG and cataract *** findings suggest that the levels of aqueous humor adipokines may reflect the inflammatory states in POAG and systemic metabolic abnormalities.

关键词： glaucoma biomarkers adipokine primary open angle glaucoma aqueous humor metabolic disorder

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Microstructure evolution and diffusion mechanism of Nb/TiAl alloy diffusion-bonded joints

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rare Metals 2023年第5期42卷 1686-1694页

作者： Kun Huang Hong-Liang Sun Ze-Wen Huang Mo-Yu Liao Yang Li School of Materials Science and Engineering Southwest Jiaotong UniversityChengdu610031China Key Laboratory of Advanced Technologies of Materials Ministry of EducationChengdu610031China

The interdiffusion behavior in Nb/TiAl alloy diffusion couples was *** process was carried out in the temperature range of 950-1400℃for 8 h in the vacuum hot-pressure sintering *** microstructural evolution was observed by optical microscopy(OM),electron backscattered diffraction(EBSd),X-ray diffraction(Xrd)technique and transmission electron microscopy(TEM).The element concentration distribution at the bonded interface was obtained by scanning electron microscopy with an energy-dispersive X-ray spectroscopy(EdS)*** thickness of reaction interface increases with bonding temperature *** formed phases in diffusion interface are found to be O-Ti_(2)AlNb,σ-Nb_(2)Al,δ-Nb_(3)Al and Nb solid solution(Nbss)at 1350℃.The average interdiffusion coefficient of the interface elements was calculated by the theory of *** results indicate that Al diffuses faster than Nb and Nb diffuses faster than Ti in the Ti-Al-Nb ***,it is found that Ti promotes the diffusion of Al and Nb and Nb inhibits the diffusion of Ti and Al in the process of diffusion.

关键词： diffusion bonding TiAl alloys Nb Interface microstructure Interdiffusion coefficient

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Quantum-resistant blockchain and performance analysis

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JOUrNAL OF SUPErCOMPUTING 2025年第3期81卷 1-42页

作者： Wu, Faguo Zhou, Bo Song, Jiale Xie, Lijia Beihang Univ Sch Artificial Intelligence Beijing 100191 Peoples R China Zhongguancun Lab Beijing 100094 Peoples R China Beihang Univ Key Lab Math Informat & Behav Semant LMIB Beijing 100191 Peoples R China Beihang Univ Beijing Adv Innovat Ctr Big Data & Brain Comp Beijing 100191 Peoples R China

Blockchain technology enables secure information and value exchange in untrusted environments by integrating cryptographic techniques such as public-private key cryptography, hash algorithms, and consensus mechanisms. It is poised to become a foundational technology for the future Internet of Value. However, the security of current mainstream blockchains relies on asymmetric encryption algorithms that are vulnerable to quantum attacks, as their security depends on the computational difficulty of solving number-theoretic problems like integer factorization and discrete logarithms in classical computing models. This paper investigates quantum-resistant blockchain technologies to address these vulnerabilities. First, it analyzes the susceptibility of existing blockchain systems to quantum attacks at multiple levels, including signature algorithms, TLS layer data exchange, consensus mechanisms, and privacy protection. Second, it provides a comprehensive comparison of promising quantum-resistant signature and key encapsulation algorithms, evaluating their characteristics and performance in terms of resource utilization, key size, and other critical metrics. Building on this analysis, the paper proposes a general framework for measuring performance indicators of quantum-resistant blockchains and suggests optimization methods to enhance system performance, focusing on aspects such as block size and consensus mechanisms. Additionally, a multidimensional comparative analysis of existing quantum-resistant blockchain solutions is presented. This work highlights the challenges in achieving quantum resistance for blockchain systems and offers valuable insights and guidance for researchers designing quantum-resistant blockchain solutions and optimizing their performance.

关键词： Blockchain Post-quantum signature TLS Consensus

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Enhanced magnetic performance of Fe-rich Sm_(2)Co_(17)-type magnets by optimizing Zr content

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Journal of Materials Science & Technology 2024年第26期193卷 178-186页

作者： Jian Li Minxia Fang Yao Liu Xin Song Wentao Jia Junming Gou Tao Yuan Yuanchao Ji Lizhong Zhao Chen Wang Tianyu Ma Frontier Institute of Science and Technology MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matterand State Key Laboratory for Mechanical Behavior of MaterialsXi’an Jiaotong UniversityXi’an 710049China The Southwest Applied Magnetism Research Institute Mianyang 621000China Institute of Advanced Magnetic Materials College of Materials&Environmental EngineeringHangzhou Dianzi UniversityHangzhou 310018China College of Materials Science and Engineering Fuzhou UniversityFuzhou 350002China

despite the high theoretical energy product and low material cost of Fe-rich 2:17-type Sm-Co-Fe-Cu-Zr magnets,it is still a big challenge to simultaneously achieve high energy product and high coercivity due to damaged cellular nanostructure,*** cell boundary *** this work,both high energy product(∼30.29 MGOe)and high coercivity(∼26.24 kOe)have been achieved in Fe-rich Sm_(24.8)Co_(bal)Fe_(20.5)Cu_(5.2)Zr_(x)(x wt%)magnets through optimizing Zr *** reveals that raising Zr content from 1.5 wt%to 2.5 wt%can effectively refine the cellular nanostructure,which corresponds to an increased volume fraction of cell boundary ***,excess Zr content(*** 2.5 wt%)leads to the formation of micron-sized Zr-rich Zr_(6)Co_(23) soft magnetic particles,weakening the hard magnetic *** particular,the high Zr-content(3.5 wt%)magnet exhibits strongly inhomogeneous chemistry as well as cellular nanostructure in the vicinity of micron-sized Zr_(6)Co_(23)particles(*** distribution of cell boundary precipitates),deteriorating both squareness factor and *** a result,the optimum magnetic property combination is achieved at an intermediate Zr concentration by balancing the contradictive effects between cell refinement and soft magnetic impurities.

关键词： Permanent magnets Magnetic properties Microstructure

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AI empowers exploration of protein universe

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Science China(Life Sciences) 2025年第2期68卷 588-589页

作者： Wuke Wang Xingxu Huang Zhejiang Provincial Key Laboratory of Pancreatic Disease The First Affiliated Hospitaland Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China

deaminases which perform the function of converting cytosine to thymine are ubiquitous in nature with over 120,000 known variants,each exhibiting significant ***,gene editing technologies have remarkably revealed that these deaminases share similar ***,the mining of novel proteins has been conducted through sequence alignment and the categorization of conserved regions to identify functional modules within protein sequences.

关键词： functions powers alignment

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Stall Angle of Attack Prediction of ridge Ice on Airfoil Using deep Neural Networks

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Journal of Aeronautics, Astronautics and Aviation 2023年第1期55卷 29-38页

作者： Yu, dinghao Ge, Huaizhi Han, Zhirong Zhang, Bin Wang, Fuxing School of Aeronautics and Astronautics Shanghai Jiao Tong University 800 Dongchuan Road Shanghai200240 China 1919 Shibo Avenue Shanghai200131 China Sichuan Research Institute Shanghai Jiao Tong University Tianfu New Area Cheng du610213 China

The study of ridge ice stall is of great significance to grasp the aerodynamic hazard mechanism and guide the anti-icing system design. Aiming at the forward quarter round ridge ice, this paper applied deep neural network to classify the data, so as to predict the stall angle of attack. The flow field of NACA23012 airfoil under different ridge shapes, reynolds numbers and angles of attack are obtained through numerical calculation. Flow results are divided into dangerous and safe cases according to whether the separated flow behind the ridge ice is bonded to the airfoil surface again. The flight safety prediction accuracy of the classification model is higher than 90%. The results based on the prediction model show that the stall angles of attack are greatly reduced in ridge ice states;the change of ridge radius plays a decisive role in aerodynamic performance;the anti-icing system shall focus on avoiding the ice ridge radius greater than 0.005 times the chord length and try to avoid the ridge ice growing at the chord position of 0.12-0.16 times the chord length. © 2023 The Aeronautical and Astronautical Society of the republic of China. All rights reserved.

关键词： deep neural networks

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Atomic layer deposition in advanced display technologies:from photoluminescence to encapsulation

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International Journal of Extreme Manufacturing 2024年第2期6卷 65-82页

作者： rong Chen Kun Cao Yanwei Wen Fan Yang Jian Wang Xiao Liu Bin Shan State Key Laboratory of Intelligent Manufacturing Equipment and Technology School of Mechanical Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074HubeiPeople’s Republic of China State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074HubeiPeople’s Republic of China

driven by the growing demand for next-generation displays,the development of advanced luminescent materials with exceptional photoelectric properties is rapidly accelerating,with such materials including quantum dots and phosphors,***,the primary challenge preventing the practical application of these luminescent materials lies in meeting the required durability *** layer deposition(ALd)has,therefore,been employed to stabilize luminescent materials,and as a result,flexible display devices have been fabricated through material modification,surface and interface engineering,encapsulation,cross-scale manufacturing,and *** addition,the appropriate equipment has been developed for both spatial ALd and fluidized ALd to satisfy the low-cost,high-efficiency,and high-reliability manufacturing *** strategic approach establishes the groundwork for the development of ultra-stable luminescent materials,highly efficient light-emitting diodes(LEds),and thin-film ***,this significantly enhances their potential applicability in LEd illumination and backlighted displays,marking a notable advancement in the display industry.

关键词： atomic layer deposition display luminescent encapsulation

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Boosting photocatalytic CO_(2)-to-CO conversion using a biomimetic dinuclear Co(Ⅱ)complex through an HCO_(3)^(-)-mediated pathway

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Science China Chemistry 2025年第3期68卷 974-979页

作者： Yuchen Wang Wenjie Shi Weixue Tao Jihong Zhang di-Chang Zhong Tongbu Lu Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and EngineeringTianjin University of TechnologyTianjin 300384China

dinuclear metal synergistic catalysis(dMSC)has been evidenced to be effective in enhancing the catalytic activity for CO_(2)***,the reaction kinetics of CO_(2)reduction is still limited by the local CO_(2)concentration around the dinuclear catalytic *** by the structure of carbonic anhydrase,we have designed and synthesized a dinuclear cobalt(Ⅱ)complex with an-OH *** complex not only exhibits dMSC for CO_(2)reduction but also possesses excellent capture capacity for CO_(2)***,the complex demonstrates high efficiency for the photocatalytic reduction of CO_(2)to CO,with turnover number reaching as high as 43,400 and a selectivity of 97%.Even in 10%CO_(2),the complex still shows stateof-the-art catalytic *** results of experiments and theoretical calculations reveal that besides the dMSC contributing to the enhanced catalytic activity,the-OH group in the dinuclear cobalt(Ⅱ)complex facilitates the capture of CO_(2)by the formation of HCO_(3)^(-)intermediates,thereby enhancing the affinity towards CO_(2)and boosting the catalytic activity for CO_(2)-to-CO conversion.

关键词： homogeneous catalyst dinuclear metal synergistic catalysis CO_(2)reduction photocatalysis enzyme mimics

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Ultrahigh Bonding Strength of dissimilar Metals Manufactured through Additive Manufacturing

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AdVANCEd FUNCTIONAL MATErIALS 2025年第0期

作者： Feng, Wei Hou, Jixin Liu, Zhonghan Liu, Pan Jiang, Tao Chen, Jiahui Yu, Yunhe Xia, Zhixin Soochow Univ Inst Laser Addit Mfg Suzhou 215021 Peoples R China

dissimilar metals have exceptional development prospects in many fields due to their unique properties. However, the formation of brittle intermetallic compounds (IMCs) in dissimilar metals significantly reduces the bonding strength and causes interface cracking. In this study, a novel solid solution design concept is proposed to solve the problem. And ultrahigh bonding strength of TC4 titanium alloy/316L stainless steel dissimilar metal is achieved through additive manufacturing, with a CrCuV solid solution alloy interlayer. By utilizing the high-entropy effect, continuous solid solutions are formed and the brittle IMCs layer is completely inhibited at the heterogeneous interface. The excellent metallurgical bonding of TC4/316L dissimilar metal results in an unprecedented shear strength of 345 MPa. This strategy successfully breaks through the bottleneck of bonding strength in dissimilar metals, greatly promotes the development and application of dissimilar metals.

关键词： bonding strength dissimilar metals intermetallic compounds solid solutions

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Integration of metal-organic layers with quantum dots for artificial photosynthesis

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Science China Chemistry 2024年第11期67卷 3712-3718页

作者： Hong Yuan Min Zhang Ji-Hua deng Tong-Bu Lu di-Chang Zhong Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and EngineeringSchool of Chemistry and Chemical EngineeringTianjin University of TechnologyTianjin 300384China

Metal-organic layers(MOLs), a type of new-emerging two-dimensional ultrathin metal-organic framework materials with large surface areas and highly exposed active sites, have shown promising applications in photocatalytic CO_(2) reduction. However, due to a lack of photosensitivity and photooxidation capability, photosensitizers and sacrificial reductants are usually necessary for MOLs-based photocatalytic CO_(2) reduction systems. In this article, by integration of MOLs and quantum dots(Qds), we constructed MOLs-based catalysts with multi-functions of photosensitivity, photoreduction and photooxidation, which thus can serve as photocatalysts for CO_(2) reduction with H_(2)O as an electron donor. Specifically, by an electrostatic self-assembly approach,nickel(Ⅱ)-based MOLs(Ni-MOLs) and CsPbBr_(3)Qds have been assembled, constructing valid Ⅱ-Scheme Ni-MOLs/CsPbBr_(3) heterojunctions with close Ni-MOLs/CsPbBr_(3)heterointerface. Such a close heterointerface shortens the charge transfer distance,thus effectively boosting the charge separation and transfer. As a result, upon illumination by visible light(λ ≥ 400 nm,100 m W cm^(-2)), the optimized photocatalyst shows high efficiency and stability in photochemical CO_(2) reduction in the absence of any photosensitizers and sacrificial reductants. The CO yield reaches as high as 124 μmol g^(-1)in 4 h, over 6 times higher than that achieved by CsPbBr_(3). Additionally, the selectivity reaches 100%. This work provides a new way to construct MOL-based catalysts for artificial photosynthesis.

关键词： metal-organic layers artificial photosynthesis CO_(2)reduction H_(2)O oxidation

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