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A concise analysis of cathode material degradation in Sodium-Ion Batteries: Insights from voltage hysteresis phenomena

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MATERIALS science AND ENGINEERING B-ADVANCED FUNCTIONAL SOLID-STATE MATERIALS 2025年 321卷

作者： Li, Yan Tian, Jie Yang, Heshan Liu, Wen Li, Siqing Shenzhen Power Supply Co Ltd Guangdong Prov Key Lab Source Grid Load Storage In Shenzhen 518000 Guangdong Peoples R China Tsinghua Shenzhen Int Grad Sch Shenzhen Peoples R China

Sodium-ion batteries have emerged as a promising next-generation energy storage technology owing to their resource abundance and cost-effectiveness. As the pivotal component determining battery performance, cathode materials critically influence the energy density and cycling stability of sodium-ion batteries. Nevertheless, the persistent challenge of voltage hysteresis significantly compromises their electrochemical performance and hinders commercialization prospects. This review provides a comprehensive analysis of voltage hysteresis in sodium-ion battery cathodes, examining the phenomenon through three critical perspectives: (1) overview of voltage hysteresis, (2) fundamental mechanisms (including phase transition kinetics, Na + diffusion barriers, and interfacial side reactions), and (3) optimization strategies (encompassing structural engineering, surface modification, and electrolyte design). Furthermore, we propose future research directions to address existing challenges, with the ultimate goal of advancing high-performance cathode materials for practical sodium-ion battery applications.

关键词： Voltage hysteresis Polarization Sodium-ion batteries Cathodes

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Combined transcriptomic and proteomic analyses reveal relevant myelin features in mice with ischemic stroke

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FUNCTIONAL & INTEGRATIVE GENOMICS 2025年第1期25卷 1-19页

作者： Qian, Qiuyang Lyu, Hao Wang, Wei Wang, Qiwen Li, Desheng Liu, Xiaojia He, Yi Shen, Mei Peoples Hosp Longhua Dept Rehabil Med 38 Jinglong Construct Rd Shenzhen 518109 Peoples R China Shenzhen Univ Affiliated Hosp 1 Shenzhen Peoples Hosp 2 Dept Neurosurg Shenzhen 518000 Peoples R China Chinese Acad Sci Shenzhen Inst Adv Technol Shenzhen 518055 Peoples R China

Ischemic stroke (IS), a leading cause of global disability and mortality, is characterized by white matter damage and demyelination. Despite advances, the molecular mechanisms driving post-IS myelin pathology remain poorly understood, limiting therapeutic development. This study investigates key myelin-related genes (MRGs) and their regulatory networks to identify novel therapeutic targets. A transient middle cerebral artery occlusion (MCAO) model was established in C57BL/6 mice, with brain tissues collected at four timepoints (Sham0D, MCAO0D, MCAO7D, MCAO14D). Transcriptomic and proteomic sequencing were performed, followed by soft clustering (Mfuzz), functional enrichment (GO/KEGG), and ROC analysis to identify key MRGs. Competing endogenous RNA (ceRNA) networks were constructed, and drug prediction was conducted using the Comparative Toxicogenomics Database (CTD) and molecular docking. Expression validation was performed via qRT-PCR and Western blot. Integrated multi-omics analysis identified Wasf3 and Slc25a5 as key MRGs, enriched in mitochondrial respiration, calcium metabolism, and cytoskeletal regulation. The AUC values of the one-to-one model scores were all greater than 0.7, suggesting that Wasf3 and Slc25a5 were able to effectively discriminate between samples from different time points. A ceRNA network revealed critical interactions, including the Wasf3-mmu-miR-423-5p-H19 axis, linking apoptosis and myelin dysfunction. Drug prediction highlighted valproic acid (VPA) as a high-affinity binder for both genes (binding energies: - 4.2 and - 4.7 kcal/mol), suggesting its potential as a therapeutic candidate for IS. Experimental validation confirmed significant downregulation of Wasf3 mRNA (p < 0.01) and protein (p = 0.069) post-IS, while Slc25a5 showed no significant changes, potentially due to sample size limitations. This study establishes Wasf3 and Slc25a5 as pivotal regulators of post-IS myelin pathology and proposes VPA as a promising therapeutic candidat

关键词： Ischemic stroke Myelin-related genes Transcriptome Proteomics

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Topotactic transformation of perovskite-based manganite film triggered via simple oxygen getter layer

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CERAMICS INTERNATIONAL 2024年第7期50卷 12632-12636页

作者： Cen, Qiaoqi Zhang, Xi Peng, Jiazhi Zeng, Xierong Huang, Chuanwei Shenzhen Univ Coll Mat Sci & Engn Shenzhen Key Lab Special Funct Mat Shenzhen 518060 Peoples R China Shenzhen Univ Electron Microscopy Ctr Shenzhen 518060 Peoples R China

Stoichiometric composition, in particular, oxygen concentration, is of critical importance for distinct crystalline structures and emergent electronic properties of strongly correlated perovskite oxides. Using manganite La0.7Sr0.3MnO3 as a model system, we study oxygen vacancy (V-O) driven regulations of coordination chemistry, crystalline structure and associated physical property of La0.7Sr0.3MnO3 film by means of capping oxygen-deficient binary oxide (Al2O3-delta or TiO2-delta) ultrathin layer. High-efficient migrations of V-O at the interface of capped La0.7Sr0.3MnO3 heterostructure give rise to tunable Mn-O coordination units, topotactic transformations and concomitant electronic modulations. A distinct perovskite-brownmillerite (PV-BM) topotactic transformation is observed for the capped La0.7Sr0.3MnO3 film, accompanying by a crossover from ferromagnetic-metallic phase to antiferromagnetic-insulating one. This facile control of oxygen concentration of perovskite-based oxides has significant implications for rational design of functional oxides with unique coordination frameworks, electronic states and emergent performances.

关键词： Perovskite oxide film Coordination framework Topotactic transformation Oxygen vacancy

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Transition from Anammox to Feammox metabolic modes: Regulation strategies for nitrite in Anammox enrichment cultures

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BIORESOURCE technology 2025年 432卷 132674页

作者： Wang, Peng He, Di Zhao, Jianshu Xiao, Zhenxiong Tan, Jun Ma, Jinxing Zheng, Min Guangdong Univ Technol Sch Ecol Environm & Resources Key Lab City Cluster Environm Safety & Green Dev Minist Educ Guangzhou 510006 Peoples R China Harbin Inst Technol Sch Civil & Environm Engn Shenzhen 518055 Peoples R China Shenzhen Pangu Environm Protect Technol Co Ltd Shenzhen 518055 Peoples R China Univ New South Wales Water Res Ctr Sch Civil & Environm Engn Sydney NSW 2052 Australia

This study achieved the metabolic transition from anaerobic ammonium oxidation (Anammox) to Fe(III)mediated ammonium oxidation (Feammox) using iron-carbon micro-electrolytic spheres as a slow-release iron source through a stepwise reduction in influent NO2--N concentration. The results demonstrated that sustained Feammox activity was governed by nitrate-dependent ferrous oxidation (NDFO) metabolism combined with-oxygen-regulated Fe(III) regeneration, resulting in a peak total nitrogen removal efficiency of 91.6 % at 40 mg/L NO2--N. While exclusive NH4+-N feeding inhibited Feammox activity, this suppression was reversible upon NO2--N supplementation. Intriguingly, Anammox activity remained robust despite decreasing NO2--N levels and showed significant positive correlation with Feammox activity, suggesting shared metabolic modules. Metagenomic profiling further identified Ca. Brocadia as the core functional genus driving NH4+-N oxidation, highlighting its niche adaptation in iron-mediated systems. These mechanistic insights establish a framework for designing energy-efficient nitrogen removal processes leveraging iron-redox cycling.

关键词： Nitrogen removal Iron redox cycle Extracellular electron transfer Metagenomics

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Targeting CLK2 and serine/arginine-rich splicing factors inhibits multiple myeloma through downregulating RAE1 by nonsense-mediated mRNA decay mechanism

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CANCER science 2025年第1期116卷 164-177页

作者： Liu, Yang Liao, Yaping Lai, Shuping Wu, Xiaoyan Liang, Laoqi Zhang, Yihao Wei, Rongfang Chen, Yan Sun Yat sen Univ Affiliated Hosp 8 Dept Hematol 3025 Shennan Middle Rd Shenzhen 518033 Peoples R China

Multiple myeloma (MM) is closely related to abnormal RNA splicing in its pathogenesis. CDC2-like kinase-2 (CLK2) regulates RNA splicing by phosphorylating serine/arginine-rich splicing factors (SRSFs), but the role of CLK2 in MM remains undefined. This study was to explore the role and mechanism of CLK2 in MM. Analyzing GEO datasets of MM patients found that high CLK2 expression predicted poor prognosis. Overexpression of CLK2 promoted the cell proliferation and cell cycle progression of MM cell ARP1 and H929. Knockdown or inhibition of CLK2 suppressed cell proliferation and induced cell apoptosis and cell cycle arrest in ARP1 and H929 cells in vitro. An MM xenograft tumor experiment showed that CLK2 overexpression promoted tumor growth, while CLK2 inhibition suppressed tumor growth in vivo. Mechanistic studies revealed that interfering CLK2 inhibited SRSF phosphorylation, and induced exon 9 skipping of RAE1, resulting in nonsense-mediated mRNA decay (NMD) of RAE1. In addition, RAE1 knockdown inhibited cell proliferation in ARP1 and H929 cells. Moreover, RAE1 overexpression promoted cell proliferation and cell cycle progression of ARP1 and H929 cells, and partially reversed the antitumor effect of CLK2 knockdown. Targeting CLK2 shows antitumor effects on MM partially through inhibiting SRSF phosphorylation and inducing NMD of RAE1. Therefore, targeting the CLK2/SRSFs/RAE1 axis could be a potential therapeutic strategy for MM.

关键词： alternative splicing CLK2 nonsense-mediated mRNA decay RAE1 SRSF

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Metabolic Profiling Reveals Diagnostic Biomarkers for Distinguishing Myocarditis From Acute Myocardial Infarction

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CARDIOVASCULAR THERAPEUTICS 2025年第1期2025卷

作者： Chen, Yuting Liu, Xiu Hong, Chengying Xu, Shunyao He, Linling Liu, Zhenmi Chen, Huaisheng Lin, Yaowang Southern Univ Sci & Technol Jinan Univ Shenzhen Peoples Hosp Dept Crit MedClin Med Coll 2Affiliated Hosp 1 Shenzhen Peoples R China Southern Univ Sci & Technol Jinan Univ Shenzhen Peoples Hosp Cardiovasc Minimally Invas Med Engn Technol Res & Shenzhen Peoples R China

Background: Distinguishing between myocarditis (MC) and acute myocardial infarction (AMI) in the early stages is crucial due to their similar symptoms yet vastly different treatment protocols. This study seeks to utilize metabolomics techniques to differentiate between MC and ***: Plasma samples from 15 patients with MC and 12 patients with AMI were collected. Metabolic profiles of plasma from the two groups of patients were obtained using ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MS), identifying metabolites with significant ***: We identified 30 significantly different metabolites in both diseases. In patients with MC, 17 metabolites were upregulated, including 5-hydroxy-L-tryptophan and LysoPC (18:2(9Z,12Z)), while 13 metabolites were downregulated, such as 11-cis-retinol, L-glutamate, and hydroxynicotinic acid. KEGG enrichment analysis revealed that the altered metabolites were enriched in tryptophan metabolism, linoleic acid metabolism, primary bile acid biosynthesis, nitrogen metabolism, and retinol metabolism. Biomarker analysis via receiver-operating characteristic curves highlighted 11-cis-retinol as the predominant biomarker, with an AUC value of ***: In conclusion, patients experiencing AMI and MC undergo significant metabolic reprogramming. Metabolites exhibiting abnormal expression in peripheral blood hold diagnostic value for distinguishing between AMI and MC in clinical settings. 11-cis-retinol proved to be the pivotal biomarker for AMI, potentially aiding in the development of a robust predictive model for distinguishing between MC and AMI in clinical settings.

关键词： 11-cis-retinol acute myocardial infarction metabolic reprogramming myocarditis retinol metabolism

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Low-exhaustion peripheral circulating γδ T cells serve as a biomarker for predicting the clinical benefit rate of non-small cell lung cancer (NSCLC) patients to chemotherapy or targeted therapy: a single-center retrospective study

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BMC CANCER 2025年第1期25卷 1-11页

作者： Zhang, Dongdong Liu, Guichao Ye, Jinhui Li, Ke Zhang, Guojun Quan, Qiang Zhu, Xinhai Li, Peng Jinan Univ Affiliated Hosp 1 Dept Thorac Surg Guangzhou Peoples R China Jinan Univ Affiliated Hosp 1 Res Ctr Canc Diag & Therapy Dept Oncol Guangzhou Peoples R China First Peoples Hosp Foshan City Dept Radiat Oncol Foshan Peoples R China First Peoples Hosp Zhaoqing Dept Breast Oncol Zhaoqing Peoples R China Sun Yat Sen Univ Affiliated Hosp 7 Dept Geriatr Shenzhen Peoples R China Hosp Southern Univ Sci & Technol Dept Clin Nutr Shenzhen Peoples R China Jinan Univ Zhuhai Peoples Hosp Zhuhai Inst Translat Med Guangdong Prov Key Lab Tumor Intervent Diag & Trea Zhuhai Peoples R China Jinan Univ Biomed Translat Res Inst Fac Med Sci Guangzhou Peoples R China

BackgroundMultiple studies have demonstrated that the abundance and functionality of gamma delta T cells are favorable prognostic indicators for prolonged survival in cancer patients. However, the association between the immunophenotype of circulating gamma delta T cells and the therapeutic response in NSCLC patients undergoing chemotherapy or targeted therapy remains *** with EGFR wild-type (EGFR-WT) or mutant (EGFR-Mut) non-small cell lung cancer (NSCLC), diagnosed between January 2020 and January 2024, were included in this study. Clinicopathological characteristics, treatment regimens, and follow-up data were retrospectively collected. Peripheral blood samples from 52 NSCLC patients were analyzed for the immunophenotypes of alpha beta T cells and gamma delta T cells using full-spectrum flow *** significant differences were observed in the proportions of alpha beta T cells or gamma delta T cells, nor in the expression of immune exhaustion markers, between epidermal growth factor receptor wild-type and mutant NSCLC patients. Notably, NSCLC patients with a high clinical benefit rate (responder, R) exhibited a higher proportion of circulating V delta 2 T cells compared to non-responders (NR), in both EGFR-Mut (NR vs. R, P = 0.0437) and EGFR-WT groups (NR vs. R, P = 0.0180). Additionally, the expression of the immune exhaustion marker PD-1 on V delta 2 T cells was significantly lower in the responder group (NR vs. R, EGFR-Mut, P = 0.0050;EGFR-WT, P = 0.0180). Moreover, responder patients exhibited elevated levels of TNF-alpha compared to non-responders, irrespective of EGFR mutation status (NR vs. R, EGFR-Mut, P = 0.0055;EGFR-WT, P = 0.0007).ConclusionsThese findings collectively suggest that circulating V delta 2 T cells with low levels of immune exhaustion are critical contributors to the effectiveness of chemotherapy and targeted therapies in NSCLC. Targeting V delta 2 T cells may represent a promising strategy for enhancing the

关键词： gamma delta T cell Immune exhaustion NSCLC Chemotherapy Targeted therapy

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Rethinking the Sustainability of Industrial Buildings in High-Density Urban Areas: Balancing Adaptability and Public Satisfaction

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BUILDINGS 2025年第5期15卷 747-747页

作者： Ding, Xiao Shao, Yuchen Feng, Botao Macau Univ Sci & Technol Fac Humanities & Arts Macau 999078 Peoples R China Shenzhen Technol Univ Sch Design & Innovat Shenzhen 518118 Peoples R China Shenzhen Univ Coll Elect & Informat Engn Shenzhen 518060 Peoples R China

In the context of land scarcity and high-density urban areas, the adaptive reuse of abandoned historical industrial buildings plays a critical role in achieving sustainable development goals. This study proposes a sustainability assessment framework for the adaptive reuse of industrial buildings as exhibition spaces within the context of high-density urban development, addressing multiple dimensions of sustainability, including the building's physical structure, economic factors, environmental impact, social considerations, and governance. The framework consists of 55 design indexes, categorized into 15 subcategories and 5 main categories. We conducted a survey of experts with experience in high-density urban renewal design and implemented a weighting analysis to identify priority intervention measures for industrial building redevelopment in the era of urban stock. Finally, a fuzzy comprehensive evaluation was carried out on ten cases in shenzhen where industrial buildings were converted into exhibition spaces over the past 12 years. The findings reveal the following: (1) "Reuse of old architectural spaces" is the most critical category to prioritize, and, at the indicator level, "adaptability and efficiency of building reuse", "public participation in the renewal process", "cooperative operation structures", and "planning vision" are identified as the four key influencing factors. (2) The functional layout, historical value, and richness of public amenities in the transformed industrial buildings have a significant positive impact on the evaluation results, while the building's construction time and floor area do not significantly affect public post-evaluation. (3) Younger and more highly educated groups tend to view the transformed exhibition spaces as tourist attractions, particularly expressing satisfaction with the repurposing of the Kinwei Brewery and OCAT B10 New Hall, and consider the adaptive reuse of industrial buildings to promote sustainable urban renew

关键词： adaptive industrial building reuse analytic hierarchy process Delphi method fuzzy comprehensive evaluation sustainable urban regeneration

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Direct quenching and double tempering obtain high strength and toughness of Cu-bearing HSLC martensitic steel

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JOURNAL OF MATERIALS RESEARCH AND technology-JMR&T 2025年 35卷 13-24页

作者： Zhao, Xingyu Zhang, Xiaoxin Zhou, Junquan Chen, Yingxue Zhang, Feifei Zhang, Jun Yan, Qingzhi Univ Sci & Technol Beijing Inst Nucl Mat Sch Mat Sci & Engn Beijing 100083 Peoples R China China Nucl Power Technol Res Inst Co Ltd Shenzhen 518000 Peoples R China

Cu-bearing high strength low carbon (HSLC) steel possesses high strength due to the existence of finely dispersed Cu-rich phases within the matrix. However, such high precipitation strengthening results in the loss of toughness. To break this strength-toughness trade-off, we propose a new strategy of direct quenching followed by double tempering (DQ-TT). Over four times higher energy was found in the DQ-TT sample (74 J) at -84(o)C compared to the other samples with single tempering (DQ-T, 13 J) and reheated quenching (RQ-TT, 6 J) without the sacrifice of strength. This high toughness is proved to be derived from: the higher cleavage fracture stress (sigma(F)) and the higher crack initiation and propagation energy. The former comes from the refined effective grain sizes (EGS, 5.66 mu m) and the optimized element segregation, where Cu (low enrichment ratio of 2.75) and Mo (high enrichment ratio of 35.20). The reduced segregation of Cu and the enrichment of Mo at the lath boundaries can effectively enhance the interfacial bonding strength. The latter is related to the orientations of the materials. It is measured that the DQ-TT sample has higher <110>//RD (47.8%) and <001>//ND (20.5%) deformation textures, which correspond to the {001} cleavage plane parallel to the RD and {110} slip plane parallel to the ND. The weak {001}//RD and strong {110}//ND ensure crack initiation and propagation along weak interfaces while preventing significant cleavage fracture. Oscilloscope impact tests reveal that DQ-TT process possesses higher crack initiation and propagation energy, which are 20 J and 37 J, respectively.

关键词： Cu-bearing HSLC steel Direct quenching and double tempering Element segregation EGS Laminated structure Strength and toughness

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Laser Powder Bed Fusion of a Novel Crack-Free γ′ Phase-Strengthened Ni-Based Alloy

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MATERIALS 2025年第2期18卷 237-237页

作者： Wu, Defan Feng, Jiafeng Wang, Yi Wang, Zhijie Wu, Meng Han, Quanquan Shandong Univ Shenzhen Res Inst Shenzhen 518057 Peoples R China Shandong Univ Sch Mech Engn Minist Educ Key Lab High Efficiency & Clean Mech Manufacture Jinan 250061 Peoples R China Weifang Vocat Coll Sch Automot Engn Weifang 262737 Peoples R China

Laser powder bed fusion (LPBF)-fabricated Ni-based alloys with high gamma ' phase fractions generally suffer from cracking that limits their applications. This study presents SD247, a novel alloy that overcomes the challenge of cracking issues and exhibits superior mechanical properties after heat treatment. Compared to CM247LC, SD247 exhibited a lower cracking tendency due to alloying element modification. After heat treatment, SD247 features primary gamma ' phases with an average diameter of 306 nm and secondary gamma ' phases averaging 25 nm, with few Ta- and Ti-rich MC-type carbides. The columnar grain structure in as-built specimens largely disappeared, and the fraction of grains in soft orientations decreased by 12.8%. The microhardness and ultimate tensile strength increased by 30% and 20%, respectively. These findings demonstrate that the superior LPBF fabrication of Ni-based alloys with a high gamma ' fraction can be achieved. Because of the excellent mechanical properties and acceptable cost, LPBF-fabricated SD247 shows great potential in aerospace hot-end components.

关键词： laser powder bed fusion Ni-based alloy cracking suppression microstructure mechanical properties

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