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Nasal or Submandibular Intubation for Anesthesia in Orthognathic Surgery to Correct Jaw Deformities Secondary to Cleft Lip and Palate: Which One Is the Optimal Choice?

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AESTHETIC PLASTIC SURGERY 2025年 1-9页

作者： Wu, Yifan Ge, Han Gao, Heyou Zhou, Zihang Ye, Bin Li, Jihua Sichuan Univ West China Hosp Stomatol State Key Lab Oral Dis Chengdu Peoples R China Sichuan Univ West China Hosp Stomatol Natl Clin Res Ctr Oral Dis Chengdu Peoples R China Sichuan Univ West China Hosp Stomatol Dept Orthognath & TMJ Surg Chengdu Peoples R China Sichuan Univ Coll Stomatol Chengdu Peoples R China

The aim of this retrospective study is to investigate the optimal airway management of orthognathic surgery anesthesia for correcting jaw deformity secondary to cleft lip and palate (CLP) by comparing the differences between nasal and submandibular intubation. Preoperative (T0), 1 week postoperatively (T1), and 6 months postoperatively (T2) CT scans and vital signs after oral intubation (S0), before reconnection of the submandibular tracheal catheter (S1), and after reconnection (S2) were collected from 54 patients who received nasal intubation (Group I) and submandibular intubation (Group II). The results were evaluated using 3D reconstruction and analysis in Mimics. During the follow-up, all patients demonstrated satisfactory facial shape and stable occlusion and no significant complications were observed. In Group II, maxillary operation duration and blood loss were significantly reduced (P < 0.001), and nasal septum deviation was distinctly improved (P < 0.001). Both groups exhibited increased nasal alar width, but Group I particularly females showed greater changes (P < 0.05). Only 2 patients (6%) in Group II developed hypertrophic scars 6 months postoperatively. This study demonstrates that submandibular intubation anesthesia represents a straightforward, safe and less complicated technique in orthognathic surgery for CLP patients. Nevertheless, this method should be carefully chosen for patients with scar constitution. Level of Evidence IV This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors ***/00266.

关键词： Submandibular intubation Orthognathic surgery Cleft lip and palate Airway management Malocclusion

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Three-way unsupervised anomaly detection of sequential patterns

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INTERNATIONAL JOURNAL OF MACHINE LEARNING AND CYBERNETICS 2025年 1-18页

作者： Chen, Gong-Suo Chandarasupsang, Tirapot Zhang, Zhi-Heng Zhou, Xiang-Bing Deng, Wu Tananchana, Annop Mu, Lei Min, Fan Chiang Mai Univ Int Coll Digital Innovat Chiang Mai 50200 Thailand Sichuan Tourism Univ Sch Informat & Engn Chengdu 610100 Peoples R China Civil Aviat Univ China Coll Elect Informat & Automat Tianjin 300300 Peoples R China Chengdu Univ Off Int Cooperat & Exchange Chengdu 610106 Peoples R China Southwest Petr Univ Sch Comp Sci & Software Engn Chengdu 610500 Peoples R China

Unsupervised anomaly detection of sequential patterns is attractive in various industries. Compared to methods that rely on prior model assumptions, model-free methods are more adaptive to different applications, while are more challenging. Some popular methods quantify the absolute error between the actual and expected frequencies of a pattern. However, they are insensitive to new patterns. In this paper, we propose a three-way anomaly detection of sequential pattern (3WADSP) method to address this issue. First, we define the error between a pattern's actual frequency relative to the expected one as anomaly metric. The detection performance is effectively improved due to the high sensitivity of the new metric. Second, we construct two trisecting-acting-outcome models for estimating expected frequency, and capturing the symptoms before the occurrence and disappearance of anomalous patterns, respectively. The former provides better interpretability, and the later brings stronger diversity. Finally, we design a smoothing technique by averaging the anomaly degrees of overlapped patterns. The ambiguity caused by the overlapping is eliminated. 3WADSP not only extends the methodology of three-way decisions, but also provides new tools and perspectives for applications such as medical and fault diagnosis.

关键词： Anomaly detection Sequence analysis Three-way decisions Unsupervised learning

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Advanced dynamic power management using model predictive control in DC microgrids with hybrid storage and renewable energy sources☆

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JOURNAL OF ENERGY STORAGE 2025年 106卷

作者： Bhayo, Muhammad Zubair Han, Yang Bhagat, Kalsoom Hussain, Jawad Sanjrani, Ali Nawaz Narejo, Attaullah Univ Elect Sci & Technol China Sch Mech & Elect Engn Chengdu 611731 Peoples R China Chengdu Univ Sch Elect Informat & Elect Engn Chengdu 611731 Peoples R China MUET SZAB Campus Dept Elect Engn Khairpur Mirs Sindh Pakistan Univ Elect Sci & Technol China Sch Comp Sci & Engn Chengdu 611731 Peoples R China

This study introduces a dynamic power management system for microgrids, utilizing hybrid energy storage systems and variable renewable energy sources. Efficient power allocation is challenging due to the differing response times of components such as batteries, electric vehicle batteries, and supercapacitors. To address this challenge and enhance microgrid operations, a dynamic power management system is essential. The contribution of this research is the novel implementation of model predictive control for operating and controlling such microgrids. The novel model predictive control approach is used to manage power electronic components, such as direct current converters and inverters connected to the grid. To assess the microgrid stability under dynamic conditions, five different scenarios are considered for the active power management of microgrids that simulate real-world conditions. The proposed dynamic power management system offers improved stabilization of the direct current bus voltage compared to the conventional sliding mode control method. Variations in the direct current bus voltage are minimal, approximately 4 % of the rated voltage, compared to the 6.1 % variation observed with the traditional sliding mode control method. Simulation results demonstrate the efficiency of the model predictive control-based dynamic power management system in stabilizing the direct current bus voltage, mitigating power fluctuations, regulating the current slope of electric vehicle batteries, and facilitating seamless transitions between standalone and grid-integrated operating modes.

关键词： Dynamic power management system Microgrid Maximum power point tracking Model predictive control Hybrid energy storage system Variable renewable energy system

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Catalytic Enantioselective Nucleophilic Desymmetrization at Phosphorus(V): A Three-Phase Strategy for Modular Preparation of Phosphoramidates

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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2025年第13期147卷 11010-11018页

作者： Nie, Xiao-kang Zhang, Shi-qi Wang, Xu-yang Yang, Wan-ting Zhang, Xia Chen, Shang-jing Cui, Xin Tang, Zhuo Li, Guang-xun Chinese Acad Sci Chengdu Inst Biol Chengdu 610041 Sichuan Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China

Chiral phosphoramidates characterized by at least a P-N bond without a P-C bond demonstrate a significant applicative value within nucleoside phosphoramidate prodrugs. Despite the availability of methodologies for the selective construction of diverse chiral organophosphorus entities, achieving P-stereocenters solely substituted by heteroatoms often relies on diastereomeric synthesis. Here, we present a catalytic enantioselective desymmetrization strategy using an electrophilic phosphorus reagent with three leaving groups as a substrate, enabling a three-phase nucleophilic attack with various alcohols and amines. By generating a broad range of possible substituent combinations around phosphorus atoms, this synthetic strategy may expedite the synthesis and screening of biologically active phosphoramidates.

关键词： Enantioselectivity

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Liquid-based kidney injury molecule-1 as a diagnostic and prognostic indicator in renal cell carcinoma: A systematic review and meta-analysis

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INTERNATIONAL UROLOGY AND NEPHROLOGY 2025年 1-12页

作者： He, Sike Liu, Dingbang Chen, Junru Zhang, Xingming Liang, Jiayu Zhao, Jinge Hu, Xu Liu, Zhenhua Zeng, Hao Sun, Guangxi West China Hosp Inst Urol Dept Urol Chengdu Peoples R China

Purpose Noninvasive biomarkers for renal cell carcinoma (RCC) are vital but scarce. Kidney injury molecule-1 (KIM-1) is a transmembranous glycoprotein that is sensitive and specific to kidney injury. KIM-1 is overexpressed in RCC, and its ectodomain can be detected in blood and urine. Here, we explored whether KIM-1 is a diagnostic or prognostic indicator in RCC. Methods A comprehensive online literature search was performed in PubMed, Web of science, Embase, Cochrane Library, ClinicalTrails, and Database of major urological or oncological congress. We screened the literature and extracted the data according to the selection criteria. The quality of eligible studies was measured via the Quality Assessment of Diagnostic Accuracy Studies-2 tool and the Newcastle-Ottawa scale. The certainty of the evidence (CoE) was assessed by the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) score. The sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), area under the curve of the summary receiver operating characteristic curve (AUROC), and survival outcomes were subsequently estimated in Stata and MetaDisc. Subgroup analysis, meta-regression, and sensitivity analysis were performed to reveal the source of heterogeneity. Results A total of eight studies were included for further analysis. The pooled sensitivity of KIM-1 for RCC diagnosis was 0.78 (95% CI: 0.69-0.85, I-2 = 84.61%, p < 0.01), and the pooled specificity was 0.79 (95% CI: 0.65-0.89, I-2 = 90.72%, p < 0.01). The AUROC was 0.85 (95% CI: 0.82-0.88). A moderate CoE was indicated by GRADE score. A higher KIM-1 level was associated with worse disease-free survival (HR = 1.76, 95% CI: 1.48-2.09, I-2 = 0.00%, p < 0.001). Study continent, number of study center, and sample type are the potential contributors of heterogeneity. Conclusion Liquid-based KIM-1 is a promising noninvasive biomarker for early RCC detection, surveillance, a

关键词： Kidney injury molecule-1 Renal cell carcinoma Diagnosis Prognosis Meta-analysis

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A New Pattern of Species Diversification Revealed by Populus on the Qinghai-Tibet Plateau

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EVOLUTIONARY BIOLOGY 2025年第1期52卷 71-83页

作者： Mi, Jia-Xuan Tian, Fei-Fei Huang, Jin-Liang Shi, Yu-Jie Li, Jing Meng, Fan-Yu He, Fang Zhong, Yu Yang, Han-Bo Zhang, Fan Chen, Liang-Hua Wan, Xue-Qin Sichuan Agr Univ Coll Forestry Chengdu 611130 Peoples R China Sichuan Prov Key Lab Ecol Forestry Engn Upper Reac Chengdu Peoples R China Sichuan Agr Univ Coll Landscape Architecture Chengdu 611130 Peoples R China Taizhou Univ Zhejiang Prov Key Lab Plant Evolutionary Ecol & Co Taizhou 318000 Peoples R China

While speciation diversity is widely acknowledged, significant debate exists regarding the universality of hybrid speciation. An 18 year systematic investigation of all Populus taxa on the Qinghai-Tibet Plateau resulted in the identification of 23 recorded taxa and 8 newly identified taxa. Morphologically, these taxa can be categorized into three groups, one of which includes 11 taxa with distinct characteristics of P. simonii. Whole-genome resequencing of 150 genotypes across 31 taxa yielded 2.28 million SNPs. Among these, P. ranwuensis, P. baibaensis, P. qingdensis, and P. erlangshanensis were identified as new species. These species, along with six other taxa displaying characteristics of P. simonii, originated through natural hybridization, with P. simonii serving as a common direct ancestral species. The another direct ancestral species of P. yunnanensis and P. trinervis is P. szechuanica, that of P. ranwuensis, P. qingdensis, P. kangdingensis, P. przewalskii, and P. schneideri var. tibetica is P. xiangchengensis, that of P. qamdoensisis is atypical P. curviserrata, and that of P. baibaensis is P. pseudoglauca. Natural hybridization is identified as a dominant driver of species diversification in Populus on the Qinghai-Tibet Plateau and a critical factor contributing to the disappearance of ancient species in the northern, western, and central regions of the plateau. The universality and evolutionary significance of hybrid speciation appear to have been substantially underestimated.

关键词： Hybrid speciation Phylogeny Populus Populus simonii Species diversification The Qinghai-Tibet Plateau

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SDRNet: A hybrid approach with deep convolutional networks for ship draft reading

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MEASUREMENT 2025年 247卷

作者： Wang, Bangping Liu, Zhiming Shen, Yantao Wang, Siming Chengdu Univ Informat Technol Sch Software Engn Chengdu 610103 Sichuan Peoples R China Aetrex Teaneck NJ 07666 USA Univ Nevada Dept Elect & Biomed Engn Reno NV 89557 USA Chengdu Neusoft Univ Sch Intelligent Sci & Engn Chengdu 610225 Peoples R China

Ship draft measurement is essential in the maritime freight transport industry, but traditional methods relying on human surveyors are prone to errors. With the rise of deep learning and computer vision, there is significant potential to improve both accuracy and efficiency in this process. This paper presents SDRNet, a novel approach leveraging deep convolutional networks for automated ship draft reading. SDRNet integrates a multi-task vision network, combining a keypoint detection sub-network for draft mark identification and a semantic segmentation sub-network for waterline extraction. Additionally, a scene text recognition network is employed to extract integer values from draft marks. Extensive experiments show that SDRNet achieves performance comparable to human surveyors, offering a promising solution to enhance the accuracy and reliability of ship draft measurement in the maritime industry.

关键词： Ship draft reading Computer vision Deep learning Keypoint detection Scene text recognition Semantic segmentation

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Predictive factors for axillary pathological complete response to neoadjuvant therapy in elderly breast cancer patients

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BMC CANCER 2025年第1期25卷 1-9页

作者： Wang, Yuying Wang, Rui Lu, Di Zeng, Yaling Tu, Xihui Liu, Shiwei Zhang, Purong Univ Elect Sci & Technol China Sch Med Chengdu Peoples R China North Sichuan Med Coll Coll Clin Med Nanchong 637000 Sichuan Peoples R China Univ Elect Sci & Technol China Sichuan Canc Hosp & Inst Sichuan Clin Res Ctr Canc Sichuan Canc CtrAffiliated Canc Hosp Chengdu Peoples R China

Purpose This study explores the predictive factors for axillary pathological complete response(apCR) during neoadjuvant therapy(NAT) for elderly breast cancer patients to supplement the indications for retaining the axilla. Methods Comprehensive clinical information was gathered from November 2016 to July 2023 from elderly patients with pathology-confirmed invasive breast cancer who underwent NAT and surgery in the Breast Department of sichuan Cancer Hospital. The relationships between clinicopathological characteristics and apCR were investigated via retrospective analysis. Univariate analysis of the clinicopathological parameters and efficacy was performed via the chi-square test or Fisher's exact test, while multivariate analysis was conducted via binary logistic regression. Results This study included 109 elderly patients with breast cancer, with an overall apCR rate of 46.8%. The univariate analysis results showed that the initial clinical lymph nodes negative(cN0) stage, Human Epidermal Growth Factor Receptor 2(HER2) positivity and breast pathological complete response(bpCR) were significantly correlated with high apCR rates(all P < 0.05). Multivariate analysis revealed that apCR exhibited a significant association with initial cN0 stage and HER2 positivity. The apCR rate for HER2-positive elderly patients with initial cN0 disease is 100.0%,whereas the lowest apCR rate is observed in HER2-negative and clinical lymph nodes positive(cN+) patients(36.0%). Subgroup analysis revealed a close relationship between molecular subtypes and apCR. Conclusion This study indicates that initial cN0 stage and HER2 positivity can serve as independent predictive factors for apCR after NAT in elderly breast cancer patients. HER2-positive elderly patients with initial cN0 stage can be considered exempt from axillary lymph node dissection(ALND) after standard NAT.

关键词： Elderly breast cancer patients Neoadjuvant therapy Axillary pathological complete response Predictive factors

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Protecting anthocyanins of postharvest blueberries through konjac glucomannan/low-acyl gellan gum coatings contained thymol microcapsule during low-temperature storage

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FOOD CHEMISTRY 2025年第Pt 2期463卷 141347页

作者： Xie, Jing Sameen, Dur E. Xiao, Zhenkun Zhu, Huiyan Lai, Yunya Tang, Tingting Rong, Xingyu Fu, Fengmei Qin, Wen Chen, Mingrui Liu, Yaowen Sichuan Agr Univ Coll Food Sci Yaan 625014 Peoples R China Chongqing Three Gorges Vocat Coll Coll Agr & Forestry Sci & Technol Chongqing 404100 Peoples R China

In order to protect the anthocyanins in blueberries during low-temperature storage, TMs/KGM/LAG (TKL) coatings were developed by composite thymol/(3-cyclodextrin ((3-CD) microcapsules (TMs), konjac glucomannan (KGM), and low acyl gellan gum (LAG). The results showed that the TMs prolonged the release of thymol for at least 30 d. The TKL was effective in maintaining the color of blueberry skin by regulating the activities of key enzymes for anthocyanin synthesis and degradation. Among the different treatment groups, TKL60 (thymol concentration of 60 mg/L) was the most effective in protecting anthocyanin. At 42 d of storage, the TKL60 group showed the highest anthocyanin levels of malvidin-3-O-galactoside (718.38 mu g/g), delphinidin-3-O-galactoside (343.75 mu g/g) and cyanidin-3-O-galactoside (40.67 mu g/g). In addition, TKL60 treatment still showed good maintain the qualities of blueberries (weight loss, decay, hardness and TSS). Thus, this study provides a new approach to protect anthocyanin in blueberries after harvest during low-temperature storage.

关键词： Blueberry Anthocyanins Thymol Coatings

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A Cathode-Anode Ratiometric Internal Standard Electrochemiluminescence Recognition Strategy Based on Hexagonal AgNCs and ZnCdSe QDs Dual-Labeled Exon Conservative Motif Aggregation for LncRNA Assay

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ANALYTICAL CHEMISTRY 2025年第9期97卷 4881-4888页

作者： Zhong, Jia Yang, Qinlan Wang, Bin Wang, Guangjie Wang, Ao Lou, Yuxin Su, Huilan Zhang, Yajie Mao, Li Chengdu Med Coll Sch Publ Hlth Chengdu 610500 Peoples R China JinJiang Dist Chengdu Ctr Dis Control & Prevent Chengdu 610021 Peoples R China Gen Hosp Western Theater Command PLA Canc Diag & Treatment Ctr Chengdu 610083 Peoples R China

A cathode-anode bipolar electrochemiluminescence (ECL) strategy on multisite recognition for highly conservative gene motifs is anticipated to anchor the >200 nt-long polynucleotide chain for precise quantification. Herein, lncRNA-HOTAIR sequences in the NCBI database, derived from four different species (Homo sapiens, Mus musculus, Pan troglodytes, Canis lupus familiaris), were blasted online to confirm three-segment conservative exon motif texts (abbreviated as motif 1, motif 2 and motif 3), whose complementary gene sequences were artfully designed as capture probe (P1, complementary with motif 1) and signal probes (P2, P3, complementary with motif 2 and motif 3 in a controllable two-base interval). By exploiting the anode potential dominant sulfate radical and reactive oxide radical reaction, a new couple of ECL signals at E-pc of -1.8 V and E-pa of 3.5 V (vs Ag/AgCl) was revealed in hexagonal silver nanocrystal (H-AgNC) coreaction-accelerated graphene oxide/persulfate (GO/S2O82-) system. While the rolling circle amplification for the adjacent sequences of motif 2/motif 3 followed by motif 1 capture on composite film, H-AgNCs and ZnCdSe QDs dual-labeled probe aggregation on the amplified motifs induced a couple of cathode-anode quenched ECL signals. In proportion to the fairly stronger internal standard signal formed by a single H-AgNC-labeled probe, the dual-label quenched ECL signal ratio (Delta I-pc/Delta I-pa) was linearly fitting as Y = 2.34X + 8.32 to reflect lncRNA HOTAIR level with a limit-of-detection (LOD) of 0.01 pg/L. The analysis performance on bipolar ECL behavior was compared upon different anode final potential to objectively assess the impact of anode polarization and the possibility in trace clinical lncRNA assay.

关键词： Free radical reactions

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