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Shimmy vibration control of straddle-type monorail vehicle with time delay compensation based on signal influence of multisource random track surface excitation

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MECHANICAL SYSTEMS AND SIGNAL PROCESSING 2025年 230卷

作者： Zhou, Junchao Jiang, Wei Huang, Shangwu Hu, Guangzhong Tang, Yongqing Liu, Xuan Du, Haiping Sichuan Univ Sci & Engn Sch Mech Engn Zigong 0813 Peoples R China Luzhou Laojiao Grp Luzhou 0803 Peoples R China Chengdu Chongqing Econ Circle Luzhou Adv Technol R Luzhou 0803 Peoples R China Univ Wollongong Sch Elect Comp & Telecommun Engn Wollongong Australia

The shimmy vibration of straddle-type monorail vehicle (SMV) induces intense interactions between the tires and the track beam, significantly compromising operational stability and passenger comfort. To enhance the lateral stability, safety, and comfort of monorail vehicles, this paper investigates the semi-active control methods for the suspension system of SMV using Magnetorheological dampers (MRD). The SMV is modeled as a mass-spring-damper system, and a simplified shimmy vibration model is derived. According to that, a semi-active robust controller, utilizing the shimmy vibration acceleration of the vehicle body as feedback variables, is developed. Inspired by biological rhythmic mechanisms, a control strategy integrating deep neural networks (DNN) with time-frequency analysis and central pattern generators (CPG) is designed to identify the time-domain signal characteristics of shimmy vibration acceleration. The identification results serve as a prerequisite for the semi-active robust controller to suppress shimmy vibration. Additionally, time delay compensation control is employed to reduce the time delay in MRD current response, thereby further enhancing control performance. To validate the proposed control strategy, a Hardware-in-the-Loop (HIL) test platform is established for the SMV system. The results confirm the effectiveness and robustness of the proposed strategy in controlling SMV shimmy vibration.

关键词： Straddle-type monorail vehicle Shimmy vibration control Deep neural networks Central pattern generators Magnetorheological dampers Random excitation

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Polysaccharide from Scutellaria baicalensis Georgi alleviates ulcerative colitis in mice by maintaining the intestinal barrier integrity via MLC/Notch signaling

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CANADIAN JOURNAL OF ANIMAL science 2025年第105期105卷 1-12页

作者： Xiao, Liang Chen, Yongpo Li, Xiaoqing Li, Shuwei Tang, Wenjie Yan, Jiayou Wei, Xiaolan Zhou, Mengjia Huang, Chongbo Diao, Hui Hunan A Long Win Biotechnol Co Ltd Changsha 410014 Hunan Peoples R China Sichuan Chelota Biotech Co Ltd Deyang 618302 Sichuan Peoples R China Agr & Rural Affairs Xiangdong Dist Pingxiang 337016 Jiangxi Peoples R China Sichuan Acad Anim Sci Anim Breeding & Genet Key Lab Sichuan Prov Chengdu 610066 Sichuan Peoples R China Sichuan Animtech Biol Dev Co Ltd Chengdu 611330 Sichuan Peoples R China Sichuan Animtech Grp Co Ltd Livestock & Poultry Biol Prod Key Lab Sichuan Prov Chengdu 610066 Sichuan Peoples R China

Ulcerative colitis is a chronic idiopathic inflammatory bowel disease (IBD) that seriously impacts human health. So far, little information has been reported on the possible benefits of polysaccharides from Scutellaria baicalensis Georgi (SBGP) in alleviating colitis. Therefore, our study investigated the potential therapeutic effects of SBGP on mice with DSS-induced colitis. Results showed that SBGP administration ameliorated the severity of clinical symptoms and enhanced immunomodulatory effects in dextran sulfate sodium (DSS)-treated mice. Additionally, SBGP was found to regulate the inflammatory response, improve mucosal barrier integrity, and maintain tight junctions in the colonic epithelium. Furthermore, SBGP was found to restrain the activation of Notch and MLCK/MLC signaling pathways, which play important roles in inflammation and epithelial barrier homeostasis. These findings suggest that SBGP may have therapeutic potential for the treatment of colitis and other IBD.

关键词： ulcerative colitis Scutellaria baicalensis Georgi polysaccharides intestinal barrier notch myosin

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An oxidation-reduction-triggered thiamine disulfide-based prodrug of 10-hydroxycamptothecin for selective tumor cell locking and therapeutic delivery

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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2025年 284卷 117233页

作者： Yang, Chunyan Yu, Peiyun Chen, Jinxia Lu, Runxin Hai, Li Yang, Zhongzhen Guo, Li Wu, Yong Sichuan Univ Key Lab Drug Targeting & Drug Delivery Syst Educ Minist Chengdu 610041 Peoples R China Sichuan Univ Sichuan Engn Lab Plant Sourced Drug Chengdu 610041 Peoples R China Sichuan Univ Sichuan Res Ctr Drug Precis Ind Technol West China Sch Pharm Chengdu 610041 Peoples R China Sichuan Univ Key Lab Birth Defects & Related Dis Women & Childr Childrens Med Key Lab Sichuan Prov Evidence Based Pharm CtrDept PharmWest China Uni Chengdu 610041 Peoples R China Sichuan Univ West China Hosp Dept Pharm Chengdu 610041 Peoples R China

Chemotherapy, a primary method of cancer treatment, has been limited in clinical application due to its lack of specificity and tumor multidrug resistance, resulting in numerous undesired side effects. Herein, a small molecule conjugate, TDK-HCPT, was designed and synthesized, which could target tumor cells and prolong the retention of chemotherapy agents within tumor cells. Moreover, a similarly designed control system, TDK-Nap, has been developed as well to enable cancer cell imaging. Two design elements are incorporated into TDK-HCPT: the thiamine disulfide (TDS) and the thioketal subunit (tk). TDS can be reduced in the high glutathione (GSH) conditions within cancer cell to form thiazolium salt, and the resulting enhanced positive charge and lipophobicity make the system difficult to be pumped out of tumor cells, thereby effectively "locking" the chemotherapy drug HCPT inside the tumor cells. Additionally, the tk subunit serves as a ROS trigger, within the tumor cells, the "locked" HCPT were then released and activated by the high ROS conditions, optimizing its targeted potential. This allows TDK-HCPT to serve as a redox-liable molecular platform that targets cancer cells selectively which decreases cancer cell migration, retards tumor growth, and lowers tumorigenesis rates as evidenced by a combination of in vitro and in vivo studies. To the best of our knowledge, this is the first time a cancer cell "lock in" has been shown to prevent tumorigenesis in an animal model.

关键词： Thiamine disulfide ROS-Responsive Drug delivery Tumor targeting Chemotherapy

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Al2O3-improved CaZr4(PO4)6 composite ceramics for matched to the thermal expansion of silicon wafers

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INTERNATIONAL JOURNAL OF APPLIED CERAMIC technology 2025年第3期22卷

作者： Ruan, Limei Li, Yuanxun Yang, Rui Li, Fuyu Univ Elect Sci & Technol China Sch Elect Sci & Engn Chengdu 610054 Peoples R China Chengdu Hongke Elect Technol Co Ltd Chengdu Peoples R China Univ Elect Sci & Technol China State Key Lab Elect Thin Films & Integrated Device Chengdu Peoples R China

During silicon wafer testing, a mismatch between the thermal expansion characteristics of the wafer probe card and the silicon wafer is likely to result in the probe not being able to maintain precise alignment with the various contact points on the wafer. To address this challenge, CaZr4(PO4)(6) + x wt% Al2O3 composite ceramics (CZPA, x = 0-25) are prepared by the solid-phase reaction method. when x = 5, the bulk density achieves the maximum value (3.17 g/cm(3)). Young's modulus reaches a maximum (58 GPa) at x = 5. The x- and y-axis shrinkages are in the range of 5.67%-8.67% and the z-axis shrinkage is in the range of 7.11%-9.91%. The coefficients of thermal expansion (CTE) gradually increase with the increase of Al2O3 doping and achieve a near-Si thermal expansion coefficient at x = 15, which means that it matches the thermal expansion of silicon wafers. This ceramic developed in this work is expected to be applied to multilayer-matched substrates matched to silicon.

关键词： Al2O3 doping composite ceramics coefficients of thermal expansion Young's modulus

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Correlation of cyclosporine A blood concentration with kidney injury for pediatric patients after hematopoietic stem cell transplantation: a retrospective cohort study

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EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 2025年第3期81卷 395-401页

作者： Shi, Wei Qiu, Xin Huang, Liang Zeng, Linan Lu, Runxin Li, Hailong Zou, Kun Jia, Zhijun Cheng, Guo Yu, Qin Zhao, Limei Zhang, Lingli Sichuan Univ West China Univ Hosp 2 Dept Pharm Chengdu 610041 Peoples R China Sichuan Univ West China Univ Hosp 2 Evidence Based Pharm Ctr Chengdu 610041 Peoples R China NMPA Key Lab Tech Res Drug Prod Vitro & Vivo Corre Chengdu 610041 Peoples R China Sichuan Univ Key Lab Birth Defects & Related Dis Women & Childr Minist Educ Chengdu 610041 Peoples R China Sichuan Univ West China Sch Pharm Chengdu 610041 Peoples R China Sichuan Univ Dept Pediat West China Univ Hosp 2 Chengdu 610041 Peoples R China Sichuan Univ Ctr Translat Med Lab Mol Translat Med Chengdu 610041 Peoples R China Sichuan Univ West China Univ Hosp 2 Natl Drug Clin Trial Inst Chengdu 610041 Peoples R China China Med Univ Shengjing Hosp Dept Pharm Shenyang 110004 Peoples R China Sichuan Univ West China Hosp Chinese Evidence Based Med Ctr Chengdu 610041 Peoples R China

Background: The potential nephrotoxicity of cyclosporine A (CsA) has been a problem for treating graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, the relationship between CsA blood concentration and acute kidney injury (AKI) in pediatric patients after allo-HSCT remains unclear. Methods: We performed a retrospective study including pediatric patients who received allo-HSCT in West China Second Hospital of sichuan University from 2000 to 2022 and collected their clinical data. Included patients' CsA blood concentration were divided into three cohorts according to the guideline. Multivariate logistic regression was used to estimate the relationship between AKI and CsA blood concentration and other factors. And the maximum cut-off value for the safe blood concentration range of CsA was obtained by the receiver operating characteristic (ROC) curve. Results: Seventy-nine patients (average age 6.75 +/- 4.25) were included. The incidence of kidney injury for three CsA blood concentration cohorts (< 200 ng/ml, 200-300 ng/ml, > 300 ng/ml) were 21.30%, 23.50%, and 66.70%, respectively. A multivariate logistic regression identified CsA blood concentration (> 300 ng/ml) and infection were risk factors for AKI (OR (<200 ng/ml): 0.115, 95% CI: 0.029-0.458;OR (200-300 ng/ml): 0.184, 95% CI: 0.036-0.929;OR (infection): 5.006, 95% CI: 1.491-16.810). Meanwhile, the maximum cut-off value for the safe blood concentration range of CsA is 276.85 ng/ml with an AUC value of 0.684 (P = 0.010). Conclusion: In conclusion, clinical treatment for the pediatric patients after allo-HSCT may be considered to control the blood concentration of CsA in 200-276.85 ng/ml and closely monitoring patients who have infections.

关键词： Cyclosporine A Blood concentration Allogeneic hematopoietic stem cells Kidney injury Pediatric patients

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Indirect 3D printing CDHA scaffolds with hierarchical porous structure to promote osteoinductivity and bone regeneration

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材料科学技术（英文版） 2025年第4期207卷 295-307页

作者： Wenling Dai Shikui Li Hengxing Jia Xingchen Zhao Chenxin Liu Changchun Zhou Yumei Xiao Likun Guo Yujiang Fan Xingdong Zhang National Engineering Research Center for Biomaterials Sichuan University29 Wangjiang RoadChengduSichuan 610064China School of Biomedical Engineering Sichuan University29 Wangjiang RoadChengduSichuan 610064China

Hierarchical porous structure,which include macropores,minor pores,and micropores in scaffolds,are essential in the multiple biological functions of bone repair and *** this study,patient-customized calcium-deficient hydroxyapatite(CDHA)scaffolds with three-level hierarchical porous struc-ture were fabricated by indirect 3D printing technology and particulate leaching *** sacrificial template scaffolds were fabricated using a photo-curing 3D printer,which provided a prerequisite for the integral structure and interconnected macropores of CDHA ***,20 wt％pore former was incorporated into the slurry to enhance the content of smaller pores within the CDHA-2 scaffolds,and then the CDHA-2 scaffolds were sintered to remove the sacrificial template scaffolds and pore *** obtained CDHA-2 scaffolds exhibited interconnected macropores(300-400 μm),minor pores(～10-100 μm),and micropores(＜10 μm)distributed throughout the scaffolds,which could promote bone tissue ingrowth,increase surface roughness,and enhance protein adsorption of *** vitro studies identified that CDHA-2 scaffolds had nanocrystal grains,high specific surface area,and outstand-ing protein adsorption capacity,which could provide a microenvironment for cell adhesion,spreading,and *** addition,the murine intramuscular implantation experiment suggested that CDHA-2 scaffolds exhibited excellent osteoinductivity and were superior to traditional BCP ceramics under condi-tions without the addition of live cells and exogenous growth *** rabbit calvarial defect repair results indicated that CDHA-2 scaffolds could enhance in situ bone *** conclusion,these findings demonstrated that the hierarchical porous structure of CDHA scaffolds was a pivotal factor in modulating osteoinductivity and bone regeneration,and CDHA-2 scaffolds were potential candidates for bone regeneration.

关键词： Calcium-deficient hydroxyapatite Indirect 3D printing technology Hierarchical porous structure Osteoinductivity Bone regeneration

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The Laminar-Turbulence Transition in Wall-Bounded Incompressible Magnetohydrodynamic Flows

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JOURNAL OF FUSION ENERGY 2025年第1期44卷 1-17页

作者： Wang, Lei Zhang, Xiujie Lv, Xinting Sun, Zhenchao Southwestern Inst Phys Ctr Fus Sci Huangjing Rd 5 Chengdu Peoples R China

Understanding the laminar-turbulence transition mechanism in wall-bounded incompressible magnetohydrodynamic (MHD) flows is particularly important for liquid metal blankets of fusion reactors. However, this physical mechanism is still not thoroughly clear until now, especially there is a lack of quantitative analysis results to indicate where within the channel the transition process is likely to occur first. Moreover, the Hartmann layer thickness-based Reynolds number (R) has been found as a single parameter to control the transition process in MHD flows, but a mathematical explanation about this parameter is still absent. In this work, the turbulence transition phenomenon of the wall-bounded incompressible MHD flow is studied by a method called the energy gradient analysis. It points out that the ratio of the total mechanical energy density gradient in the transverse direction to that in the streamwise direction of the main flow (defined by a dimensionless parameter K) characterizes the development of the disturbance in the flow field. We have found that the distance between the initial turbulence transition position in the Hartmann layer and the Hartmann wall is always 69.31% of the thickness of the Hartmann layer, independent of the value of the Hartmann number (Ha). The effects of the Hartmann number and the wall conductance ratio on the initial turbulence transition position in the side layer are also investigated. At last, the reason why the Hartmann layer thickness-based Reynolds number (R) plays the role as a single control parameter in the transition process of MHD flows is explained mathematically.

关键词： Instability Transition Turbulence Energy gradient MHD flow

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Cycle-VQA: A Cycle-Consistent Framework for Robust Medical Visual Question Answering

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PATTERN RECOGNITION 2025年 165卷

作者： Fan, Lin Gong, Xun Zheng, Cenyang Tan, Xuli Li, Jiao Ou, Yafei Southwest Jiaotong Univ Sch Comp & Artificial Intelligence Chengdu 611756 Sichuan Peoples R China Southwest Jiaotong Univ Peoples Hosp Chengdu 3 Affiliated Hosp Dept Gastroenterol Chengdu 610031 Sichuan Peoples R China Inst Sci Tokyo Inst Integrated Res IIR Yokohama Kanagawa 2268501 Japan

Medical Visual Question Answering (Med-VQA) presents greater challenges than traditional Visual Question Answering (VQA) due to the diversity of clinical questions and the complexity of visual reasoning. To address these challenges, we propose Cycle-VQA, a unified framework designed to enhance the reliability and robustness of Med-VQA systems. The framework leverages cycle consistency to establish bidirectional information flow among questions, answers, and visual features, strengthening reasoning stability and ensuring accurate feature integration. Inspired by clinical diagnostic processes, Cycle-VQA incorporates key pathological attributes and introduces a novel multi-modal attribute cross-fusion strategy designed to effectively capture shared and unique features across modalities. Experimental results on Gastrointestinal Stromal Tumors (GISTs) and public Med-VQA datasets diagnosis validate the effectiveness of Cycle-VQA, demonstrating its potential to advance medical image analysis and support reliable clinical decision-making.

关键词： Visual Question Answering Multi-modal fusion Gastrointestinal Stromal Tumor Cycle consistency Multi-attributes learning

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Contrastive learning for nested Chinese Named Entity Recognition via template words

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CAAI TRANSACTIONS ON INTELLIGENCE technology 2025年第2期10卷 450-459页

作者： Wang, Yuke Liu, Qiao Dai, Tingting Lang, Junjie Lu, Ling Chen, Yinong Univ Elect Sci & Technol China Qingshui Campus2006 Xiyuan Ave Chengdu Peoples R China China Elect Technol Grp Corp 54th Res Inst Shijiazhuang Peoples R China Chongqing Univ Technol Chongqing Peoples R China Arizona State Univ Tempe Peoples R China

Existing Chinese named entity recognition (NER) research utilises 1D lexicon-based sequence labelling frameworks, which can only recognise flat entities. While lexicons serve as prior knowledge and enhance semantic information, they also pose completeness and resource requirements limitations. This paper proposes a template-based classification (TC) model to avoid lexicon issues and to identify nested entities. Template-based classification provides a template word for each entity type, which utilises contrastive learning to integrate the common characteristics among entities with the same category. Contrastive learning makes template words the centre points of their category in the vector space, thus improving generalisation ability. Additionally, TC presents a 2D table-filling label scheme that classifies entities based on the attention distribution of template words. The proposed novel decoder algorithm enables TC recognition of both flat and nested entities simultaneously. Experimental results show that TC achieves the state-of-the-art performance on five Chinese datasets.

关键词： classification natural language processing

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Miscible Polymer Blend Membranes Bearing Pyrrolidone for Fractioning Sulfuric Acid and Sulfates

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POLYMERS FOR ADVANCED TECHNOLOGIES 2025年第1期36卷

作者： Yang, Danni Luo, Tao Zhang, Tao Lv, Li Zou, Zongpeng Tang, Shengwei Sichuan Univ Res Ctr Comprehens Utilizat & Clean Proc Engn Phos Sch Chem Engn Minist Educ Chengdu Peoples R China

Ion exchange membranes of new chemistry based on polymer blends are proposed through a convenient solution-blending process using the hydrophobic commodity polymer polyvinyl chloride (PVC) and the hydrophilic polyvinylpyrrolidone (PVP), which are completely miscible. The pyrrolidone groups can be protonated to form oxonium ions, functioning as transient fixed positive charges for fractioning sulfuric acid and sulfates via diffusion. The influence of PVC molecular weight and the membrane composition on the physical, chemical properties, and mass transfer performance of PVC-PVP blend membranes was systematically investigated. After equilibrium in 2.68 mol/L sulfuric acid, the sulfuric acid, and water contents in the blend membranes increase with the increase of the membrane PVP contents (20-75 wt%). The permeability coefficients of sulfuric acid and ferrous sulfate for the blend membranes also exhibit a gradual increase. Membranes of mass transfer properties comparable to commercial ones can be easily obtained by tuning the membrane PVP contents. It is proved that the larger sulfuric acid permeability over sulfates (FeSO4 as an example) is due to both larger solubility and diffusion coefficient of sulfuric acid in the membrane phase. The optimal PVC-PVP blend membranes have shown nice performance in fractioning sulfuric acid from sulfates, when treating titania waste acid. This study provides valuable guidance for the design of high-performance yet low-cost ion exchange membranes with pyrrolidone chemistry from commodity polymers for resource recovery.

关键词： diffusion dialysis ion exchange membranes polyvinyl chloride polyvinylpyrrolidone sulfuric acid

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