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Effect of residual carbon on the microstructure and mechanical properties of spark plasma sintered Ti-Nb-Zr-Mn alloys

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MATERIALS science AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING 2025年 920卷

作者： Chen, Bo Zhang, Jing An, Xuguang Li, Haishan Cai, Zheng Yao, Weitang Wang, Qingyuan Kong, Qingquan Chengdu Univ Sch Mech Engn Chengdu 610106 Sichuan Peoples R China Chengdu Univ Inst Adv Study Interdisciplinary Mat Res Ctr Chengdu 610106 Sichuan Peoples R China

Herein, Ti-Nb-Zr-Mn alloys were prepared by ball milling and spark plasma sintering. The effect of residual carbon on the microstructure, phase composition, and mechanical properties of the as-prepared Ti-Nb-Zr-Mn alloys was systematically studied. The incorporation of stearic acid led to the presence of residual carbon, thereby resulting in the emergence of the FCC phase, encompassing both FCC Ti and carbon-deficient Ti2C. Subsequently, the ultimate tensile strength of the Ti-Nb-Zr-Mn alloys increased from 889 +/- 13 MPa to 1166 +/- 13 MPa, while the plasticity significantly decreased from 23.6 % to 3.8 %. Meanwhile, the elastic modulus and hardness exhibited an increase in correlation with higher stearic acid content. The Ti2C phase demonstrates significantly higher hardness and modulus compared to FCC Ti;however, it is brittle and carries the risk of reducing ductility and leading to brittle fracture. To achieve a synergistic match of low elastic modulus, high strength, and preferable ductility for metastable (3 Ti, careful regulation of the carbon content in the Ti alloys is essential.

关键词： Titanium alloys Microstructure FCC phase Mechanical performance Carbon

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Facial expression recognition based on local-global information reasoning and spatial distribution of landmark features

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VISUAL COMPUTER 2025年第1期41卷 535-548页

作者： Xiong, Kunhong Qing, Linbo Li, Lindong Guo, Li Peng, Yonghong Sichuan Univ Coll Elect & Informat Engn Chengdu 610065 Peoples R China

In the field of facial expression recognition (FER), two main trends point to the data-driven FER and feature-driven FER exist. The former focused on the data problems (e.g., sample imbalance and multimodal fusion), while the latter explored the facial expression features. As the feature-driven FER is more important than the data-driven FER, for deeper mining of facial features, we propose an expression recognition model based on Local-Global information Reasoning and Landmark Spatial Distributions. Particularly to reason local-global information, multiple attention mechanisms with the modified residual module are designed for the Res18-LG module. In addition, taking the spatial topology of facial landmarks into account, a topological relationship graph of landmarks and a two-layer graph neural network are introduced to extract spatial distribution features. Finally, the experiment results on FERPlus and RAF-DB datasets demonstrate that our model outperforms the state-of-the-art methods.

关键词： Facial expression recognition Local-global information Spatial distribution feature of landmarks Augmentation loss

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Extracts from petal of the Crocus sativus (saffron) possesses detoxification effects on acetaminophen induced liver injury by inhibiting hepatocyte apoptosis via regulating Nrf2/HO-1 signaling

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FITOTERAPIA 2025年 182卷 106452页

作者： Tan, Jin Li, Fangqiong Zhang, Xin Zhu, Hongrui Liu, Jin Wu, Taoqing Zhang, Yang Zhang, Dingkun Geng, Yuefei Shen, Yongmei Gooddoctor Pharmaceut Grp Co Ltd Chengdu 610073 Peoples R China Chengdu Univ Tradit Chinese Med Pharm Sch State Key Lab Southwestern Chinese Med Resources Chengdu 611137 Peoples R China

The purpose of this study was to investigate the detoxification effect of extracts from the petal of Crocus sativus L. (PCSE) on acetaminophen (APAP) induced liver injury in mice and its related mechanisms. LC-MS/MS analysis was used to identify the main components in PCSE, and an APAP-induced acute liver injury model in mice was constructed to evaluate the detoxification effect of PCSE. Liver tissue H&E staining, liver function indexes including ALT and AST, pro-inflammatory cytokine including TNF-alpha and IL-6, as well as hepatic tissue oxidative stress levels were examined. In addition, in vitro APAP induced cell was also prepared, apoptosis levels were detected by AO/EB staining, ROS fluorescence intensity was analyzed as well as the expression levels of apoptosis-related proteins and Nrf2/HO-1 pathway-related proteins were detected by western blot, to investigate the mechanism of PCSE's action in ameliorating liver injury. The results showed that PCSE can improve the survival rate of APAP induced mice, decrease ALT, AST, TNF-alpha and IL-6 levels, and ameliorate the liver injury induced by APAP. Furthermore, the mechanism research suggested PCSE attenuated oxidative stress and apoptosis in APAP-induced liver cells, as well as activated the Nrf2/HO-1 signaling. In summary, PCSE possesses potential detoxification effects on APAP induced liver injury by inhibiting hepatocyte apoptosis via regulating Nrf2/HO-1 signaling, which provides more possibilities for the drug selection for the treatment of liver injury in clinical practice.

关键词： Crocus sativus L. Petals Acetaminophen Liver injury Nrf2/HO-1 signaling pathway

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Prominence of Microbiota to Predict Fibrous Stenosis in Crohn's Disease

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JOURNAL OF INFLAMMATION RESEARCH 2025年 18卷 1413-1423页

作者： Yang, Xue Pan, Yan Gao, Cai-Ping Li, Hang Zhang, Ying-Hui Huang, Chun-Li Cao, Lu Xiao, Shi-Yu Zhou, Zhou Univ Elect Sci & Technol China Sichuan Prov Peoples Hosp Sch Med Dept Gastroenterol Chengdu Peoples R China

Purpose: Intestinal fibrous stenosis due to Crohn's disease (CD) is highly prevalent. Although several clinical risk factors for fibrous stenosis have been identified, such as perianal fistulizing disease, small bowel disease location, and deep mucosal ulceration, predicting fibrous stenosis remains challenging. The intestinal microbiota plays a crucial role in the development and progression of CD. However, its role in intestinal fibrous stenosis is poorly understood. Leveraging a single-center cross-sectional study, we aimed to investigate the role of fecal microbiota in CD-associated fibrous stenosis. Methods: Using metagenomic analysis, we examined the differences in fecal microbiota between CD patients with intestinal fibrous stenosis and those without stenosis. We identified specific microbiota and assessed their predictive accuracy for intestinal fibrous stenosis. Additionally, we explored functional differences in intestinal microbiota between the two groups. Results: : Our investigation of fecal samples revealed no significant differences in the gut microbiota structure between patients with fibrous stenosis and those without stenosis in CD. However, taxonomically, we found 70 taxa with significantly different abundance (p < 0.05) between the two groups. Furthermore, LEfSe analysis indicated that g_Bacteroides and g_Enterocloster could predict intestinal fibrous stenosis while p_Actinobacteria, c_Actinomycetia, c_Bacilli, o_Lactobacillales, f_Streptococcaceae and g_Streptococcus could predict CD without stenosis. Functional analysis revealed differential enrichment in five metabolic pathways at the KEGG pathway level in CD patients with fibrous stenosis, including sphingolipid metabolism, lipoic acid metabolism, and biosynthesis of neomycin, kanamycin and gentamicin. In the eggNOG database, we observed differences in four functional categories between the two groups, encompassing cellular process, signaling, and metabolism. Conclusion: Fecal microbiota sign

关键词： Crohn's disease fibrous stenosis fecal microbiota metagenomic analysis

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Disparities in overall survival of gastric cancer patients after radical gastrectomy: an age and rural-urban residence-based cohort study with propensity score matching analysis

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SCIENTIFIC REPORTS 2025年第1期15卷 1-14页

作者： He, Fu-Qian Xu, Rui Zhou, Da Zhou, Xiang Chen, Xiao-Dong Sichuan Univ West China Hosp Ctr Gerontol & Geriatr Natl Clin Res Ctr Geriatr Chengdu Sichuan Peoples R China Univ Elect Sci & Technol China Sichuan Canc Hosp & Inst Dept Gastr Surg Sichuan Canc CtrSichuan Clin Res Ctr Canc 55 Sect 4South Renmin Rd Chengdu 610041 Sichuan Peoples R China

This study estimated overall survival (OS) among gastric cancer patients stratified by age and rural-urban residence after radical gastrectomy. Patients (n = 286) undergoing curative gastrectomy were categorized into four groups based on age (older >= 60 years or younger < 60 years) and residence (rural or urban), including rural older (G1), urban older (G2), rural younger (G3) and urban younger (G4) groups. G1 presented with significantly more males, upper stomach cancers and total gastrectomies, while less patients receiving >= 4 cycles of adjuvant chemotherapy. The 5-year OS rates were 39.9% for G1, 61.1% for G2, 73.1% for G3, and 71.2% for G4, with a median OS of 47 months in G1 and not reached for other groups. OS was significantly worse in G1 than other groups (P < 0.05). Multivariate Cox regression identified age, type of gastrectomy, adjuvant chemotherapy, perineural invasion, pT category and pN category as independent prognostic factors. After propensity score matching, rural older patients continued to show significantly inferior OS compared to urban older (hazard ratio = 2.269 [1.274-4.042], P = 0.005) and rural younger (hazard ratio = 2.103 [1.116-3.961], P = 0.021) patients. Rural older patients suffered poorer OS after radical gastrectomy, highlighting the need for special attention and comprehensive treatment strategies.

关键词： Gastric cancer Older Rural residence Overall survival Radical gastrectomy Propensity score matching

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Treatment of rheumatoid arthritis via tetrahedral framework nucleic acid-based efficient delivery of Jakinib: Synergistic anti-inflammatory and osteogenic effects

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CHEMICAL ENGINEERING JOURNAL 2025年 512卷

作者： Yang, Yichen Wang, Ruiqing Yin, Wumeng Yue, Ziqi Zhao, Yuxuan Jiang, Zhou Lin, Yunfeng He, Yao Gao, Shaojingya Cai, Xiaoxiao Sichuan Univ West China Hosp Stomatol Natl Ctr Stomatol Natl Clin Res Ctr Oral DisState Key Lab Oral Dis Chengdu 610041 Sichuan Peoples R China Sichuan Prov Engn Res Ctr Oral Biomat Chengdu 610041 Sichuan Peoples R China Shanghai Jiao Tong Univ Natl Ctr Translat Med Shanghai 200240 Peoples R China Macau Univ Sci & Technol Macao Translat Med Ctr Taipa 999078 Macao Peoples R China

Rheumatoid arthritis (RA) is a chronic, progressive inflammatory autoimmune disease characterized by localized destruction of articular bones and systemic bone loss, which can lead to more severe bone loss and osteoporosis. Various inflammatory factors such as Interferon-gamma (IFN-gamma), interleukin (IL-6), and tumor necrosis factor (TNF) are known to play pivotal roles in the onset and progression of RA by activating the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway. Preliminary clinical trials have demonstrated that JAK inhibitors (Jakinib) medicine such as upadacitinib (UPA) achieve better clinical outcomes., making them a routine or important treatment option for RA patients. However, the applications of Jakinibs are limited by their low bioavailability and potential hepatotoxicity and nephrotoxicity. Therefore, the development of an efficient drug delivery system that enhances therapeutic efficacy while reducing dosage requirements and improving drug bioavailability. As DNA tetrahedron delivery vehicles, tetrahedral framework nucleic acid (TDN) is utilized for delivering small molecule drugs with exceptional biocompatibility, high bioavailability, and low toxicity. In this study, TUC was developed for the treatment of RA. Our study indicated that TUC not only decreases the required drug dosage but also outperforms standalone UPA in efficacy. These results confirm that TDNs are ideal for an efficient nanodrug delivery system. Further research can explore the potential of TDNs as effective nanocarriers for the targeted delivery of therapeutic agents in the treatment of various diseases.

关键词： Rheumatoid arthritis JAK inhibitors Upadacitinib Tetrahedral framework nucleic acids JAK/STAT pathway Osteogenesis anti-inflammation

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Production of high-amylose starch with low digestibility in a green marine microalga Tetraselmis subcordiformis by delaying high-bicarbonate induction

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CARBOHYDRATE POLYMERS 2025年 356卷 123382页

作者： Shen, Yuhan Zhang, Haoyu Zhang, Bo Xie, Chenglin Liao, Longren Ran, Xiuyuan Zhang, Yongkui Yao, Changhong Sichuan Univ Sch Chem Engn Dept Pharmaceut & Biol Engn Chengdu 610065 Sichuan Peoples R China

A photoautotrophic green marine microalga Tetraselmis subcordiformis was applied to sustainably produce highamylose starch (HAS) from CO2 via high-bicarbonate (HB) induction. Delaying the addition of HB from Day 0 to Day 3 overcome the HB stress and significantly improved photosynthetic activity, resulting in 7.2-times higher starch productivity and the production of HAS with the total starch content of 21.81 % and amylose/amylopectin ratio of 1.51 obtained on Day 6, which represented the highest HAS levels among the photoautotrophic microalgae reported hitherto. The HB treatment improved the activity of granule-bound starch synthase and decreased starch branching enzymes, soluble starch synthase and amylase activity, leading to the formation of HAS by enhancing amylose production with simultaneously attenuating amylopectin biosynthesis. HB induction mainly changed the structure of amylose with increased chain lengths rather than amylopectin, and the ordered structures and degree of branching were also reduced. The produced HAS under HB induction (H-MS) was a kind of very small granular starch with A-type crystalline. It was identified to have a high proportion of short-chain amylopectin and elongated amylose that enabled low gelatinization temperatures (56-69 degrees C) and digestibility (containing 55.58 % of resistant starch). These features manifested an excellent prospect for application in sustainable food industry.

关键词： Microalgae High-bicarbonate High-amylose starch Enzyme activity Gelatinization temperature Digestibility

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Toxicity and safety profile evaluation of Shenfu injection in a murine sepsis model

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JOURNAL OF ETHNOPHARMACOLOGY 2025年 337卷

作者： Yang, Burui Wang, Shuting Yang, Yuling Wang, Yong Tianjin Univ Chinese Med Tianjin Peoples R China Chengdu Baikang Pharmaceut Ind Res Inst Pharmacol Chengdu Peoples R China

Aim: This study aimed to evaluate the preclinical safety of Shenfu injection for the treatment of sepsis. Tests were designed and conducted to determine the acute and long-term toxicity of Shenfu injection in rats, based on the recommended indications and dosage for human use. Materials and methods: Rats were administered 22.5 g of raw drug/kg/day via tail vein injection. Toxicity symptoms were monitored for 14 days following the intravenous injection of Shenfu injection, and target organs affected by toxicity were analyzed. To assess long-term toxicity, rats were given 12, 9, or 6 g of raw drug/kg/day by intraperitoneal injection, equivalent to 12, 9, and 6 times the daily clinical dose for adult sepsis patients (3.3 mL of stock solution per 1 g of raw drug/kg/day), for 30 consecutive days. This was followed by a 28-day recovery period after withdrawal of the drug. During the administration and recovery periods, signs of toxicity were observed and compared with those in the control (stromal fluid) group. The aim was to predict potential clinical adverse reactions, including the nature and severity of these reactions, dose-response and time-response relationships, and the reversibility of the effects. Additionally, the study sought to identify the target organs or tissues potentially affected by repeated administration and suggest clinical indicators that should be monitored during the product's use. Furthermore, the safety of co-administration with commonly used chemical medications for the treatment of sepsis was investigated. Results: In the acute toxicity test, administration of the maximum dose of Shenfu injection (75 mL of stock solution/22.5 g of raw drug/kg/day) via tail vein injection resulted in transient symptoms, including piloerection (vertical hair response), weight loss, and reduced food intake. In the long-term toxicity experiments, rats received intraperitoneal injections of 0.3 g/mL (stock solution), 0.225 g/mL, and 0.15 g/mL Shenfu injection per d

关键词： Shenfu injection Acute toxicity Long-term toxicity Safety evaluation Sepsis

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A Novel Laboratory-Based Strategy for Single Adipocyte and Adipose-Derived Stem Cells Extraction for Transplantation: An Experimental Research

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AESTHETIC PLASTIC SURGERY 2025年第1期49卷 367-379页

作者： Liu, Yu Zhao, Hanxing Yu, Jiaying Liao, Dongsheng Peng, Jingming Chen, Changjin Huang, Yeqian Chen, Chiaoju Li, Zhengyong Wijaya, Wilson Adrian Zhao, Ziyi Chen, Zhixing West China Hosp Sichuan Univ Dept Burn & Plast Surg 37 Guoxue Alley Chengdu Sichuan Peoples R China Univ Tradit Chinese Med TCM Regulating Metab Dis Key Lab Sichuan Prov Hosp Chengdu Chengdu Peoples R China Chengdu DosSense Biotech Co LTD Chengdu Peoples R China

Background Autologous fat grafting is widely used in plastic surgery. However, its main limitation is the low survival rate of fat grafts after transplantation. Transplantation of single adipocytes in combination with adipose-derived stem cells (ADSCs) could largely preserve the activity of the fat and improve graft survival. Objective To verify the long-term survival rate of single adipocyte graft in vivo and its viable fat morphology for future fat grafting. Methods Healthy adipose tissue was harvested and disassociated using fat dissociation solution, the Single-cell Suspension Preparation System (SSPS) was used to obtain a mixture of single adipocytes, ADSCs and stromal vascular fraction (SVF), and the structure of single adipocytes was verified by cell mask red and DAPI double staining. Nine male Balb/c nude mice were used, and three different graft volumes were established (0.05, 0.1 and 0.2 ml). For each mouse, four sites were selected for transplantation, one for macrofat and the other three for single adipocytes, and different transplant volumes 30, 60 and 90 days after transplantation. In each period, 3 mice were selected to measure the volume of fat graft. Results Double staining with cell mask red and DAPI confirmed that the nucleus was identified intracellularly, which also indicated that the adipocytes in the single-cell suspension were structurally complete. When evaluating the transplantation, the groups with a volume of 0.05 ml and 0.2 ml performed better in the single-cell fat group in all transplantation periods, the group with a volume of 0.1 ml performed better in the single-cell group in the 30- and 60-day transplantation, and the differences were significant (P<0.05). Conclusion In this study, the SSPS was used to obtain a new transplant material containing single adipocytes and ADSCs by enzymatic hydrolysis of adipose tissue and converted into single cells. It effectively improved the survival rate of fat grafting and the long-term effect of

关键词： Single adipocyte Adipose-derived stem cells Cell transplantation Fat grafting Experimental Mice

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Effect of bias voltage and deposition temperature on the microstructure, mechanical properties and lead-bismuth corrosion resistance of FeCrAlY coating

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VACUUM 2025年 234卷

作者： Wang, Rongshuo Zhang, Wei Yang, Jijun Zhong, Yilong Yang, Jian Zhu, Changda Liu, Hao Zhao, Sha Deng, Jiuguo Sichuan Univ Inst Nucl Sci & Technol Key Lab Radiat Phys & Technol Minist Educ Chengdu 610064 Peoples R China

Three kinds of FeCrAlY coatings were prepared by magnetron sputtering at different deposition temperatures and bias voltages, and were corroded in static LBE at 550 degrees C for 1000 h. The results show that the increase in temperature deteriorates the mechanical properties of the coatings. The increase in bias voltage increases the surface roughness of the coating, changes the contact mode between the coating and LBE, significantly reduces the Al content, and deteriorates the LBE corrosion resistance of the coating. At the same time, it refines the grains and improves the mechanical properties. The R0 coating has the best LBE corrosion resistance (the thickness of the oxide layer is only 60.1 +/- 7.2 nm). The internal processes of coating microstructure evolution, performance transformation, and corrosion mechanism were comprehensively elucidated.

关键词： Magnetron sputtering FeCrAlY coating LFR LBE

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