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Transcription factor GTF2I regulates osteoclast differentiation through mediating miR-134-5p and MAT2A expressions

JOURNAL OF CELL COMMUNICATION AND SIGNALING 2025年第2期19卷 e70010页

作者： Tang, Lian Liu, Yanshi Yan, Jiyuan Yuan, Lin Wang, Zhaojun Li, Zhong Southwest Med Univ Affiliated Hosp Dept Orthoped Luzhou Sichuan Peoples R China Southwest Med Univ Affiliated Hosp Dept Clin Skills Ctr Luzhou Sichuan Peoples R China Southwest Med Univ Luzhou Sichuan Peoples R China Southwest Med Univ Affiliated Hosp Stem Cell Immun & Regenerat Key Lab Luzhou Luzhou Sichuan Peoples R China

This study explored the possible effect of transcription factor GTF2I on the differentiation of osteoclasts and its regulation on the miR-134-5p/MAT2A axis. RANKL-induced osteoclasts were measured for expressions of GTF2I, miR-134-5p, and MAT2A. The number and size of osteoclasts were assessed after TRAP staining. The expressions of osteoclast differentiation biomarkers, NFATC1, TRAP, and CTSK, were detected as well. The relationships of the GTF2I/miR-134-5p/MAT2A axis were verified by ChIP, dual luciferase, and RNA pull-down assay. In vivo experiments were conducted on ovariectomized (OVX)-treated mice to determine the effect of GTF2I overexpression on osteoclast differentiation and bone loss. RANKL-induced osteoclasts had suppressed expressions of GTF2I and miR-134-5p and increased expression of MAT2A. GTF2I overexpression or miR-134-5p overexpression contributed to decreased cell number and size and suppressed cell differentiation, whereas such an effect can be abolished by overexpression of MAT2A. GTF2I can bind the miR-134-5p promoter to regulate its expression, whereas miR-134-5p can negatively regulate MAT2A expression. The protective effect of GTF2I overexpression against bone loss and cell differentiation was verified by in vivo experiments. Collectively, these results indicate that GTF2I can mediate miR-134-5p expression to increase MAT2A expression, contributing to the suppression of osteoclast differentiation.

关键词： GTF2I MAT2A miR-134-5p osteoclast differentiation OVX

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The Outstanding Ambiphilicity of Trialkylstibines among Trialkylpnictines: Power for Stepwise Deoxygenation and N-N Coupling of Nitroarenes

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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2025年第12期147卷 10066-10072页

作者： Zhang, Zichen Li, Kunlong Huang, Minghao Chen, Ting Zhou, Jiliang Sichuan Univ Coll Chem Key Lab Green Chem & Technol Minist Educ Chengdu 610065 Peoples R China Ningbo Univ Inst Drug Discovery Technol Ningbo 315211 Peoples R China

The ongoing discovery of highly reactive ambiphilic main-group species has significantly advanced the development of main-group chemistry, particularly in the realms of small molecule activation and catalysis. Theoretically, compounds featuring smaller HOMO-LUMO gaps gain stronger ambiphilicity and higher reactivity. In this work, we fundamentally demonstrate that Me3Sb holds the smallest HOMO-LUMO gap among trimethylpnictines, indicating its outstanding ambiphilicity. Correspondingly, the superior reactivity of Me3Sb toward deoxygenation of electron-deficient nitroarenes has been unambiguously revealed through control experiments. Furthermore, unprecedented SbIII/SbVO cycling between trialkylstibines and their oxides has been established for the catalytic transformation of nitroarenes into azoxyarenes/azoarenes. This study opens a new chapter for organoantimony derivatives in the fields of ambiphilic reactivity and redox catalysis.

关键词： Catalysis

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Reducing the phytotoxicity of spent mushroom substrate (SMS) for sustainable growing media by superheated steam torrefaction: effects of temperature and residence time

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BIOMASS CONVERSION AND BIOREFINERY 2025年第3期15卷 4733-4744页

作者： Chen, Jing Zhang, Dongdong Yang, Rui Lin, Wei Wang, Hong Kang, Ying Qi, Zhiyong Zhou, Wanlai Chinese Acad Agr Sci Chengdu Natl Agr Sci & Technol Ctr Inst Urban Agr Chengdu 610213 Peoples R China Chengdu Tianfu Greenway Cultural & Tourism Dev Grp Chengdu 610213 Peoples R China

The utilization of spent mushroom substrate (SMS) as growing media component holds immense promise. However, before it can be employed, it is imperative to reduce its inherent phytotoxicity. In this study, nine superheated steam (SHS) torrefaction treatments with different intensities were set up to investigate their effectiveness in removing the phytotoxicity of SMS, with a focus on changes in phytotoxicity-related substances. SHS torrefaction substantially diminished the presence of organic acids and amino acids, while significantly increased the germination index (GI). Overall, the removal of phytotoxicity escalated in line with increasing temperature and residence time. The optimal removal effect was observed at 250celcius for 40 min, and further elevating the temperature to 300celcius did not yield any additional reduction in phytotoxicity. It is concluded that SHS torrefaction can substantially reduce the phytotoxicity of SMS by modifying its chemical composition, particularly through the reduction of organic acids and amino acids. A torrefaction intensity of 250celcius for 40 min appears to be relatively optimal for this purpose. These findings underscore the potential of SHS torrefaction as a viable approach to address the phytotoxicity of SMS, thereby opening up new possibilities for its sustainable utilization as growing media component.

关键词： Superheated steam Torrefaction Spent mushroom substrate Growing media Phytotoxicity

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The NR3C2-SIRT1 signaling axis promotes autophagy and inhibits epithelial mesenchymal transition in colorectal cancer

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CELL DEATH & DISEASE 2025年第1期16卷 1-11页

作者： Li, Feng Wan, Xing Li, Zhigui Zhou, Liming Sichuan Univ West China Sch Basic Sci & Forens Med Dept Pharmacol Chengdu Peoples R China Sichuan Univ West China Hosp Dept Gen Surg Chengdu Peoples R China

Colorectal cancer (CRC) is one of the most aggressive and lethal cancers with a complex pathogenesis, there is an urgent need to find new drug therapeutic targets. This study highlights the important role of the NR3C2-SIRT1 signaling axis in the metastasis mechanism of CRC. Our findings revealed that the expression of NR3C2 in CRC tissues was lower than that in adjacent non-cancerous tissues, and was negatively correlated with N stage by bioanalysis, IHC, western blot and qRT-PCR. NR3C2 overexpression / knockdown can significantly inhibit / promote the migration and invasion of CRC cells, at the same time inhibit / promote EMT. Mechanically, the regulatory molecule SIRT1 was identified by RNA-seq, bioinformatics analysis, western blot and ChIP. SIRT1 was also involved in the metastasis process of CRC, and NR3C2 was found to regulate the expression of LC3B and SQSTM1/p62 in a SIRT1-dependent manner. Therefore, NR3C2 forms a signaling axis with SIRT1, which can directly promote autophagy and inhibit EMT process in vivo and in vitro. Collectively, our findings suggest that NR3C2 - SIRT1 signal axis promote autophagy and inhibit EMT, ultimately inhibits lung metastasis of CRC.

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Effects of the Ca/Si Ratio on the Structure and Properties of Metakaolin-Municipal Solid Waste Incineration Fly Ash-Based Geopolymer

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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH 2025年第12期64卷 6530-6540页

作者： Qin, Chuan Cheng, Yong Huang, Qingsong Sichuan Univ Sch Chem Engn Chengdu 610065 Peoples R China

Geopolymer solidification/stabilization is widely used to handle municipal solid waste incineration fly ash (MSWIFA). However, unlike metakaolin, MSWIFA contains a high content of Ca. The traditional Ca/Si ratio as a common metric cannot reveal the real Ca/Si ratio involved in hydration. In this paper, we proposed an active Ca/Si ratio calculated based on the leaching concentration as a new metric. The mechanical properties and leakage risk of heavy metals of metakaolin-MSWIFA-based geopolymer (MMG) with a series of active Ca/Si ratios were assessed. The results indicated that when the active Ca/Si ratio is <0.048, the compressive strengths of MMGs at an early stage were strengthened, and the compressive strengths of MMGs with a 0.048 Ca/Si ratio cured for 28 days can reach 34.66 MPa. After a 28-day curing, the heavy metals were effectively solidified in the geopolymer by physical coating and chemical precipitation. The leaching concentration of heavy metals was lower than the relevant standard. The geopolymer-based solidification body could be potential building materials for waste utilization.

关键词： Compressive strength

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Integrated Analysis and Design of Part-Fill and Part-Cut Subgrades and Pavements: A Review and Prospect

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INTERNATIONAL JOURNAL OF PAVEMENT RESEARCH AND technology 2025年 1-21页

作者： Gu, Hanyan Jiang, Xin Fu, Yongguo Qiu, Yanjun Southwest Jiaotong Univ Sch Civil Engn Chengdu 610031 Peoples R China Southwest Jiaotong Univ Highway Engn Key Lab Sichuan Prov Chengdu 610031 Peoples R China Southwest Jiaotong Univ Key Lab High Speed Railway Engn MOE Chengdu 610031 Peoples R China Sichuan Univ Sci & Engn Sch Civil Engn Zigong 643000 Peoples R China

While highways in mountainous regions frequently employ part-fill and part-cut subgrades with diverse formation mechanisms, frequent distress occurrences expose a gap between current engineering practices and theoretical design principles. This review aims to find an integrated approach for the analysis and design of part-fill and part-cut subgrades and pavement structures by collecting and organizing relevant research methods, data, and conclusions. For this purpose, Sect. 2 provides an overview of analytical methods and key influencing factors for the stability of part-fill and part-cut subgrades. The uncertainty of the position and shape of the sliding surface makes the strength reduction method (SRM) a more suitable stability analysis method. Recognizing differential settlement as a critical factor in the performance of pavement systems constructed on these subgrades, Sect. 3 examines recent advancements in testing and simulation techniques for evaluating differential settlement patterns. While both tests and simulations reveal "spoon"-shaped differential settlement patterns, practical analyses often simplify these to linear or parabolic shapes. Section 4 investigates the impact of differential settlement on both asphalt and concrete pavement structures, drawing upon established understanding of settlement characteristics. Section 5 reviews proposed control indexes and standards for managing settlement differentials, resulting in a three-tiered approach to control indicators: maximum differential settlement, differential settlement slope rate, and bending degree of differential settlement curve. Finally, Sect. 6 identifies key future research directions for a fully integrated approach for analyzing and designing part-fill and part-cut subgrades and pavement structures, offering valuable insights to enhance design technology in this domain.

关键词： Part-fill and part-cut subgrade Fill slope stability Differential settlement Integrated design of subgrade and pavement Pavement structural adaptability

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SNAI2, a potential crossing point between cancer and cardiovascular disease

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FASEB JOURNAL 2025年第5期39卷 e70459页

作者： Liu, Zihao Wang, Yingzi Li, Lei Liu, Linlu Li, Yuhao Li, Zhixin Xie, Yucheng Yu, Fengxu Southwest Med Univ Affiliated Hosp Dept Cardiovasc Surg Luzhou 646000 Peoples R China Cardiovasc Remodeling & Dysfunct Key Lab Luzhou Luzhou Peoples R China Metab Vasc Dis Key Lab Sichuan Prov Luzhou Peoples R China Southwest Med Univ Minist Educ Key Lab Med Electrophysiol Luzhou Peoples R China Southwest Med Univ Inst Cardiovasc Res Med Electrophysiol Key Lab Sichuan Prov Luzhou Peoples R China

Cancer and cardiovascular disease remain the leading causes of morbidity and mortality worldwide, and the two separate disease entities share several similarities and possible interactions. Patients with cancer may have underlying cardiovascular disease, which is often exacerbated by the stress of tumor growth or treatment. At the same time, cardiotoxicity induced by anti-cancer therapies or the malignant process itself can lead to new cardiovascular diseases. Efforts have been made to find a rational explanation for this phenomenon. As a classical tumor-promoting factor, we notice that SNAI2 simultaneously plays an important pathogenic role in cardiovascular diseases. Moreover, there are several striking parallels in the mechanisms of cancer and CVD, such as shared risk factors (e.g., smoking and diabetes), cellular phenotypic switching, and metabolic remodeling, all of which are mediated by SNAI2. This review aims to summarize SNAI2's role in the core mechanisms linking cancer and CVD, as well as explore therapeutic approaches targeting SNAI2 and also seeks to provide insights into the common mechanisms underlying both cancer and CVD.

关键词： cancer cardio-oncology cardiovascular disease SLUG SNAI2

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Performance Optimization of Perovskite Solar Cells via Fluorinated Carbonyl Additives

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ACS APPLIED MATERIALS & INTERFACES 2025年第8期17卷 12291-12298页

作者： Dong, Tianhe Liao, Jing Li, Haijin Li, Jiashun Li, Hongyu Li, Ze Tan, Li Chen, Xu Zhang, Wenfeng Southwest Petr Univ Sch New Energy & Mat Chengdu 610500 Peoples R China Forschungszentrum Julich IMD 3 Photovolta D-52428 Julich Germany

Perovskite solar cells (PSCs) have emerged as a promising photovoltaic technology due to their long carrier diffusion lengths, tunable bandgaps, and high light absorption coefficients. However, instability remains a significant barrier to their commercialization. In this study, we introduce two carbonyl small molecule additives with varying fluorine atom counts: 4,5-difluoro-phthalic anhydride (2FPA) and tetrafluorophthalic anhydride (4FPA). The fluorine atoms and carbonyl groups interact to passivate defects in the perovskite structure. The strong interaction between 4FPA and the perovskite facilitates slow crystal growth and effective defect passivation, significantly suppressing nonradiative recombination and enhancing carrier transport efficiency. Consequently, the power conversion efficiency (PCE) of PSCs incorporating 4FPA has improved from 21.49 to 23.21%. Additionally, the fluorine atoms in the additive interact with FA+ in the perovskite to form strong hydrogen bonds and coordinate bonds with Pb2+, thereby enhancing device stability. In unencapsulated conditions, after approximately 1000 h in ambient air with 50 to 60% humidity, the 4FPA device retains 87% of its initial efficiency.

关键词： 4,5-difluoro-phthalic anhydride tetrafluorophthalicanhydride additives passivation nonradiativerecombination stability perovskite solar cells

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Factors associated with burnout among Chinese operating room nurses: a meta-analysis

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BMC NURSING 2025年第1期24卷 1-14页

作者： Dai, Xiaoxia Xie, Caixia Wu, Yunlian Chen, Tian Lu, Fang Second Peoples Hosp Yibin Dept Nursing Yibin Peoples R China Univ Elect Sci & Technol China Sch Med Chengdu Peoples R China Univ Elect Sci & Technol China Sichuan Prov Peoples Hosp Dept Nursing Chengdu Peoples R China Army Med Univ Sch Nursing Chongqing Peoples R China

Background Burnout is prevalent among nursing staff, especially in the operating room, which is a high-intensity, high-pressure and fast-paced work environment. As the prevalence of nurse burnout increases, reducing the burnout of operating room nurses helps to improve the physical and mental health of nurses. Thus, stabilising the nursing team can also guarantee the quality of medical care, which in turn improves patient satisfaction. In this study, we conducted a meta-analysis based on the Pearson correlation coefficient to quantitatively analyse the factors related to burnout among operating room nurses and to provide a reliable basis for preventing and intervening in burnout among operating room nurses. Methods CNKI, Wanfang Database, Wipro Database, China Biomedical Database, PubMed, Web of science, Embase, CINAHL and Cochrane Library Database were searched, and the keywords 'operating room', 'nurses', 'burnout' and the corresponding English terms were used for the search. The time limit for the search was set from the creation of the databases to April 2024. Two researchers with evidence-based knowledge conducted the search, independently screened the literature according to the inclusion and exclusion criteria, extracted the information and assessed the quality of the included literature using the quality assessment criteria for observational studies recommended by the Agency for Healthcare Quality and Research, and performed a meta-analysis of the literature using the r value as an indicator of the outcome in RevMan 5.4 software. Results A total of 25 papers were included, with a sample size of 6,061 cases. The quality of the literature was moderate. The meta-analysis showed that job stress (r = 0.56, 95% confidence interval [CI]: 0.42-0.68, I-2 = 86%), work-family conflict (r = 0.52, 95% CI: 0.36-0.64, I-2 = 82%), willingness to leave (r = 0.42, 95% CI: 0.34-0.49, I-2 = 0%) and hidden absenteeism (r = 0.49, 95% CI: 0.41-0.57, I-2 = 55%) were positively corr

关键词： Operating room Nurse Burnout Meta-analysis China

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Long-Term Function Recovery Following Upper Versus Lower Lobectomy for Lung Cancer: A Multicenter Longitudinal Cohort Study

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THORACIC CANCER 2025年第1期16卷 e15505页

作者： Wei, Xing Yu, Hongfan King-Kallimanis, Bellinda Liu, Yangjun Huang, Lin Dai, Wei Yang, Ding Zhou, Xiangxi Li, Qiang Shi, Qiuling Univ Elect Sci & Technol China Sichuan Canc Hosp & Inst Sichuan Clin Res Ctr Canc Sichuan Canc CtrDept Thorac SurgAffiliated Canc Chengdu Peoples R China Chongqing Med Univ Coll Biomed Engn State Key Lab Ultrasound Med & Engn Chongqing Peoples R China LUNGevity Fdn Bethesda MD USA Karolinska Inst Dept Med Epidemiol & Biostat Stockholm Sweden Copenhagen Univ Hosp Dept Cardiothorac Surg Rigshosp Copenhagen Denmark Zhengzhou Univ Dept Thorac Surg Affiliated Hosp 1 Zhengzhou Peoples R China Chongqing Med Univ Sch Publ Hlth Chongqing Peoples R China

BackgroundThe effects of lobectomy at various lung sites on postoperative function and recovery vary. This study aimed at assessing the long-term impact of upper versus lower lobectomy on patients' postoperative daily function by analyzing patient-reported *** multicenter prospective cohort study enrolled patients from six hospitals in China. Functional impairments and symptom severity were measured using the MD Anderson Symptom Inventory-Lung Cancer. A mixed-effects linear model was employed to analyze the average trajectories of each functional item and the top five symptoms over the first year following surgery between patients undergoing upper and lower lobectomy. The median recovery days for daily function were estimated using the Kaplan-Meier method, with the log-rank test comparing differences between upper and lower *** hundred twenty-six patients met the final analysis criteria, with 137 undergoing upper and 89 undergoing lower lobectomies. Those in the lower lobectomy group reported significantly greater interference with daily activities (estimate = 0.872, SE = 0.306, p = 0.004), mood (estimate = 0.667, SE = 0.297, p = 0.025), and work (estimate = 0.856, SE = 0.358, p = 0.017), indicating a more pronounced impact on postsurgical functional recovery compared to the upper lobectomy group within the first year after surgery. They also experienced longer median recovery times for daily activities (15 vs. 4 days), mood (6 vs. 3.5 days), and walking (7 vs. 4 days) compared to the upper lobectomy *** the first year after surgery, lower lobectomy patients experienced greater impairment in daily functions and required longer recovery times compared to upper lobectomy *** RegistrationNCT03341377

关键词： function recovery lobectomy lung cancer patient-reported outcomes postoperative recovery

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