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Antidiabetic effects and mechanism of γ-polyglutamic acid on type II diabetes mice

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 2024年第PT 1期261卷 129809页

作者： Li, Ying Zhang, Weijie Tang, Chao Wang, Chen Liu, Changhui Chen, Qian Yang, Kai Gu, Yian Lei, Peng Xu, Hong Wang, Rui Nanjing Tech Univ Coll Food Sci & Light Ind Nanjing 211816 Peoples R China Nanjing Tech Univ State Key Lab Mat Oriented Chem Engn Nanjing 211816 Peoples R China

Diabetes is one of the foremost chronic non-communicable diseases worldwide, which significantly impacts people's quality of life. This study aimed to investigate the hypoglycemic effects of gamma-polyglutamic acid (gamma-PGA) on STZ-induced type II diabetes mice and its potential mechanisms. The results indicated that gamma-PGA intervention contributed to reducing fasting blood glucose levels in diabetic mice, regulating lipid metabolism in type II diabetes mice, and improving insulin resistance. Additionally, gamma-PGA could alleviate liver inflammation, enhancing the activity of hepatic antioxidant enzymes. Investigation into the insulin signaling pathway revealed that gamma-PGA significantly increased the expression of INSR, IRS-1, Akt, PI3K in diabetic mice, thereby enhancing insulin sensitivity and improving insulin resistance to regulate glucose metabolism. High-throughput sequencing of mouse gut microbiota using 16S rRNA showed that gamma-PGA increased the abundance and evenness of beneficial bacteria in the intestines of type II diabetic mice, inhibited the growth of harmful bacteria, and may exerted hypoglycemic effects by modulating and improving relevant metabolic pathways associated with diabetes symptoms. This study provides new insights into the treatment of type II diabetes and highlights the significant potential of gamma-PGA in treating type II diabetes.

关键词： gamma-Polyglutamic acid Type II diabetes Hypoglycemic effect Hypoglycemic mechanism Gut microbiota

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Bidirectional DC-DC Converter with Zero Current Ripple and Low Voltage Stress for Power Battery Equalization Systems

Bidirectional DC-DC Converter with Zero Current Ripple and L...

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2024 CPSS and IEEE International Symposium on Energy Storage and Conversion, CPSS and ISESC 2024

作者： Miao, Shan Jin, Yang Lyu, Nawei Jiang, Xin Wang, Mingchuan School of Electrical and Information Engineering Zhengzhou University Zhengzhou China

ISBN: (纸本)9798350380514

Active equalizer is a significant approach to break through the inconsistent charging of power batteries, which can improve the available capacity, endurance mileage and system safety of the electric vehicles. As the important part of active equalizer, a bidirectional converter which possesses zero current ripple on the high voltage side (HVS) and small current ripple on the low voltage side (LVS), low voltage stress with wider conversion ratio, common ground and positive polarity between the LVS and HVS, is proposed in this paper. Therefore, with the proposed converter, the improved efficiency, speed and reliability of the active equalizer can be realized. The operating principles of the converter in boost mode to achieve cell-to-string (C2S) equalization and in buck mode to complete string-to-cell (S2C) equalization are analyzed. Besides, the detailed mathematical model and related simulations are presented to verify the feasibility and effectiveness of the proposed converter in the equalization system. © 2024 IEEE.

关键词： Buck converter

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OFDM-PON physical layer encryption scheme based on chaotic Joseph ring and fractal system

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OPTICS COMMUNICATIONS 2024年 552卷

作者： Li, Qi Bi, Meihua Zhou, Yuxin Teng, Xuyang Hu, Miao Yang, Guowei Hangzhou Dianzi Univ Sch Commun Engn Xiasha Gaojiaoyuan 2nd St Hangzhou 310018 Zhe Jiang Peoples R China Shanghai Jiao Tong Univ Dept Elect Engn State Key Lab Adv Opt Commun Syst & Networks 800 Dongchuan Rd Shanghai 200240 Peoples R China Soochow Univ Res Ctr New Opt Fiber Technol & Commun Network Eng 333 Ganjiang East Rd Suzhou 215301 Jiangsu Peoples R China

In this paper, we present a novel encryption algorithm that combines the chaotic Joseph ring and fractal system to enhance system security and resistance to chosen plain text attacks (CPAs) in orthogonal frequency division multiplexing passive optical networks (OFDM-PONs). As for this scheme, a modified chaotic Joseph ring is designed and utilized to resist CPAs, which greatly increases the randomness of the output data. The fractal function is also modified to generate a larger range and random dataset, which is used to scramble the quadrature amplitude modulation (QAM) symbols to further improve the confidentiality of the system. It is noted that, a four-dimensional conserved chaotic system is also introduced into this system to generate the initial parameters of the Joseph rings and fractal systems, thereby improving the sensitivity of the encryption scheme. With these processing techniques, multiple data encryption with a key space of similar to 10(358) can be created to prevent exhaustive trials. A simulated OFDM-PON system was built to confirm the feasibility of the proposed scheme. The results show that our scheme can provide excellent confidentiality of data transmission against CPAs and brute-force attack. Besides, the grayscale images are utilized to further verify that the scheme is equally resistant to statistical and cutting attacks.

关键词： Orthogonal frequency-division multiplexing passive optical network (OFDM-PON) Conservative chaotic Joseph ring

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Catalytic Graphitized Silicone Rubber Coatings with Highly Graphitized Ceramic Layer and Superior Ablation Resistance

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MACROMOLECULAR MATERIALS AND engineering 2022年第11期307卷

作者： Chen, Yang Liu, Zhuodong Huang, Yisen Liang, Mei Zou, Huawei Sichuan Univ State Key Lab Polymer Mat Engn Polymer Res Inst Chengdu 610065 Peoples R China

The strength of the ceramic layer formed during ablation of the silicone rubber composite is closely related to its resistance to ablation. Increasing the content of graphitic carbon in the ceramic layer plays a key role in enhancing the strength of ceramic layer. In this study, series of catalytically graphitized mesophase pitch-modified silicone rubber composites with excellent ablation performance are prepared. And the average linear ablation rate of the composite is reduced to a maximum of 0.046 mm s(-1), which is 44.0% lower than that of the sample without catalyst named 5MP. XRD characterization proves that the addition of transition metal catalysts increases the content of graphitic carbon in the ceramic layers after ablation. The strength of ceramic layer of the 0.13Fe(2)O(3) reached 12.09 MPa, which is 60.3% higher than that of the 5MP. The transition metal catalyst effectively increases the content of graphitic carbon in the ceramic layers, and the strengths of the ceramic layers are significantly improved, thereby greatly improving the ablation performance of the composites.

关键词： ablation catalytically graphitized ceramic layers mesophase pitch

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Crystalline-amorphous-crystalline two-step phase transformation and the resulting supra-nano structure in a metastable iron-based alloy

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ACTA MATERIALIA 2024年 266卷

作者： Wang, Xu Fu, Yingqian Wu, Yidong Wang, Jianbiao Fan, Jitang Zhang, Fei Ruan, Haihui Wu, Yuan Ningbo Univ Minist Educ Key Lab Impact & Safety Engn Ningbo 315211 Peoples R China Beijing Inst Technol State Key Lab Explos Sci & Technol Beijing 100081 Peoples R China Univ Sci & Technol Beijing Beijing Adv Innovat Ctr Mat Genome Engn State Key Lab Adv Met & Mat Beijing 100083 Peoples R China Hong Kong Polytech Univ Dept Mech Engn Kowloon Hung Hum Hung Hum Hong Kong Peoples R China Chinese Acad Sci Inst High Energy Phys Beijing Synchrotron Radiat Facil Beijing 100049 Peoples R China Liaoning Acad Mat Inst Mat Intelligent Technol Shenyang 110010 Peoples R China

In this work, we report a crystalline-amorphous-crystalline (CAC) two-step solid -state phase transformation (SSPT) in a 15Cr-2Ni iron-based alloy that results in nanostructures. Microstructurally, the CAC process leads to a localized supra-nano structure having almost equal content of an amorphous matrix and nanocrystalline inclusions less than 6 nm. Dynamically, it is manifested as a glass-transition-like variation of Young's modulus with a sharp surge in internal friction. Through in situ heating and Neutron Scattering experiments, a reduction in the intensities of the austenite diffraction peaks is observed, which is not associated with any intensity increase in other peaks, suggesting the collapse of austenite lattice during heating. The CAC two-step SSPT occurs at temperatures far below the melting point, and the introduction of the dislocations is the indispensable condition giving rise to such a transition. Based on experimental results, we suggest the physical picture of CAC two-step SSPT and a phenomenological model to describe it. Through the analysis, we argue that the CAC two-step SSPT provides a new route to fabricate nanostructured alloys.

关键词： Solid state phase transformation Order-disorder phenomena Neutron diffraction HRTEM Kinetic analysis Supra-nano ultrastructure

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Enhancing the Humidity Stability of Perovskite Films through Interfacial Modification with Differentiated Hydrophilic Organics

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ACS APPLIED MATERIALS & INTERFACES 2024年第35期16卷 45799-45808页

作者： Wang, Rui Yang, Xudong Chen, Qiaoyun Su, Rui Wu, Wenting Cao, Ji Yu, Wei Zhou, Yi Song, Bo Li, Yongfang Soochow Univ Coll Chem Chem Engn & Mat Sci Suzhou 215123 Peoples R China Soochow Univ Lab Adv Optoelect Mat Suzhou Key Lab Novel Semicond Optoelect Mat & Devi Suzhou 215123 Peoples R China Chinese Acad Sci Inst Chem Beijing Natl Lab Mol Sci CAS Key Lab Organ Solids Beijing 100190 Peoples R China

Preparing high-quality perovskite films is a decisive step toward realizing highly efficient and stable perovskite solar cells (Pero-SCs). Water is a key factor affecting the stability of the Pero-SCs. Here, the widely used water adsorbents chitosan, sorbitol, and sodium hyaluronate (NaHA) were used as hydrophilic layers on the upper interface of the perovskite to form a barrier against water. The water adsorbents also passivated defects on the surface of the perovskite active layer due to their -OH and -COOH functional groups. The NaHA-modified devices showed the best power conversion efficiency (PCE) (PCE = 21.74%). Although the NaHA-modified Pero-SCs showed optimal photovoltaic performance, the stability of the modified devices decreased due to the strong water adsorption ability of NaHA, while with moderate water adsorption ability sorbitol-modified devices exhibited good stability and PCE. The devices were tested in the dark and room temperature at different humidity levels for 800 h. At low humidity (25% +/- 5% RH), the PCEs of the sorbitol- and NaHA-modified devices were maintained at 80% and 71% of the initial values, respectively. At high humidity (75% +/- 5% RH), the PCE was maintained at 64% and 23% of the initial values, respectively. This work provides an avenue to select adsorbents with suitable water absorption ability as the interface modification layer, thus reducing the water erosion of perovskite films and obtaining highly stable inverted Pero-SCs.

关键词： water adsorbents perovskite solar cell interfacepassivation stability materials

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Oxygen barrier resistance of HfB2-MoSi2-TaB2 coatings in a wide temperature region

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CERAMICS INTERNATIONAL 2023年第15期49卷 25504-25515页

作者： Zhang, Mingcheng Wang, Leyu Ren, Xuanru Ji, Xiang Chen, Yuexing Wu, Binbin Kan, Tengfei Zhao, Yan Chen, Jiaping Shi, Dalin Feng, Peizhong China Univ Min & Technol Sch Mat Sci & Phys Xuzhou 221116 Jiangsu Peoples R China Henan Acad Sci Inst Carbon Matrix Composites Henan Key Lab High Performance Carbon Fiber Reinfo Zhengzhou 450046 Peoples R China

HfB2-MoSi2-based ultra-high temperature ceramic (UHTC) coatings have shown remarkable antioxidant effects owing to the formation of silicate glass layers with low oxygen permeability in high-temperature environments, which shows great potential in the antioxidation of carbon structural materials. To further enhance the oxidation resistance of the HfB2-MoSi2-based coating in a wide temperature region, the influence of volume ratio between HfB2 and TaB2 on the antioxidant capacity of the HfB2-MoSi2-TaB2 coatings was investigated. The addition of 15 vol% TaB2 in the 60HfB2-40MoSi2 coating delays the initial oxidation temperature of the 60HfB2-40MoSi2 sample from 300 degrees C to 500 degrees C, which decreased the oxidation loss by 75.85% during dynamic oxidation. In oxidation process at 900 degrees C and 1700 degrees C, the weight gains of the 45HfB2-40MoSi2-15TaB2 coating reduced by 78.56% and 63.14%, respectively. Due to the coexistence of 45 vol%HfB2 and 15 vol%TaB2, the suitable Ta5+ promoted the homogenization and dispersion of Hf/Ta-oxides, which forms the coral-like Hf/Ta oxides skeleton in the glass layer, thus preventing the oxygen penetration and decreasing the inert factor of the HfB2-MoSi2 coating at 1700 degrees C by 51.19%. However, excessive TaB2 weakened the self-healing ability of the Ta-Hf-Si-O glass layer and inhibited the oxygen barrier effect of the HfB2-MoSi2-TaB2 coating.

关键词： HfB 2-MoSi 2 coating Oxygen resistance Wide temperature range

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Facile synthesis of mesoporous zirconia nanocrystals in acid/base-free conditions

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MATERIALS SCIENCE AND technology 2023年第1期39卷 62-69页

作者： Shi, Guoliang Guo, Yu Liu, Wen Zhang, Qianwei Liu, Jianhong Lv, Cunqin Jiao, Weizhou Liang, Jing Taiyuan Univ Sci & Technol Sch Chem & Biol Engn Shanxi Key Lab High Value Utilizat Coal Gangue Taiyuan Peoples R China Anhui Sci & Technol Univ Coll Chem & Mat Engn Bengbu Peoples R China State Key Lab Adv Technol Float Glass Bengbu Peoples R China North Univ China Shanxi Prov Key Lab Higee Oriented Chem Engn Taiyuan 030051 Peoples R China Shanghai Jiao Tong Univ Shanghai Gen Hosp Dept Crit Care Med Sch Med Shanghai 200080 Peoples R China

The synthesis of mesoporous zirconia was usually achieved in extreme (acid or alkaline) PH conditions, which could result in generating a great deal of wastes that were not good for the environment. The one-pot vapour-induced synthesis route alternative to conventional acidification or basification was applied to prepare the mesostructured zirconia nanocrystals using the CTAB and F127 surfactant as template, respectively, in the paper. The nanomaterials exhibit well crystallinity and narrow pore size distribution centred at ranging from 3.2 to 4.9 nm. Compared with CTAB, the F127-templated products show a smaller grain size of less than 6.1 nm, a higher specific surface area of 167 m(2 )g(-1) and a larger pore volume of 0.25 cm(3 )g(-1). The synthesised mesoporous materials probably have important prospects as catalyst carriers and adsorbents.

关键词： Mesoporous zirconia nanocrystals large pore volume high surface area environmental-friendly synthesis pore size distribution crystallinity template-assisted synthesis vapor-induced hydrolysis

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A hydrogel electrolyte with dynamically Tunable mechanical properties for wide-temperature flexible supercapacitor

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JOURNAL OF POWER SOURCES 2025年 631卷

作者： Han, Jun Fan, Changchun Li, Dian-sen Jiang, Lei Beihang Univ Sch Chem Key Lab Bioinspired Smart Interfacial Sci & Techno Minist Educ Beijing 100191 Peoples R China

The application of conductive polymer hydrogels in flexible energy storage devices has gained a great deal of attention. In this paper, the hydrogel integrating water retention and antifreeze properties is realized by the organic binding of polyvinyl alcohol (PVA) chains and NaClO4. The composite hydrogel is assembled with MnO2/ carbon fiber and activated carbon fiber to constitute a flexible quasi-solid-state supercapacitor. The capacitor can cycle 25,000 times with the capacitance retention of 81 % when exposed directly to the external environment. In addition, the capacitor can store charge consistently and stably between-40 degrees C and 40 degrees C. This demonstrates the excellent environmental stability of the composite gel, which ensures stable operation of the device under extreme conditions. Excitingly, the mechanics of PVA composite gel electrolyte can be dynamically coordinated using the Hofmeister effect. The longer the flexible quasi-solid supercapacitor is soaked in 1.5 M Na2SO4 solution, the stronger the mechanical properties are. There are new thoughts in engineering new flexible supercapacitors with this biological compatibility and multi-functional conductive hydrogel.

关键词： Antifreeze Flexibility Dynamic coordination Water retention Supercapacitor

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Verifiable Fuzzy Multi-keyword Search Over Encrypted Data With Adaptive Security

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IEEE TRANSACTIONS ON KNOWLEDGE AND DATA engineering 2023年第5期35卷 5386-5399页

作者： Tong, Qiuyun Miao, Yinbin Weng, Jian Liu, Ximeng Choo, Kim-Kwang Raymond Deng, Robert H. H. Xidian Univ Sch Cyber Engn Xian 710071 Shaanxi Peoples R China Key Lab Blockchain & Cyberspace Governance Zhejian Hangzhou 310007 Zhejiang Peoples R China Jinan Univ Coll Cyber Secur Guangzhou 510632 Guangdong Peoples R China Fuzhou Univ Sch Math & Comp Sci Key Lab Informat Secur Network Syst Fuzhou 350108 Fujian Peoples R China Univ Texas San Antonio Dept Informat Syst & Cyber Secur San Antonio TX 78249 USA Singapore Management Univ Sch Informat Syst Singapore 178902 Singapore

To ensure the security of outsourced data without affecting data availability, one can use Symmetric Searchable Encryption (SSE) to achieve search over encrypted data. Considering that query users may search with misspelled words, the fuzzy search should be supported. However, conventional privacy-preserving fuzzy multi-keyword search schemes are incapable of achieving the result verification and adaptive security. To solve the above challenging issues, in this paper we propose a Verifiable Fuzzy multi-keyword Search scheme with Adaptive security (VFSA). VFSA first employs the locality sensitive hashing to hash the misspelled and correct keywords to the same positions, then designs a twin Bloom filter for each document to store and mask all keywords contained in the document, next constructs an index tree based on the graph-based keyword partition algorithm to achieve adaptive sublinear retrieval, finally combines the Merkle hash tree structure with the adapted multiset accumulator to check the correctness and completeness of search results. Our formal security analysis shows that VFSA is secure under the IND-CKA2 model and achieves query authentication. Our empirical experiments using the real-world dataset demonstrate the practicality of VFSA.

关键词： Adaptive security fuzzy multi-keyword search result verification symmetric searchable encryption

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