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Hilbert expansion of Boltzmann equation with soft potentials and specular boundary condition in half-space

JOUrNAL OF dIFFErENTIAL EQUATIONS 2025年 414卷 143-200页

作者： Jing, Ouyang Yong, Wang Chinese Acad Sci Acad Math & Syst Sci Beijing 100190 Peoples R China Univ Chinese Acad Sci Sch Math Sci Beijing 100049 Peoples R China

Boundary effects play an important role in the study of hydrodynamic limits in the Boltzmann theory. We justify rigorously the validity of the hydrodynamic limit from the Boltzmann equation of soft potentials to the compressible Euler equations by the Hilbert expansion with multi-scales. Specifically, the Boltzmann solutions are expanded into three parts: interior part, viscous boundary layer and Knudsen boundary layer. due to the weak effect of collision frequency of soft potentials, new difficulty arises when tackling the existence of Knudsen layer solutions with space decay rate, which has been overcome under some constraint conditions and losing velocity weight arguments. (c) 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

关键词： Boltzmann equation Compressible Euler equations Hydrodynamic limit Hilbert expansion Viscous boundary layer Knudsen boundary layer

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The Impact of Non-Thyroidal Illness Syndromes on The Prognosis and Immune Profile in Severe Fever with Thrombocytopenia Syndrome Patients

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INFECTION ANd drUG rESISTANCE 2025年 18卷 1439-1449页

作者： Wu, Hongxiao Mu, Yameng Liu, Yuanni Zhang, ruihua Xu, Yanli Zhang, Yuanyuan Zhao, Chenxi Zhang, Wei Lin, Ling Chen, Zhihai Capital Med Univ Beijing Ditan Hosp Natl Key Lab Intelligent Tracking & Forecasting In Beijing Peoples R China Capital Med Univ Beijing Ditan Hosp Inst Infect Dis Beijing Key Lab Emerging Infect Dis Beijing 100015 Peoples R China Capital Med Univ Beijing Ditan Hosp Natl Ctr Infect Dis Beijing 100015 Peoples R China Yantai Qishan Hosp Dept Infect Dis Yantai Peoples R China Beijing Inst Infect Dis Beijing 100015 Peoples R China

Background: Non-thyroidal illness syndrome (NTIS) is the most common endocrine dysfunction in critically ill patients and is often associated with poor prognosis. Thyroid dysfunction and immune cell disturbances are frequently observed in patients with severe fever with thrombocytopenia syndrome (SFTS). This study aims to evaluate the impact of NTIS on the prognosis of SFTS patients and to explore the relationship between thyroid hormones (THs) and immune cell profiles. Methods: Adult patients admitted to Yantai Qishan Hospital for SFTS from January 2023 to december 2023 with no prior history of thyroid disease were retrospectively recruited. Multivariable regressions were used to assess the associations between NTIS and clinical outcomes. Spearman correlation analysis was conducted to evaluate the relationships between immune cells and THs. SFTS patients with NTIS were categorized into four subtypes based on different levels of FT4 and TSH, and the association between NTIS subtypes and mortality was further analyzed. results: Of the 84 SFTS patients included in the study, 62 (73.8%) were diagnosed with NTIS. Independent risk predictors which may affect prognosis of SFTS patients include NTIS subtype (P =0.002), viral load (P = 0.029), FT3 (P = 0.032), and FT4 (P = 0.041). SFTS patients with NTIS exhibited a higher mortality rate compared to euthyroid patients (P = 0.033). Spearman correlation analysis revealed that LYM, LYM%, MONO, MONO%, BAS, Cd3+T, Cd3+T%, Th, and Th% were positively correlated with FT3, FT4, or TSH levels. NTIS patients were more likely to present with coagulation abnormalities (APTT, P = 0.005;d-dimer, P < 0.001), liver enzyme abnormalities (AST, P = 0.001), electrolyte imbalances (Sodium, P = 0.003), elevated LdH (P = 0.001), and increased alpha-HBdH (P = 0.003). Conclusion: NTIS is common in SFTS patients, and SFTS patients with NTIS have a lower survival rate compared to euthyroid patients. The mortality risk in NTIS type 3 patients is highe

关键词： SFTS non-thyroidal illness syndrome thyroid dysfunction immune cells

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Unveiling the key Obstacle in Photocatalytic Overall Water Splitting reaction on Poly (heptazine imide) Semiconductors

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SMALL 2025年第1期21卷 e2407307页

作者： Pan, Zhiming Zhang, Guigang Zhang, Xirui Xing, Wandong Zheng, dandan Wang, Sibo Hou, Yidong Wang, Xinchen Fuzhou Univ Coll Chem State Key Lab Photocatalysis Energy & Environm Fuzhou 350116 Peoples R China Fuzhou Univ Dept Coll Environm & Safety Engn Fuzhou 350116 Peoples R China

Poly (heptazine imide) (PHI), a classic 2d polymeric photocatalyst, represents a promising organic semiconductor for photocatalytic overall water splitting (POWS). However, since the key bottleneck in POWS of PHI remains unclear, its quantum efficiency of POWS is extremely restrained. To identify the key obstacle in POWS on the PHI, a series of PHI with different stacking modes is synthesized by tuning interlayer cations. The structural characterizations revealed that tuning the interlayer cations of PHI can induce rearrangements in interlayer stacking modes. Additionally, charge carriers dynamics uncover that optimizing the interlayer stacking modes of PHI can promote exciton diffusion and prolong the photoexcited electron lifetimes, thus improving the concentration of surface-reaching charge. More importantly, this confirms that the POWS activity of PHI is closely correlated with the interlayer stacking modes. This work offers new insight into structural regulation for governing charge-transport dynamics and the activity of 2d polymeric photocatalysts.

关键词： charge transport interlayer stacking modes overall water splitting photocatalysis poly (heptazine imide)

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Iridium-catalyzed asymmetric hydrogenation of tetrahydro-γ-carboline: a versatile approach to chiral cis-hexahydro-γ-carboline derivatives compatible with C6-substituted carbolines

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OrGANIC CHEMISTrY FrONTIErS 2025年第8期12卷 2714-2719页

作者： Liu, Bowen Zhang, Chun Li, Xiuxiu Zhang, Xumu Tianjin Univ Sch Sci Dept Chem Inst Mol PlusTianjin Key Lab Mol Optoelect Sci Tianjin 300072 Peoples R China Southern Univ Sci & Technol Shenzhen Grubbs Inst Dept Chem Shenzhen Key Lab Small Mol Drug Discovery & Synth Shenzhen 518055 Peoples R China Southern Univ Sci & Technol Med Pingshan Shenzhen 518055 Peoples R China

An efficient iridium-catalyzed asymmetric hydrogenation (AH) of tetrahydro-gamma-carboline has been developed for the synthesis of chiral cis-hexahydro-gamma-carboline derivatives. This method overcomes the challenge posed by C6 substituents on the carboline ring, proceeding smoothly under mild conditions to deliver the desired products in high yields with exceptional enantioselectivities. The success of this transformation is attributed to the use of a ZhaoPhos ligand bearing an electron-withdrawing F-substituted phenyl group on phosphorus. Notably, the strategy's versatility is further demonstrated by its concise and efficient application in the synthesis of lumateperone intermediates.

关键词： Iridium

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TMEM132E ablation suppresses tumor progression and restores tamoxifen sensitivity by inducing Erα expression in triple-negative breast cancer

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Genes & diseases 2025年第2期12卷 37-40页

作者： Shang Gao Ping Sun Zekun Wang Yecheng Jin Wenjie Sun Xi Li ruonan duan Jiangxia Li Qiji Liu Key Laboratory for Experimental Teratology of the Ministry of Education Department of Medical GeneticsSchool of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinanShandong 250012China Department of Neurology Qilu Hospital of Shandong UniversityJinanShandong 250012China Key Laboratory for Experimental Teratology of the Ministry of Education and Department of Medical Genetics School of Basic Medical SciencesShandong UniversitySchool of Health and Life SciencesUniversity of Health and Rehabilitation SciencesQingdaoShandong 266071China NHC Key Laboratory of Birth Defects Prevention Institute of Reproductive HealthHenan Academy of Innovations in Medical ScienceZhengzhouHenan 451163China

Triple-negative breast cancer(TNBC)is defined by the lack of estrogen receptor(Er),progesterone receptor,and amplified human epidermal growth factor receptor *** accounts for~15%of all breast cancer cases but represen... 详细信息

关键词： expression. breast cancer

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Maternal ELL3 loss-of-function leads to oocyte aneuploidy and early miscarriage

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NATUrE STrUCTUrAL & MOLECULAr BIOLOGY 2025年第2期32卷 1-12页

作者： Zhu, Shiqi Xie, Peng Yang, Yi Wang, Yan Zhang, Chuanxin Zhang, Yu Si, Shuhan Zhang, Jin He, Jingjing Si, Hao Fang, Ke Ma, Binbin Jiang, Xu Huang, Lindi Li, Jiamin Min, Tian Zheng, Beihong da, Lincui Lin, dianliang Gao, Kun Li, Yuanyuan Huang, Mingtao Qiao, Fengchang Huo, Haiqin Feng, Haoyang Zhao, Han Chen, Zijiang Xu, Zhengfeng Xie, Jing Cao, Hua Liu, Jin Yao, Xuebiao Xie, Wei Sun, Yan Wu, Keliang Xiong, Bo Hu, Ping Luo, Zhuojuan Lin, Chengqi Southeast Univ Sch Life Sci & Technol Key Lab Dev Genes & Human Dis Nanjing Peoples R China Nantong Univ Coinnovat Ctr Neuroregenerat Nantong Peoples R China Southeast Univ Sch Biol Sci & Med Engn Nanjing Peoples R China Nanjing Med Univ Womens Hosp Dept Prenatal Diag Nanjing Peoples R China Shandong Univ Ctr Reprod Med Jinan Peoples R China Zhejiang Univ Coll Anim Sci Hangzhou Peoples R China Tongji Univ Sch Life Sci & Technol Shanghai Peoples R China Fujian Matern & Child Hlth Hosp Reprod Med Ctr Fujuan 350001 Peoples R China Chinese Univ Hong Kong Sch Data Sci Shenzhen Peoples R China Univ Sci & Technol China Sch Life Sci Lab Organelle Dynam & Plast Control Hefei 230026 Peoples R China Southeast Univ Shenzhen Res Inst Shenzhen Peoples R China Southeast Univ Sch Life Sci & Technol Jiangsu Prov Key Lab Crit Care Med Nanjing Peoples R China

Up to an estimated 10% of women experience miscarriage in their lifetimes. Embryonic aneuploidy is a leading cause for miscarriage, infertility and congenital defects. Here we identify variants of ELL3, a gene encoding a transcription elongation factor, in couples who experienced consecutive early miscarriages due to embryonic aneuploidy. Maternal ELL3 knockout leads to mouse oocyte aneuploidy, subfertility and miscellaneous embryonic defects. Mechanistically, we find that ELL3 localizes to the spindle during meiosis, and that ELL3 depletion in both mouse and human oocytes increases the incidence of meiotic spindle abnormality. ELL3 coordinates with TPX2 to ensure the proper function of the microtubule motor KIF11. Live imaging analysis shows that ELL3 is paramount for promoting spindle assembly and driving chromosome movement. Together, our findings implicate maternal ELL3 deficiency in causing oocyte aneuploidy and early miscarriage.

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runx2-NLrP3 axis orchestrates matrix stiffness-evoked vascular smooth muscle cell inflammation

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AMErICAN JOUrNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 2025年第2期328卷 C467-C482页

作者： Li, Zhiqing Wu, Hao Yao, Fang Li, Yiran Li, Yanjie Xie, Si-an Yu, Fang Fu, Yi Wang, Li Zhou, Jing Kong, Wei Peking Univ Sch Basic Med Sci Dept Physiol & Pathophysiol State Key Lab Vasc Homeostasis & Remodeling Beijing Peoples R China Chinese Acad Med Sci Fuwai Hosp Shenzhen Key Lab Cardiovasc Dis Shenzhen Peoples R China Capital Med Univ Beijing Friendship Hosp Dept Gastroenterol Beijing Peoples R China Chinese Acad Med Sci & Peking Union Med Coll Fuwai Hosp Natl Ctr Cardiovasc Dis State Key Lab Cardiovasc Dis Beijing Peoples R China Chinese Acad Med Sci Key Lab Pluripotent Stem Cells Cardiac Repair & R Beijing Peoples R China

Arterial stiffening is a hallmark of chronic kidney disease (CKd)-related cardiovascular events and is primarily attributed to the elevated matrix stiffness. Stiffened arteries are accompanied by low-grade inflammation, but the causal effects of matrix stiffness on inflammation remain unknown. For analysis of the relationship between arterial stiffness and vascular inflammation, pulse-wave velocity (PWV) and aortic inflammatory markers were analyzed in an adenine-induced mouse model of CKd in chronological order. Compared with their control littermates, mice with CKd showed elevated arterial stiffness at the early stage of disease progression, which preceded the onset of vascular inflammation. Correspondingly, the increase of matrix stiffness induced vascular smooth muscle cells (VSMCs) to transdifferentiate into an inflammatory phenotype, as indicated by the increased expression and secretion of MCP-1, IL-6, IL-1 beta, and IL-18. rNA-sequencing analysis of stiff matrix-cultured VSMCs and bioinformatics analysis with the ChIP-Atlas database revealed the potential involvement of the transcription factor runx2. The expression and the nuclear localization of runx2 were significantly increased in stiff matrix-cultured VSMCs. High-throughput ChIP-sequencing and promoter luciferase assays further revealed that NLrP3 was directly transcriptionally regulated by runx2. The inhibition of runx2 or NLrP3 inflammasome abrogated the proinflammatory effect of matrix stiffening on VSMCs. Together, these data revealed that arterial stiffness precedes vascular inflammatory responses in CKd mice and that the runx2-NLrP3 axis orchestrates matrix stiffness and the VSMC inflammatory phenotype, which may contribute to the pathogenic role in arterial stiffness-related vascular inflammation and CKd-related cardiovascular complications. NEW & NOTEWOrTHY As a hallmark of chronic kidney disease (CKd), arterial stiffening is related to increased vascular inflammation and cardiovascular morbidit

关键词： chronic kidney disease matrix stiffness NLrP3 runx2 VSMC inflammatory phenotype

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Coordinated Adaptive Impedance Control of redundantly Actuated Parallel Manipulators

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IEEE TrANSACTIONS ON HUMAN-MACHINE SYSTEMS 2025年

作者： Ma, Nan Cheneler, david He, Guangping Yuan, Junjie Bian, Gui-Bin Northwestern Polytech Univ Sch Mech & Elect Engn Xian 710072 Peoples R China Univ Lancaster Sch Engn Lancaster LA1 4YW England North China Univ Technol Dept Mech & Elect Engn Beijing 100144 Peoples R China Chinese Acad Sci Inst Automat State Key Lab Management & Control Complex Syst Beijing 100190 Peoples R China

redundantly actuated parallel mechanisms (rAPMs) have been widely adopted in advanced robotic systems and precision machine tools. It has been demonstrated that redundant actuation can improve the performance of mechatronic systems but introduce challenges with respect to control. One main difficulty is in establishing an accurate dynamic model of the rAPM system. With an inaccurate dynamic model, the torque applied by the actuators will be incorrect, leading to increased antagonistic forces in the system. To solve this problem, a novel coordinated adaptive impedance control approach based on a new adaptive impedance control law is presented here, along with proof of the stability of the closed-loop system. The control algorithm has been validated experimentally by a prototype cable-driven parallel manipulator. It can be seen from the experimental results that the proposed control method is an effective way to correct the antagonistic forces of the system, thus facilitating the improvement of its dynamic performance and its efficacy in different applications.

关键词： Impedance robots Adaptation models robot kinematics Actuators Stability analysis Kinematics Wires Steel Manipulator dynamics Actuation redundancy adaptive impedance control coordination control parallel manipulators uncertain model

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Origin and Tectonic Setting of the Ore-related Late Ordovician Porphyry in the Songshunangou district, North Qilian, Northwest china: Whole-rock Geochemical, Sr-Nd-Pb Isotopes and Zircon Hf Isotopes Constraints

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JOUrNAL OF EArTH SCIENCE 2025年 1-18页

作者： Xiang, Zuopeng Lang, Xinghai Wang, Xuhui Lohmeier, Stephanie Lehmann, Bernd deng, Yulin dong, Weicai Luo, Chao Chengdu Univ Technol Coll Earth & Planetary Sci Chengdu 610059 Peoples R China Tech Univ Clausthal Mineral Resources D-38678 Clausthal Zellerfeld Germany Sichuan Xinshun Min Co Ltd Chengdu 610041 Peoples R China

The Early Paleozoic porphyry-epithermal Au system of the Songshunangou district sits in the central segment of the North Qilian orogenic belt (NQOB). The porphyry Au mineralization is centered on the quartz diorite porphyry (QdP), which is constrained to the Late Ordovician period. However, the geochemical signatures, the origin, and the tectonic setting of the QdP are not yet known and understood and are thus in the focus here. The QdP is a high-K calc-alkaline metaluminous rocks (K2O + Na2O: 6.90-8.13;Al2O3/(CaO + Na2O + K2O): 0.69-0.90) characterized by high (87Sr/86Sr)t values (0.709 3-0.710 1) and low epsilon Nd(t) values (-2.9 to -2.7) with corresponding TdM2 (Nd) ages of 1 408 to 1 430 Ma. Zircon epsilon Hf(t) values are low (-1.51 to +2.76) with corresponding TdM2 (Hf) ages of 1 262 to 1 533 Ma. The lead isotope values are 17.695-18.476 for (206Pb/204Pb)t, 15.585-15.629 for (207Pb/204Pb)t, and 37.214-37.948 for (208Pb/204Pb)t. These data indicate that the QdP formed by the mixing of mantle-derived magmas (50%-70%) with lower crustal melts. The QdP is enriched in LrEEs and LILE (rb, Th, K) and is depleted in HFSE (Nb, Ta, Ti), expressing a clear volcanic arc affinity. High La and Th contents, and Zr/Y and Hf/Yb values suggest that the QdP formed in an Andean-type continental margin arc setting related to the northward subduction of the North Qilian oceanic slab. The Early Paleozoic subduction-related intermediate-acidic intrusions in NQOB have arc magma affinity, indicating that these rocks bear a great potential to discover further fertile porphyry deposits.

关键词： porphyry ore deposits geochemistry Songshunangou district North Qilian orogenic belt

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role of Surface Hydrophobicity in the Coalescence-Induced Bubble detachment Kinetics

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INdUSTrIAL & ENGINEErING CHEMISTrY rESEArCH 2025年第17期64卷 8943-8954页

作者： Wang, Yali Xu, Wenjin Liu, Qinshan Guo, Han Gui, Xiahui Xing, Yaowen China Univ Min & Technol State Key Lab Coking Coal Resources Green Exploita Xuzhou 221116 Peoples R China China Univ Min & Technol Chinese Natl Engn Res Ctr Coal Preparat & Purifica Xuzhou 221116 Peoples R China China Univ Min & Technol Sch Chem Engn & Technol Xuzhou 221116 Peoples R China

Bubble detachment plays a crucial role in preventing excessive accumulation in gas-liquid reactors and improving the mass transfer efficiency. This study investigates the effect of surface hydrophobicity on bubble detachment induced by coalescence through high-speed dynamic experiments and numerical simulations. The results show that on surfaces with low hydrophobicity (contact angles of 15 and 25 degrees), bubbles detach because the inner contact line contracts relatively slowly, allowing the outer contact line to coalescence quickly. In contrast, on highly hydrophobic surfaces (contact angles of 35 and 45 degrees), the simultaneous contraction of both the inner and outer contact lines prevents bubble jumping. Numerical simulations indicate that low-hydrophobicity surfaces generate sufficient kinetic energy through the pressure gradient. As hydrophobicity increases, some of the energy is dissipated through liquid-film drainage, weakening internal convection and reducing the intensity of the upward flow, which ultimately prevents bubble detachment. Energy analysis further indicates that bubble coalescence shows a weak dependence on the Bo number, while the magnitude of the adhesion energy is the key factor determining bubble jumping. When the adhesion energy exceeds approximately 20% of the released surface energy, the coalesced bubble is unable to detach.

关键词： Coalescence

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