检索结果-内蒙古大学图书馆

Silkworm pupa peptide ameliorates dextran sulfate sodium-induced colitis by enhancing gut barriers and modifying gut flora

引用

Food Science and Human Wellness 2025年第2期14卷 758-768页

作者： Yaxi Zhou Diandian Wang Hao Duan Shiqi Zhou Jinhong Guo Yu Guo Jian Zhao Wenjie Yan Beijing Key Laboratory of Bioactive Substances and Functional Food College of Biochemical EngineeringBeijing Union UniversityBeijing 100023China

The anti-inflammatory properties of silkworm pupa peptide(SPP)have been recognized for their potential benefits in colitis ***,the underlying mechanism of SPP in colitis animal models remains *** objective of our work was to investigate the improving effect and the mechanism of action of SPP on a mouse model of dextran sulfate sodium(DSS)-induced *** findings suggested that SPP effectively eased ulcerative colitis(UC)symptoms in mice by decreasing disease activity index,ameliorating histopathological injury,and decreasing serum and colonic markers of *** addition,our research findings demonstrated that SPP restored intestinal barrier function by increasing the production of tight junction proteins such as zonula occludens-1(ZO-1),claudin-1,claudin-3,occludin,and adherens junction protein ***,SPP supplementation enhanced the concentration of short-chain fatty acids and positively altered the makeup of the gut bacteria in the mice's *** findings underscore SPP's ability to slow the progression of colitis and point to its possible use as a functional component in dietary supplements for the prevention of early-stage colitis.

关键词： Silkworm pupa peptide Ulcerative colitis Intestinal barrier Gut flora Short-chain fatty acids

来源：评论

学校读者我要写书评

暂无评论

Integrated multi-omics reveals contrasting epigenetic patterns in leaf and root morphogenesis in Aegilops speltoides

引用

The Crop Journal 2025年第1期13卷 292-298页

作者： Lingfeng Miao Zhe Chen Lifeng Gao Jizeng Jia Weilong Guo Guangyao Zhao Key Laboratory of Crop Gene Resources and Breeding the National Key Facility for Crop Gene Resources and Genetic ImprovementInstitute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China Frontiers Science Center for Molecular Design Breeding Key Laboratory of Crop Heterosis and UtilizationBeijing Key Laboratory of Crop Genetic ImprovementChina Agricultural UniversityBeijing 100193China

Aegilops speltoides,the closest ancestor of the wheat B subgenome,has been well studied ***,the epigenetic landscape of *** and the effects of epigenetics on its growth and development remain poorly ***,we present a comprehensive multi-omics atlas of leaves and roots in ***,encompassing transcriptome,DNA methylation,histone modifications,and small RNA *** DNA methylation levels were detected between leaves and roots,and were associated with differences in accumulated 24-nt *** methylation changes in promoters and gene bodies showed strong connections with altered expression between leaves and *** regulatory networks(TRN)reconstructed between leaves and roots were driven by tissue-specific TF *** methylation and histone modification act together as switches that shape root and leaf morphogenesis by modulating the binding of tissue-specific TFs to their target *** TRNs in leaves and roots reshaped during wheat polyploidization were associated with alterations in epigenetic ***,these results not only shed light on the critical contribution of epigenetic regulation in the morphogenesis of leaves and roots in *** but also provide new insights for future investigations into the complex interplay of genetic and epigenetic factors in the developmental biology of common wheat.

关键词： Aegilops speltoides DNA methylation Histone modification Transcriptional regulatory network

来源：评论

学校读者我要写书评

暂无评论

Untargeted metabolomics combined with 16S rRNA sequencing reveals the characteristics of intestinal metabolism and gut microbiota in hazelnut Cor a 14-allergic BALB/c mice

引用

Food Science and Human Wellness 2025年第2期14卷 692-705页

作者： Chen Chen Kaiyu Mu Qiang Xie Wentong Xue College of Food and Bioengineering Zhengzhou University of Light IndustryZhengzhou 450001China College of Food Science and Nutritional Engineering China Agricultural UniversityBeijing 100083China

Cor a 14 is one of the most vital allergens in ***,the features of intestinal metabolites and microbiota associated with Cor a 14-induced allergy remain *** this study,we established a hazelnut Cor a 14-allergic BALB/c mice model,which was distinguished by the dropped temperature and enhanced allergic inflammatory factor levels in *** were collected to detect characteristics of the intestinal metabolites by untargeted metabolomics and the gut microbiota by 16S rRNA ***α-andβ-diversity of gut microbiota in Cor a 14-allergic mice differed from the controls with elevated relative abundance of Lactobacillus and reduced relative abundances of Odoribacter,Chloroplast,Alistipes and Lachnospiraceae_NK4A136_*** metabolomics results revealed that 238 significantly differential metabolites(111 up-regulated,127 down-regulated)were identified,of which,L-tryptophan,histamine and N-acetylhistamine were remarkably accumulated and primarily enriched in the enhanced L-tryptophan and histidine metabolism *** correlation analysis suggested that L-tryptophan was positively correlated with allergic indicators and screened as the potential biomarker for Cor a 14 ***,our findings uncovered the characteristics of intestinal metabolites and gut microbiota during Cor a 14 anaphylaxis and provided new potential insights for diagnosis of hazelnut allergy.

关键词： Food allergy Hazelnuts Cor a 14 Untargeted metabolomics Gut microbiota L-Tryptophan

来源：评论

学校读者我要写书评

暂无评论

D‑mannose alleviates intervertebral disc degeneration through glutamine metabolism

引用

Military Medical research 2025年第3期12卷 313-338页

作者： Zheng-Lin Dong Xin Jiao Zeng-Guang Wang Kai Yuan Yi-Qi Yang Yao Wang Yun-Tao Li Tian-Chang Wang Tian-You Kan Jian Wang Hai-Rong Tao Department of Orthopedics Shanghai Key Laboratory of Orthopedic ImplantShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China School of Medicine Shanghai UniversityShanghai 200444China

Background:Intervertebral disc degeneration(IVDD)is a multifaceted condition characterized by heterogeneity,wherein the balance between catabolism and anabolism in the extracellular matrix of nucleus pulposus(NP)cells plays a central ***,the available treatments primarily focus on relieving symptoms associated with IVDD without offering an effective cure targeting its underlying pathophysiological processes.D-mannose(referred to as mannose)has demonstrated anti-catabolic properties in various ***,its therapeutic potential in IVDD has yet to be ***:The study began with optimizing the mannose concentration for restoring NP *** analyses were employed to identify the mediators influenced by mannose,with the thioredoxin-interacting protein(TXNIP)gene showing the most significant ***,small interfering RNA(siRNA)technology was used to demonstrate that TXNIP is the key gene through which mannose exerts its *** such as colocalization analysis,molecular docking,and overexpression assays further confirmed the direct regulatory relationship between mannose and *** elucidate the mechanism of action of mannose,metabolomics techniques were employed to pinpoint glutamine as a core metabolite affected by ***,various methods,including integrated omics data and the Gene Expression Omnibus(GEO)database,were used to validate the one-way pathway through which TXNIP regulates ***,the therapeutic effect of mannose on IVDD was validated,elucidating the mechanistic role of TXNIP in glutamine metabolism in both intradiscal and orally treated ***:In both in vivo and in vitro experiments,it was discovered that mannose has potent efficacy in alleviating IVDD by inhibiting *** a mechanistic standpoint,it was shown that mannose exerts its anti-catabolic effects by directly targeting the transcription factor max-like protein X-interacting protein(MondoA),re

关键词： D-mannose Intervertebral disc degeneration(IVDD) Thioredoxin-interacting protein(TXNIP) Glutamine

来源：评论

学校读者我要写书评

暂无评论

Abundant geographical divergence of Clostridioides difficile infection in china: a prospective multicenter cross-sectional study

引用

BMC INFECTIOUS DISEASES 2025年第1期25卷 1-14页

作者： Bai, Lulu Xu, Telong Zhang, Wenzhu Jiang, Yajun Gu, Wenpeng Zhao, Wei Luan, Yang Xiong, Yanfeng Zou, Nianli Zhang, Yalin Luo, Ming Lu, Jinxing Zhang, Bike Wu, Yuan Chinese Ctr Dis Control & Prevent Natl Inst Communicable Dis Control & Prevent Natl Key Lab Intelligent Tracking & Forecasting In Beijing 102206 Peoples R China Inst Acute Infect Dis Control & Prevent Yunnan Prov Ctr Dis Control & Prevent Kunming 650500 Yunnan Peoples R China Jilin Prov Ctr Dis Control & Prevent Changchun 132001 Jilin Peoples R China Xian Municipal Ctr Dis Control & Prevent Xian 710054 Shaanxi Peoples R China Ganzhou Ctr Dis Control & Prevent Ganzhou 341000 Peoples R China Zigong Ctr Dis Control & Prevent Zigong 643002 Sichuan Peoples R China Hainan Prov Ctr Dis Control & Prevent Haikou 570203 Hainan Peoples R China Yulin Ctr Dis Control & Prevent Yulin 537006 Guangxi Peoples R China

Clostridioides difficile is the predominant pathogen in hospital-acquired infections and antibiotic-associated diarrhea. Dedicated networks and annual reports for C. difficile surveillance have been established in Europe and North America, however the extensive investigation on the prevalence of C. difficile infection (CDI) in china is limited. In this study, 1528 patients with diarrhea were recruited from seven geographically representative regions of china between July 2021 and July 2022. The positivity rate of toxigenic C. difficile using real-time fluorescence quantitative PCR test of feces was 10.2% (156/1528), and 125 (8.2%, 125/1528) strains were successfully isolated. The isolates from different geographical areas had divergent characteristics after multilocus sequence typing, toxin gene profiling, and antimicrobial susceptibility testing. No isolate from clade 2 were found, and clade 1 was still the main clade for these clinical isolates. Interestingly, clade 4, especially ST37, previously known as the characteristic type of china, showed a strong geographical divergence. Clade 3, although rare in china, has been detected in Hainan and Sichuan provinces. Most C. difficile isolates (76.8%, 96/125) were toxigenic. Clindamycin, erythromycin, and moxifloxacin were the top three antibiotics to which resistance was observed, with resistance rates of 81.3%, 63.6%, and 24.0%, respectively. Furthermore, 34 (27.2%, 34/125) multidrug-resistant (MDR) strains were identified. All the strains were sensitive to metronidazole, vancomycin, and meropenem. The genotype of C. difficile varies greatly among the different geographical regions in china, and new types are constantly emerging. Therefore, comprehensive, longitudinal, and standardized surveillance of C. difficile infections is needed in china, covering typical geographical areas.

关键词： Clostridioides difficile infections Molecular epidemiology Multilocus sequence typing Toxin gene profile Antimicrobial susceptibility

来源：评论

学校读者我要写书评

暂无评论

A morphological and anatomical study for tracking the growth and development of individual flowers and pods in soybean(Glycine max L.)

引用

The Crop Journal 2025年第1期13卷 304-309页

作者： Fang Li Yi-Ping Shao Irsa Ejaz Zhen-Yuan Chen Zhi-Wei Wang Xin Wang Shun-Li Zhou College of Agronomy and Biotechnology China Agricultural UniversityBeijing 100193China Innovation Center of Agricultural Technology for Lowland Plain of Hebei Wuqiao 061802HebeiChina

A morphology-based growth stage system should describe the growth and development of a crop and thereby help farmers and agronomists in formulating reasonable managementmeasures conducive to the development of marketable ***,existing growth stage systems for soybean are either based on plant growth or covered particular phases of flower or pod development,making it difficult to use for tracking the entire growth period of individual flowers and ***,the first flower and pod,located at the base of the primary raceme in the eighth trifoliate node of the main stem,were chosen to illustrate growth dynamics during the full reproductive *** size and fresh weight of the primary raceme in the eighth trifoliate leaf axil,the first flower and pod,the pistils in the first flower,and seeds in the first pod were examined,and the growth of these organs was *** the morphological characteristics and growth features of flowers and pods,as well as existing growth stage systems,the growth and development were delineated in 13 *** detail,we classified the flower phase based on the relative positions of floral components,inspired by the ratio of bract to flower used for staging,refined the lag phase proposed previously,retained the use of pod length to define the early pod phase,and innovatively described the late pod phase by the seed *** developmental events in each stage of flower and pod were distinctive and closely connected to the corresponding *** together,a more detailed growth stage system for describing individual flowers and pods in soybean was *** system will serve as a valuable research tool for describing the development,gene expression,and cellular metabolism associated with the formation of flowers,pods,and seeds.

关键词： Soybean Growth stage system Flower and pod Morphology Anatomy Growth and development

来源：评论

学校读者我要写书评

暂无评论

Thermal coupling study during the co-processing of coal and biomass in the lab-scale adiabatic reactor

引用

Chinese Journal of Chemical Engineering 2025年 78卷 303-313页

作者： Wang, Laisong Du, Zhidi Feng, Jie Shi, Xiaolong Li, Wenying State Key Laboratory of Clean and Efficient Coal Utilization Taiyuan University of Technology Taiyuan030024 China

A lab-scale adiabatic reactor has been self-made to characterize the coupled properties of heat and reactions during the co-thermal-processing of coal and biomass with steam or steam/O2 gasification agents. Results showed that the synergistic effects caused by heat transfer between corncob and coal at different mixing ratios were heavily determined by coal rank and gasification agent. During steam co-processing, the heat transfer from corncob char to adjacent bituminous coal char promoted the water-gas reaction on coal char and contributed to synergistic effects;the heat transfer from anthracite char to adjacent corncob char reduced the kinetic rate of the water-gas reaction on coal char and contributed to inhibitory effects, and the inhibitory effect caused by heat transfer was greater than the promotion effects of biomass mass transfer. The introduction of O2 diminished the impact of inter-particle heat transfer and altered the intensity of synergy, decreasing the values of synergy factor of bituminous coal/corncob blends by 17% and increasing the value of synergy factor of anthracite/corncob blends by 142.5%. This study provides sufficient support for the process conditions selection for the production of syngas with specific H2/CO molar ratios and the desired level of gasification performance. © 2024 Chemical Industry and Engineering Society of china (CIESC) and Chemical Industry Press Co., Ltd. (CIP)

关键词： Anthracite

来源：评论

学校读者我要写书评

暂无评论

Reflective Semiconductor Optical Amplifier Chip with Low Ripple for C-Band External Cavity Narrow-Linewidth Laser

引用

PHOTONICS 2025年第3期12卷 193-193页

作者： Li, Shaojie Yu, Haiyang Bao, Haotian Ren, Menghan Liu, Jianguo Liu, Zeqiu Cao, Yulian Univ Chinese Acad Sci Sch Integrated Circuits Beijing 100083 Peoples R China Chinese Acad Sci Inst Semicond Nanometer Optoelect Lab Beijing 100083 Peoples R China

The main characteristic of a reflective semiconductor optical amplifier chip (RSOA) is that it does not generate optical resonance under electric pumping and maintains the operation state of spontaneous emission. In this paper, a Nb2O5/SiO2/Nb2O5/SiO2 (four-layer Nb2O5/SiO2) film system is employed as the coating material for the output facet of the RSOA. The 3 dB spectral width of the spontaneous emission spectrum from this RSOA reaches 79.4 nm, with a ripple of less than 1 dB occurring across this wavelength range. Notably, around the 1550 nm wavelength, the ripple is as low as 0.5 dB. This represents the best performance reported for this type of chip. The RSOA is packaged as a narrow-linewidth external cavity laser. Under test conditions of 25 degrees C and 180 mA, the external cavity laser produces an output power of 12.6 mW and achieves a linewidth of 299.8 Hz. Furthermore, by adjusting the Fabry-P & eacute;rot (FP) standard cavity, filtering, and other external cavity parameters, the lasing spectrum of the narrow-linewidth external cavity laser based on the RSOA is tunable across a wavelength range from 1535.83 nm to 1561.42 nm, which shows the usability of the proposed ROSA for a C-band external cavity narrow-linewidth laser.

关键词： RSOA narrow-linewidth external cavity laser ripple

来源：评论

学校读者我要写书评

暂无评论

Space-marching inverse design of subsonic,transonic,and supersonic internal flowfields

引用

Chinese Journal of Aeronautics 2025年第2期38卷 15-30页

作者： Bo ZHANG Shihe YI Yuxin ZHAO Rui YANG Ziyuan ZHU Ruitong ZENG College of Aerospace Science and Engineering National University of Defense TechnologyChangsha 410072China

Flowfield inverse design can obtain the desired flow and contour with high design efficiency,short design cycle,and small modification *** this study,the Euler equations are formulated in the stream-function coordinates and combined with the given boundary conditions to derive a gridless space-marching method for the inverse design of subsonic,transonic,and supersonic *** can prescribe the flow parameters along the reference streamline to design flowfields and aerodynamic *** method is validated by the theoretical transonic solution,computational fluid dynamics,and experimental data,*** method supports the fabrication of a Mach 2.0 single expansion *** calibration data agree well with the prescribed pressure *** method is successfully applied to inverse design of contractions,nozzles,and asymmetric *** to classical analytic contractions,the contractions designed by the space-marching method provide a more accurate transonic *** to the classical Sivells’nozzle,the nozzle designed by the space-marching method provides a smaller workload,a more flexible velocity distribution,a 20%reduction in length,and an equally uniform ***,the space-marching method is applied to design the asymmetric channels under various Mach *** asymmetric channels perfectly eliminate Mach waves,achieving the shock-free flow turning and high flow *** results validate the feasibility of the space-marching method,making it a good candidate for the inverse design of subsonic,transonic,and supersonic internal flowfields and aerodynamic contours.

关键词： Flowfield Inverse design Compressible flow Contraction Nozzle Asymmetric channel

来源：评论

学校读者我要写书评

暂无评论

PVA/PEGDA microgels loaded with L-cysteine for corrosion inhibition coating on fragile bronze

引用

JOURNAL OF COATINGS TECHNOLOGY AND research 2025年第2期22卷 631-649页

作者： Hu, Hengrui Huang, Xia Chen, Jiachang Chen, Junying Zhengzhou Univ Sch Chem Engn Zhengzhou 450001 Henan Peoples R China Zhengzhou Univ Sch Mat Sci & Engn Zhengzhou 450001 Henan Peoples R China Henan Prov Inst Cultural Rel & Archaeol Zhengzhou 450000 Henan Peoples R China

Bronze holds immense artistic, historical, and scientific significance, representing a valuable component of humanity's cultural heritage. Despite its cultural value, bronze is susceptible to corrosion and damage caused by environmental factors. This paper prepared an environmentally friendly poly(vinyl alcohol)/ poly(ethylene glycol) diacrylate (PVA/PEGDA) microgel loaded with L-cysteine (Cys), which effectively protects fragile bronze artifacts. In this study, the color and microstructure of the bronze coatings were characterized using a camera, colorimeter and scanning electron microscope. The results showed that the PVA/PEGDA microgels loaded with Cys (PVA/PEGDA + Cys microgels coating) not only did not change the color and appearance of the bronze, but also adhered and bonded well to the bronze surface. Confocal microscopy confirmed the soft and self-healing properties of the PVA/PEGDA + Cys microgels coating. Electrochemical testing and analysis showed that the PVA/PEGDA + Cys microgels coating exhibited excellent corrosion inhibition performance, with a corrosion inhibition efficiency of as high as 95.66%. The compressive test shows that the PVA/PEGDA + Cys microgels coating has certain reinforcement properties for bronze. The complete removal of PVA/PEGDA + Cys microgels coating can be achieved by spraying ethanol solution, indicating the enormous potential of microgels coating in protecting corroded bronze artifacts in the short term.

关键词： Microgel coating L-cysteine Corrosion inhibition Bronze preservation

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：