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Celecoxib attenuates hepatocellular proliferative capacity during hepatocarcinogenesis by modulating a PTEN/NF-κB/PRL-3 pathway

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RSC ADVANCES 2019年第36期9卷 20624-20632页

作者： Zhang, Cong Zhou, Junxuan Hu, Junjie Lei, Sheng Yuan, Ming Chen, Liang Wang, Guihong Qiu, Zhenpeng Hubei Univ Chinese Med Coll Pharm 1 West Huangjiahu Rd Wuhan Hubei Peoples R China Hubei Univ Chinese Med Key Lab Chinese Med Resource & Compound Prescript Minist Educ Wuhan Hubei Peoples R China Hubei Univ Chinese Med Key Lab Resources & Chem Chinese Med Wuhan Hubei Peoples R China

Although the efficacy of celecoxib on various cancer cell behaviors, including aberrant proliferation, in cultured hepatocellular carcinoma (HCC) cells has been demonstrated, whether celecoxib regulates cell proliferation by targeting PRL-3-associated signaling transduction during hepatocarcinogenesis in vivo has been incompletely studied. Here, we investigate the anti-proliferative efficacy of celecoxib in a rapid HCC mouse model established by hydrodynamic transfection of activated AKT and c-Met proto-oncogenes. The results show that celecoxib is effective at delaying the malignant transformation of hepatocytes by reducing the protein expression of Ki67, Cyclin D1 and c-Myc in the AKT/c-Met HCC-bearing mice. Mechanistically, celecoxib increases the protein expression of PTEN and suppresses the protein expression of NF-kappa B and PRL-3 in the liver of the HCC mice. Using PTEN-silenced and LPS-stimulated approaches in vitro, a mechanism by which celecoxib regulates a PTEN/NF-kappa B/PRL-3 pathway in HCC cells was illuminated. Altogether, our study demonstrates that celecoxib attenuates the hepatocellular proliferative capacity during hepatocarcinogenesis, which is probably attributable to its regulation of the PTEN/NF-kappa B/PRL-3 pathway.

关键词： PTP4A3 gene Protein Expression Hepatocarcinogenesis malignant transformation Celebrex human-centered computing

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Evaluating Existing Strategies to Limit Video Game Playing Time

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IEEE COMPUTER GRAPHICS AND APPLICATIONS 2016年第2期36卷 47-57页

作者： Davies, Bryan Blake, Edwin Univ Cape Town ZA-7700 Rondebosch South Africa Univ Cape Town Comp Sci ZA-7700 Rondebosch South Africa

Public concern surrounding the effects video games have on players has inspired a large body of research, and policy makers in China and South Korea have even mandated systems that limit the amount of time players spend in game. The authors present an experiment that evaluates the effectiveness of such policies. They show that forcibly removing players from the game environment causes distress, potentially removing some of the benefits that games provide and producing a desire for more game time. They also show that, with an understanding of player psychology, playtime can be manipulated without significantly changing the user experience or negating the positive effects of video games.

关键词： computer graphics Entertainment industry Games human factors human-centered computing Psychology software psychology Video games Visual computing

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Principles for Interaction Design, Part 3: Spanning the Creativity Gap

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IEEE INTELLIGENT SYSTEMS 2015年第6期30卷 82-91页

作者： Bennett, Kevin B. Hoffman, Robert R. Wright State Univ Psychol Human Factors Ind Org PhD program Dayton OH 45435 USA Florida Inst Human & Machine Cognit Ocala FL USA

The various responsibilities in intelligent systems design--responsibilities to acquire certain knowledge and skills--suggest strongly that effective interaction design is inherently interdisciplinary. As a consequence, gaps in knowledge acquisition and creativity on the part of design teams are bound to emerge as long as responsibilities are abrogated because they are tied to roles (such as cognitive systems engineers versus systems engineers). Communication, collaboration, and knowledge sharing are essential components of success, and a language that cuts across discipline-specific jargon is likely to make the development effort much more effective. This essay describes similarities between two related approaches to interaction design that resonate with each other and share principles: ecological interface design and human-centered computing. These similarities are emphasized by noting similarities between two different interfaces for computer network defense that were independently developed from each approach.

关键词： human computer interaction knowledge acquisition user interfaces collaboration sharing communication sharing computer network defense creativity gap ecological interface design human-centered computing intelligent systems design interaction design knowledge acquisition knowledge sharing skills acquisition Analytical models Biological system modeling Cognition Software engineering ecological design intelligent systems interaction design interface design network defense

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Visual Cue Based Corrective Feedback for Motor Skill Training in Mixed Reality: A Survey

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IEEE TRANSACTIONS ON VISUALIZATION AND COMPUTER GRAPHICS 2024年第7期30卷 3121-3134页

作者： Diller, Florian Scheuermann, Gerik Wiebel, Alexander Hsch Worms Univ Appl Sci UX Vis Grp D-67549 Worms Germany Univ Leipzig BSV Grp D-04109 Leipzig Germany

When learning a motor skill it is helpful to get corrective feedback from an instructor. This will support the learner to execute the movement correctly. With modern technology, it is possible to provide this feedback via mixed reality. In most cases, this involves visual cues to help the user understand the corrective feedback. We analyzed recent research approaches utilizing visual cues for feedback in mixed reality. The scope of this article is visual feedback for motor skill learning, which involves physical therapy, exercise, rehabilitation etc. While some of the surveyed literature discusses therapeutic effects of the training, this article focuses on visualization techniques. We categorized the literature from a visualization standpoint, including visual cues, technology and characteristics of the feedback. This provided insights into how visual feedback in mixed reality is applied in the literature and how different aspects of the feedback are related. The insights obtained can help to better adjust future feedback systems to the target group and their needs. This article also provides a deeper understanding of the characteristics of the visual cues in general and promotes future, more detailed research on this topic.

关键词： Visualization Mixed reality Augmented reality Training Task analysis Sports Feedback loop human-centered computing visualization visualization techniques and methodologies interaction techniques virtual and augmented reality

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Driving Towards the Future: Exploring human-centered Design and Experiment of Glazing Projection Display Systems for Autonomous Vehicles

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INTERNATIONAL JOURNAL OF human-COMPUTER INTERACTION 2024年第15期40卷 4087-4102页

作者： Zhu, Yancong Geng, Yunke Huang, Ruonan Zhang, Xiaonan Wang, Lu Liu, Wei Beijing Normal Univ Beijing Key Lab Appl Expt Psychol Fac Psychol Natl Demonstrat Ctr Expt Psychol Educ Beijing Peoples R China Zhejiang Jikrypton Intelligent Technol Co Ltd Dept Z Prod Line User Experience Beijing Peoples R China St Gobain Res Sekurit R&D Shanghai Peoples R China

The automotive glazing projection display pertains to projecting information onto unique glazing materials in a car through projection equipment, a new direction of human-Computer Interaction (HCI) in the intelligent cockpit. The core issue in glazing projection is determining what information should be projected onto the car's glazing and the area to which it should be projected. To address this issue, we conducted a focus group comprising 12 people. We distributed 1082 questionnaires to investigate future autonomous driving contexts, user information demands based on glazing projection, and regional preferences for displaying such information. We selected five contexts and nine high-rated features to design a driver-specific display interface. We conducted eye-movement experiments to investigate the effect of the projection interface on the driver's gaze behaviors under different display areas and subsequently modified the display areas. This study confirms the feasibility of the glazing projection display and provides theoretical support for HCI development in the intelligent cockpit.

关键词： human-centered computing human computer interaction (HCI) HCI theory concepts and models Glazing projection display intelligent cockpit information demand driving context display area eye-movement experiment user experience

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human-Agent Collaboration for Time-Stressed Multicontext Decision Making

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IEEE TRANSACTIONS ON SYSTEMS MAN AND CYBERNETICS PART A-SYSTEMS AND humanS 2010年第2期40卷 306-320页

作者： Fan, Xiaocong McNeese, Michael Sun, Bingjun Hanratty, Timothy Allender, Laurel Yen, John Penn State Univ University Pk PA 16802 USA Telenav Inc Sunnyvale CA 94086 USA USA Res Lab Aberdeen Proving Ground MD 21005 USA

Multicontext team decision making under time stress is an extremely challenging issue faced by various real-world application domains. In this paper, we employ an experience-based cognitive agent architecture (called R-CAST) to address the informational challenges associated with military command and control (C-2) decision-making teams, the performance of which can be significantly affected by dynamic context switching and tasking complexities. Using context switching frequency and task complexity as two factors, we conducted an experiment to evaluate whether the use of R-CAST agents as teammates and decision aids can benefit C-2 decision-making teams. Members from a U. S. Army Reserve Officer Training Corps organization were randomly recruited as human participants. They were grouped into ten human-human teams, each composed of two participants, and ten human-agent teams, each composed of one participant and two R-CAST agents, as teammates and decision aids. The statistical inference of experimental results indicates that R-CAST agents can significantly improve the performance of C-2 teams in multi-context decision making under varying time-stressed situations.

关键词： Cognitive agents context switching human-centered computing naturalistic decision making

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Transparent decision support using statistical reasoning and fuzzy inference

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IEEE TRANSACTIONS ON KNOWLEDGE AND DATA ENGINEERING 2006年第8期18卷 1125-1137页

作者： Hamilton-Wright, Andrew Stashuk, Daniel W. Univ Guelph Dept Comp & Informat Sci Guelph ON N1G 2W1 Canada Univ Waterloo Dept Syst Design Engn Waterloo ON N2L 3G1 Canada

A framework for the development of a decision support system (DSS) that exhibits uncommonly transparent rule-based inference logic is introduced. A DSS is constructed by marrying a statistically based fuzzy inference system (FIS) with a user interface, allowing drill-down exploration of the underlying statistical support, providing transparent access to both the rule-based inference as well as the underlying statistical basis for the rules. The FIS is constructed through a "Pattern Discovery" based analysis of training data. Such an analysis yields a rule base characterized by simple explanations for any rule or data division in the extracted knowledge base. The reliability of a fuzzy inference is well predicted by a confidence measure that determines the probability of a correct suggestion by examination of values produced within the inference calculation. The combination of these components provides a means of constructing decision support systems that exhibit a degree of transparency beyond that commonly observed in supervised-learning-based methods. A prototype DSS is analyzed in terms of its workflow and usability, outlining the insight derived through use of the framework. This is demonstrated by considering a simple synthetic data example and a more interesting real-world example application with the goal of characterizing patients with respect to risk of heart disease. Specific input data samples and corresponding output suggestions created by the system are presented and discussed. The means by which the suggestions made by the system may be used in a larger decision context is evaluated.

关键词： fuzzy rule-based classification systems fuzzy inference systems pattern discovery decision support software engineering human-centered computing

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A curcumin derivative, WZ35, suppresses hepatocellular cancer cell growth via downregulating YAP-mediated autophagy

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FOOD & FUNCTION 2019年第6期10卷 3748-3757页

作者： Wang, Lihua Zhu, Zheng Han, Lei Zhao, Liqian Weng, Jialei Yang, Hongbao Wu, Shijia Chen, Kaiyuan Wu, Liang Chen, Tongke Wenzhou Med Univ Hosp Eye Sch Ophthalmol & Optometry Wenzhou 325000 Zhejiang Peoples R China State Key Lab Ophthalmol Optometry & Visual Sci Wenzhou 325000 Zhejiang Peoples R China Wenzhou Med Univ Lab Anim Ctr Wenzhou 325000 Zhejiang Peoples R China Wenzhou Med Univ Affiliated Hosp 1 Key Lab Diag & Treatment Severe Hepatopancreat Di Wenzhou 325000 Peoples R China Wenzhou Med Univ Affiliated Hosp 1 Dept Pathol Wenzhou 325000 Zhejiang Peoples R China

Hepatocellular carcinoma (HCC) is a common cancer type throughout the world. Due to the high occurrence rate and mortality, liver cancer is one of the leading causes of cancer associated death. With the development of monoclonal antibodies and immunotherapy, the mortality of HCC cancer patients has reduced. However, the recurrence and outcomes of patients remain poor. Therefore, there is an urgent need to develop more effective drugs for HCC therapy. WZ35, a novel curcumin derivative, exhibits potential anti-tumor activity in gastric cancer cells by regulating ROS dependent JNK activation and ER stress. Here, we evaluated the tumor suppressive activity of WZ35 in hepatocellular carcinoma in vitro and in vivo. CCK-8 was used to detect cell viability with or without curcumin or WZ35;cell apoptosis was determined by flow cytometry analysis;GFP-LC3 plasmids were used to investigate the level of autophagy-associated LC3;siRNA transfection was applied to silence endogenous YAP;and western blot was performed to detect the alteration of indicated molecules. Bioinformatics analysis and IHC assay were applied to evaluate the YAP level in normal and liver cancer tissues. In this study, we found that WZ35 effectively suppresses HCC cancer cell growth in vitro and in vivo by promoting cell apoptosis. Importantly, downregulation of YAP contributes to WZ35 caused autophagy inhibition which is different from that of curcumin. We also confirmed that WZ35 is more effective at suppressing HCC cell growth in vivo. Finally, we confirmed that YAP was significantly overexpressed in liver cancer tissues. Collectively, these data indicate that WZ35 could be considered as a promising compound for HCC therapy.

关键词： Cancer of Liver occurrence rate Curcumin Hepatocellular Cancer YY1AP1 gene Cancer Cell Growth cancer tissue Autophagy human-centered computing

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UACAP: A Unified Auxiliary Channel Authentication Protocol

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IEEE TRANSACTIONS ON MOBILE computing 2013年第4期12卷 710-721页

作者： Mayrhofer, Rene Fuss, Juergen Ion, Iulia Univ Appl Sci Upper Austria A-4232 Hagenberg Im Austria Univ Appl Sci Upper Austria Dept Secure Informat Syst A-4232 Hagenberg Im Austria Google Inc Mountain View CA 94043 USA

Authenticating spontaneous interactions between devices and users is challenging for several reasons: the wireless (and therefore invisible) nature of device communication, the heterogeneous nature of devices, and lack of appropriate user interfaces in mobile devices, and the requirement for unobtrusive user interaction. The most promising approach that has been proposed in literature involves the exploitation of the so-called auxiliary channels for authentication to bridge the gap between usability and security. This concept has spawned the independent development of various authentication methods and research prototypes, that, unfortunately, remain hard to compare and interchange and are rarely available to potential application developers. We present a novel, unified cryptographic authentication protocol framework (UACAP) to unify these approaches on using auxiliary channels and analyze its security properties. This protocol and a selection of auxiliary channels aimed at authentication of mobile devices has been implemented and released in an open-source ubiquitous authentication toolkit (OpenUAT). We also present an initial user study evaluating four of these channels.

关键词： Network architecture and design/wireless communication security and protection/authentication information systems applications/miscellaneous algorithm/protocol design and analysis ubiquitous computing mobile environments human-centered computing mobile applications

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Technology futures: Towards understanding how to design awe-inspiring futures

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INTERNATIONAL JOURNAL OF human-COMPUTER STUDIES 2023年 170卷

作者： Mueller, Florian Petersen, Marianne Graves Li, Zhuying Monash Univ Dept Human Ctr Comp Exert Games Lab Melbourne Australia Univ Aarhus Aarhus Denmark Southeast Univ SEU Sch Comp Sci & Engn Nanjing Jiangsu Peoples R China

Future technology can inspire "awe", the deep feeling of astonishment that can include fear, resulting in often "awe-some" but sometimes also "aw(e)-ful" experiences. We are interested in exploring the potential of future technology beyond any immediate obvious application domain and hence draw from prior work and our own design research (through three case studies) to propose the "technology futures" approach that uses awe as a driver for exploring future technology's potential. Guided by awe's need for sense-making, the approach suggests that experiencing future technology in alternative, playful ways and through a first-hand approach can allow for shared reflections, leading to a more informed view of future technology's potential. Our "technology futures" approach has three stages (envisioning, concretizing, and futuring) towards awe-inspiring futures. We illustrate these stages using three case studies: jogging with a quadcopter, ingestible play, and shape-changing furniture. Furthermore, we use these case studies to articulate a set of strategies to help those who want to engage with the technology futures approach. Ultimately, with our work, we aim to enhance our understanding of how HCI can engage with designing awe-inspiring futures to support reflections around possible futures.

关键词： human-centered computing Interaction design Design research Future technologies

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