Hepatocellular carcinoma (HCC) represents a challenging malignancy of worldwide importance: It is the sixth most common cancer and the third most common cause of cancer-related death globally [1]. In recent years, the...
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Hepatocellular carcinoma (HCC) represents a challenging malignancy of worldwide importance: It is the sixth most common cancer and the third most common cause of cancer-related death globally [1]. In recent years, there have been renewed interests and active research efforts in HCC for several reasons: (i) The latest epidemiology trend has shown that the incidence rates for HCC in the United States and western Europe have been rising [2, 3].
This essay focuses on the forces and constraints of procurement versus the goals of human centering, especially the creation of intelligent technologies that are usable, useful, and understandable. The procurement pro...
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This essay focuses on the forces and constraints of procurement versus the goals of human centering, especially the creation of intelligent technologies that are usable, useful, and understandable. The procurement process tends to de-emphasize these goals and focus on adherence to rules and regulations. As a result, software system development processes are misaligned with the challenges faced by development teams. This misalignment between \"actual world problems\" and normative documentation repeatedly results in failed systems. A real-life practitioner\'s account illustrates this point by describing how a group of individuals, acting on their own initiative and at their own risk, short-circuited the rules and constraints of the procurement process to turn a procurement process failure into a success.
A letter to the editor is presented in response to the article on management of hepatocellular carcinoma (HCC) by R. Cabrera and colleagues in the 2010 issue.
A letter to the editor is presented in response to the article on management of hepatocellular carcinoma (HCC) by R. Cabrera and colleagues in the 2010 issue.
This paper addresses a context-awareness handoff planning mechanism in heterogeneous wireless networks for seamless ubiquitous access. The proliferation of digital devices with communication capability heralds the era...
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ISBN:
(纸本)9783642163548
This paper addresses a context-awareness handoff planning mechanism in heterogeneous wireless networks for seamless ubiquitous access. The proliferation of digital devices with communication capability heralds the era of ubiquitous computing, as predicted by Mark Weiser. Mobile devices with multi-mode interfaces can access heterogeneous wireless networks, such as wireless local area network (WLAN), worldwide interoperability for microwave access (WiMAX) network and third generation (3G) network. In heterogeneous wireless networks, different network provides different network capability, transmission range, data rate, access cost, security policy and quality of service. Therefore, a ubiquitous access aims to provide users intelligent human-centric context-aware handoff mechanism in heterogeneous wireless networks at anytime anywhere is gradually become an important issue. Optimal handoff planning in heterogeneous wireless networks considers the needs of users, accessing service and the surrounding context. However, most of existing handoff mechanisms only considered few contexts that lead to not able to select the most suitable network for individual user. In this paper, we propose a human-centric context-aware solution to access most appropriate network that satisfies individual user's requirement, fulfills seamless data transmission and reduces handoff delay. We develop two integrated approaches for context-awareness handoff planning mechanisms, namely MADM approach and GA approach. The MADM approach contains initial process and decision process. Initial process weights context by Analytic Hierarchy Process (AHP) method while decision process selects the most appropriate network by Technique for Order Preference by Similarity to Ideal Solution (TOPSIS). The GA approach uses Genetic Algorithm to minimize handoff under given QoS constraints. Performance of proposed mechanisms is evaluated under different services with different QoS considerations. Our simulation resu
This break-scheduling system, which is included in Operating Hours Assistant 3.6, helps professional planners create high-quality shift plans, while satisfying labor rules and staffing requirements.
This break-scheduling system, which is included in Operating Hours Assistant 3.6, helps professional planners create high-quality shift plans, while satisfying labor rules and staffing requirements.
Sorafenib, a multikinase inhibitor, is now the standard treatment of advanced hepatocellular carcinoma (HCC) [1, 2]. Several clinical studies assessing sorafenib in advanced HCC have shown that it is generally a well-...
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Sorafenib, a multikinase inhibitor, is now the standard treatment of advanced hepatocellular carcinoma (HCC) [1, 2]. Several clinical studies assessing sorafenib in advanced HCC have shown that it is generally a well-tolerated drug. The main side-effects are gastrointestinal disorders like diarrhoea and hand-foot syndrome [1-3]. No significant increase of hemorrhagic events was observed in cirrhotic patients with advanced HCC treated with sorafenib, even in patients with Child-Pugh B cirrhosis [4]. However, a recent meta-analysis showed a significant two-times increased risk of bleeding events with sorafenib and sunitinib [5]. Most events were of low grade, but some were reported as fatal, mainly in pulmonary neoplasms. In patients with advanced HCC treated with sorafenib, only one bleeding-related death due to intracranial haemorrhage was reported [3,5].
Sorafenib (Nexavar?; Bayer, Leverkusen, Germany) is a multikinase inhibitor that shows efficacy in a variety of tumours and has been recently approved for the treatment of multifocal and surgically unre-sectable hepat...
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Sorafenib (Nexavar?; Bayer, Leverkusen, Germany) is a multikinase inhibitor that shows efficacy in a variety of tumours and has been recently approved for the treatment of multifocal and surgically unre-sectable hepatocellular carcinoma (HCC). Sorafenib blocks the growth of tumour cells by inhibition of several pathways that both interfere with angiogen-esis and induce apoptosis of HCC cells. Both in HCC cell lines and in murine models, sorafenib has been shown to antagonize the angiogenic effect of vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) on their receptors VEGFR2 and PDGFR respectively.
The hands are highly suited to interact with large public displays. It is, however, not apparent which gestures come naturally for easy and robust use of the interface. We first explored how uninstructed users gesture...
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ISBN:
(纸本)9783642125522
The hands are highly suited to interact with large public displays. It is, however, not apparent which gestures come naturally for easy and robust use of the interface. We first explored how uninstructed users gesture when asked to perform basic tasks. Our subjects gestured with great similarity and readily produced gestures they had seen before;not necessarily in a human-computer interface. In a second investigation these and other gestures were rated by a hundred subjects. A gesture set for explicit command-giving to large displays emerged from these ratings. It is notable that for a selection task, tapping the index finger in mid-air, like with a traditional mouse, scored highest by far. It seems that the mouse has become a metaphor in everyday life.
Understanding the human-computer interface factors that influence users' behavior with virtual humans will enable more effective human-virtual human encounters. This paper presents experimental evidence that using...
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ISBN:
(纸本)9783642158919
Understanding the human-computer interface factors that influence users' behavior with virtual humans will enable more effective human-virtual human encounters. This paper presents experimental evidence that using a mixed reality display configuration can result in significantly different behavior with a virtual human along important social dimensions. The social dimensions we focused on were engagement, empathy, pleasantness, and naturalness. To understand how these social constructs could be influenced by display configuration, we video recorded the verbal and non-verbal response behavior to stimuli from a virtual human under two fundamentally different display configurations. One configuration presented the virtual human at life-size and was embedded into the environment, and the other presented the virtual human using a typical desktop configuration. We took multiple independent measures of participant response behavior using a video coding instrument. Analysis of these measures demonstrates that display configuration was a statistically significant multivariate factor along all dimensions.
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