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The Practitioner's cycles, Part 1: Actual World Problems

IEEE INTELLIGENT SYSTEMS 2010年第2期25卷 4-9页

作者： Deal, Steven V. Hoffman, Robert R. Deal S.V Hoffman R.R

This essay focuses on the forces and constraints of procurement versus the goals of human centering, especially the creation of intelligent technologies that are usable, useful, and understandable. The procurement process tends to de-emphasize these goals and focus on adherence to rules and regulations. As a result, software system development processes are misaligned with the challenges faced by development teams. This misalignment between \"actual world problems\" and normative documentation repeatedly results in failed systems. A real-life practitioner\'s account illustrates this point by describing how a group of individuals, acting on their own initiative and at their own risk, short-circuited the rules and constraints of the procurement process to turn a procurement process failure into a success.

关键词： actual world problem artificial intelligence human-centered computing practitioner procurement software system development process

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Antiangiogenic therapy combined with TACE - more beneficial therapeutic effect in HCC

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ALIMENTARY PHARMACOLOGY & THERAPEUTICS 2010年第10期31卷 1153-1154页

作者： Wang, Z. Li, z. Xi An Jiao Tong Univ Sch Med Affiliated Hosp 2 Dept Gen Surg Xian Peoples R China

A letter to the editor is presented in response to the article on management of hepatocellular carcinoma (HCC) by R. Cabrera and colleagues in the 2010 issue.

关键词： antiangiogenesis therapy Molecular Targeted Therapy human-centered computing interdisciplinary approach

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Context-Awareness Handoff Planning in Heterogeneous Wireless Networks

Context-Awareness Handoff Planning in Heterogeneous Wireless...

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7th International Conference on Autonomic and Trusted computing

作者： Huang, Hsiao-Yun Wang, Chiung-Ying Hwang, Ren-Hung Natl Chung Cheng Univ Dept Comp Sci & Informat Engn Taipei Taiwan Transworld Univ Dept Informat & Management Taipei Taiwan

ISBN: (纸本)9783642163548

This paper addresses a context-awareness handoff planning mechanism in heterogeneous wireless networks for seamless ubiquitous access. The proliferation of digital devices with communication capability heralds the era of ubiquitous computing, as predicted by Mark Weiser. Mobile devices with multi-mode interfaces can access heterogeneous wireless networks, such as wireless local area network (WLAN), worldwide interoperability for microwave access (WiMAX) network and third generation (3G) network. In heterogeneous wireless networks, different network provides different network capability, transmission range, data rate, access cost, security policy and quality of service. Therefore, a ubiquitous access aims to provide users intelligent human-centric context-aware handoff mechanism in heterogeneous wireless networks at anytime anywhere is gradually become an important issue. Optimal handoff planning in heterogeneous wireless networks considers the needs of users, accessing service and the surrounding context. However, most of existing handoff mechanisms only considered few contexts that lead to not able to select the most suitable network for individual user. In this paper, we propose a human-centric context-aware solution to access most appropriate network that satisfies individual user's requirement, fulfills seamless data transmission and reduces handoff delay. We develop two integrated approaches for context-awareness handoff planning mechanisms, namely MADM approach and GA approach. The MADM approach contains initial process and decision process. Initial process weights context by Analytic Hierarchy Process (AHP) method while decision process selects the most appropriate network by Technique for Order Preference by Similarity to Ideal Solution (TOPSIS). The GA approach uses Genetic Algorithm to minimize handoff under given QoS constraints. Performance of proposed mechanisms is evaluated under different services with different QoS considerations. Our simulation resu

关键词： Ubiquitous computing human-centered computing context-awareness MADM genetic algorithm handoff heterogeneous wireless networks

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An AI-Based Break-Scheduling System for Supervisory Personnel

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IEEE INTELLIGENT SYSTEMS 2010年第2期25卷 60-73页

作者： Beer, Andreas Gaertner, Johannes Musliu, Nysret Schafhauser, Werner Slany, Wolfgang Graz Univ Technol Software Technol Grp Dept Software Technol A-8010 Graz Austria Vienna Univ Technol Inst Informat Syst Vienna Austria

This break-scheduling system, which is included in Operating Hours Assistant 3.6, helps professional planners create high-quality shift plans, while satisfying labor rules and staffing requirements.

关键词： Operating Hours Assistant 3.6 Ximes artificial intelligence break-scheduling system constraint satisfaction human-centered computing metaheuristic optimization minimum-conflicts heuristic supervisory personnel constraint satisfaction problems scheduling system Artificial Intelligence oversight Personnel human-centered computing

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Fatal hemobilia in advanced hepatocellular carcinoma invading biliary tract after treatment with sorafenib and biliary stenting

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ANNALS OF ONCOLOGY 2010年第6期21卷 1381-U264页

作者： Verset, G. Marechal, R. Bali, M. A. Deviere, J. Van Laethem, J. L. Erasme Univ Hosp Gastrointestinal Oncol Unit B-1070 Brussels Belgium Erasme Univ Hosp Radiol Unit B-1070 Brussels Belgium

Sorafenib, a multikinase inhibitor, is now the standard treatment of advanced hepatocellular carcinoma (HCC) [1, 2]. Several clinical studies assessing sorafenib in advanced HCC have shown that it is generally a well-tolerated drug. The main side-effects are gastrointestinal disorders like diarrhoea and hand-foot syndrome [1-3]. No significant increase of hemorrhagic events was observed in cirrhotic patients with advanced HCC treated with sorafenib, even in patients with Child-Pugh B cirrhosis [4]. However, a recent meta-analysis showed a significant two-times increased risk of bleeding events with sorafenib and sunitinib [5]. Most events were of low grade, but some were reported as fatal, mainly in pulmonary neoplasms. In patients with advanced HCC treated with sorafenib, only one bleeding-related death due to intracranial haemorrhage was reported [3,5].

关键词： Biliary Tract Hemorrhage sorafenib Intracranial Hemorrhages Lung Neoplasms Hepatocellular Cancer Biliary Stent Implantation Biliary Tract human-centered computing

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Sorafenib as a feasible therapeutic option in haemophiliacs with hepatocellular carcinoma

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HAEMOPHILIA 2010年第1期16卷 185-187页

作者： Lapecorella, M. Napolitano, M. Tudini, M. Bruera, G. Lucchesi, A. Giordano, A. V. Mariani, G. Ricevuto, E. Univ Aquila Osped San Salvatore Ctr Emofil & Trombosi Unita Operat Med Interna 2 Ematol I-67100 Laquila Italy Univ Aquila Dept Expt Med I-67100 Laquila Italy Univ Aquila Dept Radiol I-67100 Laquila Italy

Sorafenib (Nexavar?; Bayer, Leverkusen, Germany) is a multikinase inhibitor that shows efficacy in a variety of tumours and has been recently approved for the treatment of multifocal and surgically unre-sectable hepatocellular carcinoma (HCC). Sorafenib blocks the growth of tumour cells by inhibition of several pathways that both interfere with angiogen-esis and induce apoptosis of HCC cells. Both in HCC cell lines and in murine models, sorafenib has been shown to antagonize the angiogenic effect of vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) on their receptors VEGFR2 and PDGFR respectively.

关键词： Hepatocellular Cancer Vascular Endothelial Growth Factor A Platelet-derived growth factors sorafenib Neoplastic Cell Growth Factors human-centered computing Cell Line

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Gestures for Large Display Control

Gestures for Large Display Control

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8th International Gesture Workshop

作者： Fikkert, Wim van der Vet, Paul van der Veer, Gerrit Nijholt, Anton Univ Twente NL-7500 AE Enschede Netherlands

ISBN: (纸本)9783642125522

The hands are highly suited to interact with large public displays. It is, however, not apparent which gestures come naturally for easy and robust use of the interface. We first explored how uninstructed users gesture when asked to perform basic tasks. Our subjects gestured with great similarity and readily produced gestures they had seen before;not necessarily in a human-computer interface. In a second investigation these and other gestures were rated by a hundred subjects. A gesture set for explicit command-giving to large displays emerged from these ratings. It is notable that for a selection task, tapping the index finger in mid-air, like with a traditional mouse, scored highest by far. It seems that the mouse has become a metaphor in everyday life.

关键词： human-centered computing user interfaces input devices and strategies intuitive hand gestures large display interaction

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The Impact of a Mixed Reality Display Configuration on User Behavior with a Virtual human

The Impact of a Mixed Reality Display Configuration on User ...

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10th International Conference on Intelligent Virtual Agents (IVA)

作者： Johnsen, Kyle Beck, Diane Lok, Benjamin Univ Georgia Fac Engn Athens GA 30602 USA Univ Florida Coll Pharm Gainesville FL USA Univ Florida Gainesville FL 32611 USA

ISBN: (纸本)9783642158919

Understanding the human-computer interface factors that influence users' behavior with virtual humans will enable more effective human-virtual human encounters. This paper presents experimental evidence that using a mixed reality display configuration can result in significantly different behavior with a virtual human along important social dimensions. The social dimensions we focused on were engagement, empathy, pleasantness, and naturalness. To understand how these social constructs could be influenced by display configuration, we video recorded the verbal and non-verbal response behavior to stimuli from a virtual human under two fundamentally different display configurations. One configuration presented the virtual human at life-size and was embedded into the environment, and the other presented the virtual human using a typical desktop configuration. We took multiple independent measures of participant response behavior using a video coding instrument. Analysis of these measures demonstrates that display configuration was a statistically significant multivariate factor along all dimensions.

关键词： virtual humans embodied agents human-centered computing medicine displays

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Bevacizumab-induced Hypovascular Hepatocellular Carcinoma Treated by Transarterial Chemoembolization in a Patient with Metastatic Colon Cancer

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JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY 2010年第3期21卷 412-414页

作者： Iwazawa, Jin Ohue, Shoichi Hashimoto, Naoko Yasumasa, Keigo Abe, Hisashi Mitani, Takashi Nissay Hosp Dept Radiol Nishi Ku Osaka Japan Nissay Hosp Dept Surg Nishi Ku Osaka Japan Komatsu Hosp Dept Radiol Neyagawa Osaka Japan

The angiogenesis of hepatocellular carcinoma (HCC) is mediated by growth factors, particularly vascular endo-thelial growth factor. Serum vascular endothelial growth factor levels in patients with HCC correlate with malignant behavior and clinical outcomes. Early clinical studies have shown that the anti-vascular endothelial growth factor antibody bevacizumab might be able to deregulate angiogenesis in HCC. Angiogenesis inhibited by bevacizumab appears as a significant reduction in tumor enhancement on computed tomography (CT) per-fusion and dynamic contrast-enhanced magnetic resonance images. Here, we treated a patient with his-topathologically proven HCC and metastatic colon cancer by transarterial chemoembolization before and after chemotherapy with bevacizumab.

关键词： Vascular Endothelial Growth Factor A X-Ray Computed Tomography Bevacizumab Angiogenesis stage IV colon cancer Growth Factors human-centered computing

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SIREN: Mediated Informal Communication for Serendipity

SIREN: Mediated Informal Communication for Serendipity

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4th International Conference on Mobile Ubiquitous computing, Systems, Services and Technologies (UBICOMM)

作者： Batalas, Nikolaos Bruikman, Hester Turzynska, Dominika Vakili, Vanesa Voynarovskaya, Natalia Markopoulos, Panos Eindhoven Univ Technol Dept Ind Design Dolech 2 NL-5612 AZ Eindhoven Netherlands

ISBN: (纸本)9781612081007

The process of education and innovation often involves individuals, whose expertise lies in diverse fields. Informal communication amongst them can prove to be invaluable towards their collaboration, but rarely does it extend beyond one's already established social circle. This paper proposes SIREN, a system, which makes use of sensor nodes to detect encounters between colleagues in their workplace, as they undertake their daily tasks and spreads information virally from one to another. The aim is to introduce a channel of informal communication that is not disruptive to their routine. We developed a system prototype and conducted a field test to detemine whether the premise of encounter-based information sharing offers any added value over information sharing without discrimenation, amongst users in the same work setting. The results indicate that SIREN can help break down barriers and promote subsequent direct communication between users.

关键词： human-centered computing wireless sensor networks serendipity

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