检索结果-内蒙古大学图书馆

Detecting human Behavior Models From Multimodal Observation in a Smart Home

IEEE TRANSACTIONS ON AUTOMATION SCIENCE AND ENGINEERING 2009年第4期6卷 588-597页

作者： Brdiczka, Oliver Langet, Matthieu Maisonnasse, Jerome Crowley, James L. Xerox Corp Palo Alto Res Ctr Comp Sci Lab Palo Alto CA 94304 USA INRIA Rhone Alpes Lab LIG Project PRIMA Rhone Alpes France

This paper addresses learning and recognition of human behavior models from multimodal observation in a smart home environment. The proposed approach is part of a framework for acquiring a high-level contextual model for human behavior in an augmented environment. A 3-D video tracking system creates and tracks entities (persons) in the scene. Further, a speech activity detector analyzes audio streams coming from head set microphones and determines for each entity, whether the entity speaks or not. An ambient sound detector detects noises in the environment. An individual role detector derives basic activity like "walking" or "interacting with table" from the extracted entity properties of the 3-D tracker. From the derived multimodal observations, different situations like "aperitif" or "presentation" are learned and detected using statistical models (HMMs). The objective of the proposed general framework is two-fold: the automatic offline analysis of human behavior recordings and the online detection of learned human behavior models. To evaluate the proposed approach, several multimodal recordings showing different situations have been conducted. The obtained results, in particular for offline analysis, are very good, showing that multimodality as well as multiperson observation generation are beneficial for situation recognition. Note to Practitioners-This paper was motivated by the problem of automatically recognizing human behavior and interactions in a smart home environment. The smart home environment is equipped with cameras and microphones that permit the observation of human activity in the scene. The objective is first to visualize the perceived human activities (e. g., for videoconferencing or surveillance of elderly people), and then to provide appropriate services based on these activities. We adopt a layered approach for human activity recognition in the environment. The layered framework is motivated by the human perception of human behavior in the sce

关键词： Context-awareness human-centered computing individual role detection multimodal human behavior modeling and detection situation modeling

来源：评论

学校读者我要写书评

暂无评论

Multimodal interfaces: Challenges and perspectives

引用

JOURNAL OF AMBIENT INTELLIGENCE AND SMART ENVIRONMENTS 2009年第1期1卷 23-30页

作者： Sebe, Nicu Univ Amsterdam NL-1012 WX Amsterdam Netherlands Univ Trento Trento Italy

The development of interfaces has been a technology-driven process. However, the newly developed multimodal interfaces are using recognition-based technologies that must interpret human-speech, gesture, gaze, movement patterns, and other behavioral cues. As a result, the interface design requires a human-centered approach. In this paper we review the major approaches to multimodal human Computer Interaction, giving an overview of the user and task modeling, and of the multimodal fusion. We highlight the challenges, open issues, and the future trends in multimodal interfaces research.

关键词： Multimodal interfaces human-centered computing adaptability fusion interface design

来源：评论

学校读者我要写书评

暂无评论

human-centered computing in health information systems Part 1: Analysis and design

引用

JOURNAL OF BIOMEDICAL INFORMATICS 2005年第1期38卷 1-3页

作者： Zhang, JJ Univ Texas Hlth Sci Ctr Sch Hlth Informat Sci Houston TX USA

Available online 7 January 2005.

关键词： human-centered computing human–computer interaction Health information system Patient safety User interface

来源：评论

学校读者我要写书评

暂无评论

Aberrant DNA methylation profile of hepatocellular carcinoma and surgically resected margin

引用

CANCER SCIENCE 2009年第6期100卷 996-1004页

作者： Lou, Cheng Du, Zhi Yang, Bin Gao, YingTang Wang, YiJun Fang, ShuChang Tianjin Med Univ Cent Hosp 3 Dept Hepatobiliary Surg Tianjin 300170 Peoples R China Tianjin Key Lab Artificial Cell Tianjin 300170 Peoples R China Nankai Univ Coll Life Sci Dept Genet Tianjin 300071 Peoples R China

Field cancerization currently described the theory of tumorigenesis and, until now, has been described in almost all organ systems except in liver. For this reason, we explore the presence of field cancerization in liver and its underlying clinical implication in hepatocellular carcinoma (HCC). In our study, methylation profile of HCC and surgically resected margin (SRM) were established by methylation-specific PCR. Liver cirrhosis (LC), chronic hepatitis and normal liver were treated in the same way as the background control. The correlation analysis among the methylation profile of HCC, SRM and clinicopathological data of HCC patients was made respectively. Our results showed that methylation abnormities related to HCC, but not background disease existed in histologically negative SRM. Monoclonal and polyclonal models may coexist in field cancerization in liver. Patients with RIZ1 methylation in SRM had a shorter disease free survival. The local recurrence trend of early and later recurrence in HCC is potentially related to a second field tumor. From these results, we can suggest that field cancerization exists in liver. The study of field cancerization in liver plays an important role in hepatocarcinogenesis. Second field tumor derived form field cancerization may have important implications in HCC prognosis assessment that is worthy of further study. (Cancer Sci 2009;100: 996-1004).

关键词： Tumor margin status Liver Body Systems standard reference materials Hepatocellular Cancer liver normal Correlation analysis Aberrant DNA Methylation DNA Methylation human-centered computing Methylation

来源：评论

学校读者我要写书评

暂无评论

Once More, Into the Soup

引用

IEEE INTELLIGENT SYSTEMS 2009年第5期24卷 9-13页

作者： Stappers, Pieter Jan Hoffman, Robert R. Delft Univ Technol NL-2600 AA Delft Netherlands

In one of the earlier essays in this department, we discussed a number of acronyms all having to do with system design, and all having the form \"x-centered design.\" The purpose of that essay was to demonstrate a broad framework within which to understand human-centered computing (HCC), and also to show the various convergences and divergences of the communities of practice that have introduced their own x-centered-design designations. Among them are learner-centered design, client-centered design, designer-centered design, decision-centered design, and work-oriented design.

关键词： user centred design client-centered design decision-centered design designer-centered design learner-centered design system design work-oriented design x-centered design human-centered computing co-creation contextual design design metadesign participatory design user-centered design

来源：评论

学校读者我要写书评

暂无评论

Differential Roles of Insulin-like Growth Factor Receptor- and Insulin Receptor-mediated Signaling in the Phenotypes of Hepatocellular Carcinoma Cells

引用

NEOPLASIA 2009年第9期11卷 835-U177页

作者： Chen, Ya-Wen Boyartchuk, Victor Lewis, Brian C. Univ Massachusetts Sch Med Program Gene Funct & Express Worcester MA 01605 USA Univ Massachusetts Sch Med Program Mol Med Worcester MA 01605 USA Univ Massachusetts Sch Med Ctr Canc Worcester MA 01605 USA

Intrahepatic and extrahepatic metastases are common findings in hepatocellular carcinoma (HCC). Insulin-like growth factor 2 (IGF2) expression is frequently induced in HCC, and serum IGF2 levels correlate with the presence of extrahepatic metastases. Yet, the role of IGF-induced signaling in the dissemination of HCC remains unclear. We have previously observed elevated IGF2 levels in tumors with metastatic potential in an HCC mouse model. Here, we demonstrate that inhibition of IGF2, or its receptor IGF1R, impairs the migration and invasion activities of murine HCC cells. Furthermore, inhibition of IGF1R also impairs the ability of HCC cells to colonize the lungs after introduction into the circulation through the tail vein but does not impair subcutaneous tumor growth. Collectively, these findings suggest that IGF1R-mediated signaling plays a causative role in tumor dissemination but is not required for tumor growth per se. Although previous studies indicate that IGF ligands can signal through IGF1R/insulin receptor (IR) heterodimers, and IR-A homodimers, we demonstrate that the IR is not required for invasion and metastasis by HCC cells. Finally, we identify matrix metalloproteinase 2 as a mediator of the invasive phenotype downstream of IGF1R-induced signaling. Thus, our studies demonstrate the importance of IGF2-induced signaling in the dissemination of HCC cells.

关键词： Phenotype Hepatocellular Cancer carcinoma cell metastasis Dissemination insulin-like growth factor II Matrix Metalloproteinase 2 tumor growth Growth Factor Receptors Caudal Vein Somatomedins human-centered computing

来源：评论

学校读者我要写书评

暂无评论

Diet-induced hepatocellular carcinoma in genetically predisposed mice

引用

human MOLECULAR GENETICS 2009年第16期18卷 2975-2988页

作者： Hill-Baskin, Annie E. Markiewski, Maciej M. Buchner, David A. Shao, Haifeng DeSantis, David Hsiao, Gene Subramaniam, Shankar Berger, Nathan A. Croniger, Colleen Lambris, John D. Nadeau, Joseph H. Case Western Reserve Univ Dept Genet Sch Med Cleveland OH 44106 USA Univ Penn Dept Pathol & Lab Med Philadelphia PA 19104 USA Case Western Reserve Univ Dept Nutr Sch Med Cleveland OH 44106 USA Univ Calif San Diego Dept Bioengn San Diego CA 93093 USA Case Western Reserve Univ Sch Med Case Ctr Transdisciplinary Res Energet & Canc Cleveland OH 44106 USA Case Western Reserve Univ Sch Med Case Comprehens Canc Ctr Cleveland OH 44106 USA

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death worldwide, with similar to 70% of cases resulting from hepatitis B and C viral infections, aflatoxin exposure, chronic alcohol use or genetic liver diseases. The remaining similar to 30% of cases are associated with obesity, type 2 diabetes and related metabolic diseases, although a direct link between these pathologies and HCCs has not been established. We tested the long-term effects of high-fat and low-fat diets on males of two inbred strains of mice and discovered that C57BL/6J but not A/J males were susceptible to non-alcoholic steatohepatitis (NASH) and HCC on a high-fat but not low-fat diet. This strain-diet interaction represents an important model for genetically controlled, diet-induced HCC. Susceptible mice showed morphological characteristics of NASH (steatosis, hepatitis, fibrosis and cirrhosis), dysplasia and HCC. mRNA profiles of HCCs versus tumor-free liver showed involvement of two signaling networks, one centered on Myc and the other on NF kappa B, similar to signaling described for the two major classes of HCC in humans. miRNA profiles revealed dramatically increased expression of a cluster of miRNAs on the X chromosome without amplification of the chromosomal segment. A switch from high-fat to low-fat diet reversed these outcomes, with switched C57BL/6J males being lean rather than obese and without evidence for NASH or HCCs at the end of the study. A similar diet modification may have important implications for prevention of HCCs in humans.

关键词： MicroRNAs Inbred Strain of Mice X Chromosome Metabolic Diseases Fat-Restricted Diet High-Fat Diet Obesity Dietary Modification human-centered computing

来源：评论

学校读者我要写书评

暂无评论

Activated hepatic stellate cells promote tumorigenicity of hepatocellular carcinoma

引用

CANCER SCIENCE 2009年第4期100卷 646-653页

作者： Amann, Thomas Bataille, Frauke Spruss, Thilo Muehlbauer, Marcus Gaebele, Erwin Schoelmerich, Juergen Kiefer, Paul Bosserhoff, Anja-Katrin Hellerbrand, Claus Univ Regensburg Dept Internal Med 1 D-93053 Regensburg Germany Univ Regensburg Inst Pathol D-93053 Regensburg Germany Univ Regensburg Inst Pharm D-93053 Regensburg Germany Univ Regensburg Inst Clin Chem D-93053 Regensburg Germany

Liver cirrhosis is the main risk factor for the development of hepatocellular carcinoma (HCC). Activated hepatic stellate cells (HSC) are the effector cells of hepatic fibrosis and also infiltrate the HCC stroma where they might play a critical role in HCC progression. Here we aimed to analyze the effects of activated HSC on the proliferation and growth of HCC cell lines in vitro and in vivo. Conditioned media (CM) collected from HSC significantly induced proliferation and migration of HCC cells cultured in monolayers. In a 3-dimensional spheroid coculture system, HSC promoted HCC growth and diminished the extent of central necrosis. In accordance, in vivo simultaneous implantation of HSC and HCC cells into nude mice promoted tumor growth and invasiveness, and inhibited necrosis formation. As potential mechanism of the tumorigenic effects of HSC we identified activation of NFkappaB and extracellular-regulated kinase (ERK) in HCC cells, two signaling cascades that play a crucial role in HCC progression. In summary, our data indicate that stromal HSC promotes HCC progression and suggest the HSC-HCC interaction as an interesting tumor differentiation-independent target for therapy of this highly aggressive cancer. (Cancer Sci 2009;100: 646-653)

关键词： hepatic stellate cell Progression Primary carcinoma of the liver cells progressions Tumorigenicity Hepatocellular Cancer Hepatic Stellate Cells human-centered computing Risk Factors Ito Cells

来源：评论

学校读者我要写书评

暂无评论

Intra-hepatic arterial administration with miriplatin suspended in an oily lymphographic agent inhibits the growth of human hepatoma cells orthotopically implanted in nude rats

引用

CANCER SCIENCE 2009年第1期100卷 189-194页

作者： Hanada, Mitsuharu Baba, Akemi Tsutsumishita, Yasuyuki Noguchi, Toshihiro Yamaoka, Takashi Dainippon Sumitomo Pharma Co Ltd Pharmacol Res Labs Konohana Ku Osaka 5540022 Japan

Miriplatin is a lipophilic platinum complex which contains myristates as leaving groups and diaminocyclohexane as a carrier ligand. In order to examine in vivo the antitumor activities of miriplatin suspended in an oily lymphographic agent )Lipiodol Ultra-Fluide (R), LPD) against human hepatocellular carcinoma (HCC) after the intra-hepatic arterial administration, we have developed a novel orthotopic model of HCC in which the human hepatoma cell line Li-7 was successively implanted and maintained in the liver of nude rats. Li-7 tumors established in nude rat livers displayed a trabecular structure similar to their original morphology, and were exclusively supplied by the hepatic artery, suggesting that they exhibited in part the conditions of human HCC. Miriplatin suspended in LPD (miriplatin/LPD) administered into the hepatic artery of this model dose-dependently inhibited the growth of Li-7 tumors without markedly enhancing body weight loss and caused a significant reduction in the growth rate at a dose of 400 mu g/head compared to LPD alone. In addition, at the therapeutic dose, miriplatin/LPD as well as cisplatin suspended in LPD )400 mu g/head) was shown to be more active than zinostatin stimalamer suspended in LPD )20 mu g/head) against Li-7 tumors after a single intra-hepatic arterial administration. These results suggest miriplatin to be a suitable candidate for use in transarterial chemoembolization (Cancer Sci 2009;100: 189-194)

关键词： Nude Rats Hepatocellular Cancer LITHIUM 7 Growth rate Hepatic Artery Arteries platinum complex human-centered computing Suspended

来源：评论

学校读者我要写书评

暂无评论

Surgical Resection Versus Laparoscopic Radiofrequency Ablation in Patients With Hepatocellular Carcinoma and Child-Pugh Class A Liver Cirrhosis

引用

ANNALS OF SURGICAL ONCOLOGY 2009年第12期16卷 3289-3298页

作者： Santambrogio, Roberto Opocher, Enrico Zuin, Massimo Selmi, Carlo Bertolini, Emanuela Costa, Mara Conti, Matteo Montorsi, Marco Milanocuore SpA Osped Classificato San Giuseppe USD Chirurg Epatobiliopancreat Milan Italy Univ Milan Dipartimento Med Chirurg & Odontoiatria Azienda Osped San Paolo UO Chirurg 2 Milan Italy Univ Milan Dipartimento Med Chirurg & Odontoiatria Azienda Osped San Paolo Cattedra Med Interna Milan Italy Univ Milan IRCCS Ist Clin Humanitas Dipartimento Med Interna Milan Italy Univ Milan IRCCS Ist Clin Humanitas Cattedra Chirurg Gen Milan Italy

This study compared two homogeneous groups of patients submitted to either surgical resection (HR) or laparoscopic radiofrequency ablation (LRFA) for the treatment of hepatocellular carcinoma (HCC). When compatible with the liver functional reserve, HR remains the treatment of choice for HCC, while LRFA seems to be a promising, less invasive alternative. We thus compared HR or LRFA for short- and long-term outcomes in patients with a single HCC nodule and Child-Pugh class A liver cirrhosis. We enrolled 152 cirrhotic patients out of 372 cases consecutively evaluated for HCC. Enrolled patients with similar baseline characteristics underwent HR (n = 78) or LRFA (n = 74), in both cases with intraoperative ultrasonography, and they were then followed for similar durations (mean +/- A standard deviation, 36.2 +/- A 23.5 months for HR vs. 38.2 +/- A 28.4 for LRFA). Outcomes included short- and long-term morbidity, HCC recurrence, and overall survival. Short-term morbidity was far higher in the HR group while, during follow-up, HCC recurrence (mainly local) was more frequent in patients treated with LRFA. More importantly, baseline alfa-fetoprotein levels and early HCC recurrence after treatment greatly influenced overall survival, while the use of HR or LRFA did not predict it. On the other hand, HCC recurrence was found to be determined by the surgical approach and ultrasound characteristics of the tumor. Our data were obtained from a large number of HCC cases and support similar survival rates after HR or LRFA for single HCC nodules on Child-Pugh class A liver cirrhosis, despite a marked increase in HCC recurrence rates after LRFA.

关键词： Hepatocellular Cancer radiofrequency ablation ectomy Liver Cirrhosis human-centered computing Heart Rate class A Relapse Patients

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：