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Proceedings of the 16th ACM Conference on Embedded Networked Sensor Systems

作者： Chenxi Yang Yang Chen Yuan Xuan School of Computer Science Fudan University China

ISBN: (纸本)9781450359528

Nowadays, people spend more and more time with their smart-phones. They want to make good use of smartphones to achieve an efficient time management. However, many people fail to control the time spent on smartphones effectively and end up with a low task completion rate. We design a time management APP targeted to analyze the time management task completion. In this way, a clear picture of the reasons for a low task completion rate is drawn by us, which could be very useful to help people better manage their time and complete their tasks.

关键词： Sensing Time Management Wearble Devices human-centered computing

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Raman Based Hepatocellular Carcinoma Biomarker Detection

Raman Based Hepatocellular Carcinoma Biomarker Detection

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Annual International Conference of the IEEE Engineering in Medicine and Biology Society

作者： M. A. Santiago-Cordoba P. R. Romano A. MacKay M. C. Demirel Chemistry Department Pennsylvania State University Microbiology and Immunology Drexel Institute for Biotechnology and Virology Research and The Institute for Hepatitis and Virus Research Materials Research Institute and Department of Engineering Science Pennsylvania State University

ISBN: (纸本)9781424441211

Highly sensitive and selective biomarker detection is required for early detection of hepatocellular carcinoma (HCC). Disease progression has been shown to correlate with specific fucosylation of a validated HCC serum glycoprotein biomarker, alpha-fetoprotein (AFP) Carbohydrate binding proteins, such as lectins, can be used as diagnostic indicators for monitoring glycosylation changes during disease progression in hepatitis B virus (HBV) or hepatitis C virus (HCV) infected patients. We prepared surface-enhanced Raman spectroscopy (SERS) substrates, which provide controllable, well-organized nanoparticles on the surface, for the analysis of a fucose binding lectin AAL. The SERS based assay provides fast (<10 s), and reproducible (<5% variation) detection.

关键词： Raman Lectins Biological Markers Disease Progression Hepatocellular Cancer alpha-Fetoproteins Early Diagnosis diagnostic indicator Hepatitis B virus surface enhanced Raman scattering human-centered computing Hepatitis C virus

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Incidentally Detected Hepatocellular Carcinoma in Cirrhotic Children

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INDIAN JOURNAL OF PEDIATRICS 2014年第8期81卷 826-826页

作者： Bhatia, Vidyut Seth, Swati Kapoor, Akshay Sibal, Anupam Indraprastha Apollo Hosp Apollo Ctr Adv Pediat New Delhi 110076 India

To the Editor: Unlike hepatoblastoma, hepatocellular carcinoma (HCC) in children is rare and generally develops in the presence of some underlying liver disease and/or cirrhosis. In children it is usually associated with viral hepatitis, tyrosinemia, progressive familial intrahepatic cholestasis (PFIC) or rarely in biliary atresia [1]. Although, regular surveillance done by ultrasound examination and alpha-fetoprotein (AFP) testing leads to early detection of HCC, it can be missed and only detected incidentally during the histopathological analysis of explanted liver tissue [2–4].

关键词： Early Diagnosis Editors Progressive familial intrahepatic cholestasis Tyrosinemias Hepatoblastoma Biliary Atresia liver tissue ATP8B1 gene human-centered computing Child Viral Hepatitis

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Differential network biology reveals a positive correlation between a novel protein-protein interaction and cancer cells migration

Differential network biology reveals a positive correlation ...

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Annual International Conference of the IEEE Engineering in Medicine and Biology Society

作者： Chia-Hung Liu Tzu-Chi Chen Chun-Houh Chen Cheng-Yan Kao Chi-Ying F. Huang Graduate Institute of Biomedical Electronic and Bioinformatics National Taiwan University Institute of Clinical Medicine National Yang-Ming University Institute of Statistical Science Academia Sinica

ISBN: (纸本)9781457702150

This paper introduces a differential network biology for discovering tumor migration. We applied statistical methods to prioritize PPI candidates and an in situ proximity ligation assay to verify 67 endogenous PPIs among 21 interlinked pathways in two hepatocellular carcinoma (HCC) cells, Huh7 (minimally migratory cells) and Mahlavu (highly migratory cells). Differential network biology analysis was applied to determine the novel interaction, CRKL-FLT1, has a high centrality ranking, and the expression of this interaction is strongly correlated with the migratory ability of HCC and other cancer cell lines. Knockdown of CRKL and FLT1 in HCC cells leads to a decrease in cell migration. This study demonstrated that functional exploration of a disease network with differential network in interlinked pathways via PPIs can be used to discover tumor migration.

关键词： Cell Migration Cell Locomotion Protein-Protein Interaction human-centered computing Biological Science Disciplines biology Immigration Migrations Network pulse position indicator Differential Exploration Statistical methods cancer cell Circulating Neoplastic Cells

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Aromatase inhibitors may be effective in the management of advanced hepatocellular carcinoma

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MEDICAL HYPOTHESES 2006年第6期66卷 1257-1257页

作者： Altundag, O Altundag, K Turen, S Gunduz, E Atik, MA Univ Hacettepe Inst Oncol Dept Med Oncol TR-06100 Ankara Turkey Univ Texas Houston Med Sch Med Mem Hermann Hosp Dept Pulm & Crit Care Houston TX 77030 USA Okayama Univ Grad Sch Med & Dent Dept Oral Pathol & Med Okayama 7008530 Japan Baylor Coll Med Dept Neurosurg Houston TX 77030 USA

Hepatocellular carcinoma (HCC) represents the sixth leading cancer and the third most common cause of death from cancer worldwide. There is no firstline option for patients with advanced HCC (vascular invasion, extrahepatic spread, or cancer-related symptoms). Systemic doxorubicin provides partial responses in 10% of cases, without proven survival advantages, and well-known treatment-related complications. Several other treatments, such as immunotherapy, internal radiation, tamoxifen, or anti-androgen agents, have not shown any relevant anti-tumoral effect or survival benefit . Experimentally, estrogens are involved in stimulating hepa-tocyte proliferation in vitro and may act as liver tumor inducers or promoters in vivo. Inefficacy of anti-estrogen tamoxifen however, could be partly attributable to the presence of variant estrogen receptor (ER) forms , or to alternative, non-recep-torial mechanisms potentially involved in growth regulation of both normal and cancer human liver cells by estrogen . By assuming that estrogen plays a role in hepatoma cell growth through non-receptor pathways, we can think of a strategy as reducing estrogen concentration in tumor tissue through aromatase inhibitors that deplete estrogen by inhibiting aromatase, the enzyme that synthesizes estrogen from androgens. One study has investigated the activity and expression of aromatase enzyme in non-tumoral, cirrhotic, and malignant human liver tissues and cells using both chromatographic and reverse transcription) (RT)-PCR analyses. They reported that human HCC tissues showed elevated aromatase activity, with increased estrogen formation rates, as opposed to non-tumoral hepatic tissues . Therefore, aromatase inhibitors may be considered in the management of advanced HCC.

关键词： Aromatase Inhibitors Carcinoma Hepatocellular Estrogens Liver Neoplasms Aromatase Inhibitors Estrogens Cause of Death Aromatase Liver Neoplasms human-centered computing Carcinoma

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Hepatocellular carcinoma in GNMT-/- mice

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TOXICOLOGY AND APPLIED PHARMACOLOGY 2009年第2期237卷 246-246页

作者： Wagner, Conrad Luka, Zigmund Mato, Jose M. Vanderbilt Univ Sch Med Dept Biochem Nashville TN 37232 USA CIBERehd CIC bioGUNE Bizkaia Spain

The article "Glycine N-methyltransferase affects the metabolism of aflatoxin Bl and blocks its carcinogenic effect" from a group under the leadership of Dr. Arthur Chen in Taiwan is misleading (Yen, 2009). The first sentence of the abstract states that "Previously, we reported that glycine N-methyl-transferase (GNMT) knockout mice develop chronic hepatitis and hepatocellular carcinoma (HCC) spontaneously." This implies that these authors were the first to demonstrate this when, in fact, our group (Luka, Mato and Wagner) demonstrated this earlier.

关键词： Hepatocellular Cancer Taiwan Leadership GNMT gene knockout mouse Glycine N-Methyltransferase Aflatoxins Glycine Chronic Hepatitis human-centered computing snow goose

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Comparison of SVPWM, SPWM and HCC control techniques in power control of PMSG used in wind turbine systems

Comparison of SVPWM, SPWM and HCC control techniques in powe...

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International Aegean Conference on Electrical Machines and Power Electronics, ACEMP

作者： Naim Suleyman Ting Yusuf Yasa Ismail Aksoy Yakup Sahin Electrical Engineering Department Yildiz Technical University Istanbul Turkey

In this paper, the performance of space vector pulse width modulation (SVPWM), sinusoidal pulse width modulation (SPWM) and hysteresis current control (HCC) control techniques used in power control with back to back converter of permanent magnet synchronous generator used in wind turbines are comparatively analyzed in terms of dynamic response, total harmonic distortion (THD), torque ripple and current ripple. Furthermore, SVPWM and SPWM are compared in terms of the using DC link voltage. Analysis of system is realized with MATLAB/Simulink program. There is not paper that together of these three control techniques are compared in terms of common results or values in literature. Permanent magnet synchronous generator (PMSG) is used in simulations is surface mounted, bipolar and its power is 1.8 kW. However, PMSM's energy transmission to grid is made with Field Oriented Control (FOC). According to analysis results, it has been observed that SVPWM generally has more efficient results than both HCC and SPWM control technique. Also, it is observed that SVPWM can produce about 15 percent higher than SPWM in output voltage.

关键词： Field oriented control PMSG back to back converter hysteresis control space vector pulse width modulation Space vector pulse width modulation sinusoidal pulse width modulation Pregnant Mare Serum Gonadotropins machine vector control hysteresis control Power control Wind Energy Conversion Systems human-centered computing

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Systematic review of outcome of downstaging hepatocellular cancer before liver transplantation in patients outside the Milan criteria (Br J Surg 2011;98: 1201-1208)

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BRITISH JOURNAL OF SURGERY 2011年第9期98卷 1209-1209页

作者： Mirza, D. F. Univ Hosp Birmingham NHS Trust Queen Elizabeth Hosp Birmingham B15 2TH W Midlands England

The aim of this systematic review was to assess the evidence on tumour downstaging before liver transplantation in patients with hepatocellular carcinoma (HCC) initially staged beyond the Milan criteria.

关键词： Liver Cirrhosis Review, Systematic Patients partial hepatectomy Hepatocellular Cancer Cirrhosis bromine Patient Selection Nodule size human-centered computing Transplantation Liver Transplantation

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Cryptogenic hepatocellular carcinoma (HCC) had worse overall survival of disease than viral HCC patients

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LIVER INTERNATIONAL 2018年第6期38卷 1140-1140页

作者： Xie, Yi-Lian Chu, Jin-Guo Li, Guo-Xiang Ningbo First Hosp Dept Infect & Liver Dis Ningbo Zhejiang Peoples R China

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Key-point-guided adaptive convolution and instance normalization for continuous transitive face reenactment of any person

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COMPUTER ANIMATION AND VIRTUAL WORLDS 2024年第3期35卷

作者： Xu, Shibiao Hua, Miao Zhang, Jiguang Zhang, Zhaohui Zhang, Xiaopeng Beijing Univ Posts & Telecommun Sch Artificial Intelligence Beijing Peoples R China Beijing Bytedance Technol Co Ltd Beijing Peoples R China Chinese Acad Sci Inst Automat Beijing Peoples R China

Face reenactment technology is widely applied in various applications. However, the reconstruction effects of existing methods are often not quite realistic enough. Thus, this paper proposes a progressive face reenactment method. First, to make full use of the key information, we propose adaptive convolution and instance normalization to encode the key information into all learnable parameters in the network, including the weights of the convolution kernels and the means and variances in the normalization layer. Second, we present continuous transitive facial expression generation according to all the weights of the network generated by the key points, resulting in the continuous change of the image generated by the network. Third, in contrast to classical convolution, we apply the combination of depth- and point-wise convolutions, which can greatly reduce the number of weights and improve the efficiency of training. Finally, we extend the proposed face reenactment method to the face editing application. Comprehensive experiments demonstrate the effectiveness of the proposed method, which can generate a clearer and more realistic face from any person and is more generic and applicable than other methods. This work presents a continuous transitive face reenactment algorithm that uses face key points information to gradually reenact faces based on two stages GAN, which contains the key face points transformation module and the facial expression generation module. The process involves transforming key points from the source face and generating corresponding facial expressions on the target face. image

关键词： face reenactment human-centered computing visualization visualization application domains

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