Nowadays, people spend more and more time with their smart-phones. They want to make good use of smartphones to achieve an efficient time management. However, many people fail to control the time spent on smartphones ...
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ISBN:
(纸本)9781450359528
Nowadays, people spend more and more time with their smart-phones. They want to make good use of smartphones to achieve an efficient time management. However, many people fail to control the time spent on smartphones effectively and end up with a low task completion rate. We design a time management APP targeted to analyze the time management task completion. In this way, a clear picture of the reasons for a low task completion rate is drawn by us, which could be very useful to help people better manage their time and complete their tasks.
Highly sensitive and selective biomarker detection is required for early detection of hepatocellular carcinoma (HCC). Disease progression has been shown to correlate with specific fucosylation of a validated HCC serum...
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ISBN:
(纸本)9781424441211
Highly sensitive and selective biomarker detection is required for early detection of hepatocellular carcinoma (HCC). Disease progression has been shown to correlate with specific fucosylation of a validated HCC serum glycoprotein biomarker, alpha-fetoprotein (AFP) Carbohydrate binding proteins, such as lectins, can be used as diagnostic indicators for monitoring glycosylation changes during disease progression in hepatitis B virus (HBV) or hepatitis C virus (HCV) infected patients. We prepared surface-enhanced Raman spectroscopy (SERS) substrates, which provide controllable, well-organized nanoparticles on the surface, for the analysis of a fucose binding lectin AAL. The SERS based assay provides fast (<10 s), and reproducible (<5% variation) detection.
To the Editor: Unlike hepatoblastoma, hepatocellular carcinoma (HCC) in children is rare and generally develops in the presence of some underlying liver disease and/or cirrhosis. In children it is usually associated w...
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To the Editor: Unlike hepatoblastoma, hepatocellular carcinoma (HCC) in children is rare and generally develops in the presence of some underlying liver disease and/or cirrhosis. In children it is usually associated with viral hepatitis, tyrosinemia, progressive familial intrahepatic cholestasis (PFIC) or rarely in biliary atresia [1]. Although, regular surveillance done by ultrasound examination and alpha-fetoprotein (AFP) testing leads to early detection of HCC, it can be missed and only detected incidentally during the histopathological analysis of explanted liver tissue [2–4].
This paper introduces a differential network biology for discovering tumor migration. We applied statistical methods to prioritize PPI candidates and an in situ proximity ligation assay to verify 67 endogenous PPIs am...
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ISBN:
(纸本)9781457702150
This paper introduces a differential network biology for discovering tumor migration. We applied statistical methods to prioritize PPI candidates and an in situ proximity ligation assay to verify 67 endogenous PPIs among 21 interlinked pathways in two hepatocellular carcinoma (HCC) cells, Huh7 (minimally migratory cells) and Mahlavu (highly migratory cells). Differential network biology analysis was applied to determine the novel interaction, CRKL-FLT1, has a high centrality ranking, and the expression of this interaction is strongly correlated with the migratory ability of HCC and other cancer cell lines. Knockdown of CRKL and FLT1 in HCC cells leads to a decrease in cell migration. This study demonstrated that functional exploration of a disease network with differential network in interlinked pathways via PPIs can be used to discover tumor migration.
Hepatocellular carcinoma (HCC) represents the sixth leading cancer and the third most common cause of death from cancer worldwide. There is no firstline option for patients with advanced HCC (vascular invasion, extrah...
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Hepatocellular carcinoma (HCC) represents the sixth leading cancer and the third most common cause of death from cancer worldwide. There is no firstline option for patients with advanced HCC (vascular invasion, extrahepatic spread, or cancer-related symptoms). Systemic doxorubicin provides partial responses in 10% of cases, without proven survival advantages, and well-known treatment-related complications. Several other treatments, such as immunotherapy, internal radiation, tamoxifen, or anti-androgen agents, have not shown any relevant anti-tumoral effect or survival benefit . Experimentally, estrogens are involved in stimulating hepa-tocyte proliferation in vitro and may act as liver tumor inducers or promoters in vivo. Inefficacy of anti-estrogen tamoxifen however, could be partly attributable to the presence of variant estrogen receptor (ER) forms , or to alternative, non-recep-torial mechanisms potentially involved in growth regulation of both normal and cancer human liver cells by estrogen . By assuming that estrogen plays a role in hepatoma cell growth through non-receptor pathways, we can think of a strategy as reducing estrogen concentration in tumor tissue through aromatase inhibitors that deplete estrogen by inhibiting aromatase, the enzyme that synthesizes estrogen from androgens. One study has investigated the activity and expression of aromatase enzyme in non-tumoral, cirrhotic, and malignant human liver tissues and cells using both chromatographic and reverse transcription) (RT)-PCR analyses. They reported that human HCC tissues showed elevated aromatase activity, with increased estrogen formation rates, as opposed to non-tumoral hepatic tissues . Therefore, aromatase inhibitors may be considered in the management of advanced HCC.
The article "Glycine N-methyltransferase affects the metabolism of aflatoxin Bl and blocks its carcinogenic effect" from a group under the leadership of Dr. Arthur Chen in Taiwan is misleading (Yen, 2009). T...
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The article "Glycine N-methyltransferase affects the metabolism of aflatoxin Bl and blocks its carcinogenic effect" from a group under the leadership of Dr. Arthur Chen in Taiwan is misleading (Yen, 2009). The first sentence of the abstract states that "Previously, we reported that glycine N-methyl-transferase (GNMT) knockout mice develop chronic hepatitis and hepatocellular carcinoma (HCC) spontaneously." This implies that these authors were the first to demonstrate this when, in fact, our group (Luka, Mato and Wagner) demonstrated this earlier.
In this paper, the performance of space vector pulse width modulation (SVPWM), sinusoidal pulse width modulation (SPWM) and hysteresis current control (HCC) control techniques used in power control with back to back c...
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In this paper, the performance of space vector pulse width modulation (SVPWM), sinusoidal pulse width modulation (SPWM) and hysteresis current control (HCC) control techniques used in power control with back to back converter of permanent magnet synchronous generator used in wind turbines are comparatively analyzed in terms of dynamic response, total harmonic distortion (THD), torque ripple and current ripple. Furthermore, SVPWM and SPWM are compared in terms of the using DC link voltage. Analysis of system is realized with MATLAB/Simulink program. There is not paper that together of these three control techniques are compared in terms of common results or values in literature. Permanent magnet synchronous generator (PMSG) is used in simulations is surface mounted, bipolar and its power is 1.8 kW. However, PMSM's energy transmission to grid is made with Field Oriented Control (FOC). According to analysis results, it has been observed that SVPWM generally has more efficient results than both HCC and SPWM control technique. Also, it is observed that SVPWM can produce about 15 percent higher than SPWM in output voltage.
The aim of this systematic review was to assess the evidence on tumour downstaging before liver transplantation in patients with hepatocellular carcinoma (HCC) initially staged beyond the Milan criteria.
The aim of this systematic review was to assess the evidence on tumour downstaging before liver transplantation in patients with hepatocellular carcinoma (HCC) initially staged beyond the Milan criteria.
Face reenactment technology is widely applied in various applications. However, the reconstruction effects of existing methods are often not quite realistic enough. Thus, this paper proposes a progressive face reenact...
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Face reenactment technology is widely applied in various applications. However, the reconstruction effects of existing methods are often not quite realistic enough. Thus, this paper proposes a progressive face reenactment method. First, to make full use of the key information, we propose adaptive convolution and instance normalization to encode the key information into all learnable parameters in the network, including the weights of the convolution kernels and the means and variances in the normalization layer. Second, we present continuous transitive facial expression generation according to all the weights of the network generated by the key points, resulting in the continuous change of the image generated by the network. Third, in contrast to classical convolution, we apply the combination of depth- and point-wise convolutions, which can greatly reduce the number of weights and improve the efficiency of training. Finally, we extend the proposed face reenactment method to the face editing application. Comprehensive experiments demonstrate the effectiveness of the proposed method, which can generate a clearer and more realistic face from any person and is more generic and applicable than other methods. This work presents a continuous transitive face reenactment algorithm that uses face key points information to gradually reenact faces based on two stages GAN, which contains the key face points transformation module and the facial expression generation module. The process involves transforming key points from the source face and generating corresponding facial expressions on the target face. image
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