检索结果-内蒙古大学图书馆

Proceedings of the third international ACM conference on Assistive technologies

作者： Richard A. Foulds Arthur W. Joyce University of Delaware 1600 Rockland Road Wilmington DE

ISBN: (纸本)9781581130201

n this paper, we describe the preliminary results of an NSF sponsored invitational workshop entitled Expanded Interaction: Broadening human-centered computing. The workshop brought together members of academia, industry and government, as well as individuals with disabilities to examine the commonalities and expansion of human-computer interaction and universal design. The underlying theme was to encourage a scientific understand of the diversity of human performance.

关键词： telecommunications universal access intermedia human-centered computing disabilities multimodal

来源：评论

学校读者我要写书评

暂无评论

Analysis of the IGF axis in preneoplastic hepatic foci and hepatocellular neoplasms developing after low-number pancreatic islet transplantation into the livers of streptozotocin diabetic rats

引用

LABORATORY INVESTIGATION 2000年第9期80卷 1399-1411页

作者： Scharf, JG Ramadori, G Dombrowski, F Univ Gottingen Dept Med Div Gastroenterol & Endocrinol D-37075 Gottingen Germany Univ Bonn Inst Pathol D-5300 Bonn Germany

Preneoplastic hepatic foci have been demonstrated in liver acini, which drain the blood from intraportally transplanted pancreatic islets in streptozotocin-induced diabetic rats with mild persisting diabetes. In long-term studies of this animal model, hepatocellular adenomas and carcinomas (HCC) developed after a sequence of characteristic preneoplastic hepatic fool. In this experimental model, the local hyperinsulinism is thought to have a causative role. Because insulin and the insulin-like growth factor (IGF) axis are closely linked, an altered gene expression of the IGF axis components is likely. Therefore, preneoplastic hepatic foci and HCC were studied for the expression of IGF axis components. Glycogen-storing "early" preneoplastic hepatic fool were detectable several days after pancreatic islet transplantation. Northern blot analysis, in-situ hybridization, and immunohistochemical studies of these "early" lesions demonstrated increased expressions of IGF-I and IGF binding protein-4 (IGFBP-4) in altered parenchymal cells, and a decreased expression of IGFBP-1. IGF-II was not detected in these preneoplastic fool. HCC arising in this model had decreased expressions of IGF-I and IGFBP-4 but IGFBP-1 expression was not significantly altered. Some HCC showed a more than 100-fold overexpression of IGF-II, whereas other tumors were completely negative for IGF-II expression. Low IGF-I receptor expression was detected in preneoplastic foci and adjacent nonaltered liver tissue. However, HCC tissue consistently showed an increased IGF-I receptor expression, rendering these tissues susceptible to the mitogenic effects of IGF. The altered gene expression in glycogen-storing preneoplastic hepatic foci, especially the up-regulation of IGF-I and IGFBP-4 with the down-regulation of IGFBP-1, resemble the insulin-dependent regulation of these components in normal rat hepatocytes. These data agree with previous studies demonstrating a correspondence of the focal character, morpho

关键词： Diabetes Mellitus Experimental Islets of Langerhans Transplantation Liver Neoplasms 糖尿病实验性胰岛移植肝肿瘤癌前状态 Insulin-Like Growth Factor Binding Protein 4 Insulin-Like Growth Factor Binding Protein 1 Islets of Langerhans Transplantation Hepatic Organ System Liver Somatomedins Diabetes Mellitus human-centered computing Liver Neoplasms

来源：评论

学校读者我要写书评

暂无评论

Recurrent chromosome alterations in hepatocellular carcinoma detected by comparative genomic hybridization

引用

GENES CHROMOSOMES & CANCER 2000年第2期29卷 110-116页

作者： Guan, XY Fang, Y Sham, JST Kwong, DLW Zhang, YQ Liang, QW Li, HM Zhou, H Trent, JM Univ Hong Kong Queen Mary Hosp Dept Clin Oncol Hong Kong Hong Kong Peoples R China Sun Yat Sen Univ Inst Canc Guangzhou Peoples R China Sun Yat Sen Univ Canc Hosp Guangzhou Peoples R China NHGRI Canc Genet Branch NIH Bethesda MD 20892 USA

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide and has a very poor prognosis. Fifty primary HCC cases have been analyzed in the present study to explore the association between genomic alteration in primary HCC and clinical features. Several recurrent chromosomal abnormalities were identified in this study. The most frequently detected chromosomal gains involved chromosome arms Iq (33/50 cases, 66%), 8q (24/50 cases, 48%), and 20q (10/50 cases, 20%). High-copy-number amplifications involving Iq (4 cases), 8q (3 cases), and 20q (3 cases) were detected, and a minimum overlapping amplified region at 1q12-q22 was identified. The most frequently detected loss of chromosomal material involved 16q (35/50 cases, 70%), 17p (26/50 cases, 52%), 19p (21/50 cases, 42%), 4q (20/50 cases, 40%), 1p(18/50 cases, 36%), 8p(16/50 cases, 32%), and 22q (14/50 cases, 28%). The associations between genomic alterations detected in the present study and clinical features including clinical stage, tumor size, HBV infection, chronic liver disease, and liver cirrhosis were explored. Our CGH results suggest that the gain of 20q and deletion of 8p are late genetic alterations in HCC, because the incidence of these alterations was obviously increased in the advanced clinical stages. Another finding showed that loss of 8p and gain of 8q and 20q are associated with tumor size. The recurrent gain and loss of chromosomal regions identified in this study provide candidate regions that may contain oncogenes or tumor suppressor genes respectively involved in HCC development and progression. (C) 2000 Wiley-Liss, Inc.

关键词： Carcinoma Hepatocellular Chromosome Abnormalities Liver Neoplasms 癌肝细胞染色体异常肝肿瘤 Chromosome Aberrations Carcinoma Tumor Suppressor Genes Oncogenes Liver Neoplasms tumor size human-centered computing cases (containers) Gain clinical stages

来源：评论

学校读者我要写书评

暂无评论

Loss of cell-cell contact is induced by integrin-mediated cell-substratum adhesion in highly-motile and highly-metastatic hepatocellular carcinoma cells

引用

LABORATORY INVESTIGATION 2000年第3期80卷 387-394页

作者： Genda, T Sakamoto, M Ichida, T Asakura, H Hirohashi, S Natl Canc Ctr Res Inst Div Pathol Chuo Ku Tokyo Japan Niigata Univ Fac Med Dept Internal Med 3 Niigata Japan

The cadherin-mediated cell-cell adhesion system plays a critical role in normal development and morphogenesis. Inactivation of this system is thought to be responsible for cancer invasion and metastasis. A human hepatocellular carcinoma (HCC) cell line, KYN-2, was observed to have great potential for intrahepatic metastasis when orthotopically implanted into the liver of SCID mice. In vitro cultures of KYN-2 cells showed that they formed trabecular structures in suspension but lost tight cell-cell adhesion and became scattered when attached to a substratum such as collagen or fibronectin. In response to adhesion to the substratum, subcellular colocalization of E-cadherin and actin filaments were shown to be reduced, and a significant amount of alpha-catenin was dissociated from the E-cadherin-catenin complex in KYN-2 cells. These changes of cell-cell adhesion were blocked by inhibitory monoclonal antibodies against beta 1 and beta 5 integrins. We found that c-Src was coimmunoprecipitated with E-cadherin-catenin complex and was tyrosine-dephosphorylated and activated in the adherent cells. The tyrosine dephosphorylation of c-Src was induced by cell adhesion to the substratum and inhibited by addition of inhibitory monoclonal antibodies against beta 1 and beta 5 integrins. These findings indicate that integrin-mediated cell-substratum adhesion inhibits cadherin-mediated cell-cell adhesion, possibly through c-Src activation, and suggest that this cross-talk mediates transient inactivation of the cadherin system and plays an important role in intrahepatic metastasis of human HCC. Modulation of this interaction might provide a new approach to prevent metastasis and recurrence of HCC.

关键词： Carcinoma Hepatocellular Cell Adhesion Cell Communication Integrins 癌肝细胞细胞粘附细胞交流结合素类肝肿瘤 Cell Adhesion metastasis Adhesion c-src Genes human-centered computing integrin beta5 SCID Mice Carcinoma Integrins Cell Communication

来源：评论

学校读者我要写书评

暂无评论

Resection or transplantation for hepatocellular carcinoma in cirrhotic patients: Outcomes based on indicated treatment strategy

引用

JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS 2000年第5期190卷 580-587页

作者： Figueras, J Jaurrieta, E Valls, C Ramos, E Serrano, T Rafecas, A Fabregat, J Torras, J Univ Barcelona Ciutat Sanitaria Univ Bellvitge Liver Transplant Unit Barcelona Spain

Background: Surgical resection has been the treatment of choice for hepatocellular carcinoma (HCC), but the resection rate remains low in cirrhotic patients and recurrence is common. Unfavorable results compared with benign disease and the shortage of organ donors have led to a restricted indication for orthotopic liver transplantation (OLT) for HCC. Study Design: The aim of this study was to analyze the results of our surgical approach to HCC in patients with cirrhosis. The first treatment strategy indicated in these patients was OLT. From January 1990 to May 1999, 85 patients underwent OLT and the remaining 35 had surgical resection. Results: One-, 3-, and 5-year survival rates were 84%, 74%, and 60% versus 83%, 57%, and 51%, respectively, in the OLT and resection groups (p = 0.34). Hepatic tumor recurrence was much less frequent in the OLT group than in the resection group. The 1-, 3-, and 5-year disease-free survival rates were 83%, 72%, and 60% versus 70%, 44%, and 31%, respectively (p = 0.027). In the multivariate Cox regression analysis, macroscopic vascular invasion was the only factor independently associated with death or recurrence after OLT (p = 0.006). After partial liver resection, the tumors significantly associated with mortality and recurrence in the multivariate analysis were solitary or multiple tumors greater than 2 cm with microscopic vascular invasion (pathologic pT3) (p = 0.01). Conclusions: Our results confirm that in cirrhotic patients, OLT may provide better outcomes than liver resection in carefully selected HCC and that longterm survival is similar to the results of OLT in cirrhotic patients without tumors. (J Am Coil Surg 2000;190: 580-587. (C) 2000 by the American College of Surgeons).

关键词： Carcinoma Hepatocellular Hepatectomy Liver Cirrhosis Liver Neoplasms 癌肝细胞肝切除术肝硬化肝肿瘤肝移植 Liver Cirrhosis Organ Donors Survival Rate Carcinoma Hepatocellular Cancer Hepatectomy Liver Neoplasms Relapse human-centered computing Optical Line Terminal Transplantation ectomy

来源：评论

学校读者我要写书评

暂无评论

Mesohepatectomy for centrally located hepatocellular carcinoma: An appraisal of a rare procedure

引用

JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS 1999年第5期188卷 508-515页

作者： Wu, CC Ho, WL Chen, JT Tang, CS Yeh, DC Liu, TJ P'eng, FK Taichung Vet Gen Hosp Chung Shan Med Coll Dept Surg Taichung Taiwan Taichung Vet Gen Hosp Chung Shan Med Coll Dept Pathol Taichung Taiwan Natl Yang Ming Univ Sch Med Dept Surg Taipei 112 Taiwan

Background: For centrally located hepatocellular carcinoma (HCC), extended major hepatectomy is usually recommended, but the risk of postoperative liver failure is high when liver function is not sound. Mesohepatectomy (en bloc resection of Goldsmith and Woodburne's left medial and right anterior segments or Couinaud's segments IV, V, and VIII) is a rare procedure, so its role in treating HCC is unclear. Study Design: We retrospectively reviewed 364 patients who underwent a curative resection for HCC. Among them, 15 patients were treated by mesohepatectomy, Their nontumorous liver revealed cirrhosis in 11 and chronic hepatitis in 4. The mean tumor diameter was 12.8 cm. In 10 of the 15 patients, HCC also invaded adjacent organs. The operative results of another 25 patients with different disease extent who underwent extended major hepatectomy were compared. Results: The hepatic inflow occlusion time for mesohepatectomy was longer than for extended hepatectomy (p = 0.01). The mean operative blood loss, amount of blood transfusion, operating time, and postoperative hospital stay in the mesohepatectomy group were 2,450 mL, 1,100 mL, 7.9 hours, and 14.9 days, respectively. In the extended-hepatectomy group, the: values were 1,863 mL, 768 mL, 5.8 hours, and 16.8 days, respectively (all p > 0.05 compared with mesohepatectomy). No patient died after mesohepatectomy;but after extended hepatectomy there was one death from liver failure. The Union Internationale contre le cancer (UICC) TNM stages of patients who underwent mesohepatectomy were as follows: stage II in 1, stage III in 4, and stage IVA in 10. All patients who underwent extended hepatectomy presented with stage IVA disease. The 6-year disease-free and actuarial survival rates after mesohepatectomy were 21% and 30%, respectively The 6-year disease-free survival rate after extended hepatectomy was 9% (p = 0.11 compared with mesohepatectomy). Conclusion: Although mesohepatectomy is time-consuming, it is justified for

关键词： Carcinoma Hepatocellular Hepatectomy Liver Neoplasms 癌肝细胞肝切除术肝肿瘤 Acute Liver Failure Survival Rate Goldsmith Hepatectomy Liver Neoplasms human-centered computing Carcinoma

来源：评论

学校读者我要写书评

暂无评论

Cutaneous metastasis from hepatocellular carcinoma resembling pyogenic granuloma

引用

CLINICAL AND EXPERIMENTAL DERMATOLOGY 1999年第2期24卷 78-80页

作者： Kubota, Y Koga, T Nakayama, J Fukuoka Univ Sch Med Dept Dermatol Fukuoka 8140180 Japan

A case of skin metastasis from hepatocellular carcinoma (HCC) is reported that resembled pyogenic granuloma. An easily bleeding, cutaneous nodule on the chin of a 62-year-old Japanese male was resected under the diagnosis of pyogenic granuloma. Histology, however, indicated HCC. Cutaneous metastases from HCC are very rare, but the possibility must be considered for unusual nodules resembling pyogenic granuloma.

关键词： Carcinoma Hepatocellular Granuloma Pyogenic Liver Neoplasms Skin Neoplasms 癌肝细胞肉芽肿脓性肝肿瘤皮肤肿瘤 Skin Nodule Hodgkin Disease Metastatic Malignant Neoplasm to the Skin Skin Neoplasms Pyogenic Granuloma Granuloma Liver Neoplasms human-centered computing Carcinoma Chin

来源：评论

学校读者我要写书评

暂无评论

Aflatoxin and liver cancer in Sudan

引用

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL 1998年第3期32卷 174-180页

作者： Omer, RE Bakker, MI van't Veer, P Hoogenboom, RLAP Polman, THG Alink, GM Idris, MO Kadaru, AMY Kok, FJ Univ Khartoum Fac Agr Dept Crop Protect Khartoum Sudan Univ Khartoum Fac Med Dept Med Khartoum Sudan Wageningen Univ Agr Div Human Nutr & Epidemiol Wageningen Netherlands Wageningen Univ Agr Dept Toxicol Wageningen Netherlands RIKILT DLO State Inst Qual Control Agr Prod Wageningen Netherlands

This study investigated whether aflatoxin contamination of peanut products mall contribute to the incidence of hepatocellular carcinoma (HCC) in Sudan. Thirty-seven peanut butter and peanut samples were collected from local markets. Aflatoxin concentrations were significantly higher in West Sudan [87.4 +/- 197.3 (SD) mu g/kg] a high-risk area, than in Central Sudan (8.5 +/- 6.8 mu g/kg), a low-risk area. In West Sudan, humid local storage conditions of peanut products were related to high aflatoxin concentrations. In a small case-control study of HCC patients (n = 24) and controls (n = 34), an odds ratio of 7.5 (95% confidence interval 1.4-40.2) was observed for humid vs. dry local storage conditions. Development of an index of individual HCC exposure was less successful, probably because of year-to-year variability in aflatoxins in food. These preliminary findings justify further. research into the role of aflatoxins and hepatitis in HCC incidence in Sudan.

关键词： Aflatoxins Carcinogens Carcinoma Hepatocellular Food Contamination Liver Neoplasms 黄曲霉毒素类致癌物癌肝细胞食品污染肝肿瘤 local storage Peanut products Cancer of Liver Carcinoma Food Contamination Liver Neoplasms Sudan Carcinogens Aflatoxins human-centered computing

来源：评论

学校读者我要写书评

暂无评论

Segment-oriented hepatic resection in the management of malignant neoplasms of the liver

引用

JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS 1998年第5期187卷 471-481页

作者： Billingsley, KG Jarnagin, WR Fong, Y Blumgart, LH Mem Sloan Kettering Canc Ctr Dept Surg Hepatobiliary Serv New York NY 10021 USA

Background: Improvements in the understanding of intrahepatic anatomy and radiographic technology have facilitated a segment-oriented approach to ii-ver resection. This approach involves the resection of isolated anatomic segments or sectors of the liver as dictated by the extent of the;intrahepatic pathology. Segment-oriented resection allows maximal conservation of normal liver parenchyma while clearing tumor. This report describes the technical features and the results of a prospective evaluation of segmental and sectoral resections in the treatment of malignant hepatic neoplasms. Study Design: Patients with malignant hepatic neoplasms that were treated with a segment-oriented hepatic resection were identified from a prospective clinical data base. After undergoing segment-oriented liver resection, the patients were followed at regular intervals. Recurrent disease was the end point of the study. Followup is reported at a median of 12 months. This review outlines the technique of resection, intraoperative events, operating time, blood loss, and the ability to obtain negative resection margins. Results: During the 5-year period between July 1992 and July 1997, 400 patients underwent liver resection for metastatic neoplasms and hepatocellular carcinoma (HCC). During this period, 79 patients (20%) were treated with a segment-oriented resection. These patients represent the study group for this report. The overall mortality rate was 2.5%;all postoperative deaths occurred in patients with HCC and cirrhosis. Overall morbidity was 26%, The median hospital stay was 8 days. Mean transfusion requirements were 1.0 +/- 0.3 U of packed red blood cells. Patients with HCC showed a greater transfusion requirement than did patients without HCC: 2.7 +/- 1.2 U versus 0.6 +/- 0.2 U (p < 0.05). Of the patients without HCC, 17% required transfusion. During the 12-month median followup period, the overall disease recurrence rate was 23%. Disease recurred at the hepatic-resection margin

关键词： Hepatectomy Liver Neoplasms 肝切除术肝肿瘤 End Point Malignancy ectomy Mortality Hepatectomy liver parenchyma Liver Liver Neoplasms human-centered computing Patients technical features

来源：评论

学校读者我要写书评

暂无评论

HEPATITIS-C AND HEPATOCELLULAR-CARCINOMA

引用

SEMINARS IN LIVER DISEASE 1995年第1期15卷 64-69页

作者： DIBISCEGLIE, AM Department of Internal Medicine St Louis University Health Sciences Center St. Louis Missouri

Sufficient evidence has accumulated that chronic infection with HCV substantially increases the risk of HCC, particularly in the presence of cirrhosis. HCV appears to represent a major underlying cause of HCC in southern Europe and Japan, regions where HCC incidence is intermediate, whereas its impact is smaller in sub-Saharan Africa and China, where HBV-related HCC predominates, and in the developed western world, where the majority of cases of HCC are associated with cirrhosis of unknown etiology.

关键词： Carcinoma Hepatocellular Hepatitis C Liver Neoplasms 癌肝细胞肝炎丙型肝肿瘤 chronic infection Western World Liver Cirrhosis Africa south of the Sahara Southern Europe Liver Neoplasms human-centered computing Hepatitis C Carcinoma

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：