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Systematic review of catheter-based intra-arterial therapies in hepatocellular carcinoma: state of the art and future directions

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BRITISH JOURNAL OF RADIOLOGY 2015年第1052期88卷 20140564-20140564页

作者： Duran, R. Chapiro, J. Schernthaner, R. E. Geschwind, J-F H. Johns Hopkins Univ Hosp Russell H Morgan Dept Radiol & Radiol Sci Div Vasc & Intervent Radiol Baltimore MD 21287 USA

Intra-arterial therapies (IATs) play a pivotal role in the management of patients with primary and secondary liver malignancies. The unique advantages of these treatments are their ability to selectively deliver a high dose of anticancer treatment while preserving healthy liver tissue. The proven efficacy of these catheter-based locoregional therapies in a highly systemic chemoresistant cancer such as hepatocellular carcinoma (HCC), along with the minimally invasive nature of these treatments, quickly yielded wide acceptance in themedical community and revolutionized the field of Interventional Oncology. In this article, we describe the clinical rationale and background of catheter-based IATs. We provide an overview of clinical achievements of these treatments alone and in combination with sorafenib in patients with HCC.

关键词： Hepatocellular Cancer Arts sorafenib Review, Systematic liver tissue human-centered computing state of the art

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AccessibleWeb Development: Opportunities to Improve the Education and Practice of web Development with a Screen Reader

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ACM TRANSACTIONS ON ACCESSIBLE computing 2021年第2期14卷 08-08页

作者： Kearney-Volpe, Claire Hurst, Amy NYU Dept Occupat Therapy 82 Washington Sq East6th Floor New York NY 10003 USA

There are a growing number of jobs related to web development, yet there is little formal literature about the accessibility of web development with a screen reader. This article describes research to explore (1) web development accessibility issues and their impact on blind learners and programmers;(2) tools and strategies used to address issues;and (3) opportunities for creating inclusive web development curriculum and supportive tools. We conducted a Comprehensive Literature Review (CLR) to formulate accessibility issue categories, then interviewed 12 blind programmers to validate and expand on both issues in education and practice. The CLR yielded five issue categories: (1) visual information without an accessible equivalent, (2) orienting, (3) navigating, (4) lack of support, and (5) knowledge and use of supportive technologies. Our interview findings validated the use of CLR-derived categories and revealed nuances specific to learning and practicing web development. Blind web developers grapple with the inaccessibility of demonstrations and explanations of web design concepts, wireframing software, independent verification of computed Cascading Style Sheets (CSS), and navigating browser-based developer tool interfaces. Tools and strategies include seeking out alternative education materials to learn independently, use of CSS frameworks, collaboration with sighted colleagues, and avoidance of design and front-end development. This work contributes to our understanding of accessibility issues specific to web development and the strategies that blind web developers employ in both educational and applied contexts. We identify areas in which greater awareness and application of accessibility best practices are required in Web education, a need to disseminate existing screen reader strategies and accessible tools, and to develop new tools that support Web design and validation of CSS. Finally, this research signals future directions for the development of accessible

关键词： Accessibility human-centered computing visually impaired/blind programmers screen reader accessible web development accessible design tools accessible web design

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Use of Mobile Clinical Decision Support Software by Junior Doctors at a UK Teaching Hospital: Identification and Evaluation of Barriers to Engagement

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JMIR MHEALTH AND UHEALTH 2015年第3期3卷 e80页

作者： Patel, Rakesh Green, William Shahzad, Muhammad Waseem Larkin, Chris Univ Leicester Dept Med & Social Care Educ Leicester LE1 7LA Leics England Univ Hosp Leicester NHS Trust Leicester Leics England Univ Leicester Sch Management Leicester LE1 7LA Leics England Hlth Educ East Midlands Ruddington Notts England

Background: Clinical decision support (CDS) tools improve clinical diagnostic decision making and patient safety. The availability of CDS to health care professionals has grown in line with the increased prevalence of apps and smart mobile devices. Despite these benefits, patients may have safety concerns about the use of mobile devices around medical equipment. Objective: This research explored the engagement of junior doctors (JDs) with CDS and the perceptions of patients about their use. There were three objectives for this research: (1) to measure the actual usage of CDS tools on mobile devices (mCDS) by JDs, (2) to explore the perceptions of JDs about the drivers and barriers to using mCDS, and (3) to explore the perceptions of patients about the use of mCDS. Methods: This study used a mixed-methods approach to study the engagement of JDs with CDS accessed through mobile devices. Usage data were collected on the number of interactions by JDs with mCDS. The perceived drivers and barriers for JDs to using CDS were then explored by interviews. Finally, these findings were contrasted with the perception of patients about the use of mCDS by JDs. Results: Nine of the 16 JDs made a total of 142 recorded interactions with the mCDS over a 4-month period. Only 27 of the 114 interactions (24%) that could be categorized as on-shift or off-shift occurred on-shift. Eight individual, institutional, and cultural barriers to engagement emerged from interviews with the user group. In contrast to reported cautions and concerns about the impact of clinicians' use of mobile phone on patient health and safety, patients had positive perceptions about the use of mCDS. Conclusions: Patients reported positive perceptions toward mCDS. The usage of mCDS to support clinical decision making was considered to be positive as part of everyday clinical practice. The degree of engagement was found to be limited due to a number of individual, institutional, and cultural barriers. The majority of

关键词： clinical decision support systems health care technology human-centered computing medical education patient safety ubiquitous and mobile computing

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NF-κB, JNK, and TLR Signaling Pathways in Hepatocarcinogenesis

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GASTROENTEROLOGY RESEARCH AND PRACTICE 2010年第Toll/Like...期2010卷 367694-367694页

作者： Maeda, Shin Yokohama City Univ Dept Gastroenterol Kanazawa Ku Yokohama Kanagawa 2360004 Japan

Hepatocellular carcinoma (HCC) is the third largest cause of cancer deaths worldwide. The role of molecular changes in HCC have been used to identify prognostic markers and chemopreventive or therapeutic targets. It seems that toll-like receptors (TLRs) as well as the nuclear factor (NF)-kappa B, and JNK pathways are critical regulators for the production of the cytokines associated with tumor promotion. The cross-talk between an inflammatory cell and a neoplastic cell, which is instigated by the activation of NF-kappa B and JNKs, is critical for tumor organization. JNKs also regulate cell proliferation and act as oncogenes, making them the main tumor-promoting protein kinases. TLRs play roles in cytokine and hepatomitogen expression mainly in myeloid cells and may promote liver tumorigenesis. A better understanding of these signaling pathways in the liver will help us understand the mechanism of hepatocarcinogenesis and provide a new therapeutic target for HCC.

关键词： JNK Pathway Tumor Promotion NF-kappa B Cytokines Inflammatory cell Hepatocarcinogenesis Chemopreventive Agent Oncogenes Liver Neoplastic Cell human-centered computing Bone Marrow Cells

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Smart Device-Based Notifications to Promote Healthy Behavior Related to Childhood Obesity and Overweight

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SENSORS 2018年第1期18卷 271页

作者： Lopez, Gustavo Gonzalez, Ivan Jimenez-Garcia, Elitania Fontecha, Jesus Brenes, Jose A. Guerrero, Luis A. Bravo, Jose Univ Costa Rica Res Ctr Commun & Informat Technol CITIC San Jose 11501 Costa Rica Univ Castilla La Mancha MAmI Res Lab E-13071 Ciudad Real Spain Autonomous Univ Baja California Fac Engn Architecture & Design Ensenada 21100 Baja California Mexico

Obesity is one of the most serious public health challenges of the 21st century and it is a threat to the life of people according to World Health Organization. In this scenario, family environment is important to establish healthy habits which help to reduce levels of obesity and control overweight in children. However, little efforts have been focused on helping parents to promote and have healthy lifestyles. In this paper, we present two smart device-based notification prototypes to promote healthy behavior with the aim of avoiding childhood overweight and obesity. The first prototype helps parents to follow a healthy snack routine, based on a nutritionist suggestion. Using a fridge magnet, parents receive graphical reminders of which snacks they and their children should consume. The second prototype provides a graphical reminder that prevents parents from forgetting the required equipment to practice sports. Prototypes were evaluated by nine nutritionists from three countries (Costa Rica, Mexico and Spain). Evaluations were based on anticipation of use and the ergonomics of human-system interaction according to the ISO 9241-210. Results show that the system is considered useful. Even though they might not be willing to use the system, they would recommend it to their patients. Based on the ISO 9241-210 the best ranked features were the system's comprehensibility, the perceived effectiveness and clarity. The worst ranked features were the system's suitability for learning and its discriminability.

关键词： ubiquitous computing health human-centered computing

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Liver Invasion of the Duodenum Due to Hepatocellular Carcinoma

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CLINICAL GASTROENTEROLOGY AND HEPATOLOGY 2012年第5期10卷 XXV-XXV页

作者： Sauer, Bryan G. Dustin, Simone M. Caldwell, Stephen H. Univ Virginia Div Gastroenterol Charlottesville VA 22903 USA Univ Virginia Dept Pathol Charlottesville VA 22903 USA

A 68-year-old man with hepatocellular carcinoma (HCC) presented with upper-gastrointestinal bleeding for the fifth time in 7 months and new-onset severe nausea and vomiting. Over the past year, the patient had undergone transarterial chemoemboli-zation as well as radiotherapy with concurrent capecitabine (Xe-loda; Genetech, San Francisco, CA) for treatment of HCC. Prior upper endoscopies showed a pyloric channel ulceration with numerous interventional attempts to control bleeding, including epinephrine injection and endoscopic clipping, and angiographic coiling of branches of the gastroduodenal artery, left gastric artery, and left hepatic artery. A biopsy obtained 5 months before the presentation revealed fibrinopurulent debris in addition to large atypical cells with relatively abundant eosinophilic cytoplasm that reacted with the hepatocyte paraffin 1 (Hep Par 1) antibody (a monoclonal antibody to hepatocyte mitochondria) (Figure A, 40 X).

关键词： Hepatocellular Cancer Hepatocytes Gastroduodenal artery Injection of epinephrine Hemorrhage Left gastric artery Radiotherapy Gastric Artery Duodenum human-centered computing Cytologic Atypia Left hepatic artery

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Multi-modal data collection for measuring health, behavior, and living environment of large-scale participant cohorts

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GIGASCIENCE 2021年第6期10卷 giab044页

作者： Wu, Congyu Fritz, Hagen Bastami, Sepehr Maestre, Juan P. Thomaz, Edison Julien, Christine Castelli, Darla M. de Barbaro, Kaya Bearman, Sarah Kate Harari, Gabriella M. Craddock, R. Cameron Kinney, Kerry A. Gosling, Samuel D. Schnyer, David M. Nagy, Zoltan Univ Texas Austin Dept Psychol 108 E Dean Keeton St Austin TX 78712 USA Univ Texas Austin Dept Civil Environm & Architectural Engn 301 E Dean Keeton St Austin TX 78712 USA Univ Texas Austin Dept Elect & Comp Engn 2501 Speedway Austin TX 78712 USA Univ Texas Austin Dept Kinesiol & Hlth Educ 2109 San Jacinto Blvd Austin TX 78712 USA Univ Texas Austin Dept Educ Psychol 1912 Speedway Austin TX 78712 USA Stanford Univ Dept Commun 450 Serra Mall Stanford CA 94305 USA Univ Texas Austin Dept Diagnost Med 1601 Trinity St Austin TX 78712 USA Univ Melbourne Melbourne Sch Psychol Sci Grattan St Parkville Vic 3010 Australia

Background: As mobile technologies become ever more sensor-rich, portable, and ubiquitous, data captured by smart devices are lending rich insights into users' daily lives with unprecedented comprehensiveness and ecological validity. A number of human-subject studies have been conducted to examine the use of mobile sensing to uncover individual behavioral patterns and health outcomes, yet minimal attention has been placed on measuring living environments together with other human-centered sensing data. Moreover, the participant sample size in most existing studies falls well below a few hundred, leaving questions open about the reliability of findings on the relations between mobile sensing signals and human outcomes. Results: To address these limitations, we developed a home environment sensor kit for continuous indoor air quality tracking and deployed it in conjunction with smartphones, Fitbits, and ecological momentary assessments in a cohort study of up to 1,584 college student participants per data type for 3 weeks. We propose a conceptual framework that systematically organizes human-centric data modalities by their temporal coverage and spatial freedom. Then we report our study procedure, technologies and methods deployed, and descriptive statistics of the collected data that reflect the participants' mood, sleep, behavior, and living environment. Conclusions: We were able to collect from a large participant cohort satisfactorily complete multi-modal sensing and survey data in terms of both data continuity and participant adherence. Our novel data and conceptual development provide important guidance for data collection and hypothesis generation in future human-centered sensing studies.

关键词： multi-modal sensing human-centered computing smartphone Fitbit BEVO Beacon ecological momentary assessment health college students

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Laparoscopic Isolated Total Caudate Lobectomy for Hepatocellular Carcinoma Located in the Paracaval Portion of the Cirrhotic Liver

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ANNALS OF SURGICAL ONCOLOGY 2019年第9期26卷 2980-2980页

作者： Liu, Fei Wei, Yonggang Li, Bo Sichuan Univ West China Hosp Dept Liver Surg Chengdu Sichuan Peoples R China Sichuan Univ West China Hosp Liver Transplantat Ctr Chengdu Sichuan Peoples R China

Background Despite the widespread use of laparoscopic hepatectomies in past decades, laparoscopic isolated total caudate lobectomy for hepatocellular carcinoma (HCC) remains challenging,(1,2) especially for patients with cirrhosis. Moreover, a laparoscopic isolated total caudate lobectomy for HCC originating in the paracaval portion of the caudate lobe is very rare. We herein present a video showing laparoscopic total caudate lobectomy for a cirrhotic patient with HCC located in the paracaval portion of the caudate lobe. Methods A 58-year-old woman who suffered from hepatitis C virus-related cirrhosis was admitted to our institution. The preoperative computed tomography showed a 2.5 x 2.0 cm liver mass located in segment I that was very close to the right hepatic pedicle. Although her liver function was Child-Pugh A, the indocyanine green (ICG)-15 test was high at 10.9%. Right hepatectomy plus caudate lobectomy was not adopted because of the severe cirrhosis and the elevated ICG-15. Thus, laparoscopic isolated total caudate lobectomy was contemplated. Results The patient was placed in the supine position. After full mobilization, the caudate lobe was exposed. The third porta of the liver was then dissected and the short hepatic veins were controlled with clips and LigaSure. The dissection was finished when the whole third porta of the liver was freed. Subsequently, the portal branches to the caudate lobe were ligated and cut. The combination between the left- and right-sided laparoscopic approaches was used to transect liver parenchyma. The superficial parenchyma was divided using an harmonic scalpel, while the deeper tissue was divided using a Cavitron ultrasonic aspirator (CUSA). The Pringle maneuver was used intermittently during the parenchymal transection as necessary. In the left-sided approach, the caudate lobe was resected along the left and middle hepatic vein toward the right side, to expose the dorsal semicircle of the right hepatic vein. In the right-sid

关键词： Caudate Lobe Hepatocellular Cancer laparoscopic surgery lobectomy Right hepatic vein Liver human-centered computing

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Expression of Potential Cancer Stem Cell Marker ABCG2 is Associated with Malignant Behaviors of Hepatocellular Carcinoma

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GASTROENTEROLOGY RESEARCH AND PRACTICE 2013年第unknown期2013卷 782581页

作者： Zhang, Guang Wang, Zhongxia Luo, Weihuan Jiao, Hongbo Wu, Junhua Jiang, Chunping Nanjing Univ Sch Med Affiliated Drum Tower Hosp Dept Hepatobiliary Surg Nanjing 210008 Jiangsu Peoples R China Nanjing Med Univ Drum Tower Clin Med Coll Dept Hepatobiliary Surg Nanjing 210008 Jiangsu Peoples R China Nanjing Univ Sch Med Nanjing 210093 Jiangsu Peoples R China

Background. Despite improvement in treatment, the prognosis of hepatocellular carcinoma (HCC) remains disastrous. Cancer stem cells (CSCs) may be responsible for cancer malignant behaviors. ATP-binding cassette, subfamily G, member 2 (ABCG2) is widely expressed in both normal and cancer stem cells and may play an important role in cancer malignant behaviors. Methods. The expression of ABCG2 in HCC tissues and SMMC-7721 cells was examined, and the relevance of ABCG2 expression with clinical characteristics was analyzed. ABCG2+ and ABCG2- cells were sorted, and the potential of tumorigenicity was determined. Expression level of ABCG2 was manipulated by RNA interference and overexpression. Malignant behaviors including proliferation, drug resistance, migration, and invasion were studied in vitro. Results. Expression of ABCG2 was found in a minor group of cells in HCC tissues and cell lines. ABCG2 expression showed tendencies of association with unfavorable prognosis factors. ABCG2 positive cells showed a superior tumorigenicity. Upregulation of ABCG2 enhanced the capacity of proliferation, doxorubicin resistance, migration, and invasion potential, while downregulation of ABCG2 significantly decreased these malignant behaviors. Conclusion. Our results indicate that ABCG2 is a potential CSC marker for HCC. Its expression level has a close relationship with tumorigenicity, proliferation, drug resistance, and metastasis ability.

关键词： ABCG2 protein, human Hepatocellular Cancer Tumorigenicity human-centered computing Neoplastic Stem Cells

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PPAR Could Contribute to the Pathogenesis of Hepatocellular Carcinoma

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PPAR RESEARCH 2012年第unknown期2012卷 574180-574180页

作者： Kimura, Osamu Kondo, Yasuteru Shimosegawa, Tooru Tohoku Univ Hosp Div Gastroenterol Aoba Ku Sendai Miyagi 9808574 Japan

Viral hepatitis with hepatitis C virus or hepatitis B virus and chronic liver disease such as alcoholic or nonalcoholic steatohepatitis are critical factors in the development of hepatocellular carcinoma (HCC). Furthermore, diabetes is known as an independent risk factor for HCC. Peroxisome proliferator-activated receptor (PPAR) is known to have an important role in fatty liver, and the mechanism of carcinogenesis has been clarified. PPAR controls ligand-dependent transcription, and three subtypes (alpha, delta, and gamma) in humans are known. PPARs could contribute to the mechanisms of cell cycling, anti-inflammatory responses, and apoptosis. Therefore, to clarify the pathogenesis of HCC, we should examine PPAR signaling. In this paper, we have summarized the relevance of PPARs to the pathogenesis of HCC and cancer stem cells and possible therapeutic options through modifying PPAR signaling.

关键词： Fatty Liver Hepatitis B virus Peroxisome Proliferator-Activated Receptors Risk Factors Viral Hepatitis Neoplastic Stem Cells Hepatocellular Cancer key factors Nonalcoholic Steatohepatitis chronic liver disease human-centered computing pathogenesis Alcoholics Carcinogenesis

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