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NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL 1998年第3期32卷 174-180页

作者： Omer, RE Bakker, MI van't Veer, P Hoogenboom, RLAP Polman, THG Alink, GM Idris, MO Kadaru, AMY Kok, FJ Univ Khartoum Fac Agr Dept Crop Protect Khartoum Sudan Univ Khartoum Fac Med Dept Med Khartoum Sudan Wageningen Univ Agr Div Human Nutr & Epidemiol Wageningen Netherlands Wageningen Univ Agr Dept Toxicol Wageningen Netherlands RIKILT DLO State Inst Qual Control Agr Prod Wageningen Netherlands

This study investigated whether aflatoxin contamination of peanut products mall contribute to the incidence of hepatocellular carcinoma (HCC) in Sudan. Thirty-seven peanut butter and peanut samples were collected from local markets. Aflatoxin concentrations were significantly higher in West Sudan [87.4 +/- 197.3 (SD) mu g/kg] a high-risk area, than in Central Sudan (8.5 +/- 6.8 mu g/kg), a low-risk area. In West Sudan, humid local storage conditions of peanut products were related to high aflatoxin concentrations. In a small case-control study of HCC patients (n = 24) and controls (n = 34), an odds ratio of 7.5 (95% confidence interval 1.4-40.2) was observed for humid vs. dry local storage conditions. Development of an index of individual HCC exposure was less successful, probably because of year-to-year variability in aflatoxins in food. These preliminary findings justify further. research into the role of aflatoxins and hepatitis in HCC incidence in Sudan.

关键词： Aflatoxins Carcinogens Carcinoma Hepatocellular Food Contamination Liver Neoplasms 黄曲霉毒素类致癌物癌肝细胞食品污染肝肿瘤 local storage Peanut products Cancer of Liver Carcinoma Food Contamination Liver Neoplasms Sudan Carcinogens Aflatoxins human-centered computing

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Segment-oriented hepatic resection in the management of malignant neoplasms of the liver

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JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS 1998年第5期187卷 471-481页

作者： Billingsley, KG Jarnagin, WR Fong, Y Blumgart, LH Mem Sloan Kettering Canc Ctr Dept Surg Hepatobiliary Serv New York NY 10021 USA

Background: Improvements in the understanding of intrahepatic anatomy and radiographic technology have facilitated a segment-oriented approach to ii-ver resection. This approach involves the resection of isolated anatomic segments or sectors of the liver as dictated by the extent of the;intrahepatic pathology. Segment-oriented resection allows maximal conservation of normal liver parenchyma while clearing tumor. This report describes the technical features and the results of a prospective evaluation of segmental and sectoral resections in the treatment of malignant hepatic neoplasms. Study Design: Patients with malignant hepatic neoplasms that were treated with a segment-oriented hepatic resection were identified from a prospective clinical data base. After undergoing segment-oriented liver resection, the patients were followed at regular intervals. Recurrent disease was the end point of the study. Followup is reported at a median of 12 months. This review outlines the technique of resection, intraoperative events, operating time, blood loss, and the ability to obtain negative resection margins. Results: During the 5-year period between July 1992 and July 1997, 400 patients underwent liver resection for metastatic neoplasms and hepatocellular carcinoma (HCC). During this period, 79 patients (20%) were treated with a segment-oriented resection. These patients represent the study group for this report. The overall mortality rate was 2.5%;all postoperative deaths occurred in patients with HCC and cirrhosis. Overall morbidity was 26%, The median hospital stay was 8 days. Mean transfusion requirements were 1.0 +/- 0.3 U of packed red blood cells. Patients with HCC showed a greater transfusion requirement than did patients without HCC: 2.7 +/- 1.2 U versus 0.6 +/- 0.2 U (p < 0.05). Of the patients without HCC, 17% required transfusion. During the 12-month median followup period, the overall disease recurrence rate was 23%. Disease recurred at the hepatic-resection margin

关键词： Hepatectomy Liver Neoplasms 肝切除术肝肿瘤 End Point Malignancy ectomy Mortality Hepatectomy liver parenchyma Liver Liver Neoplasms human-centered computing Patients technical features

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HEPATITIS-C AND HEPATOCELLULAR-CARCINOMA

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SEMINARS IN LIVER DISEASE 1995年第1期15卷 64-69页

作者： DIBISCEGLIE, AM Department of Internal Medicine St Louis University Health Sciences Center St. Louis Missouri

Sufficient evidence has accumulated that chronic infection with HCV substantially increases the risk of HCC, particularly in the presence of cirrhosis. HCV appears to represent a major underlying cause of HCC in southern Europe and Japan, regions where HCC incidence is intermediate, whereas its impact is smaller in sub-Saharan Africa and China, where HBV-related HCC predominates, and in the developed western world, where the majority of cases of HCC are associated with cirrhosis of unknown etiology.

关键词： Carcinoma Hepatocellular Hepatitis C Liver Neoplasms 癌肝细胞肝炎丙型肝肿瘤 chronic infection Western World Liver Cirrhosis Africa south of the Sahara Southern Europe Liver Neoplasms human-centered computing Hepatitis C Carcinoma

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THE INFRARED AND NEAR-INFRARED SPECTRA OF HCC AND DCC TRAPPED IN SOLID NEON

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JOURNAL OF MOLECULAR SPECTROSCOPY 1995年第1期170卷 178-214页

作者： FORNEY, D JACOX, ME THOMPSON, WE NIST DIV MOLEC PHYSGAITHERSBURGMD 20899

Spectra have been recorded from 700 to 12 000 cm(-1) for HCC and DCC trapped in solid neon. In this region, which includes not only the groundstate absorptions but also all of the absorptions of appreciable intensity in the highly perturbed A (II)-I-2 state, all of the matrix shifts are to lower frequencies, and none of them exceeds 30 cm(-1). The ($) over tilde X(OnO) and ($) over tilde X(Onl) progressions of HCC, recently reported in the photoelectron spectrum of HCC-, also appear in the infrared spectrum. The spectra of the singly and doubly carbon-13 substituted species of HCC and of doubly carbon-13 substituted DCC are presented. Except in a few regions of very strong mixing of energy levels of the ($) over tilde X and ($) over tilde A states, correlations of the HCC and DCC bands with their carbon-13 substitution counterparts are possible, and the resulting isotopic shift data are useful in assigning the vibronic spectra. Assignments are proposed for a considerable number of HCC and DCC bands. These assignments are aided by the carbon-13 shift data, by the results of recent ab initio calculations. and, where they are available, by the upper-state symmetries of bands observed in the gas phase. Absorptions of C-2, C-2(-), C-4, HC4, HCCO, and C2H3 isolated in a neon matrix are also identified. (C) 1995 Academic Press, Inc.

关键词： Laser kinetic spectroscopy Hyperfine coupling-constants Submillimeter-wave spectra Lying electronic states Radical v3 band Vibronic structure C2h spectrum Induced fluorescence Potential surfaces Transition VIBRONIC STRUCTURE Scanning Kinetic Spectroscopy(SKS) DCC Genes COUPLING CONSTANTS human-centered computing Infrared radiation electron states absorption

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MACROREGENERATIVE (DYSPLASTIC) NODULES AND HEPATOCARCINOGENESIS - THEORETICAL AND CLINICAL CONSIDERATIONS

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SEMINARS IN LIVER DISEASE 1995年第4期15卷 360-371页

作者： THEISE, ND Department of Pathology Tisch Hospital New York University Medical Center New York

Over the last decade or so, we have seen the development of an interesting new area of liver pathology, new because advanced imaging techniques coupled with careful screening of population at risk for HCC have focused attention on nodular hepatocellular lesions that have been previously ignored. Careful searching for these nodules has led to the acknowledgment that they are not restricted to the populations in which they were first identified and in which the association with HCC was first made, but are probably a universal phenomenon and one extremely important pathway for the development of HCC. Moving beyond these epidemiological associations, we see that careful consideration of the morphology of these lesions leads to insights into the early stages of human hepatocarcinogenesis, setting the stage for the development of a clinically useful system of nomenclature and, perhaps, new approaches to screening for early HCC. Additional important work lies ahead, as concepts from animal models of hepatocarcinogenesis are applied to these human lesions, molecular approaches to research and diagnostics are applied, and extensive prospective screening and clinicopathologic correlation studies are carried out.

关键词： Carcinoma Hepatocellular Liver Liver Neoplasms Liver Regeneration 癌肝细胞肝肝肿瘤肝再生 Developmental stages focused attention Hepatocarcinogenesis Liver Liver Regeneration Liver Neoplasms human-centered computing Dysplastic Carcinoma Correlation analysis

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RELATIONSHIP BETWEEN GENERAL OR SPECIFIC IMMUNOREACTIVITY AND PROGNOSIS IN POSTOPERATIVE-PATIENTS WITH HEPATOCELLULAR-CARCINOMA

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CANCER IMMUNOLOGY IMMUNOTHERAPY 1990年第2期31卷 107-114页

作者： YAMASAKI, H OKAMOTO, E KOMATSU, T MANABE, Y SHINKA, S HYOGO MED UNIV DEPT SURG 1 NISHINOMIYA HYOGO 663 JAPAN HYOGO MED UNIV DEPT IMMUNOL & MED ZOOL NISHINOMIYA HYOGO 663 JAPAN

The levels of a variety of immunological parameters were examined in 203 preoperative patients with hepatocellular carcinoma (HCC) at various stages (I-IV). The changes in the peripheral blood lymphocyte (PBL) count, the serum level of immunosuppressive acidic protein and the degree of the skin reaction to purified protein derivative were associated significantly with the stage of HCC progression. However, the percentages of lymphocyte subsets, mitogenic responsiveness of PBL and serum immunoglobulin concentration remained at the levels of stage I. Further study demonstrated that in patients undergoing hepatic artery ligation, there were statistically significant correlations between the PBL count, immunosuppressive acidic protein concentration and intensity of the skin reaction to purified protein derivative, assayed 1 month after surgery, and the prognosis. HCC-specific immunity was examined in 34 patients treated by hepatic resection or hepatic artery ligation using in vitro responses of PBL to HCC extracts (ATS test). This test was performed using culture medium containing added arginine. None of the PBL from the patients showed a positive response to allogeneic HCC extracts, but the PBL from 12 patients (9 hepatic resections, 3 hepatic artery ligations) were stimulated significantly (SI .gtoreq. 2.5) with autologous HCC extracts. In 7 of 9 hepatic resection patients who were positive in the ATS test, tumor recurrence was identified. Statistical analysis indicated that the ATS test result was significantly correlated with tumor recurrence in hepatic resection patients. Autologous-PBL-stimulating activities were isolated in a fraction at pH 8.3 and in fractions at pH 6.7-7.0 by chromatofocusing of the crude extract. Although identification of the HCC-specific antigen remains to be done, use of the above fractions may simplify the ATS test procedure and improve its sensitivity.

关键词： ATS SATELLITES Purified Protein Derivative of Tuberculin Hepatocellular Cancer Prognosis immunosuppressive acidic protein Fendiline Serum levels ectomy AUTOMATIC TRANSFER SWITCH Peripheral Blood Lymphocyte artery ligation fractions hepatic artery ligation human-centered computing Recurrent Neoplasm

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TRANSCATHETER ARTERIAL CHEMOEMBOLIZATION FOR HEPATOCELLULAR-CARCINOMA

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CANCER CHEMOTHERAPY AND PHARMACOLOGY 1989年第1-Sup期23卷 S26-S28页

作者： YANG, CF HO, YZ CHANG, JM CHIANG, RH LAI, KH LEE, SD TSAI, YT LUI, WY LIU, TJ CHEN, GH VET GEN HOSP TAIPEI TAIWAN

Hepatocellular carcinoma (HCC) was treated with transcatheter arterial chemoembolization (TACE) in a sample of 129 patients. The cumulative survival rate was 49% at 1 year and 22% at 2 years. The median survival time was 11.9 months. The survival rates at 1 year of 84 patients in Child's group A and 27 in Child's group B were 56% and 40%; out of 52 HCC patients with portal vein patent and 77 with portal vein invasion 75% and 40% survived, and the 1-year survival rates for 33 HCC patients with capsule intact, 14 with caspule broken and 82 with no capsule were 85%, 65% and 40% respectively. From the above results there were statistically significant differences in survival time in those with good clinical performance status by Child's classification, those showing patency of the portal vein and those where the capsule was present. Therefore, we would like to recommend, TACE of HCC in well-selected patients presenting with good clinical status, patency of the portal vein and without broken capsule, in order to achieve better clinical results.

关键词： survival time CAPSULES BREAKS Survival Rate Portal Vein human-centered computing

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HEPATOCELLULAR-CARCINOMA WITH SARCOMATOUS CHANGE - A SPECIAL REFERENCE TO THE RELATIONSHIP WITH ANTICANCER THERAPY

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CANCER CHEMOTHERAPY AND PHARMACOLOGY 1989年第1-Sup期23卷 S4-S8页

作者： KOJIRO, M SUGIHARA, S KAKIZOE, S NAKASHIMA, O KIYOMATSU, K 1. First Department of Pathology Kurume University School of Medicine 830 Kurume Japan

Among 579 autopsy cases of hepatocellular carcinoma (HCC), 55 cases (9.4%) exhibited a sarcomatous appearance. The incidence of HCC with a sarcomatous appearance has been increasing over the past 17 years. A sarcomatous appearance was found in 20 out of 335 autopsy cases of HCC (5.9%) during the 12 years from 1969 to 1980, and in 35 out of 244 autopsy cases of HCC (14.3%) during the last 6 years, when effective anticancer therapies, such as the one-shot injection of anticancer agents into the hepatic artery (one-shot therapy) and transcatheter arterial embolization (TAE), have become popular. A sarcomatous appearance was found in 20.9% of the cases undergoing anticancer therapy and in 4.2% of the cases not undergoing anticancer therapy. Among the various anticancer therapies, the sarcomatous appearance was most frequent (27.6%) in cases with repeated TAE. Thus, a close relationship between the sarcomatous appearance in HCC and anticancer therapies was suggested. Regarding the development of the sarcomatous appearance, we presume that it may be caused by the pyenotypic change of HCC cells caused by anticancer therapy, or that a number of factors, including anticancer therapy, may accelerate the proliferation of the sarcomatous cells existing in the original tumor as one of the histological components. In order to clarify the true nature of sarcomatous lesions in HCC, further histological and biological studies are required.

关键词： Hepatocellular Cancer Autopsy cases (containers) human-centered computing Medicine

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