As tools for design get increasingly complex and powerful, it is increasingly important that their users have a solid grounding in what it is these tools do and how they do it. When these tools are software engineerin...
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ISBN:
(纸本)9781605584362
As tools for design get increasingly complex and powerful, it is increasingly important that their users have a solid grounding in what it is these tools do and how they do it. When these tools are software engineering tools, we can assume that their users have formal training in computing. However, when the tools are for designing art or multimedia objects, the artists using the tools typically don't have much background in the computing technology they are using. While interdisciplinary design teams can work around the shortcomings of individual team members, they might be more effective teams if they shared a common language and understanding of certain key aspects of the design process. At the University of Washington we have begun a project to study the use of the theory of problem solving as shared knowledge by design teams engaged in creating of multimedia games. The theory we used is derived from early work in artificial intelligence. The concepts of state space, search, operators and evaluation functions are key components of the shared knowledge. The theory is embodied in a software system called T-STAR (Transparent STate-spaces search ARchitecture) which supports a collaborative interface for problem-solving. A key question for the project is "to what extent will interdisciplinary design teams adopt and exploit the theory of problem solving when given an opportunity to do so?"
This paper proposes a novel easy extrinsic calibration algorithm for an off-the-shelf VR system and a multi-camera based marker-less motion capture system. To realize interactions between 3D user motions and virtual o...
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ISBN:
(纸本)9781728147666
This paper proposes a novel easy extrinsic calibration algorithm for an off-the-shelf VR system and a multi-camera based marker-less motion capture system. To realize interactions between 3D user motions and virtual objects reconstructed from multi-view videos in a common 3D space, the extrinsic calibration of the VR system and the multiple cameras must be conducted beforehand. This calibration, which involves estimating the pose and position of each coordinate system, is a key technology for handling 3D information in a system with various type of input sources. In general, extrinsic calibration is carried out by identifying and utilizing some common 3D points. However, since most of off-the-shelf VR systems do not include any imaging device, it is difficult to apply conventional automatic calibration approaches as there are no common points shared with the cameras. Against this problem, this paper introduces an easy calibration algorithm by generating corresponding points from the trajectories of the user's motion with VR devices and 3D human pose reconstructed from multi-view videos. Our study provides the following two contributions; (1) our method does not need to introduce additional devices, such as a chessboard and (2) our method does not need manual processes as the extrinsic parameters are automatically estimated. We demonstrate the performance of the proposed method in a practical scenario.
Highly sensitive and selective biomarker detection is required for early detection of hepatocellular carcinoma (HCC). Disease progression has been shown to correlate with specific fucosylation of a validated HCC serum...
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ISBN:
(纸本)9781424441211
Highly sensitive and selective biomarker detection is required for early detection of hepatocellular carcinoma (HCC). Disease progression has been shown to correlate with specific fucosylation of a validated HCC serum glycoprotein biomarker, alpha-fetoprotein (AFP) Carbohydrate binding proteins, such as lectins, can be used as diagnostic indicators for monitoring glycosylation changes during disease progression in hepatitis B virus (HBV) or hepatitis C virus (HCV) infected patients. We prepared surface-enhanced Raman spectroscopy (SERS) substrates, which provide controllable, well-organized nanoparticles on the surface, for the analysis of a fucose binding lectin AAL. The SERS based assay provides fast (<10 s), and reproducible (<5% variation) detection.
To the Editor: Unlike hepatoblastoma, hepatocellular carcinoma (HCC) in children is rare and generally develops in the presence of some underlying liver disease and/or cirrhosis. In children it is usually associated w...
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To the Editor: Unlike hepatoblastoma, hepatocellular carcinoma (HCC) in children is rare and generally develops in the presence of some underlying liver disease and/or cirrhosis. In children it is usually associated with viral hepatitis, tyrosinemia, progressive familial intrahepatic cholestasis (PFIC) or rarely in biliary atresia [1]. Although, regular surveillance done by ultrasound examination and alpha-fetoprotein (AFP) testing leads to early detection of HCC, it can be missed and only detected incidentally during the histopathological analysis of explanted liver tissue [2–4].
Nowadays, people spend more and more time with their smart-phones. They want to make good use of smartphones to achieve an efficient time management. However, many people fail to control the time spent on smartphones ...
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ISBN:
(纸本)9781450359528
Nowadays, people spend more and more time with their smart-phones. They want to make good use of smartphones to achieve an efficient time management. However, many people fail to control the time spent on smartphones effectively and end up with a low task completion rate. We design a time management APP targeted to analyze the time management task completion. In this way, a clear picture of the reasons for a low task completion rate is drawn by us, which could be very useful to help people better manage their time and complete their tasks.
This paper introduces a differential network biology for discovering tumor migration. We applied statistical methods to prioritize PPI candidates and an in situ proximity ligation assay to verify 67 endogenous PPIs am...
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ISBN:
(纸本)9781457702150
This paper introduces a differential network biology for discovering tumor migration. We applied statistical methods to prioritize PPI candidates and an in situ proximity ligation assay to verify 67 endogenous PPIs among 21 interlinked pathways in two hepatocellular carcinoma (HCC) cells, Huh7 (minimally migratory cells) and Mahlavu (highly migratory cells). Differential network biology analysis was applied to determine the novel interaction, CRKL-FLT1, has a high centrality ranking, and the expression of this interaction is strongly correlated with the migratory ability of HCC and other cancer cell lines. Knockdown of CRKL and FLT1 in HCC cells leads to a decrease in cell migration. This study demonstrated that functional exploration of a disease network with differential network in interlinked pathways via PPIs can be used to discover tumor migration.
In this paper, the performance of space vector pulse width modulation (SVPWM), sinusoidal pulse width modulation (SPWM) and hysteresis current control (HCC) control techniques used in power control with back to back c...
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In this paper, the performance of space vector pulse width modulation (SVPWM), sinusoidal pulse width modulation (SPWM) and hysteresis current control (HCC) control techniques used in power control with back to back converter of permanent magnet synchronous generator used in wind turbines are comparatively analyzed in terms of dynamic response, total harmonic distortion (THD), torque ripple and current ripple. Furthermore, SVPWM and SPWM are compared in terms of the using DC link voltage. Analysis of system is realized with MATLAB/Simulink program. There is not paper that together of these three control techniques are compared in terms of common results or values in literature. Permanent magnet synchronous generator (PMSG) is used in simulations is surface mounted, bipolar and its power is 1.8 kW. However, PMSM's energy transmission to grid is made with Field Oriented Control (FOC). According to analysis results, it has been observed that SVPWM generally has more efficient results than both HCC and SPWM control technique. Also, it is observed that SVPWM can produce about 15 percent higher than SPWM in output voltage.
The article "Glycine N-methyltransferase affects the metabolism of aflatoxin Bl and blocks its carcinogenic effect" from a group under the leadership of Dr. Arthur Chen in Taiwan is misleading (Yen, 2009). T...
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The article "Glycine N-methyltransferase affects the metabolism of aflatoxin Bl and blocks its carcinogenic effect" from a group under the leadership of Dr. Arthur Chen in Taiwan is misleading (Yen, 2009). The first sentence of the abstract states that "Previously, we reported that glycine N-methyl-transferase (GNMT) knockout mice develop chronic hepatitis and hepatocellular carcinoma (HCC) spontaneously." This implies that these authors were the first to demonstrate this when, in fact, our group (Luka, Mato and Wagner) demonstrated this earlier.
The aim of this systematic review was to assess the evidence on tumour downstaging before liver transplantation in patients with hepatocellular carcinoma (HCC) initially staged beyond the Milan criteria.
The aim of this systematic review was to assess the evidence on tumour downstaging before liver transplantation in patients with hepatocellular carcinoma (HCC) initially staged beyond the Milan criteria.
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