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Proceedings of the 2007 Symposium on Science of Design

作者： Steven L. Tanimoto University of Washington

ISBN: (纸本)9781605584362

As tools for design get increasingly complex and powerful, it is increasingly important that their users have a solid grounding in what it is these tools do and how they do it. When these tools are software engineering tools, we can assume that their users have formal training in computing. However, when the tools are for designing art or multimedia objects, the artists using the tools typically don't have much background in the computing technology they are using. While interdisciplinary design teams can work around the shortcomings of individual team members, they might be more effective teams if they shared a common language and understanding of certain key aspects of the design process. At the University of Washington we have begun a project to study the use of the theory of problem solving as shared knowledge by design teams engaged in creating of multimedia games. The theory we used is derived from early work in artificial intelligence. The concepts of state space, search, operators and evaluation functions are key components of the shared knowledge. The theory is embodied in a software system called T-STAR (Transparent STate-spaces search ARchitecture) which supports a collaborative interface for problem-solving. A key question for the project is "to what extent will interdisciplinary design teams adopt and exploit the theory of problem solving when given an opportunity to do so?"

关键词： user interfaces tree visualization statespace search design process methodology human-centered computing language of design collaborative learning

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Easy Extrinsic Calibration of VR System and Multi-camera Based Marker-Less Motion Capture System

Easy Extrinsic Calibration of VR System and Multi-camera Bas...

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IEEE International Symposium on Mixed and Augmented Reality Workshops (ISMARW)

作者： Kosuke Takahashi Dan Mikami Mariko Isogawa Siqi Sun Yoshinori Kusachi NTT Media Intelligence Laboratories

ISBN: (纸本)9781728147666

This paper proposes a novel easy extrinsic calibration algorithm for an off-the-shelf VR system and a multi-camera based marker-less motion capture system. To realize interactions between 3D user motions and virtual objects reconstructed from multi-view videos in a common 3D space, the extrinsic calibration of the VR system and the multiple cameras must be conducted beforehand. This calibration, which involves estimating the pose and position of each coordinate system, is a key technology for handling 3D information in a system with various type of input sources. In general, extrinsic calibration is carried out by identifying and utilizing some common 3D points. However, since most of off-the-shelf VR systems do not include any imaging device, it is difficult to apply conventional automatic calibration approaches as there are no common points shared with the cameras. Against this problem, this paper introduces an easy calibration algorithm by generating corresponding points from the trajectories of the user's motion with VR devices and 3D human pose reconstructed from multi-view videos. Our study provides the following two contributions; (1) our method does not need to introduce additional devices, such as a chessboard and (2) our method does not need manual processes as the extrinsic parameters are automatically estimated. We demonstrate the performance of the proposed method in a practical scenario.

关键词： human-centered computing human computer interaction Interaction paradigms Virtual reality computing methodologies Artificial intelligence Computer vision Image and video acquisition human-centered computing computer human interaction motion capture images computer vision Artificial Intelligence Variable reluctance Coordinate system Imaging Device multiple camera

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Raman Based Hepatocellular Carcinoma Biomarker Detection

Raman Based Hepatocellular Carcinoma Biomarker Detection

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Annual International Conference of the IEEE Engineering in Medicine and Biology Society

作者： M. A. Santiago-Cordoba P. R. Romano A. MacKay M. C. Demirel Chemistry Department Pennsylvania State University Microbiology and Immunology Drexel Institute for Biotechnology and Virology Research and The Institute for Hepatitis and Virus Research Materials Research Institute and Department of Engineering Science Pennsylvania State University

ISBN: (纸本)9781424441211

Highly sensitive and selective biomarker detection is required for early detection of hepatocellular carcinoma (HCC). Disease progression has been shown to correlate with specific fucosylation of a validated HCC serum glycoprotein biomarker, alpha-fetoprotein (AFP) Carbohydrate binding proteins, such as lectins, can be used as diagnostic indicators for monitoring glycosylation changes during disease progression in hepatitis B virus (HBV) or hepatitis C virus (HCV) infected patients. We prepared surface-enhanced Raman spectroscopy (SERS) substrates, which provide controllable, well-organized nanoparticles on the surface, for the analysis of a fucose binding lectin AAL. The SERS based assay provides fast (<10 s), and reproducible (<5% variation) detection.

关键词： Raman Lectins Biological Markers Disease Progression Hepatocellular Cancer alpha-Fetoproteins Early Diagnosis diagnostic indicator Hepatitis B virus surface enhanced Raman scattering human-centered computing Hepatitis C virus

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Incidentally Detected Hepatocellular Carcinoma in Cirrhotic Children

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INDIAN JOURNAL OF PEDIATRICS 2014年第8期81卷 826-826页

作者： Bhatia, Vidyut Seth, Swati Kapoor, Akshay Sibal, Anupam Indraprastha Apollo Hosp Apollo Ctr Adv Pediat New Delhi 110076 India

To the Editor: Unlike hepatoblastoma, hepatocellular carcinoma (HCC) in children is rare and generally develops in the presence of some underlying liver disease and/or cirrhosis. In children it is usually associated with viral hepatitis, tyrosinemia, progressive familial intrahepatic cholestasis (PFIC) or rarely in biliary atresia [1]. Although, regular surveillance done by ultrasound examination and alpha-fetoprotein (AFP) testing leads to early detection of HCC, it can be missed and only detected incidentally during the histopathological analysis of explanted liver tissue [2–4].

关键词： Early Diagnosis Editors Progressive familial intrahepatic cholestasis Tyrosinemias Hepatoblastoma Biliary Atresia liver tissue ATP8B1 gene human-centered computing Child Viral Hepatitis

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Sensing People's Time Management Behaviors: A Study Using Wearable Devices 18

Sensing People's Time Management Behaviors: A Study Using We...

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Proceedings of the 16th ACM Conference on Embedded Networked Sensor Systems

作者： Chenxi Yang Yang Chen Yuan Xuan School of Computer Science Fudan University China

ISBN: (纸本)9781450359528

Nowadays, people spend more and more time with their smart-phones. They want to make good use of smartphones to achieve an efficient time management. However, many people fail to control the time spent on smartphones effectively and end up with a low task completion rate. We design a time management APP targeted to analyze the time management task completion. In this way, a clear picture of the reasons for a low task completion rate is drawn by us, which could be very useful to help people better manage their time and complete their tasks.

关键词： Sensing Time Management Wearble Devices human-centered computing

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Differential network biology reveals a positive correlation between a novel protein-protein interaction and cancer cells migration

Differential network biology reveals a positive correlation ...

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Annual International Conference of the IEEE Engineering in Medicine and Biology Society

作者： Chia-Hung Liu Tzu-Chi Chen Chun-Houh Chen Cheng-Yan Kao Chi-Ying F. Huang Graduate Institute of Biomedical Electronic and Bioinformatics National Taiwan University Institute of Clinical Medicine National Yang-Ming University Institute of Statistical Science Academia Sinica

ISBN: (纸本)9781457702150

This paper introduces a differential network biology for discovering tumor migration. We applied statistical methods to prioritize PPI candidates and an in situ proximity ligation assay to verify 67 endogenous PPIs among 21 interlinked pathways in two hepatocellular carcinoma (HCC) cells, Huh7 (minimally migratory cells) and Mahlavu (highly migratory cells). Differential network biology analysis was applied to determine the novel interaction, CRKL-FLT1, has a high centrality ranking, and the expression of this interaction is strongly correlated with the migratory ability of HCC and other cancer cell lines. Knockdown of CRKL and FLT1 in HCC cells leads to a decrease in cell migration. This study demonstrated that functional exploration of a disease network with differential network in interlinked pathways via PPIs can be used to discover tumor migration.

关键词： Cell Migration Cell Locomotion Protein-Protein Interaction human-centered computing Biological Science Disciplines biology Immigration Migrations Network pulse position indicator Differential Exploration Statistical methods cancer cell Circulating Neoplastic Cells

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Comparison of SVPWM, SPWM and HCC control techniques in power control of PMSG used in wind turbine systems

Comparison of SVPWM, SPWM and HCC control techniques in powe...

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International Aegean Conference on Electrical Machines and Power Electronics, ACEMP

作者： Naim Suleyman Ting Yusuf Yasa Ismail Aksoy Yakup Sahin Electrical Engineering Department Yildiz Technical University Istanbul Turkey

In this paper, the performance of space vector pulse width modulation (SVPWM), sinusoidal pulse width modulation (SPWM) and hysteresis current control (HCC) control techniques used in power control with back to back converter of permanent magnet synchronous generator used in wind turbines are comparatively analyzed in terms of dynamic response, total harmonic distortion (THD), torque ripple and current ripple. Furthermore, SVPWM and SPWM are compared in terms of the using DC link voltage. Analysis of system is realized with MATLAB/Simulink program. There is not paper that together of these three control techniques are compared in terms of common results or values in literature. Permanent magnet synchronous generator (PMSG) is used in simulations is surface mounted, bipolar and its power is 1.8 kW. However, PMSM's energy transmission to grid is made with Field Oriented Control (FOC). According to analysis results, it has been observed that SVPWM generally has more efficient results than both HCC and SPWM control technique. Also, it is observed that SVPWM can produce about 15 percent higher than SPWM in output voltage.

关键词： Field oriented control PMSG back to back converter hysteresis control space vector pulse width modulation Space vector pulse width modulation sinusoidal pulse width modulation Pregnant Mare Serum Gonadotropins machine vector control hysteresis control Power control Wind Energy Conversion Systems human-centered computing

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Hepatocellular carcinoma in GNMT-/- mice

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TOXICOLOGY AND APPLIED PHARMACOLOGY 2009年第2期237卷 246-246页

作者： Wagner, Conrad Luka, Zigmund Mato, Jose M. Vanderbilt Univ Sch Med Dept Biochem Nashville TN 37232 USA CIBERehd CIC bioGUNE Bizkaia Spain

The article "Glycine N-methyltransferase affects the metabolism of aflatoxin Bl and blocks its carcinogenic effect" from a group under the leadership of Dr. Arthur Chen in Taiwan is misleading (Yen, 2009). The first sentence of the abstract states that "Previously, we reported that glycine N-methyl-transferase (GNMT) knockout mice develop chronic hepatitis and hepatocellular carcinoma (HCC) spontaneously." This implies that these authors were the first to demonstrate this when, in fact, our group (Luka, Mato and Wagner) demonstrated this earlier.

关键词： Hepatocellular Cancer Taiwan Leadership GNMT gene knockout mouse Glycine N-Methyltransferase Aflatoxins Glycine Chronic Hepatitis human-centered computing snow goose

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Systematic review of outcome of downstaging hepatocellular cancer before liver transplantation in patients outside the Milan criteria (Br J Surg 2011;98: 1201-1208)

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BRITISH JOURNAL OF SURGERY 2011年第9期98卷 1209-1209页

作者： Mirza, D. F. Univ Hosp Birmingham NHS Trust Queen Elizabeth Hosp Birmingham B15 2TH W Midlands England

The aim of this systematic review was to assess the evidence on tumour downstaging before liver transplantation in patients with hepatocellular carcinoma (HCC) initially staged beyond the Milan criteria.

关键词： Liver Cirrhosis Review, Systematic Patients partial hepatectomy Hepatocellular Cancer Cirrhosis bromine Patient Selection Nodule size human-centered computing Transplantation Liver Transplantation

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Cryptogenic hepatocellular carcinoma (HCC) had worse overall survival of disease than viral HCC patients

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LIVER INTERNATIONAL 2018年第6期38卷 1140-1140页

作者： Xie, Yi-Lian Chu, Jin-Guo Li, Guo-Xiang Ningbo First Hosp Dept Infect & Liver Dis Ningbo Zhejiang Peoples R China

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