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Efficacy and safety of micafungin versus intravenous itraconazole as empirical antifungal therapy for febrile neutropenic patients with hematological malignancies: a randomized, controlled, prospective, multicenter study

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ANNALS OF HEMATOLOGY 2016年第2期95卷 337-344页

作者： Jeong, Seong Hyun Kim, Dae Young Jang, Jun Ho Mun, Yeung-Chul Choi, Chul Won Kim, Sung-Hyun Kim, Jin Seok Park, Joon Seong Ajou Univ Sch Med Dept Hematol Oncol Ajou Univ Hosp Suwon 441749 South Korea Univ Ulsan Coll Med Dept Hematol Asan Med Ctr Seoul South Korea Sungkyunkwan Univ Sch Med Samsung Med Ctr Div Hematol & Oncol Seoul South Korea Ewha Womans Univ Sch Med Mokdong Hosp Dept Internal Med Seoul South Korea Korea Univ Guro Hosp Dept Internal Med Div Oncol Hematol Seoul South Korea Dong A Univ Coll Med Dept Internal Med Busan South Korea Yonsei Univ Coll Med Severance Hosp Div HematolDept Internal Med Seoul South Korea

Micafungin, a clinically important echinocandin antifungal drug, needs to be investigated as empirical therapy in febrile neutropenia in comparison with azole compounds. A prospective randomized study was conducted to compare clinical outcomes between micafungin and intravenous itraconazole as an empirical therapy for febrile neutropenia in hematological malignancies. The antifungal drug (micafungin 100 mg or itraconazole 200 mg IV once daily) was given for high fever that was sustained despite the administration of appropriate antibiotics. Treatment success was determined by composite end points based on breakthrough invasive fungal infection (IFI), survival, premature discontinuation, defervescence, and treatment of baseline fungal infection. Duration of fever, hospital stay, and overall survival (OS) were studied. A total of 153 patients were randomized to receive micafungin or itraconazole. The overall success rate was 7.1 % point higher in the micafungin group (64.4 vs. 57.3%, p=0.404), satisfying the statistical criteria for the non-inferiority of micafungin. The duration of fever and hospital stay were significantly shorter in the micafungin group (6 vs. 7 days, p=0.014;22 vs. 27 days, p=0.033, respectively). Grade 3 adverse events including hyperbilirubinemia (2 vs. 7), elevation of transaminase levels (2 vs. 4), electrolyte imbalance (1 vs. 2), atrial fibrillation (1 vs. 0), and anaphylaxis (1 vs. 0) occurred in 7 and 13 patients in the micafungin (10.4 %) and itraconazole (18.8 %) groups, respectively. Micafungin, when compared with itraconazole, had favorably comparable success rate and toxicity profiles on febrile neutropenia in patients with hematological malignancies. In addition, it showed superior effect on shortening the hospital stay.

关键词： Micafungin empirical Febrile neutropenia

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An empirical comparison of MRPII and Demand-Driven MRP

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IFAC-PapersOnLine 2016年第12期49卷 1725-1730页

作者： Miclo, R. Fontanili, F. Lauras, M. Lamothe, J. Milian, B. Industrial Engineering Department University of Toulouse Mines Albi Route de Teillet Albi81000 France AGILEA S.A.S. 9 rue Michel Labrousse Toulouse31100 France

The Demand-Driven MRP (DDMRP) is a method for managing flows in manufacturing and distribution that is supposed to manage uncertainties better than traditional Manufacturing Resources Planning (MRP) using some principles of pull approaches. In this paper, a case-study is investigated in order to objectively and quantitatively compare these two systems. A Discrete-Event Simulation (DES) approach is used to evaluate impacts on system behaviors regarding both methods. Results show insights on the interests of DDMRP. © 2016

关键词： Manufacture Discrete event simulation Production control Demand driven empirical comparisons Flexible manufacturing System behaviors Traditional manufacturing

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Multi Variable empirical Formula for SFRC Compressive, Tensile, And Shear Strength

Multi Variable Empirical Formula for SFRC Compressive, Tensi...

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International Conference on Studies in Arts, Humanities and Social Sciences (SAHSS-2017);Int’l Conference on Studies in Law, Education, Business and Corporate Social Responsibilities (LEBCSR-17);International Conference on Literature, English, Religious and Interdisciplinary Studies (LERIS-2017);Int’l Conference on Research & Innovation in Computer, Electronics and Manufacturing Engineering (RICEME-17);International Conference on Chemical, Agricultural, Biological and Health Sciences (CABHS-2017);International Conference on Civil, Disaster Management and Environmental Sciences (CDMES-17)

作者： Sheikha Mohammed AL-Shukaili Qadir Bux alias Imran Latif Department of Civil and Environmental Engineering College of EngineeringUniversity of Nizwa (UoN)

Steel fiber-reinforced concrete(SFRC) is a cementations material reinforced with discrete fiber. Since 4 decades SFRC mechanical properties has been investigated and used as a construction material for different civil engineering projects such as concrete pavements, etc. A number of studies have demonstrated the technical merits and de-merits of SFRC over conventional concrete. Different types of steel fiber can be used as steel fiber reinforcement in concrete, such as plain, hooked, crimped and twisted etc. Each of them has different effects on the concrete depended on its shape physical and mechanical properties. In this paper new multivariable empirical formulas have been developed for compressive, tensile and shear strength of SFRC. It is found that new developed equation based on multiple variables predicts good results in comparison with experimental data.

关键词： SFRC empirical Steel fiber Multiple Variable Compressive Shear Tensile

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Chinese Astronomers Created an empirical Stellar Spectra Library from LAMOST

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Bulletin of the Chinese Academy of Sciences 2018年第4期32卷 235-235页

Astronomers from the National Astronomical Observatories of Chinese Academy of Sciences(NAOC) present an empirical stellar spectra library created with spectra from the LAMOST Data Release 5 (DR5). This library repres... 详细信息

关键词： Chinese Astronomers an empirical Stellar Spectra Library LAMOST

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empirically derived Coloured Dissolved Organic Matter absorption coefficient using in-situ and Sentinel 3/OLCI in coastal waters of India

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INTERNATIONAL JOURNAL OF REMOTE SENSING 2022年第4期43卷 1430-1450页

作者： Sahay, Arvind Ali, Syed Moosa Raman, Mini Gupta, Anurag Motwani, Gunjan Thakker, Rohan Tirkey, Anima Solanki, Hitesh A. Shanmugam, Palanisamy Space Applicat Ctr ISRO Marine Ecosyst Div Ahmadabad Gujarat India Univ Gujarat Dept Bot Ahmadabad Gujarat India Indian Inst Technol Madras Dept Ocean Engn Chennai Tamil Nadu India

Chromophoric Dissolved Organic Matter (CDOM) is the fraction of dissolved organic matter that absorbs sun light in ultra-violet and visible region of the electromagnetic radiation. CDOM is abundantly found in marine and coastal waters and is very important to studying optical properties of water columns and biogeochemistry of the water. It is a proxy to study dissolved organic carbon pools in marine and freshwater pools. This research aims to establish a relation between CDOM absorption and remote sensing reflectance in coastal waters of India using a large pool of in-situ data set. This study is very significant to studying CDOM distribution, its variability and the coastal processes that influence its distribution on larger time scales (seasonal to decadal changes) through ocean colour sensors. This study presents a new empirical algorithm for estimation of CDOM absorption (412nm) in Indian coastal waters using remote sensing reflectance that has not been reported so far. The study also presents its slope and variability in different regions of coastal waters of India using in-situ data. A large pool of 409 datasets has been generated using NASA bio-Optical Marine Algorithm Dataset/SeaWiFS Bio-Optical Archive and Storage System (NOMAD/SeaBASS) datasets and Indian coastal waters datasets collected during 2014-18 exclusively for coastal waters of India. A power equation is obtained using the ratio of remote sensing reflectance (Rrs412/Rrs555) to derive CDOM absorption with R-2=0.74. The retrieved absorption coefficient is further validated with independent in-situ data set using another 58 station points with R-2=0.84. The root mean square error is 0.03 m(-1) (with 20% standard error in modelled data). CDOM slope (S412-443) is also estimated from in-situ data and it varies from 0.010-0.020 (units nm(-1)) with a mean value of 0.015 (nm(-1)) for Indian coastal waters. CDOM absorption coefficient (412 nm) varies between 0.01-0.8 m(-1) for 90% of the stations whereas re

关键词： empirical algorithm coastal waters coloured dissolved organic matter (CDOM) CDOM absorption slope etc

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An empirical Study on the Effect of Financial Resources Allocation Efficiency on International Trade Growth from the Perspective of Supply Side Reform

An Empirical Study on the Effect of Financial Resources Allo...

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2nd International Conference on Humanities Science,Management and Education Technology(HSMET 2017)

作者： Lu-xia Yi Yu-cong You Guangzhou College of Business and Technology

In the era of post-crisis, the international trade environment faced by Guangdong Province has undergone significant changes. With the popularization of the Internet, the flow of international transnational capital has become increasingly rapid and convenient, and the atmosphere of global financial liberalization has become increasingly strong. This makes the breadth of the efficiency of the allocation of financial resources exert an impact on the international trade growth, which has already become the focus of international trade scholars. In order to better determine and make use of the financial moderation principle in the development of international trade in Guangdong Province, it is necessary and urgent to study the effect of the allocation of financial resources in Guangdong Province on the growth of international trade. This paper, through the establishment of the Regression Model, has analyzed and discussed the data of the efficiency of the allocation of financial resources, as well as the breadth of the efficiency of the allocation of financial resources. The conclusion is that Guangdong Province has crossed the turning point of financial moderation "inverted U" curve and it can not blindly expand the financial scale or else the distorted market may lead to new financial risks. Some suggestions are put forward accordingly in light of the conclusion.

关键词： supply side reform financial resources allocation financial moderation trade empirical

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Influencing Factors Increasing Popularity on Facebook - empirical Insights from European Users 1

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19th International Conference on Business Information Systems (BIS)

作者： Schmidt, Rainer Mohring, Michael Harting, Ralf-Christian Reichstein, Christopher Keller, Barbara Aalen Univ Appl Sci Business Informat Syst Aalen Germany Munich Univ Appl Sci Business Informat Syst Munich Germany

ISBN: (数字)9783319394268

ISBN: (纸本)9783319394268;9783319394251

Popularity in social networks is a significant indicator of social success in western societies. The social capital within social networks has become an important element of social status. Therefore, the paper investigates why some users on Facebook receive more likes than others. The authors created eight hypotheses to test the influence of determinants on the popularity on the social media platform Facebook. The results show that especially gender, age, written posts and uploaded pictures or videos as well as adding new friends influences the popularity on Facebook.

关键词： Social media behavior Facebook Likes Popularity empirical study empirical Popularity

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Cluster analysis in empirical OM research: survey and recommendations

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INTERNATIONAL JOURNAL OF OPERATIONS & PRODUCTION MANAGEMENT 2017年第3期37卷 300-320页

作者： Brusco, Michael J. Singh, Renu Cradit, J. Dennis Steinley, Douglas Florida State Univ Tallahassee FL 32306 USA South Carolina State Univ Dept Mkt Orangeburg SC USA Florida State Univ Dept Analyt Informat Syst & Supply Chain Tallahassee FL 32306 USA Univ Missouri Columbia MO USA

Purpose - The purpose of this paper is twofold. First, the authors provide a survey of operations management (OM) research applications of traditional hierarchical and nonhierarchical clustering methods with respect to key decisions that are central to a valid analysis. Second, the authors offer recommendations for practice with respect to these decisions. Design/methodology/approach - A coding study was conducted for 97 cluster analyses reported in six OM journals during the period spanning 1994-2015. Data were collected with respect to: variable selection, variable standardization, method, selection of the number of clusters, consistency/stability of the clustering solution, and profiling of the clusters based on exogenous variables. Recommended practices for validation of clustering solutions are provided within the context of this framework. Findings - There is considerable variability across clustering applications with respect to the components of validation, as well as a mix of productive and undesirable practices. This justifies the importance of the authors' provision of a schema for conducting a cluster analysis. Research limitations/implications - Certain aspects of the coding study required some degree of subjectivity with respect to interpretation or classification. However, in light of the sheer magnitude of the coding study (97 articles), the authors are confident that an accurate picture of empirical OM clustering applications has been presented. Practical implications - The paper provides a critique and synthesis of the practice of cluster analysis in OM research. The coding study provides a thorough foundation for how the key decisions of a cluster analysis have been previously handled in the literature. Both researchers and practitioners are provided with guidelines for performing a valid cluster analysis. Originality/value - To the best of the authors' knowledge, no study of this type has been reported in the OM literature. The authors' recommend

关键词： empirical Literature review Methodology for operations management

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Challenges of empirical Antibiotic Therapy for Community-Acquired Pneumonia in Children

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CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL 2017年 84卷 E7-E11页

作者： Rodrigues, Charlene M. C. Univ Oxford Dept Zool Tinbergen BldgS Pk Rd Oxford OX1 3PS England Newcastle Upon Tyne Hosp Fdn Trust Dept Paediat Immunol & Infect Dis Great North Childrens Hosp Newcastle Upon Tyne Tyne & Wear England

Background: Community-acquired pneumonia (CAP) is a leading cause of morbidity and mortality globally, responsible for more than 14% of deaths in children younger than 5 years of age. Due to difficulties with pathogen identification and diagnostics of CAP in children, targeted antimicrobial therapy is not possible, hence the widespread use of empirical antibiotics, in particular penicillins, cephalosporin, and macrolides. Objectives: This review aimed to address medical, societal, and political issues associated with the widespread use of empirical antibiotics for CAP in the United Kingdom, India, and Nigeria. Methods: A literature review was performed identifying the challenges pertaining to the use of widespread empirical antibiotics for CAP in children. A qualitative analysis of included studies identified relevant themes. empirical guidance was based on guidelines from the World Health Organization, British Thoracic Society, and Infectious Diseases Society of America, used in both industrialized and resource-poor settings. Results: In the United Kingdom there was poor adherence to antibiotics guidelines. There was developing antibiotic resistance to penicillins and macrolides in both developing and industrialized regions. There were difficulties accessing the care and treatment when needed in Nigeria. Prevention strategies with vaccination against Streptococcus pneumonia, Haemophilus influenza, and measles are particularly important in these regions. Conclusions: Effective and timely treatment is required for CAP and empirical antibiotics are evidence-based and appropriate in most settings. However, better diagnostics and education to target treatment may help to prevent antibiotic resistance. Ensuring the secure financing of clean food and water, sanitation, and public health infrastructure are also required to reduce the burden of disease in children in developing countries. (C) 2017. The Authors. Published by Elsevier Inc.

关键词： antibiotics chest infection community-acquired pneumonia empirical lower respiratory tract infection management

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Exploring the archetypes of engineer-to-order: an empirical analysis

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INTERNATIONAL JOURNAL OF OPERATIONS & PRODUCTION MANAGEMENT 2016年第3期36卷 242-264页

作者： Willner, Olga Powell, Daryl Gerschberger, Markus Schonsleben, Paul ETH BWI Ctr Ind Management Dept Management Technol & Econ Zurich Switzerland Norwegian Univ Sci & Technol Fac Engn Sci & Technol Dept Prod & Qual Engn Trondheim Norway Univ Appl Sci Upper Austria Logistikum Steyr Austria

Purpose - The purpose of this paper is to conceptualize archetypes of engineer-to-order (ETO) to support companies in determining the appropriate degree of design standardization and automation, and as a result achieve superior performance. Products of ETO manufacturers are classified in a 2 x 2 matrix using annual units sold and engineering complexity as dimensions. Design/methodology/approach - This research adopted a theory refining approach based on multiple case studies. Seven ETO manufacturers from different industry sectors participated in the study. Data collection was primarily based on a series of in-depth interviews supported by observations and archival sources. Findings - The paper proposes four distinct archetypes of ETO (complex, basic, repeatable, and non-competitive) and empirically validates three of them. The organizational structures and processes most suitable for the different archetypes are described, and standardization and automation strategies are linked to the quadrants of the matrix. The matrix can support practitioners in making strategic choices and provides a framework for benchmarking their ETO products and processes. Originality/value - Existing conceptualizations of ETO consider the company as the primary object of investigation, rather than the product or product family. However, companies often have different product families demanding different strategies. Also, there is little or no focus on the engineering perspective. The authors move the engineering perspective to the center of investigation and identify a set of standardization and automation strategies for different types of ETO products.

关键词： Operations strategy Classification empirical Case study Engineer-to-order Mass customization

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