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中国误诊学杂志 2010年第13期10卷 3027-3028页

作者：丁宇陈倩张丽杨庭树解放军总医院南楼心血管一科北京100853

目的:探讨舒张性心衰(DHF)患者血清三碘甲状腺原氨酸(T3)与脑利钠肽(BNP)的关系。方法:96例慢性舒张性心力衰竭患者测定血清T3和BNP浓度。其中低T3血症的舒张性心衰患者45例(低T3组),血清T3水平正常的舒张性心衰患者51例(正常T3组),观... 详细信息

目的:探讨舒张性心衰(DHF)患者血清三碘甲状腺原氨酸(T3)与脑利钠肽(BNP)的关系。方法:96例慢性舒张性心力衰竭患者测定血清T3和BNP浓度。其中低T3血症的舒张性心衰患者45例(低T3组),血清T3水平正常的舒张性心衰患者51例(正常T3组),观察两组BNP水平。结果:低T3组与正常T3组的舒张性心衰患者血清BNP水平均高于正常,两组分别为(557.4±92.4)ng/L和(308.9±84.6)ng/L,低T3血症组的BNP水平显著升高(P<0.01)。结论:舒张性心衰伴低T3血症患者,血清BNP升高更明显。

关键词：心力衰竭,充血性/血液三碘甲状腺原氨酸/血液利钠肽,脑/血液

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慢性肾功能不全患者血清T3、T4、TSH含量变化的临床意义

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中华肾脏病杂志 1989年第4期5卷 251-252页

作者：柯永胜陶月玉严文魁李苏俞国华陈月萍王荣鑫皖南医学院戈矶山医院同位素室皖南医学院戈矶山医院内科

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甲状腺功能低下症血液TSH、T_4、T_3水平与甲状腺形态变化278例分析

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中国误诊学杂志 2007年第22期7卷 5340-5341页

作者：臧桂运山东省兖州市铁路医院检验科 272100

目的:探究甲状腺功能低下症血液TSH、T4、T3含量与甲状腺形态学变化的关系。方法:对278例先天性甲状腺功能低下症行甲状腺核素扫描,并测定血清TSH、T4、T3含量。结果:暂时性甲状腺功能低下症和甲状腺基本正常的永久性甲状腺功能低下症血... 详细信息

目的:探究甲状腺功能低下症血液TSH、T4、T3含量与甲状腺形态学变化的关系。方法:对278例先天性甲状腺功能低下症行甲状腺核素扫描,并测定血清TSH、T4、T3含量。结果:暂时性甲状腺功能低下症和甲状腺基本正常的永久性甲状腺功能低下症血液TSH、T4、T3含量与甲状腺形态和功能异常者差异有显著性(P<0.01),甲状腺缺如、异位患儿血液TSH、T4、T3含量与甲状腺发育不良、摄锝功能低下患儿差异有显著性(P<0.01)。结论:甲状腺形态和功能的变化与血液TSH、T4、T3水平有关。

关键词：甲状腺功能减退症/血液/病理学甲状腺/病理学促甲状腺素/血液三碘甲状腺原氨酸/血液人类

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肝硬化患者血清FT_3、FT_4和hTSH检测的临床意义

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吉林大学学报（医学版） 2004年第1期30卷 135-137页

作者：魏丽琴徐伟郭宏华吉林大学中日联谊医院核医学科吉林长春130031 吉林大学第二医院内科吉林长春130041 吉林大学中日联谊医院消化内科吉林长春130031

目的 :探讨肝硬化患者血清游离三碘甲腺原氨酸 (FT3)、游离甲状腺素 (FT4 )和高灵敏促甲状腺素(h TSH )变化与肝硬化患者的病情程度、预后、血清白蛋白、凝血酶原时间及总胆红素的关系。方法 :应用时间分辨荧光免疫分析测定 2 1 6例不... 详细信息

目的 :探讨肝硬化患者血清游离三碘甲腺原氨酸 (FT3)、游离甲状腺素 (FT4 )和高灵敏促甲状腺素(h TSH )变化与肝硬化患者的病情程度、预后、血清白蛋白、凝血酶原时间及总胆红素的关系。方法 :应用时间分辨荧光免疫分析测定 2 1 6例不同程度肝硬化患者血清 FT3、 FT4 和 h TSH含量 ,用 L X- 2 0全自动生化分析仪测定血清白蛋白和总胆红素 ,用 ACL - 2 0 0血凝分析仪测定凝血酶原时间。结果 :肝硬化静止期和肝硬化活动期与正常对照比较 FT3、 FT4 和 TSH差异均有显著性 (P<0 .0 1 )。低 FT3和 FT4 血症与凝血酶原时间延长呈负相关(r=0 .2 6 8,P<0 .0 5 ;r=0 .2 2 0 ,P<0 .0 5 ) ,与白蛋白浓度呈正相关 (r=0 .5 0 ,P<0 .0 5 ;r=0 .4 0 ,P<0 .0 5 ) ,与胆红素浓度无关。结论 :血清 FT3和 FT4

关键词：肝硬化/血液三碘甲状腺原氨酸/血液甲状腺素/血液血清白蛋白/分析凝血酶原时间胆红素/血液

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慢性心力衰竭合并甲状腺功能病态综合征142例临床分析

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陕西医学杂志 2007年第12期36卷 1653-1655页

作者：芦广萍闫爱春庞学书河北北方学院校医院张家口075000

目的:探讨慢性心力衰竭(CHF)合并正常甲状腺功能病态综合征(ESS)的发生率及其特点。方法:检测142例CHF患者(观察组)及87例健康者(对照组)血清T3、T4、FT3、FT4、TSH,对比两组甲状腺功能检查结果,统计ESS的发生率,分析CHF程度与ESS的关系... 详细信息

目的:探讨慢性心力衰竭(CHF)合并正常甲状腺功能病态综合征(ESS)的发生率及其特点。方法:检测142例CHF患者(观察组)及87例健康者(对照组)血清T3、T4、FT3、FT4、TSH,对比两组甲状腺功能检查结果,统计ESS的发生率,分析CHF程度与ESS的关系,观察ESS对预后的影响。结果:观察组甲状腺功能明显异常,ESS发生率22.5%,随着心力衰竭的加重,ESS的发生率增加,合并ESS组病死率明显高于非ESS组。结论:CHF常合并ESS,是CHF患者预后不良的指标,严重CHF患者补充甲状腺素治疗可改善预后。

关键词：心力衰竭充血性/并发症 @甲状腺功能病态综合征三碘甲状腺原氨酸/血液甲状腺素/血液

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HYPOTHALAMIC-PITUITARY FUNCTION IN ANOREXIA-NERVOSA

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ACTA ENDOCRINOLOGICA 1975年第2期78卷 209-221页

作者： FRANKEL, RJ JENKINS, JS ST GEORGES HOSP LONDON SW1ENGLAND

Hypothalamic-pituitary function was studied in 4 patients with anorexia nervosa of different degree of severity before and after refeeding. Gonadotrophin secretion was low in all subjects and improved in two after a prolonged period of feeding. In one subject there was a failure of pituitary gonadotrophin secretion after the administration of hypothalamic gonadotrophin-releasing hormone but the response was restored to normal after treatment. Thyroid function was reduced in one patient only but returned to normal after intravenous therapy for 6 days. Growth hormone and cortisol levels were elevated in all patients, and in one severe case the growth hormone values were extremely high. There was also a disturbance of the hypothalamic control of growth hormone and pituitary-adrenal function, which returned to normal after refeeding. One patient with severe hypothermia was resistant to the administration of a pyrogen, but developed a normal febrile response after treatment.

关键词：神经性厌食/血液神经性厌食/膳食疗法神经性厌食/病理生理学血糖发热卵泡刺激素/血液促性腺素释放激素生长激素/血液下丘脑-垂体系统/病理生理学低温/病理生理学促黄体激素/血液卵巢/病理生理学垂体肾上腺系统/病理生理学热原睾酮/血液甲状腺/病理生理学促甲状腺素/血液甲状腺素/血液三碘甲状腺原氨酸/血液青少年成年人女(雌)性人类男(雄)性

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The two thyroid hormone receptor genes have opposite effects on estrogen-stimulated sex behaviors

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NATURE NEUROSCIENCE 2000年第5期3卷 472-475页

作者： Dellovade, TL Chan, J Vennstrom, B Forrest, D Pfaff, DW Rockefeller Univ Neurobiol & Behav Lab New York NY 10021 USA Karolinska Inst Dept Cell & Mol Biol Dev Biol Lab Stockholm Sweden CUNY Mt Sinai Sch Med Dept Human Genet New York NY 10029 USA

The two genes coding for thyroid hormone receptors (TR) alpha 1 and beta have opposite effects on female sex behaviors. Deletion of TR alpha 1 reduced them, whereas deletion of TRP actually increased them. These results could not be attributed to altered levers of hormones in the blood, general alterations in estrogen responsiveness or altered general activity. Instead, they indicate a previously unknown molecular mechanism upon which the two TR genes exert opposite influences.

关键词：体重/药物作用雌二醇/类似物和衍生物雌二醇/血液雌二醇/药理学雌激素类/血液雌激素类/药理学基因缺失小鼠近交系小鼠基因敲除器官测量/药物作用催产素/分析下丘脑室旁核/化学下丘脑室旁核/细胞学体位视前区/化学视前区/细胞学孕酮/药理学受体雌激素/分析受体甲状腺激素/遗传学受体甲状腺激素/生理学性行为动物/药物作用甲状腺素/血液三碘甲状腺原氨酸/血液子宫/药物作用子宫/生长和发育血管升压素类/分析动物女(雌)性男(雄)性小鼠

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HYPER-THYROIDISM IN THE ELDERLY

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JOURNAL OF THE AMERICAN GERIATRICS SOCIETY 1979年第4期27卷 152-155页

作者： KAWABE, T KOMIYA, I ENDO, T KOIZUMI, Y YAMADA, T SHINSHU UNIV SCH MED INST ADAPTAT MED DEPT MED MATSUMOTO 390 JAPAN

In 65 elderly hyperthyroid patients (age range 50-78 yr), sex differences, signs and symptoms and thyroid function were studied and the data were compared with those on 48 young hyperthyroid patients (age range 20-29 yr). The incidence of hyperthyroidism was 3.5 times higher in females than in males among the young patients, whereas it was approximately equal in males and females among the elderly patients. Signs and symptoms conformed with the textbook description in the young subjects but not in the elderly ones. Measurements of serum triiodothyronine (T3) and thyroxine (T4) proved useful in preventing false diagnoses in elderly patients with atypical symptoms. In some elderly subjects with marginal increases of serum T3 and T4 concentrations, measurement of serum thyroid-stimulating hormone (TSH) after administration of thyrotropin-releasing hormone (TRH) was required to achieve an accurate diagnosis. Serum T3 and T4 levels and the thyroidal uptake of radioiodine were slightly but not significantly lower in the elderly than in the young patients. A high titer of circulating thyroid auto-antibody in the elderly may be related to this slight decrease in thyroid function. Serum T3 levels were significantly lower in the elderly than in the young subjects;this suggests impairment of peripheral monodeiodination of T4. Any abnormal serum levels of T4, T3, and TSH before and after administration of TRH could easily be restored to normal by treatment with antithyroid drugs in the elderly patients.

关键词：诊断鉴别甲状腺功能亢进症/血液甲状腺功能亢进症/诊断甲状腺功能亢进症/药物疗法甲巯咪唑/治疗应用促甲状腺素/血液促甲状腺素释放激素甲状腺素/血液三碘甲状腺原氨酸/血液成年人老年人女(雌)性人类男(雄)性中年人

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THYROID-FUNCTION TESTS IN THYROXINE-BINDING GLOBULIN DEFICIENCY

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ANNALS OF CLINICAL BIOCHEMISTRY 1979年第NOV期16卷 313-314页

作者： CUSICK, CF WARWICKSHIRE HOSP COVENTRY CV1 4FH ENGLAND

Results are presented on 2 patients with complete and 2 with partial thyroxine-binding globulin (TBG) deficiency. All 4 subjects had lowered serum thyroxine but were clinically euthyroid. While thyroid hormone uptake tests or TBG assay were effective in the recognition of such individuals, indices based on these tests were misleading in assessing their thyroid status. Results within the reference range were obtained with the Immophase Free Thyroxine assay.

关键词：球蛋白类/缺乏血清球蛋白类/缺乏甲状腺功能试验促甲状腺素/血液甲状腺素/血液甲状腺素结合蛋白质类/缺乏三碘甲状腺原氨酸/血液青少年成年人女(雌)性人类男(雄)性中年人

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Leptin and the pituitary-thyroid axis: a comparative study in lean, obese, hypothyroid and hyperthyroid subjects

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CLINICAL ENDOCRINOLOGY 1998年第5期49卷 583-588页

作者： Pinkney, JH Goodrick, SJ Katz, J Johnson, AB Lightman, SL Coppack, SW Mohamed-Ali, V Univ Bristol Bristol Royal Infirm Dept Med Bristol BS2 8HW Avon England UCL Div Med London England Southmead Hosp Dept Endocrinol & Diabet Bristol Avon England

OBJECTIVE To study interactions between leptin and the pituitary-thyroid axis, both in euthyroid and dysthyroid states, SUBJECTS AND MEASUREMENTS We investigated the relationships of plasma leptin to levels of free thyroid hormones and TSH in 18 patients with newly diagnosed hyperthyroidism, 22 with newly diagnosed primary hypothyroidism, and 32 lean (body mass index [BMI] < 30) and 37 obese (BMI > 30 kg/m(2)) euthyroid subjects. Hypothyroid patients were restudied during thyroxine replacement treatment, RESULTS Median [interquartile range] plasma leptin concentrations were highest in obese euthyroid subjects (31.5 [19.0-48.0] and in untreated hypothyroid patients (19.2 [11.5-31.5]), and lowest levels in untreated hyperthyroid patients (8.9 [5.5-11.1]) and lean euthyroid control subjects (6.6 [3.9-14.4] mu g/l (Kruskall-Wallis one-way analysis of variance;P< 0.0001). In euthyroid subjects, plasma leptin levels were higher in obese than in lean subjects (P< 0.00001). in obese subjects plasma levels of TSH correlated with percentage body fat (r = 0.67;P< 0.001) and plasma leptin (r = 0.61;P<0.001). In untreated hyperthyroid subjects plasma leptin was unrelated to free T3, and in untreated hypothyroidism plasma leptin was unrelated to either free T3 or TSH concentrations tall P = NS), In untreated hyperthyroid, but not hypothyroid, patients plasma leptin concentrations correlated with BMI (r = 0.57;P = 0.02). Treatment of hypothyroidism with thyroxine resulted in a significant reduction in plasma leptin concentrations from 20.8 (11.8 to 31.6) to 12.9 (4.6-21.2) mu g/l (P = 0.005), but BMI did not change significantly in the hypothyroid subjects being studied prospectively, CONCLUSIONS (i) In euthyroid subjects, plasma leptin and TSH levels correlate, and both are positively correlated with adiposity, (ii) Plasma leptin was significantly elevated in hypothyroid subjects, to levels similar to those seen in obese euthyroid subjects. (iii) Treatment of hypothyroidism resul

关键词：方差分析人体质量指数甲状腺功能亢进症/代谢甲状腺功能减退症/药物疗法甲状腺功能减退症/代谢瘦素肥胖症/代谢垂体/代谢蛋白质类/代谢甲状腺疾病/药物疗法甲状腺疾病/代谢甲状腺/代谢促甲状腺素/血液甲状腺素/治疗应用三碘甲状腺原氨酸/血液成年人女(雌)性人类男(雄)性中年人

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