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Effects of topical diclofenac and prednisolone eyedrops in laser in situ keratomileusis patients

JOURNAL OF CATARACT AND REFRACTIVE SURGERY 1999年第6期25卷 836-841页

作者： Vantesone, DL Luna, JD Muiño, JC Juárez, CP Fdn Ver RA-500 Cordoba Argentina

Purpose: To compare the effects of a topical nonsteroidal anti-inflammatory agent, diclofenac, and prednisolone acetate on wound healing, postoperative inflammation, and other clinical parameters in laser in situ keratomileusis (LASIK) patients. Setting: Fundacion VER, Cordoba, Argentina. Methods: Laser in situ keratomileusis for myopia was performed simultaneously in both eyes of 16 patients by 1 surgeon. Patients were prospectively randomized to receive diclofenac eyedrops in the right eyes and prednisolone acetate eyedrops in the left, Postoperatively, the drops were administered topically every 2 hours the first day, every 6 hours the first week, every 8 hours the second week, and once a day the fourth week. Preoperatively and at each postoperative visit, evaluation of visual acuity, slitlamp biomicroscopy, corneal topography, and clinical scoring (0-III) of pain and photophobia were done;epithelial interface opacities were objectively evaluated. Follow-up was at 24, 48, and 72 hours, 1, 2, and 3 weeks, and 1, 2, 3, and 6 months. A paired t test was used for statistical analysis. Results: Mean age of the 16 patients was 29.4 years +/- 6.5 (SD). Preoperatively, mean spherical equivalent was -5.83 +/- 3.61 diopters (D) in the right eyes and -6.96 +/- 4.66 D in the left eyes. At 6 months postoperatively, it was -1.83 +/- 1.87 D and -1.88 +/- 2.13 D, respectively. In the first 24 hours, there were significant clinical symptoms in the diclofenac group. Conclusions: Wound healing was stable, with no regression, in the diclofenac and prednisolone groups. Both anti-inflammatory agents worked well in LASIK patients. J Cataract Refract Surg 1999;25:836-841 (C) 1999 ASCRS and ESCRS.

关键词：投药局部消炎药/投药和剂量消炎药/治疗应用消炎药非甾类/投药和剂量消炎药非甾类/治疗应用角膜/药物作用角膜/外科学角膜移植/方法二氯酚酸/投药和剂量二氯酚酸/治疗应用双盲法炎症/药物疗法激光疗法近视/外科学眼药水/投药和剂量眼药水/治疗应用泼尼松龙/投药和剂量泼尼松龙/类似物和衍生物泼尼松龙/治疗应用前瞻性研究葡萄膜炎前/药物疗法伤口愈合/药物作用成年人女(雌)性人类男(雄)性

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Evaluation of different mathematical methods describing drug liberation from new, "soft-patch" type matrix systems

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PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY 1999年第2期4卷 291-294页

作者： Csóka, G Dredán, J Marton, S Antal, I Rácz, I Semmelweis Univ Med Inst Pharmaceut H-1092 Budapest Hungary

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关键词：消炎药非甾类/投药和剂量二氯酚酸/投药和剂量药物释放系统凝胶类数学溶解度硬脂酸盐类/投药和剂量

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Percutaneous transport of diclofenac sodium from mixtures of fatty alcohol (or fatty acid) and propylene glycol through the rabbit abdominal skin

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DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY 1999年第11期25卷 1209-1213页

作者： Wong, CY Guu, YB Wang, MT Wang, DP Natl Def Med Ctr Sch Pharm Taipei Taiwan Kaohsiung Vet Gen Hosp Dept Orthopaed Kaohsiung Taiwan Tri Serv Gen Hosp Dept Pharm Taipei Taiwan

Diclofenac sodium is a nonsteroidal anti-inflammatory drug with analgesic, antipyretic, and anti-inflammatory activity. When used in a topical application, diclofenac can diffuse through the skin and into the subcutaneous tissue to effect the anti-inflammatory action. In this study, in vitro evaluations of the percutaneous transport of diclofenac sodium in various bases containing fatty alcohols/propylene glycol or fatty acid/propylene glycol mixtures through the abdominal skin of the rabbit were investigated. Results show that the transdermal flux of diclofenac sodium in the fatty alcohol/propylene glycol bases of the same ratio is affected by the chain length of the fatty alcohol, and its effect is in the order of C-10 > C-12 > C-14 > C-18. However, the transdermal flux of diclofenac sodium in the fatty acid/propylene glycol bases of the same ratio is also affected by the chain length of the fatty acid but no absolute relationship was found. For the same chain length of fatty acid and fatty alcohol used in the formulation base that was otherwise the same, the transdermal flux of diclofenac sodium is higher in the formula containing fatty alcohol than that containing fatty acid.

关键词：腹部投药皮肤投药局部消炎药/投药和剂量消炎药/药代动力学色谱法高压液相二氯酚酸/投药和剂量二氯酚酸/药代动力学脂肪酸类脂肪族醇类软膏基质丙二醇类皮肤吸收/生理学甾类动物兔

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甲钴胺联合扶他林乳胶剂治疗带状疱疹后遗神经痛疗效观察

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中国医师杂志 2012年第5期14卷 711-712页

作者：罗习林梁丽湘乡市人民医院皮肤科湖南省湘潭411400

目的观察甲钴胺联合扶他林乳胶剂治疗带状疱疹后遗神经痛的临床疗效。方法将92例带状疱疹后遗神经痛患者分为两组，观察组（47例）：给予甲钴胺0．5mg口服3次／d，扶他林乳胶剂涂患处，4次／d；对照组（45例）：消炎痛25mg口服，3次／d... 详细信息

目的观察甲钴胺联合扶他林乳胶剂治疗带状疱疹后遗神经痛的临床疗效。方法将92例带状疱疹后遗神经痛患者分为两组，观察组（47例）：给予甲钴胺0．5mg口服3次／d，扶他林乳胶剂涂患处，4次／d；对照组（45例）：消炎痛25mg口服，3次／d，维生素B，10mg口服，3次／d，雷尼替丁胶囊0．15g口服，2Z~／d，2组疗程均为4周。于治疗前和治疗2、4、6、8周采用视觉模拟量表进行疼痛评分，比较两组疗较及不良反应。结果92例患者在治疗中无一例脱落，顺利完成疗程。观察组治愈38例，治愈率80．9％，对照组治愈25例，治愈率55．6％，观察组治愈率明显高于对照组（P〈0．01）。两组患者治疗前VAS评分比较，差异无统计学意义（P〉0．05），在治疗后第2、4、6、8周观察组患者VAS评分明显低于对照组，其差异均有统计学意义（P〈0．01），观察组不良反应发生率低于对照组（x2=5．414，P〈0．05）。结论甲钴胺联合扶他林乳胶剂治疗带状疱疹后遗神经痛可明显缓解疼痛，提高治愈率，不良反应极少，值得推广应用。

关键词：钴胺酰胺类/投药和剂量二氯酚酸/类似物和衍生物二氯酚酸/投药和剂量药物疗法联合神经痛带状疱疹后/药物疗法

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双氯酚酸超前镇痛用于小儿日间手术的效果

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医学临床研究 2010年第1期27卷 30-32页

作者：张薏欧英余四川省成都市第六人民医院麻醉科四川省成都市妇幼保健院麻醉科四川成都610031

【目的】探讨双氯酚酸超前镇痛用于小儿日间手术的效果。【方法】选取进行日间手术的患儿138例，其中男120例，女18例，年龄11个月至7岁，体重10～30kg。根据给药时间的不同，将患儿随机分成实验组和对照组。对患儿苏醒时（P1）、苏醒后... 详细信息

【目的】探讨双氯酚酸超前镇痛用于小儿日间手术的效果。【方法】选取进行日间手术的患儿138例，其中男120例，女18例，年龄11个月至7岁，体重10～30kg。根据给药时间的不同，将患儿随机分成实验组和对照组。对患儿苏醒时（P1）、苏醒后30min（P2）及60min（P3）分别进行疼痛评分并监测其生命体征。【结果】实验组患儿P1、P2时点的疼痛评分均明显低于对照组（P〈0．05），P3时点两组疼痛评分比较无明显差异。【结论】双氯酚酸超前镇痛能部分有效地抑制小儿日间手术后疼痛。

关键词：镇痛二氯酚酸/投药和剂量

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双氯灭痛直肠给药治疗肾绞痛72例报告

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中华泌尿外科杂志 1992年第6期13卷 471-471页

作者：陈修诚徐耀庭马鹏程白进良李平翟所迪张虹兰州医学院第一附属医院泌尿外科兰州医学院第一附属医院药剂科

于1991年1月起,应用自制双氯灭痛胶浆剂经直肠给药治疗肾(疒交)痛72例。取得显著疗效,现报告如下。临床资料 1.病例选择:72例中男46例,女26例。年龄22～60岁,平均36.2岁。全部病例均有典型的肾(疒交)痛症状和体征,伴镜下或肉眼血尿。58... 详细信息

于1991年1月起,应用自制双氯灭痛胶浆剂经直肠给药治疗肾(疒交)痛72例。取得显著疗效,现报告如下。临床资料 1.病例选择:72例中男46例,女26例。年龄22～60岁,平均36.2岁。全部病例均有典型的肾(疒交)痛症状和体征,伴镜下或肉眼血尿。58例肾图显示患侧梗阻曲线。42例经KUB检查发现上尿路结石。15

关键词：二氯酚酸/投药和剂量绞痛/药物疗法肾疾病/药物疗法投药直肠人类

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Effect of anti-inflammatory agents on corneal wound-healing process after surface excimer laser keratectomy

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JOURNAL OF CATARACT AND REFRACTIVE SURGERY 2000年第3期26卷 426-431页

作者： Kaji, Y Amano, S Oshika, T Obata, H Ohashi, T Sakai, H Shirasawa, E Tsuru, T Yamashita, H Univ Tokyo Fac Med Dept Ophthalmol Bunkyo Ku Tokyo 1138655 Japan New York State Univ Dept Cell Biol New York NY USA Santen Pharmaceut Co Ltd Nara Res & Dev Ctr Nara Japan Jichi Med Sch Dept Ophthalmol Minami Kawachi Tochigi Japan Yamagata Univ Sch Med Dept Ophthalmol Yamagata 99023 Japan

Purpose: To investigate the effect of anti-inflammatory agents on conjunctival inflammation and corneal haze formation after excimer laser keratectomy. Setting: Department of Ophthalmology, University of Tokyo Faculty of Medicine, Tokyo, Japan. Methods: After excimer laser keratectomy was performed in 21 rabbits (42 eyes), saline, betamethasone 0.1%, or diclofenac 0.1% was topically applied 6 times a day for weeks and then 3 times a day for 8 weeks. The degree of conjunctival inflammation was determined 1, 2, 3, and 7 days after the keratectomy. The degree of corneal haze was quantitatively measured using a digital analyzer before and once a week after the keratectomy. The expression of type IV collagen in the corneas at baseline and 4 and 2 weeks after the keratectomy was examined immunohistochemically. Results: Compared with saline, betamethasone and diclofenac significantly decreased early-phase conjunctival inflammation. Betamethasone significantly inhibited corneal haze formation compared with saline at 3 to 5 and 8 to 12 weeks. Diclofenac did not inhibit corneal haze formation significantly. Although betamethasone tended to be more effective in inhibiting corneal haze formation and deposition of type IV collagen than diclofenac, there was no statistical difference between the 2 anti-inflammatory agents. Conclusion: Topically applied betamethasone effectively suppressed corneal haze formation after excimer laser keratectomy. Diclofenac was not statistically effective in inhibiting corneal haze formation. J Cataract Refract Surg 2000;26:426-431 (C) 2000 ASCRS and ESCRS.

关键词：消炎药/投药和剂量消炎药非甾类/投药和剂量倍他米松/投药和剂量胶原/代谢结膜炎/预防和控制角膜/药物作用角膜/代谢角膜/病理学角膜/外科学角膜混浊/病理学角膜混浊/预防和控制二氯酚酸/投药和剂量疾病模型动物激光准分子眼药水屈光性角膜切削术手术后并发症/预防和控制伤口愈合/药物作用动物男(雄)性兔

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Lack of correlation between intraocular inflammation and after-cataract formation in the rabbit eye

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JOURNAL OF CATARACT AND REFRACTIVE SURGERY 2000年第9期26卷 1389-1397页

作者： Wallentin, N Lundgren, B Lundberg, C Uppsala Univ Dept Pharmaceut Biosci Uppsala Sweden Pharmacia AB Dept Pharmacol S-75182 Uppsala Sweden Pharmacia AB Dept Preclin Ophthalmol S-75182 Uppsala Sweden Med Prod Agcy Uppsala Sweden

Purpose: To determine whether an increased or reduced inflammatory response following cataract surgery influences the development of after-cataract. Setting: Department of Preclinical Ophthalmology, Pharmacia, Uppsala, Sweden. Methods: Rabbits that had had cataract surgery were given endotoxin, ovalbumin, dexamethasone, or diclofenac. Aqueous humor, leukocytes, and prostaglandin E-2 (PGE(2)) were analyzed. and the wet weight of the after-cataract was determined. Results: The wet weight of the after-cataract was unaffected by endotoxin and 67% lower in the eyes treated with ovalbumin than in the control eyes on day 56. Aqueous humor concentrations of leukocytes and PGE(2) were 94% and 87% lower in the group treated with dexamethasone than in the control group on day 7, and the concentration of PGE(2) was 98% lower in the diclofenac group;however, the wet weight of the after-cataract was unaffected by both treatments. Conclusion: This study suggests that an increased inflammatory response does not increase the development of after-cataract and a reduction in the inflammatory response does not reduce the development of after-cataract. (C) 2000 ASCRS and ESCRS.

关键词：消炎药非甾类/投药和剂量眼房水/细胞学眼房水/代谢白内障摘除术/副作用地塞米松/投药和剂量二氯酚酸/投药和剂量地诺前列酮/代谢内毒素类/毒性糖皮质激素类/投药和剂量白细胞/病理学眼药水卵白蛋白/毒性试点项目葡萄膜炎前/药物疗法葡萄膜炎前/病因学葡萄膜炎前/代谢葡萄膜炎前/病理学动物兔

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New pieces for the puzzle: Nonsteroidal anti-inflammatory drugs and corneal ulcers

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JOURNAL OF CATARACT AND REFRACTIVE SURGERY 2000年第9期26卷 1263-1265页

作者： Price, FW

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Re:: Gastrointestinal tolerability of meloxicam compared to diclofenac in osteoarthritis patients (C.!Hawkey et al., Br J Rheumatol 1998;37:937-45)

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RHEUMATOLOGY 1999年第8期38卷 793-793页

作者： Jones, AKP Hope Hosp Human Physiol & Pain Res Lab Ctr Rheumat Dis Salford M6 8HD Lancs England

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