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DIMETHYL-SULFOXIDE THERAPY IN NON-MONGOLOID INFANTILE OLIGOPHRENIA

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 1975年第JAN27期243卷 432-448页

作者： GILLER, A DEBERNADOU, ME PIROVANO HOSP BUENOS AIRES ARGENTINA NATL DEPT STUDENT HLTH LAB GENET BUENOS AIRES ARGENTINA

We are herein submitting the results obtained with a group of 13 nonmongoloid, oligophrenic children after 180 days' treatment with DAT, and we have compared the results with those of a control group that received only conventional treatment. The children were examined before and after the treatment by means of the Binet-Simon tests, which have been standardized by Kuhlmann, and the Wise and Terman Merrill test. The control of organic lesion was determined by the Bender test. The variation mean of the control group was 0.08, and that of the DAT-treated group was 0.954; 0.874 was the mean difference, and 0.543 and 1.205 were the degrees of reliability. The difference between the results obtained from the DAT-treated group and the one that received conventional medication was significant (P equal 0.01). None of the 13 cases treated showed any signs of toxicity.

关键词：临床试验(主题) 二甲亚砜/治疗应用手/病理生理学智力障碍/分类智力障碍/药物疗法智力障碍/病因学智力障碍/病理生理学语言发展/药物作用运动技能/药物作用体位心理测定学时间知觉/药物作用视知觉/药物作用青少年儿童儿童学龄前女(雌)性人类男(雄)性

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POTENTIATION OF ANTINEOPLASTIC COMPOUNDS BY ORAL DIMETHYL-SULFOXIDE IN TUMOR-BEARING RATS

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ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 1975年第JAN27期243卷 194-208页

作者： WARREN, J SACKSTEDER, MR JAROSZ, H WASSERMAN, B ANDREOTTI, PE NOVA UNIV LEO GOODWIN INST CANC RES FT LAUDERDALE FL 33314 USA

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DIMETHYL-SULFOXIDE THERAPY IN SUBJECTIVE TINNITUS OF UNKNOWN ORIGIN

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ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 1975年第JAN27期243卷 468-474页

作者： ZUNIGACARO, A MANUEL ARRIARAN CHILDRENS HOSP OTORHINOLARYNGOL SERV SANTIAGO CHILE

In fifteen patients affected by essential nonvibratory tinnitus, local applications in the external auditive canal of 2 ml medicated DMSO spray were made. The spray solution contained DMSO integrated with anti-inflammatory and vasodilatory substances. This application was repeated every four days for a month. At the same time each patient was administered a daily intramuscular injection of a preparation that contained DMSO and a vasodilatory component. The therapeutic effect was evaluated through the subjective modification of the symptom and functional tests of the auditory system. Of the fifteen patients treated, the tinnitus symptom completely disappeared in nine, and did not return during a one-year observation period. The patient's symptoms diminished in two cases, and in four cases the permanent tinnitus became occasional, triggered principally by environmental cold. It is important to note that among the concomitant signs, the five patients with vertigo noted improvement. Hypacusis diminished in three of the six patients affected. Insomnia disappeared in eight and diminished in seven cases. The rise in the average tympanic membrane temperature from 36.8 degrees C before to 37.9 degrees C after treatment was noteworthy. This could indicate an improvement of the blood flow in the inner ear.

关键词：消炎药/治疗应用测听法体温二甲亚砜/治疗应用耳内窥镜检查耳鸣/诊断耳鸣/药物疗法耳鸣/病因学耳鸣/病理生理学鼓膜/病理生理学血管舒张药/治疗应用成年人老年人人类中年人

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PHARMACOLOGIC AND BIOCHEMICAL CONSIDERATIONS OF DIMETHYL-SULFOXIDE

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ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 1975年第JAN27期243卷 7-19页

作者： WOOD, DC WOOD, J MEDLAB COMP SERV SALT LAKE CITY UT 84102 USA

DMSO has multiple known pharmacological properties. In addition to those referred to include: cryoprotective action, radioprotective effect, influence on serum cholesterol in experimental hypercholesteremia, and platelet aggregation antagonism. How the multiple properties of this chemical affect therapy in clinical medicine must yet be explained. It is clear, however, that DMSO does affect biological systems, and that this influence has many clinical applications. Perhaps one of the most interesting and significant properties of DMSO is its ability to move other drugsthrough membranes. When mixed with DMSO, many drugs appear to be potentiated in their physiologic effect; thus smaller doses are required and less toxicity is demonstrated. In cancer chemotherapy, this value already has practical use. Some of the studies to be reported in this monograph will describe additional, almost unbelievable observations. Perhaps the mechanism of action of these clinical phenomena will be found in one or more of the pharmacological properties described. It would not be surprising, however, if we were to conclude with a resolution to search for new explantations of the mystery of DMSO, for it would appear that DMSO is really a new principle in medicine and cannot always be measured by existing standards.

关键词：消炎药/治疗应用细菌/药物作用胆碱酯酶抑制剂/药理学胶原/代谢二甲亚砜/代谢二甲亚砜/药理学二甲亚砜/治疗应用利尿/药物作用药物相互作用抗药性炎症/药物疗法膜/代谢肌松弛药中枢性/药理学神经元/药物作用皮肤吸收/药物作用血管舒张药/药理学动物猫人类小鼠大鼠

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EXPERIENCE IN USE OF DIMETHYL-SULFOXIDE IN DISEASES OF SUPPORTING MOTOR APPARATUS AND GENERAL SUPPURATIVE SURGERY

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ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 1975年第JAN27期243卷 494-496页

作者： DUBINSKY, MB SKAGER, AA RIGA MED INST POSTGRAD FAC DEPT SURG RIGA LATVIA SECOND TOWNS HOSP DEPT SURG RIGA LATVIA

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DIMETHYL-SULFOXIDE THERAPY IN VARIOUS DERMATOLOGICAL DISORDERS

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ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 1975年第JAN27期243卷 395-402页

作者： SEHTMAN, L ALVEAR HOSP BUENOS AIRES ARGENTINA

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Photodynamic therapy of superficial basal cell carcinoma with 5-aminolevulinic acid with dimethylsulfoxide and ethylendiaminetetraacetic acid: A comparison of two light sources

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PHOTOCHEMISTRY AND PHOTOBIOLOGY 2000年第6期71卷 724-729页

作者： Soler, AM Angell-Petersen, E Warloe, T Tausjo, J Steen, HB Moan, J Giercksky, KE Norwegian Radium Hosp Dept Surg Oncol Photodynam Out Patient Clin N-0310 Oslo Norway Norwegian Radium Hosp Dept Oncol N-0310 Oslo Norway Norwegian Radium Hosp Dept Biophys N-0310 Oslo Norway Inst Canc Res N-0310 Oslo Norway

The aim of this prospective randomized study was to compare the clinical and cosmetic outcome of superficial basal cell carcinomas (BCC), using either laser or broadband halogen light, in photodynamic therapy with topical 5-aminolevulinic acid (ALA). A total of 83 patients with 245 superficial BCC were included in the study. Standard treatment involved 15 min of local pretreatment with 99% dimethylsulfoxide (DMSO) before topical application of 20% ALA with DMSO (2%) and ethylendiaminetetraacetic acid (2%) as cofactors for 3 h before light exposure with either laser or a broadband lamp (BL). A complete response was achieved in 95 lesions (86%) in the laser group and 110 lesions (82%) in the BL group 6 months after treatment. Of these, 80 lesions (84%) in the laser group and 101 lesions (92%) in the lamp group were independently evaluated to have an excellent or good cosmetic post-treatment score. No serious adverse events were reported. This study shows that there is no statistical significant difference in cure the rate (P = 0.49) and the cosmetic outcome (P = 0.075) with topical application of a modified ALA-cream between light exposure from a simple BL with continuous spectrum (570-740 nm) or from a red-fight laser (monochromatic 630 nm), Cost and safety are further elements in favor of the BL in this setting.

关键词：氨基酮戊酸/治疗应用癌基底细胞/药物疗法二甲亚砜/治疗应用依地酸/治疗应用光光化学疗法/副作用皮肤肿瘤/药物疗法女(雌)性人类男(雄)性中年人

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DIMETHYL-SULFOXIDE THERAPY IN CHRONIC SKIN ULCERS

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ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 1975年第JAN27期243卷 408-411页

作者： MIRANDATIRADO, R UNIV CHILE FAC MED SANTIAGO CHILE

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DIMETHYL-SULFOXIDE THERAPY IN BRONCHIOLITIS

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ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 1975年第JAN27期243卷 460-467页

作者： ZUNIGA, A BURDACH, R RUBIO, S MANUEL ARRIARAN CHILDRENS HOSP DEPT OTORHINOLARYNGOL & BRONCHOPULM DIS SANTIAGO CHILE

The action of a medicinal spray that contains anti-inflammatory and bacterio-static drugs integrated with the penetrating and potentiating agent DMSO has been evaluated clinically in 60 infants with acute respiratory obstruction. A dose of 2 ml of this spray is applied in the posterior pharynx and the tonsil region; 1 to 4 applications are made, according to the clinical evolution of the case. Two groups were chosen at random; 60 patients were paired off, and one of each pair received the treatment with DMSO spray. All the patients received ampicillin (50-100 mg/kg body weight). The following clinical results were observed. First there was an immediate recovery, after an average lapse of 30 min; improvement of sensorial involvement was observed in 80% of the cases, reduction of the intercostal retraction in 75%, reduction of polypnea in 76%, and transformation of the obstructive syndrome into a catarrhal syndrome in 80% (with fluidification of the secretions, which were expelled more easily by the upper air tracts). There was also a deferred or maintenance effect, which evaluated in comparsion with the control group that received similar treatment except for the nebulizations with DMSO spray. A sequential design, based on whether or not it was necessary to use the croupette, demonstrated the superiority of the DMSO spray over the control treatment in the bronchiolar process; in the group treated with DMSO spray it was not necessary to use the croupette. The sequential design based on the effect of this therapy on the general condition and the tabulated clinical factors permitted the inference that the therapeutic responses are more favorable in the group treated with DMSO spray than in the control group. In the sequential design, the line of significance is cut at the fifteenth pair (an error of 0.05 and P equals 0.95%). Since the application is easy, there are no toxic side effects and in view of the favorable results in the clinical evolution of the acute respirat

关键词：气雾剂气道阻塞/药物疗法氨苄西林/治疗应用支气管疾病/药物疗法细支气管炎病毒性/并发症细支气管炎病毒性/药物疗法细支气管炎病毒性/病理生理学二甲亚砜/投药和剂量二甲亚砜/副作用二甲亚砜/治疗应用复方合剂儿童学龄前人类婴儿婴儿新生男(雄)性

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Dimethylsulfoxide for renal dysfunction caused by systemic amyloidosis complicating Crohn's disease

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GASTROENTEROLOGY 1999年第4期117卷 1031-1032页

作者： Iwakiri, R Sakemi, T Fujimoto, K Saga Med Sch Dept Internal Med Saga Japan

GASTROENTEROLOGY 1999;117:1031-1032

关键词：淀粉样变性/并发症 Crohn病/并发症二甲亚砜/治疗应用肾疾病/药物疗法肾疾病/病因学人类

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