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中华医学杂志 1992年第11期72卷 650-650,705页

作者：陈沙力傅文永郭惠君冷丽武玉梅郑永晨白求恩医科大学第一临床医学院儿科白求恩医科大学地方病研究所病毒室

1985年～1990年对长春地区1017例急性呼吸道感染(ARI)小儿进行了病毒病原连续监测。现将结果报道如下。一、材料和方法上呼吸道感染(URI)组206例。下呼吸道感染(LRI)组811例。双份血清共516份。病毒分离、鉴定及血清学检查方法按文献[... 详细信息

1985年～1990年对长春地区1017例急性呼吸道感染(ARI)小儿进行了病毒病原连续监测。现将结果报道如下。一、材料和方法上呼吸道感染(URI)组206例。下呼吸道感染(LRI)组811例。双份血清共516份。病毒分离、鉴定及血清学检查方法按文献[新实验病毒学.第1版.北

关键词：呼吸道感染/微生物学呼吸道合胞病毒/分离和提纯腺病毒人/分离和提纯

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Co-expression of CD56 and CD30 in lymphomas with primary presentation in the skin: clinicopathologic, immunohistochemical and molecular analyses of seven cases

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JOURNAL OF CUTANEOUS PATHOLOGY 2000年第8期27卷 392-399页

作者： Natkunam, Y Warnke, RA Haghighi, B Su, LD Le Boit, PE Kim, YH Kohler, S Stanford Univ Med Ctr Dept Pathol Stanford CA 94305 USA Stanford Univ Med Ctr Dept Dermatol Stanford CA 94305 USA Univ Michigan Ann Arbor MI 48109 USA Univ Calif San Francisco Sch Med Dept Dermatol San Francisco CA 94143 USA Univ Calif San Francisco Sch Med Dept Pathol San Francisco CA 94143 USA

Background: Natural killer and natural killer-like T-cell lymphomas presenting in the skin usually demonstrate aggressive behavior, an angiocentric distribution and a characteristic immunophenotype. In contrast, primary cutaneous CD30+ lymphoproliferative disorders form a heterogeneous spectrum including anaplastic large cell lymphomas, the majority of which display a good prognosis. Lymphomas with coexpression of CD56 and CD30 are extremely rare and the significance of this co-expression is unknown. Methods: Seven retrospectively identified cases of lymphomas with co-expression of CD56 and CD30 presenting in the skin comprise this study. Immunohistochemistry, in situ hybridization for Epstein-Barr virus and T-cell receptor gel-re rearrangement studies were performed on paraffin sections. Results: This subset of cutaneous lymphomas showed a variable clinical course that ranged from resolution without treatment, treatment-failure and recurrence, to death from disease. Histologic, immunophenotypic and molecular studies were of limited utility in predicting prognosis. Conclusions: Cutaneous lymphomas co-expressing CD56 and CD30 share many clinicopathologic features with natural killer and natural killer-like T-cell lymphomas or anaplastic large cell lymphomas, two entities with widely disparate clinical behavior. It is important to recognize that these lymphomas may behave more aggressively than primary cutaneous anaplastic large cell lymphomas do. Longer follow-up and further investigations on larger numbers of cases are necessary to fully characterize this rare subset of cutaneous lymphomas.

关键词：抗原 CD36/代谢抗原 CD56/代谢荧光抗体技术直接疱疹病毒4型人/遗传学疱疹病毒4型人/分离和提纯原位杂交 Ki-67抗原/分析淋巴瘤 T细胞皮肤/代谢淋巴瘤 T细胞皮肤/病理学 RNA 病毒/分析皮肤肿瘤/代谢皮肤肿瘤/病理学成年人老年人女(雌)性人类男(雄)性中年人

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Pediatric AIDS-associated lymphocytic interstitial pneumonia and pulmonary arterio-occlusive disease - Role of VCAM-1/VLA-4 adhesion pathway and human herpesviruses

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AMERICAN JOURNAL OF PATHOLOGY 1999年第5期154卷 1453-1464页

作者： Brodie, SJ de la Rosa, C Howe, JG Crouch, J Travis, WD Diem, K Univ Washington Sch Med Dept Lab Med Vaccine Virol DivRetrovirol Lab Seattle WA 98195 USA Yale Univ Dept Lab Med New Haven CT USA Armed Forces Inst Pathol Dept Pulm & Mediastinal Pathol Washington DC USA

Because the mechanisms of lymphocyte accumulation in the lungs of children with AIDS-associated lymphocytic interstitial pneumonia (LIP) are unknown, we studied the relative contributions of known adhesion pathways in mediating lymphocyte adherence to endothelium and the potential role of human herpesviruses in the expansion of these lesions. LTP was characterized by lymphoid hyperplasia of the bronchus-associated lymphoid tissue (BALT) and infiltration of the pulmonary interstitium with CD8(+) T lymphocytes, In some individuals there was expansion of the alveolar septae with dense aggregates of B lymphocytes, many containing the Epstein-Barr viral (EBV) genome. Patients with concurrent EBV infection also demonstrated large-vessel arteriopathy characterized by thickening of the intimae with collagen and smooth muscle. Venular endothelium from the lung of children with LIP, but not uninflamed lung from other children with ADDS or lung from children with nonspecific pneumonitis, expressed high levels of vascular cell adhesion molecule-1 (VCAM-1) protein. In turn, inflammatory cells expressing very late activation antigen-4 (VLA-4), the leukocyte ligand for VCAM-1, were the predominant perivascular infiltrate associated with vessels expressing VCAM-1. Expression of other endothelial adhesion molecules, including intracellular adhesion moleucle-1 and E-selectin, was not uniformly associated with LIP. Using a tissue adhesion assay combined with immunohistochemistry for VCAM-1, we show that CD8(+) T cell clones that express VLA-4 bind preferentially to pulmonary vessels in sites of LIP: vessels that expressed high levels of VCAM-1, When tissues and cells were pretreated with antibodies to VCAM-1 or VLA-4, respectively, adhesion was inhibited by greater than or equal to 80%. Thus, infiltration of alveolar septae with CD8(+) T cells was highly correlative with VCAM-1/VLA-4 adhesive interactions, and focal expansion of B cells was coincidental to co-infection with EBV.

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Nosocomial respiratory syncytial virus infections in children's wards

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DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE 2000年第4期37卷 237-246页

作者： Mlinaric-Galinovic, G Varda-Brkic, D Univ Zagreb Sch Med A Stampar Sch Publ Hlth Dept Microbiol Zagreb 10000 Croatia Zabok Gen Hosp Zabok 49210 Croatia

During community outbreak, nosocomial infections caused by both groups (A and B) of respiratory syncytial virus (RSV) occur as the most common nosocomial infections at pediatric wards. RSV cross-infection is considered to have taken place when a child acquires an infection after being in the ward longer than 7 days, and its frequency at the ward could be calculated in several ways. That frequency ranges worldwide between 30% and 70% in neonatal units, and between 20% and 40% at pediatric wards. The infections are manifested as lower respiratory tract infections (LRTI) in 20-60% and 30-40% of cases, respectively. These Infections could be early diagnosed by an RSV rapid detection method. In RSV-positive children who develop LRTI and belong to the category with a high risk of developing severe RSV disease, a specific therapy is recommended. The frequency of RSV nosocomial infections at children's wards could be considerably reduced (to only a few per cent) by providing education to hospital personnel in the etiology and transmission of respiratory viruses and by compliance with pediatric droplet precautions (cohort nursing, and gown and glove wearing/handwashing in any contact with infected children). (C) 2000 Elsevier Science Inc. All rights reserved.

关键词：交叉感染/流行病学疾病暴发流行医院儿科住院时间呼吸道合胞体病毒感染/诊断呼吸道合胞体病毒感染/流行病学呼吸道合胞体病毒感染/传播呼吸道合胞体病毒感染/病毒学呼吸道合胞体病毒人/分离和提纯危险因素儿童儿童学龄前人类婴儿婴儿新生

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SCREENING FOR EPSTEIN-BARR AND HUMAN CYTOMEGALOVIRUS IN NORMAL AND ABNORMAL CERVICAL SMEARS BY FLUORESCENT INSITU CYTOHYBRIDIZATION

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ARCHIVES OF VIROLOGY 1992年第1-4期125卷 205-214页

作者： SCHON, HJ SCHURZ, B MARZ, R KNOGLER, W KUBISTA, E UNIV VIENNA DEPT GYNECOL & OBSTET 1A-1010 VIENNAAUSTRIA

Using the routine Papanicolaou test for grouping, 35 normal and 148 abnormal cervical smears were screened by fluorescent in situ cytohybridization for Epstein-Barr (EBV) and human cytomegalovirus (HCMV). Viral presence was detected in 55% of all hybridized smears while routine Papanicolaou tests exposed no morphological evidence for HCMV or EBV. Thus in situ cytohybridization is necessary and suitable for direct identification of EBV and HCMV. The prevalence of viral infection for women with normal cervical smears was 29% for HCMV and 34% for EBV. Even smears of three of the four virgins were positive for HCMV and two had a mixed infection with EBV. The infection rate with at least one of these two herpesviruses was 51% in the control group, 56% in smears with reactive and reparative cell changes, 54% in mild (slight) dysplasias and 56% in moderate or severe dysplasias. Thus infection with HCMV and EBV did not differ significantly in controls and prevention groups. Both viruses were most frequently found in the age group 20 to 29 years. These data suggest that HCMV and EBV are not involved in the etiology of intraepithelial neoplasias and carcinomas of the uterine cervix.

关键词：巨细胞病毒/分离和提纯巨细胞病毒感染/微生物学 DNA探针 DNA 病毒/分析疱疹病毒4型人/分离和提纯核酸杂交 RNA 病毒/分析肿瘤病毒感染/微生物学宫颈非典型增生/微生物学阴道涂片青少年成年人女(雌)性人类中年人

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Rabbit model for human EBV-associated hemophagocytic syndrome (HPS) - Sequential autopsy analysis and characterization of IL-2 dependent cell lines established from herpesvirus papio-induced fatal rabbit lymphoproliferative diseases with HPS

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AMERICAN JOURNAL OF PATHOLOGY 2003年第5期162卷 1721-1736页

作者： Hayashi, K Jin, ZS Onoda, S Joko, H Teramoto, N Ohara, N Oda, W Tanaka, T Liu, YX Koirala, TR Oka, T Kondo, E Yoshino, T Takahashi, K Akagi, T Okayama Univ Grad Sch Med & Dent Dept Pathol Okayama 7008558 Japan Okayama Univ Sch Hlth Sci Okayama Japan

Epstein-Barr virus-associated hemophagocytic syndrome (EBV-AHS) is often associated with fatal infectious mononucleosis or T-cell lymphoproliferative diseases (LPD). To elucidate the true nature of fatal LPD observed in Herpesvirus papio (HVP)-induced rabbit hemophagocytosis, reactive or neoplastic, we analyzed sequential development of HVP-induced rabbit LPD and their cell lines. All of the seven Japanese White rabbits inoculated intravenously with HVP died of fatal LPD 18 to 27 days after inoculation. LPD was also accompanied by hemophagocytic syndrome (HPS) in five of these seven rabbits. Sequential autopsy revealed splenomegaly and swollen lymph nodes, often accompanied by bleeding, which developed in the last week. Atypical lymphoid cells infiltrated many organs with a "starry sky" pattern, frequently involving the spleen, lymph nodes, and liver. HVP-small RNA-1 expression in these lymphoid cells was clearly demonstrated by a newly developed in situ hybridization (ISH) system. HVP-ISH of immunomagnetically purified lymphoid cells from spleen or lymph nodes revealed HVP-EBER1+ cells in each CD4+, CD8+, or CD79a+ fraction. Hemophagocytic histiocytosis was observed in the lymph nodes, spleen, bone marrow, and thymus. HVP-DNA was detected in the tissues and peripheral blood from the infected rabbits by PCR or Southern blot analysis. Clonality analysis of HVP-induced LPD by Southern blotting with TCR gene probe revealed polyclonal bands, suggesting polyclonal proliferation. Six IL-2-dependent rabbit T-cell lines were established from transplanted scid mouse tumors from LPD. These showed latency type I/II HVP infection and had normal karyotypes except for one line, and three of them showed tumorigenicity in nude mice. These data suggest that HVP-induced fatal LPD in rabbits is reactive polyclonally in nature.

关键词：尸体解剖细胞系爱泼斯坦巴尔病毒感染/遗传学爱泼斯坦巴尔病毒感染/病理学爱泼斯坦巴尔病毒核抗原/遗传学疱疹病毒4型人/遗传学疱疹病毒4型人/分离和提纯白细胞介素2/药理学淋巴细胞/免疫学淋巴细胞/病理学狒狒属受体抗原 T细胞 α-β/遗传学综合征病毒基质蛋白质类/遗传学动物人类兔

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Neurological complications of varicella-zoster virus infection in adults with human immunodeficiency virus infection

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SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES 2000年第3期32卷 263-269页

作者： de la Blanchardiere, A Rozenberg, F Caumes, E Picard, O Lionnet, F Livartowski, J Coste, J Sicard, D Lebon, P Salmon-Cèron, D Hop St Vincent de Paul Dept Virol F-75674 Paris France Hop La Pitie Salpetriere Dept Infect Dis Paris France Hop St Antoine Dept Internal Med F-75571 Paris France Ctr Hosp Gen Dept Hematol Argenteuil France Hop Antoine Beclere Dept Internal Med Clamart France Hop Cochin Dept Biostat FR-75679 Paris France Univ Paris CHU Cochin APHP Dept Internal Med F-75252 Paris France

This multicentre retrospective study describes the clinical features and prognostic significance of Varicella-zoster virus (VZV)-associated neurological complications. The study was performed in patients with human immunodeficiency virus (HIV) infection, hospitalized for VZV neurological complications, confirmed in every case by positive VZV polymerase chain reaction (PCR) in cerebrospinal fluid (CSF). Between 1990 and 1995, 34 HIV-infected patients were included in the study. At diagnosis, 59% had AIDS, with a median CD4 count of 11 x 10(9)/l. A past history of tester was noted in 35% of cases. A concomitant herpes tester rash and/or acute retinal necrosis were noted in 71% and 12% of patients, respectively, The predominant neurological manifestations were encephalitis (13), myelitis (8), radiculitis (7) and meningitis (6). The mean CSF white blood cell count was 126/mm(3) and the mean CSF protein concentration was 2.3 g/l. Interferon-alpha level was increased in 36% of patients. VZV was isolated from CSF cultures in 2/6 cases. Magnetic resonance imaging was abnormal, demonstrating encephalitis lesions. After intravenous antiviral therapy, complete recovery was obtained in 18 cases (53%), serious sequelae were observed in 10 cases (29%) and 6 patients died (18%), Severe symptoms and a low CD4 cell count appeared to be associated with death or sequelae. In conclusion, VZV should be considered as a possible cause of encephalitis, myelitis. radiculitis or meningitis in HIV-infected patients, especially in patients with a history of or concomitant herpes tester or acute retinal necrosis. VZV-PCR in the CSF may allow rapid diagnosis and early specific antiviral treatment.

关键词： CD4淋巴细胞计数中枢神经系统感染/脑脊髓液中枢神经系统感染/并发症中枢神经系统感染/诊断中枢神经系统感染/药物疗法疾病恶化 HIV感染/并发症带状疱疹/脑脊髓液带状疱疹/并发症带状疱疹/诊断带状疱疹/药物疗法疱疹病毒3型人/分离和提纯磁共振成像聚合酶链反应预后回顾性研究体层摄影术 X线计算机成年人女(雌)性人类男(雄)性中年人

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Human herpesvirus 6 limbic encephalitis after stem cell transplantation

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ANNALS OF NEUROLOGY 2001年第5期50卷 612-619页

作者： Wainwright, MS Martin, PL Morse, RP Lacaze, M Provenzale, JM Coleman, E Morgan, MA Hulette, C Kurtzberg, J Bushnell, C Epstein, L Lewis, DV Duke Univ Med Ctr Dept Pediat Durham NC 27710 USA Northwestern Univ Sch Med Childrens Mem Hosp Div Pediat Neurol Chicago IL USA Duke Univ Med Ctr Dept Radiol Durham NC 27710 USA Duke Univ Med Ctr Dept Pathol Durham NC 27710 USA Duke Univ Med Ctr Dept Med Durham NC 27710 USA

Central nervous system complications are common in stem cell transplant recipients, but selective involvement of the medial temporal area is unusual. The 5 patients reported here presented after stem cell transplantation with increased hippocampal T2 signal on magnetic resonance imaging and increased hippocampal glucose uptake on [F-18]fluorodeoxyglucose-positron emission tomography (FDG-PET) associated with short-term memory loss, insomnia, and temporal lobe electrographic seizure activity. The initial scalp electroencephalograms (EEGs) failed to detect seizure activity in these patients, although the memory dysfunction along with the magnetic resonance imaging and FDG-PET findings suggested subcortical seizure activity. However, extended EEG monitoring revealed repetitive temporal lobe electrographic seizure activity. Follow-up MRIs in 2 patients and postmortem findings on 1 patient suggested that hippocampal sclerosis had developed following the clinical syndrome. Cerebrospinal fluid studies revealed the presence of human herpesvirus 6, variant B, DNA in all of 3 patients who had lumbar punctures. Immunohistochemical staining for the P41 and P101 human herpesvirus 6 protein antigens showed numerous immunoreactive astrocytes and neurons in the hippocampus of 1 of the patients who died from other causes. Because of its subtle clinical presentation, this syndrome may be underrecognized, but can be diagnosed with appropriate magnetic resonance imaging techniques, EEG monitoring, and cerebrospinal fluid viral studies.

关键词：肾上腺脑白质营养不良/并发症肾上腺脑白质营养不良/治疗贫血 Diamond-Blackfan/并发症贫血 Diamond-Blackfan/治疗 DNA 病毒/脑脊髓液脑电描记术脑炎病毒性/脑脊髓液脑炎病毒性/诊断脑炎病毒性/病毒学致命性结局胎血氟脱氧葡萄糖F18/诊断应用疱疹病毒6型人/分离和提纯海马/病理学海马/病理生理学海马/放射性核素显像免疫组织化学白血病/并发症白血病/治疗边缘叶脑炎/脑脊髓液边缘叶脑炎/诊断边缘叶脑炎/病毒学磁共振成像记忆障碍/病因学发作/病因学睡眠障碍/病因学体层摄影术发射型计算机 β地中海贫血/并发症 β地中海贫血/治疗青少年成年人儿童人类

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Poliomyelitis-like syndrome associated with Epstein-Barr virus infection

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PEDIATRIC NEUROLOGY 1999年第3期20卷 235-237页

作者： Wong, M Connolly, AM Noetzel, MJ Washington Univ Sch Med Div Pediat Neurol Dept NeurolSt Louis Childrens Hosp St Louis MO 63110 USA

A 20-month-old male presented with an acute clinical syndrome resembling poliomyelitis, characterized by a flaccid monoplegia, areflexia of the involved limb, and preserved sensation. Electrophysiologic studies supported a neuronopathic localization involving the anterior horn cells. Although laboratory evidence for a polio virus infection was absent, serologic and polymerase chain reaction studies documented an active central nervous system infection with Epstein-Barr virus, indicating that a poliomyelitis-like syndrome may be produced by infectious agents other than enteroviruses. (C) 1999 by Elsevier Science Inc, All rights reserved.

关键词：诊断鉴别肌电描记术爱泼斯坦巴尔病毒感染/脑脊髓液爱泼斯坦巴尔病毒感染/并发症爱泼斯坦巴尔病毒感染/诊断疱疹病毒4型人/分离和提纯磁共振成像脊髓炎横贯性/病因学截瘫/病因学脊髓灰质炎/诊断治疗结果人类婴儿男(雄)性

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Higher prevalence of parvovirus B19 in Belgian as compared to Tunisian blood donors: Differential implications for prevention of transfusional transmission

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TRANSFUSION SCIENCE 1997年第4期18卷 523-530页

作者： Letaief, M Vanham, G Boukef, K Yacoub, S Muylle, L Mertens, G Inst Trop Med Dept Microbiol Immunol Unit B-2000 Antwerp 1 Belgium

Serious anaemia can be induced by human parvovirus B19 (HPV) infection in immune-compromised patients or subjects with an haemolytic disorder. Routine inactivation procedures are insufficient to neutralize the virus, but screening for HPV is an effective means to avoid transmission by transfusion of blood components. In the present study, we have compared for the first time the IgG and IgM seroprevalence in a North African (Tunisian) and Western European (Belgian) population of blood donors. The prevalence of HPV-specific IgM was less than 2% in both populations, pointing to the absence of an epidemic. The prevalence HPV IgG was significantly (p<0.01) higher in Belgium (74%) than in Tunisia (65%), without any relationship with age or sex. This finding may suggest a south-north gradient of this infectious disease. Since the presence or absence of HPV-specific antibodies does not preclude transfusional transmission, screening for the virus itself should be done to avoid iatrogenic infection in HPV-naive subjects at risk. In view of the different transfusion policies in Belgium and Tunisia, a strategy for each of both countries is proposed. (C) 1997 Elsevier Science Ltd.

关键词：比利时/流行病学供血者细小病毒科感染/流行病学细小病毒科感染/传播细小病毒B19 人/分离和提纯患病率突尼斯/流行病学青少年成年人女(雌)性人类男(雄)性中年人

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