目的 探讨T ei 指数在传染性单核细胞增多症（IM ）合并心肌损害儿童左心功能评价的意义。方法 检测并比较 IM 合并心肌损害患儿96例（观察组）和正常对照组40例（对照组）左心室射血分数（EF）、二尖瓣舒张早期血流速度峰值（E峰）及...
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目的 探讨T ei 指数在传染性单核细胞增多症（IM ）合并心肌损害儿童左心功能评价的意义。方法 检测并比较 IM 合并心肌损害患儿96例（观察组）和正常对照组40例（对照组）左心室射血分数（EF）、二尖瓣舒张早期血流速度峰值（E峰）及舒张晚期血流速度峰值（A峰）、（E／A ）比值、左心室等容收缩时间（ICT）、等容舒张时间（IRT）、射血时间（ET），计算Tei指数。结果 观察组EF、E／A比值与对照组比较差异无统计学意义（P ＞0．05），左室Tei指数较对照组明显增大（0．48±0．09vs0．39±0．08，P ＜0．05），且Tei指数与EF、E／A无显著相关（ P ＞0．05）。结论 IM合并心肌损害患儿存在心脏整体功能异常，Tei指数能简便、敏感检测其功能变化。
Background: Infectious mononucleosis, which is caused by the Epstein-Barr virus, has been associated with an increased risk for Hodgkin's disease. Little is known, however, about how infectious mononucleosis affec...
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Background: Infectious mononucleosis, which is caused by the Epstein-Barr virus, has been associated with an increased risk for Hodgkin's disease. Little is known, however, about how infectious mononucleosis affects longterm risk of Hodgkin's disease, how this risk varies with age at infectious mononucleosis diagnosis, or how the risk for Hodgkin's disease varies in different age groups. In addition, the general cancer profile among patients who have had infectious mononucleosis has been sparsely studied. Methods: Population-based cohorts of infectious mononucleosis patients in Denmark and Sweden were followed for cancer occurrence. The ratio of observed-to-expected numbers of cancers (standardized incidence ratio [SIR]) served as a measure of the relative risk for cancer. SIRs of Hodgkin's disease in different subsets of patients were compared with the use of Poisson regression analysis. All statistical tests including the trend tests were two-sided. Results: A total of 1381 cancers were observed during 689619 person-years of follow-up among 38562 infectious mononucleosis patients (SIR = 1.03;95% confidence interval [CI] = 0.98-1.09). Apart from Hodgkin's disease (SIR = 2.55;95% CI = 1.87-3.40;n = 46), only skin cancers (SIR = 1.27;95% CI = 1.13-1.43;n = 291) occurred in statistically significant excess. In contrast, the SIR for lung cancer was reduced (SIR = 0.71;95% CI = 0.58-0.86;n = 102). The SIR for Hodgkin's disease remained elevated for up to two decades after the occurrence of infectious mononucleosis but decreased with time since diagnosis of infectious mononucleosis (P for trend <.001). The SIR for Hodgkin's disease tended to increase with age at diagnosis of infectious mononucleosis (P for trend =.05). Following infectious mononucleosis, the SIR for Hodgkin's disease at ages 15-34 years was 3.49 (95% CI = 2.46-4.81;n = 37), which was statistically significantly higher than the SIR for any other age group (P for difference = .001). Conclusion: The increas
We report the association of neurological and intestinal disorders with the reactivation of Epstein-Barr virus (EBV) in a child. This previously healthy 13-yr-old boy presented with pharyngitis and acute abdominal ile...
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We report the association of neurological and intestinal disorders with the reactivation of Epstein-Barr virus (EBV) in a child. This previously healthy 13-yr-old boy presented with pharyngitis and acute abdominal ileus. Laparotomy excluded a mechanical obstruction. Postoperatively, he suffered from prolonged intestinal obstruction, pandysautonomia, and encephalomyelitis. Histological examination of the appendix and a rectal biopsy taken 3 months after the onset showed an absence of ganglion cells (appendix) and hypoganglionosis (rectum), with a mononucleate inflammatory infiltrate in close contact with the myenteric neural plexuses. EBV-PCR was positive in the blood and cerebrospinal fluid, and in situ hybridization with the Epstein-Barr virus encoded RNA probe showed positive cells throughout the appendix wall including the myenteric area, in a mesenteric lymph node, and in the gastric biopsies. EBV spontaneous lymphocytic proliferation was noted in the blood. The serology for EBV showed previous infection but anti-early antigen antibodies were present. No immunodeficiency was found. Neurological and GI recovery occurred after 6 months of parenteral nutrition and bethanechol. The omnipresence of EBV associated with the neurointestinal symptoms suggest that the virus was the causal agent. This is the first documented case of acquired hypoganglionnosis due to EBV reactivation. (Am J Gastroenterol 2000,95: 280-284. (C) 2000 by Am. Coll. of Gastroenterology).
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