检索结果-内蒙古大学图书馆

立止血与凝血酶配伍治疗经典型新生儿出血症32例

引用

陕西医学杂志 2008年第9期37卷 1248-1249页

作者：成钧张毅延安大学附属医院新生儿科延安716000 陕西省榆林市第二医院

我院于2002年5月至2006年4月,收治新生儿出血症64例采用立止血配伍凝血酶治疗32例,并设对照组观察,现分析报告如下.

关键词：出血/药物疗法凝血酶/治疗应用血凝素类药/治疗应用婴儿新生

来源：评论

学校读者我要写书评

暂无评论

Reduction in the need for hospitalization for recurrent ischemic events and bleeding with clopidogrel instead of aspirin

引用

AMERICAN HEART JOURNAL 2000年第1期140卷 67-73页

作者： Bhatt, DL Hirsch, AT Ringleb, PA Hacke, W Topol, EJ Cleveland Clin Fdn Dept Cardiol Cleveland OH 44195 USA Univ Minnesota Sch Med Vasc Med Program Minneapolis MN 55455 USA Heidelberg Univ Sch Med Dept Neurol Heidelberg Germany

Background Repeat hospitalizations of patients with atherosclerosis represent a considerable burden on the health care system. We sought to determine whether clopidogrel compared with aspirin decreases the need for rehospitalization for ischemia and bleeding. Methods and Results The Clopidogrel Versus Aspirin in Patients at Risk of Ischemic Events (CAPRIE) trial was a randomized, blinded, multicenter, trial of 19,185 patients with atherosclerotic disease manifested as recent ischemic stroke or myocardial infarction or symptomatic peripheral arterial disease. Without any double-counting of events, the number of rehospitalizations for ischemic events (defined as angina, transient ischemic attack, or limb ischemia) or bleeding events was determined for the entire cohort. There was a significant reduction in the total number of rehospitalizations for ischemic events or bleeding with clopidogrel use compared with aspirin (1502 vs 1673;P = .010) over an average of 1.6 years of treatment. This reduction in rehospitalization was consistent across individual outcomes of angina, transient ischemic attack, limb ischemia, and bleeding. Compared with aspirin, clopidogrel also resulted in a 7.9% relative risk reduction in a combined end point of vascular death, stroke, myocardial infarction, or rehospitalization for ischemic events or bleeding (15.1% to 13.7% at 1 year;P = .011). Adjusting for baseline prognostic variables, clopidogrel therapy was an independent predictor for reduction of vascular death, stroke, myocardial infarction, or rehospitalization for ischemic events or bleeding (P = .009). Conclusions Treatment with clopidogrel results in a significant decrease in the need for rehospitalization for ischemic events or bleeding compared with aspirin. This meaningful end point tracks well with other, more traditional measures of outcome and has incremental value beyond such end points.

关键词：阿司匹林/投药和剂量脑缺血/药物疗法脑缺血/病因学脑缺血/死亡率死亡原因置信区间双盲法出血/药物疗法出血/死亡率住院/统计学和数值数据发病率缺血/药物疗法缺血/病因学缺血/死亡率多元分析心肌梗死/并发症心肌梗死/药物疗法心肌梗死/死亡率外周血管疾病/并发症外周血管疾病/药物疗法外周血管疾病/死亡率血小板聚集抑制剂/投药和剂量概率预后比例危险度模型复发/预防和控制危险性评估存活率分析噻氯匹定/投药和剂量噻氯匹定/类似物和衍生物女(雌)性人类男(雄)性中年人

来源：评论

学校读者我要写书评

暂无评论

Protective effect of anti-P-selectin monoclonal antibody in lipopolysaccharide-induced lung hemorrhage

引用

INFLAMMATION 1999年第5期23卷 461-469页

作者： Ohnishi, M Imanishi, N Tojo, SJ Sumitomo Pharmaceut Co Ltd Res Ctr Konohana Ku Osaka 5540022 Japan

Excessive leukocyte accumulation is involved in the pathogenesis of the sepsis-induced acute lung injury. Selectins are essential to the interaction between leukocytes and endothelial cells. In this report, we investigated the role of selectins in the severe lung injury induced by lipopolysaccharide (LPS). Significant lung hemorrhage was observed 24 h after the intravenous administration of LPS (1 mg/kg). First, we evaluated the effect of sialyl Lewis X-oligosaccharide (SLeX-OS), a derivative of sialyl Lewis X which is one of the ligands for E-, P- and L-selectins. The treatment with SLeX-OS (26.5 mg/kg iv bolus + 19.8 mg/kg iv infusion) resulted in a decrease of lung hemorrhage by 49.5% (P < 0.05 versus the control group). Second, we tested the effect of anti-P-selectin monoclonal antibody (MAb), PB1.3, to investigate the role of P-selectin. The bolus administration of PB 1.3 at a dose of 5 mg/kg attenuated the lung hemorrhage by 74.6% (P < 0.05 versus the control group). In addition, we also detected an increase of soluble P-selectin in plasma 24 h after the injection of LPS. These results suggest that P-selectin has a substantial role in the pathogenesis of the lung injury induced by LPS.

关键词：抗体单克隆/免疫学抗体单克隆/药理学抗体单克隆/治疗应用出血/化学诱导出血/药物疗法出血/免疫学脂多糖类/毒性肺/病理生理学 P选择素/免疫学大鼠 Sprague-Dawley 动物男(雄)性大鼠

来源：评论

学校读者我要写书评

暂无评论

Topical formalin for management of bleeding malignant ulcers

引用

WORLD JOURNAL OF SURGERY 2000年第5期24卷 518-520页

作者： Adebamowo, CA Univ Coll Hosp Dept Surg Surg Oncol Unit Ibadan Oyo State Nigeria

Hemorrhage, an infrequent but serious complication of malignant ulceration, can be difficult to manage. Although many methods exist for treatment, none is wholly satisfactory. The use of topical formalin was studied in a group of patients with bleeding from malignant ulcers, and the results show that the agent achieved control of bleeding in 86% of the patients after two applications. There were no significant complications arising from the treatment, Topical formalin is a safe, inexpensive, effective agent for control of bleeding from malignant ulcers.

关键词：投药局部甲醛/投药和剂量出血/药物疗法出血/病因学肿瘤/并发症皮肤溃疡/药物疗法皮肤溃疡/病因学青少年成年人女(雌)性人类男(雄)性中年人

来源：评论

学校读者我要写书评

暂无评论

A prospective randomized double-blind trial of fibrin glue for pain and bleeding after tonsillectomy

引用

LARYNGOSCOPE 1999年第4期109卷 652-655页

作者： Stoeckli, SJ Moe, KS Huber, A Schmid, S Univ Zurich Hosp Clin Otorhinolaryngol Head & Neck Surg CH-8091 Zurich Switzerland

Objectives: The notable morbidity of tonsillectomy includes considerable postoperative pain and a rate of postoperative bleeding that have remained largely uninfluenced by modern surgical techniques or medication, Fibrin glue is known to have a hemostatic effect in some settings, and there is research suggesting it may also reduce postoperative pain. The objectives of this study were to evaluate the effect of fibrin glue on pain and bleeding after tonsillectomy, Study Design: A prospective randomized double-blind study was performed on 50 consecutive adult patients undergoing tonsillectomy for chronic tonsillitis. Methods: After removal of both tonsils the tonsillar fossa randomly assigned to the treatment protocol was coated with fibrin glue, The other side was left unaltered. The patient was then monitored for postoperative bleeding and wound healing, and a patient-based pain assessment instrument was used to evaluate symptoms every 8 hours for 10 days after surgery, Results: Detailed evaluation of the pain scores allowed the authors to create a pain profile for what the typical patient experiences over the first 10 postoperative days, as well as during the course of a single day. The pain remains relatively constant for the first 7 days and begins to decrease only on the eighth postoperative day. During a single day there is increased pain in the morning compared with noon and evening. However, no statistically significant difference was detected in postoperative pain, bleeding, or healing between the wounds treated with fibrin glue and controls. Conclusions: The patient-based pain evaluation data should aid the physician in preoperative outcome counselling and targeted prescription of pain medication. However, contrary to previous indications, the authors cannot substantiate a significant beneficial effect;of fibrin glue in postoperative pain control, Furthermore, we did not find its action as a hemostatic agent clinically applicable in this setting, and thus fi

关键词：双盲法纤维蛋白组织黏着剂出血/药物疗法疼痛测定疼痛手术后/诊断疼痛手术后/药物疗法手术后并发症/药物疗法前瞻性研究时间因素扁桃体切除术/方法青少年成年人女(雌)性人类男(雄)性

来源：评论

学校读者我要写书评

暂无评论

PRELIMINARY TRIAL OF CYCLOPHOSPHAMIDE IN MANAGEMENT OF HEMOPHILIACS WITH FACTOR-VIII INHIBITORS

引用

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 1975年第JAN20期240卷 412-418页

作者： RUGGERI, ZM MANNUCCI, PM ALLAIN, JP FROMMEL, D UNIV MILAN HEMOPHILIA & THROMBOSIS CTR MILAN ITALY FRENCH RED CROSS HEMOPHILIA CTR LA QUEUE LES YVELINES FRANCE CTR NATL TRANSF SANGUINE PARIS FRANCE

来源：评论

学校读者我要写书评

暂无评论

Long-acting anticoagulant overdose: Brodifacoum kinetics and optimal vitamin K dosing

引用

ANNALS OF EMERGENCY MEDICINE 2000年第3期36卷 262-267页

作者： Bruno, GR Howland, MA McMeeking, A Hoffman, RS SUNY Hlth Sci Ctr Dept Emergency Med Brooklyn NY 11203 USA NYU Bellevue Hosp Med Ctr Dept Emergency Med New York NY USA St Johns Coll Pharm New York NY USA New York Poison Control Ctr New York NY USA

Ingestion of long-acting anticoagulant rodenticides such as brodifacoum can lead to prolonged and life-threatening coagulopathy. A paucity of conflicting information is available on brodifacoum's half-life and elimination pharmacokinetics. In addition, the optimal dose, duration, and route of administration of vitamin K-1 therapy are unknown. We report the case of a 52-year-old man who ingested eight 43-g boxes of a rodenticide (d-Con Mouse-Prufe II;0.005% brodifacoum;Reckitt & Colman, Wayne, NJ). This case demonstrates that after stabilization with fresh frozen plasma, high-dose oral vitamin K-1 therapy (congruent to 7 mg/kg per 24 hours divided every 6 hours) was effective in treating brodifacoum-induced coagulopathy. The concentration of vitamin K-1 required for normal coagulation in this case was less than the accepted value of 1 mu g/mL, which is derived from a rabbit model. In this case, brodifacoum appears to follow zero-order elimination pharmacokinetics. In future cases of patients with ingestions of long-acting anticoagulants who present with coagulopathy, it may be useful to obtain serial brodifacoum concentrations to determine elimination curves to help predict the duration of oral vitamin K-1 therapy.

关键词： 4-羟基香豆素类/血液 4-羟基香豆素类/药代动力学 4-羟基香豆素类/中毒投药口服随访研究半衰期出血/化学诱导出血/药物疗法代谢清除率服药过量血浆杀啮齿动物药/血液杀啮齿动物药/药代动力学杀啮齿动物药/中毒自杀未遂维生素K/投药和剂量维生素K/治疗应用人类男(雄)性中年人

来源：评论

学校读者我要写书评

暂无评论

USE OF ANIMAL AHG CONCENTRATES (FACTOR-VIII) IN TREATMENT OF LIFE-THREATENING HEMORRHAGE IN PATIENTS WITH FACTOR-VIII ANTIBODIES

引用

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 1975年第JAN20期240卷 362-369页

作者： RUBIN, R NIEMETZ, J ESTREN, S MT SINAI SCH MED BRONX NY 10468 USA VET ADM HOSP BRONX NY 10468 USA

来源：评论

学校读者我要写书评

暂无评论

ANTITHROMBIN AND ANTITHROMBOPLASTIN ACTIVITY ACCOMPANYING IGG MYELOMA - REPORT OF A CASE WITH A SEVERE BLEEDING TENDENCY

引用

AMERICAN JOURNAL OF CLINICAL PATHOLOGY 1975年第1期63卷 57-67页

作者： HARBAUGH, ME HILL, EM CONN, RB JOHNS HOPKINS MED INST DEPT LAB MEDBALTIMOREMD 21205

Four basic coagulation tests, the prothrombin time, thrombin time, partial thromboplastin time, and prothrombin consumption time, were used, with relatively simple modifications, to demonstrate the presence of two cir... 详细信息

关键词：抗凝血酶类/分离和提纯血液凝固试验耳疾病/并发症因子Ⅸ/分析因子Ⅴ/分析因子Ⅷ/分析血凝集抑制试验血肿/并发症出血/并发症出血/药物疗法出血/病因学热温度免疫电泳免疫球蛋白G/分析美法仑/治疗应用多发性骨髓瘤/并发症血浆去除术泼尼松/治疗应用凝血酶原时间凝血致活酶/拮抗剂和抑制剂凝血致活酶/分离和提纯人类男(雄)性中年人

来源：评论

学校读者我要写书评

暂无评论

Fibrin sealant: Update on clinical studies

引用

TRANSFUSION SCIENCE 1996年第3期17卷 341-342页

作者： Murphy, WG Milne, AA Ruckley, CV Kubba, AK Palmer, KR Scottish National Blood Transfusion Science Edinburgh Vascular Surgery & GI Unit U.K.

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：