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Severe anaphylaxis after a chlorhexidine bath

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY 1999年第5期40卷 771-772页

作者： Snellman, E Rantanen, T Paijat Hame Cent Hosp Dept Dermatol FIN-15850 Lahti Finland

Anaphylaxis to chlorhexidine is rare. We report a patient who experienced anaphylaxis during a whole body bath with chlorhexidine. Early signs of a type I allergy may have been masked because of previous concomitant t... 详细信息

关键词：投药皮肤过敏反应/化学诱导呼吸暂停/化学诱导浴/副作用头孢氨苄/投药和剂量头孢氨苄/治疗应用头孢菌素类/投药和剂量头孢菌素类/治疗应用氯己定/投药和剂量氯己定/副作用氯己定/类似物和衍生物皮炎刺激性/药物疗法皮肤科用药/投药和剂量皮肤科用药/副作用超敏反应速发型/化学诱导低血压/化学诱导 PUVA疗法痒疹/药物疗法人类男(雄)性中年人

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Evaluation of aloe vera gel gloves in the treatment of dry skin associated with occupational exposure

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AMERICAN JOURNAL OF INFECTION CONTROL 2003年第1期31卷 40-42页

作者： West, DP Zhu, YF Northwestern Univ Feinberg Sch Med Dept Dermatol Chicago IL 60611 USA Shen Wei Zhangjiagang Dayu Rubber Prod Jiangsu Peoples R China

Objective: An examination glove that delivers aloe vera (AV) gel to the gloved hand was studied in 30 adult females with bilateral occupational dry skin with or without irritant contact dermatitis (with or without erythema, fissures, and excoriations). Methods: All participants were factory assembly-line workers with repeated superficial skin trauma who attributed their dry, irritated, emollient-dependent skin to a common cause (occupational exposure). Participants were sequentially enrolled (after written informed consent, n = 29 evaluable participants) into an open, contralateral comparison study to evaluate efficacy of AV glove use 8 h/day to one hand versus no use to the opposite hand for 30 days, followed by 30 days rest, followed by 10 days of repeated use. Participant's dorsal hands were documented by standardized photos at baseline, during, and at the end of study. Results: Unblinded investigator baseline assessment rated dry skin as mild to moderate (n = 27), or moderate to severe (n = 2). Mean time to noticeable improvement for the AV glove hand was 3.5 days (range: 2-6 days) whereas marked improvement was 10.4 days (range: 7-17 days) for the AV glove hand. No improvement was detected for nonglove hands. Blinded photo assessment was rated independently by dermatology research staff. End-of-study mean global assessment of AV glove hands versus nonglove hands was 1.3 for AV glove hand (0 = no change, 1 = good [10%-89% global improvement], 2 = marked improvement [90%-100% global improvement]) versus 0 for nonglove hand (P < .0001). Mean global end-of-study assessments by the participants = 2.0 for AV glove hand versus 0 for nonglove hand. Conclusion: Dry-coated AV gloves that provide for gradual delivery of AV gel to skin produced a uniformly positive outcome of improved skin integrity, decreased appearance of fine wrinkling, and decreased erythema in the management of occupational dry skin and irritant contact dermatitis.

关键词：芦荟皮炎刺激性/药物疗法凝胶类手套防护手皮肤病/药物疗法职业病/药物疗法植物药疗法/方法植物制剂/治疗应用单盲法皮肤疾病/药物疗法成年人女(雌)性人类中年人

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Efficacy of a skin-protective foam in the treatment of chronic hand dermatitis

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American Journal of Contact Dermatitis 2000年第3期11卷 165-169页

作者： Fowler J.F. Jr. Division of Dermatology Department of Medicine University of Louisville School of Medicine Louisville KY United States

Background: Irritant and/or allergic hand dermatitis in individuals who are unable to avoid causative exposures is difficult to control. Usefulness of protective creams has been generally unsatisfactory. Objective: To determine if hand dermatitis, primarily of an occupational nature, could be improved by the use of a protective foam containing dimethicone and glycerin. Methods: Adult male and female subjects with chronic hand dermatitis for at least 12 months, felt to be either allergic, irritant, or combined in nature were given the study foam for routine application after a 2-week observation period. At 2 and 6 weeks the skin was evaluated by the investigator and subject for parameters including redness, scaling, fissuring, blistering, and pruritus on a numerical scale. A global evaluation also was performed. Photographs were taken at each visit. Usage of topical corticosteroids was recorded. No systemic therapies other than antihistamines were allowed. Results: Thirty-one subjects were enrolled in the study and 28 completed it. The physician and subject's initial global evaluations averaged 6.13 and 5.48, respectively (0-10 scale). The final scores were 3.68 and 4.75, respectively (P < .001 for physician rating;P = .259 for subject rating). Topical corticosteroid usage was reduced in 16 of 30 (53.6%) subjects. Twenty-one of 30 subjects (70.0%) had improved over the course of the study. No adverse effects were noted. Conclusion: This protective foam greatly or moderately improved chronic hand dermatitis in a sizable number of individuals with previously uncontrolled dermatitis despite continuing in their regular occupation. Copyright (C) 2000 by W.B. Saunders Company.

关键词：投药局部消炎药/治疗应用慢性病皮炎接触性/分类皮炎接触性/药物疗法皮炎接触性/病理学皮炎刺激性/分类皮炎刺激性/药物疗法皮炎刺激性/病理学皮炎职业性/分类皮炎职业性/药物疗法皮炎职业性/病理学二甲基聚硅氧烷类随访研究甘油/化学甘油/治疗应用手皮肤病/分类手皮肤病/药物疗法手皮肤病/病理学氢化可的松职业/统计学和数值数据疾病严重程度指数二甲聚硅氧烷/化学二甲聚硅氧烷/治疗应用治疗结果成年人女(雌)性人类男(雄)性

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