An individual cell is a chemical reactor with thousands of reactions operated under a highly sophisticated control system,and it is a self-regulated reactor that can alter its biosynthetic machinery to meet its demand...
详细信息
An individual cell is a chemical reactor with thousands of reactions operated under a highly sophisticated control system,and it is a self-regulated reactor that can alter its biosynthetic machinery to meet its demands in a changing environment.A simple mathematical model for the growth of a single cell of hybridoma is presented in this work in which the cell is divided into structural and genetic *** model can describe the changes in cell component,cell shape,cell size,substrate uptake, byproduct release and other temporal events during the cell division *** model parameters were regressed with experimental gross data of hybridoma in continuous culture,and specific uptake rate of glucose and glutamine of hybridoma in continuous culture were *** predicted values were in good agreement with experimental *** average relative deviation is 13.8%.
暂无评论