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FOLLOW-UP STUDIES OF CORTISONE TERATOGENICITY IN CD1 STRAIN MICE

JOURNAL OF DENTAL RESEARCH 1976年第4期55卷 598-601页

作者： LOEVY, HT UNIV ILLINOIS COLL DENT DEPT PEDODONTICS CHICAGO IL 60680 USA

Female newborns of cortisone-injected CD1 strain of mice were mated to siblings, were then injected during pregnancy with 5 mg of cortisone on either the 11th or the 12th day of gestation and were killed 1 day after delivery. The incidence of induced cleft palate was as high as the incidence of cortisone-induced cleft palate previously reported for this strain.

关键词：腭裂/化学诱导可的松/投药和剂量随访研究孕龄生长/药物作用母体胎儿间交换生殖/药物作用致畸剂动物女(雌)性男(雄)性小鼠妊娠

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Acute cortisone administration impairs retrieval of long-term declarative memory in humans

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NATURE NEUROSCIENCE 2000年第4期3卷 313-314页

作者： de Quervain, DJF Roozendaal, B Nitsch, RM McGaugh, JL Hock, C Univ Zurich Dept Psychiat Res CH-8029 Zurich Switzerland Univ Basel Dept Psychiat CH-4025 Basel Switzerland Univ Calif Irvine Ctr Neurobiol Learning & Memory Irvine CA 92697 USA Univ Calif Irvine Dept Neurobiol & Behav Irvine CA 92697 USA

Studies the detrimental influence of acute cortisone administration on the retrieval of long-term declarative memory in humans. Administration of placebo and cortisone to healthy male and female humans; Similarity of cortisol levels after the pharmacological treatment with that induced by major psychological stress; Indication that cortisone impairs free recall of verbal material.

关键词：消炎药/投药和剂量消炎药/分析可的松/投药和剂量可的松/分析回忆/药物作用唾液/化学时间因素言语学习/药物作用成年人女(雌)性人类男(雄)性

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A rare case of osteoporotic spine fracture associated with epidural lipomatosis causing paraplegia following long-term cortisone therapy

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ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY 2000年第7-8期120卷 484-486页

作者： Andress, HJ Schürmann, M Heuck, A Schmand, J Lob, G Univ Munich Klinikum Grosshadern Dept Surg Traumatol Unit D-81377 Munich Germany Univ Munich Klinikum Grosshadern Inst Clin Radiol D-81377 Munich Germany

Cushing's syndrome is frequently associated with osteoporosis. Therefore, the incidence of osteoporotic spine fractures is significant. They are a rare cause of paraplegic syndromes. Additionally, epidural lipomatosis may occur in those patients. The combination of both fracture and lipomatosis may cause neurological deficit. A case of a young patient suffering from drug-induced Cushing's syndrome is reported. She developed progressive paraplegia, Radiographs demonstrated kyphosis of the thoracic spine from T7 to T9 and pathologic fractures. Urgent operation was planned to stabilize and decompress the spinal cord in the area of the kyphosis. Fortunately, magnetic resonance imaging (MRI) was conducted first. It confirmed pathologic fractures of T7-9 but also showed massive epidural fat extending from the level of T1 to T9. As suspected, laminectomy alone in the area of the fracture proved to be insufficient, as shown by myelography during operation. For treatment of paraplegia in this case of symptomatic epidural lipomatosis, an expanded laminectomy was necessary to remove all the epidural fat. Having undergone this procedure, the patient is now recovering from paraplegia. Our experience suggests that care should be taken before operative treatment of patients with pathological fractures in combination with Cushing's syndrome. In addition to vertebral fractures, epidural lipomatosis has to be taken into consideration. Those patients with neurological deficits have to be treated by an extensive laminectomy.

关键词：结肠炎溃疡性/药物疗法可的松/投药和剂量硬膜外腔骨折自发性/化学诱导骨折自发性/放射摄影术骨折自发性/外科学脊柱后凸/化学诱导脊柱后凸/放射摄影术脊柱后凸/外科学脂肪瘤样病/化学诱导脂肪瘤样病/放射摄影术脂肪瘤样病/外科学磁共振成像骨质疏松/化学诱导骨质疏松/放射摄影术骨质疏松/外科学截瘫/化学诱导截瘫/放射摄影术截瘫/外科学脊髓压迫症/化学诱导脊髓压迫症/放射摄影术脊髓压迫症/外科学脊柱骨折/化学诱导脊柱骨折/放射摄影术脊柱骨折/外科学脊柱融合术胸椎/损伤胸椎/放射摄影术胸椎/外科学成年人女(雌)性人类

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高糖-可的松混合液治疗超乳术后角膜水肿的临床疗效

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医学临床研究 2010年第6期27卷 1153-1154页

作者：肖蓉蓉王适宜肖建雄湖南省邵阳市第一人民医院眼科湖南邵阳422001

【目的】探讨高糖一可的松混合液对超声乳化术后角膜水肿的治疗作用。【方法】对术后第一天出现角膜水肿的患眼进行随机分组，实验组用高糖一可的松混合液点术眼，每小时一次，对照组用可的松眼药水点术眼，每小时一次，对滴药疗效进行... 详细信息

【目的】探讨高糖一可的松混合液对超声乳化术后角膜水肿的治疗作用。【方法】对术后第一天出现角膜水肿的患眼进行随机分组，实验组用高糖一可的松混合液点术眼，每小时一次，对照组用可的松眼药水点术眼，每小时一次，对滴药疗效进行分析评价。【结果】2～4级角膜水肿实验组疗效显著优于对照组，且差异有显著性（P〈0．05）。【结论】高糖一可的松混合液可提高白内障超乳术后2～4级角膜水肿的疗效，缩短患者的住院日期。

关键词：超声乳化白内障吸除术角膜水肿可的松/投药和剂量

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IATROGENIC HOMOSEXUALITY - GENDER IDENTITY IN 7 46,XX CHROMOSOMAL FEMALES WITH HYPER-ADRENOCORTICAL HERMAPHRODITISM BORN WITH A PENIS, 3 REARED AS BOYS, 4 REARED AS GIRLS

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JOURNAL OF HOMOSEXUALITY 1976年第4期1卷 357-371页

作者： MONEY, J DALERY, J JOHNS HOPKINS UNIV HOSP DEPT PSYCHIATBALTIMOREMD 21205 JOHNS HOPKINS UNIV HOSP DEPT PEDIATBALTIMOREMD 21205

This paper describes seven chromosomal and gonadal females with the adrenogenital syndrome who were born with a penis as a result of extreme fetal androgenization. Four of them were reared as girls and differentiated a female gender identity with tomboyism. The other three were reared as boys, differentiated a male gender identity, and performed sexually as men with women partners. Even though these men are by no means homosexual in the everyday meaning of the term, the sexual relation is homosexual on the criteria of chromosomal and gonadal sex. The prenatal hormonal environment as well as the social experience of the rearing have thus demonstrated a formula for creating the perfect female homosexual.

关键词：成就适应心理学肾上腺增生先天性/遗传学儿童抚养可的松/投药和剂量随访研究性别特性同性恋/病因学医原性疾病认同(心理学) 核型分析运动活动游戏和玩具假两性畸形/遗传学性染色体性行为青少年儿童儿童学龄前女(雌)性人类婴儿婴儿新生

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Experimental hormonal tenolysis by cortisone therapy

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Archiv für Orthopädische und Unfall-Chirurgie 1976年第1期84卷 1-12页

作者： Walcher, K. v. Lüdinghausen, M. Kuzmany, J. Matzen, K.A. Küsswetter, W. Orthopädische Klinik und Poliklinik der Universität München Germany Anatomisches Institut der Universität München Germany Chirurgische Abteilung II (Unfallchirurgie) St. Joseph-Krankenhaus Berlin-Tempelhof Germany

To prevent tendons from postoperative proliferation and adhesion to surrounding structures is still a main problem in handsurgery. In addition to numerous modifications of atraumatic handsurgical techniques which have been developed some sporadic attempts are made by animal experiments and clinical trials in order to avoid postoperative adhesive tenosynovitis by hormone therapy. Because of the high doses of cortisone which are required this method of treatment is generally not accepted. Using a new method of postoperative fixation of flexor tendon sutures in rabbits the possibility of a "hormonal tenolysis" by extremely high doses of cortisone could be confirmed. In a following study it is planned to perform breaking experiments on tendons after hormone therapy in order to determine the upper limit of the therapeutical range of cortisone medication. © 1976 J. F. Bergmann-Verlag.

关键词：黏连/预防和控制可的松/投药和剂量可的松/治疗应用手/外科学手术后医护手术后并发症/预防和控制腱/病理学腱/外科学腱鞘炎/预防和控制时间因素动物兔

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Fear of cortison: In pulmonary rehabilitation less than expected. Results of a patient's questionnaire

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Pneumologie 2000年第2期54卷 68-71页

作者： Hirschbichler, A. Spohn, S. Petro, W. Klin. Bad Reichenhall LVA Ndb.-O. Fachklinik Enkrankungen A. Bad Reichenhall Germany Klin. Bad Reichenhall LVA Ndb.-O. 83435 Bad Reichenhall Salzburger Str. 8-11 Germany

Background: The treatment of diseases of the upper and lower respiratory tracts can't be imagined without corticoids, applied systemically of locally. In specialist literature one can find indications of a certain reservation towards this kind of medication on the part of many patients. Sometimes, this reservation is so strong that it can be referred to as a regular fear of cortison. Bad compliance and with it, frequently, a deterioration of the symptoms, are inevitable consequences. The aim of the study was to find out how distinct the fear of cortison is with patients in pneumological rehabilitation and wether there are any relations with other spheres of attitude. Method: Patients with COPD and asthma with inhalative and/or systemic corticoid medication received an extensive questionnaire during their rehabilitation as in-patients for four weeks. 102 questionnaires were evaluated. Results: The statements of the patients indicated high compliance regarding corticoid medication. As to the fear of such preparation, only 5/102 (4.9%) of those questioned produced results which suggest strong fear of cortison. Fear of cortison is, among other things, slightly related to general psychic stress and a general negative attitude towards medicine. There is a negative correlation between compliance at the taking of medicine and fear of cortison. Conclusions: Contrary to statements in specialist literature of wide-spread reservations and fear towards cortison, we have found out that these play only a minor part, at least with the mostly elderly clientele of pneumological rehabilitation. Different explanations are discussed.

关键词：可的松/投药和剂量恐惧健康知识态度实践肺疾病阻塞性/心理学肺疾病阻塞性/康复病人接受卫生保健的程度病人入院疾病角色成年人老年人老年人 80以上女(雌)性人类男(雄)性中年人

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