Specific features of hantavirus infection in bank vole (Clethrionomys glareolus) were studied in the endemic area of hemorrhagic fever with renal syndrome (HFRS) in the foothills of the Ural mountains, using long-term...
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Specific features of hantavirus infection in bank vole (Clethrionomys glareolus) were studied in the endemic area of hemorrhagic fever with renal syndrome (HFRS) in the foothills of the Ural mountains, using long-term observations on living animals by the capture-mark-recapture (CMR) method. The results demonstrated that the infection naturally circulating in the voles is chronic (lasting for up to 15 months) and asymptomatic, with a peak of Puumala virus accumulation and release from the organism during the first month after infection. It was shown that the bank vole population includes young animals with maternal immunity, which remain resistant to the Puumala virus infection for 3-3.5 months. The infection rate in voles depended on the age and sexual maturity of animals. The greatest proportion of seropositive animals was observed among overwintered males. Seroconversion in voles was more frequent during the period of high reproductive activity.
The recently described virus-induced pneumonia in guinea pigs was experimentally reproducible in newborn animals, though not in preadult animals. Baby hamsters and newborn rats were also not susceptible to infection. ...
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The recently described virus-induced pneumonia in guinea pigs was experimentally reproducible in newborn animals, though not in preadult animals. Baby hamsters and newborn rats were also not susceptible to infection. Of 11 infected newborn guinea pigs, 10 developed pathological changes identical with those found in spontaneous cases. The incubation period was from 5 to 10 days. The agent could not be cultivated in vitro, and therefore no applicable serological tests could be established. The morphology of the virus, its intranuclear location, the course of the disease and the histopathological and ultrastructural changes strongly suggest that the virus is an adenovirus specific for guinea pigs. The virus did not crossreact with human or fowl adenoviruses. It was ether resistant and nononcogenic in baby rats and hamsters. During a 5-yr period a total of 51 spontaneous death cases diagnosed as adenovirus pneumonia was registered in the experimental guinea pigs, 4 from the breeding colony.
作者：
WARD, JMLOCK, ACOLLINS, MJGONDA, MAREYNOLDS, CWNCI
BIOL RESPONSE MODIFIERS PROGRAM FREDERICK MD 21701 USA NIH
DIV RES SERV VET RESOURCES BRANCH COMPARAT PATHOL SECT BETHESDA MD 20205 USA NCI
FREDERICK CANC RES FACIL PROGRAM RESOURCES INC ANIM HLTH DIAGNOST LAB FREDERICK MD 21701 USA NCI
FREDERICK CANC RES FACIL PROGRAM RESOURCES INC ELECTRON MICROSCOPY LAB FREDERICK MD 21701 USA
A wasting disease was found in 32 athymic nude rats. The rats had parotid sialoadenitis with intranuclear inclusion bodies in ductal and acinar epithelial cells. Other common lesions included bronchitis, bronchiolitis...
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A wasting disease was found in 32 athymic nude rats. The rats had parotid sialoadenitis with intranuclear inclusion bodies in ductal and acinar epithelial cells. Other common lesions included bronchitis, bronchiolitis and secondary bacterial pneumonia. Less commonly, rhinitis and Harderian adenitis were seen. Intranuclear inclusions were also seen in bronchial epithelium of 1 rat, Harderian gland acini of 1 rat and laryngeal glands of 2 rats. Viral particles, averaging 45 nm in diameter, sometimes in crystalline arrays, were found in the nucleus of parotid epithelial cells. By the use of the avidin-biotin-peroxidase complex (ABC) immunoperoxidase technique, antibodies to disrupted SV40 virus (the group specific antigen of the polyoma virus (miopapova virus) genus of the papova virus family) reacted with intranuclear inclusions and cytoplasm of parotid epithelium and inclusions in lung and Harderian gland. The viral antigen did not cross-react with antibodies to mouse polyoma, mouse K or disrupted bovine papillomaviruses.
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