Objective: To determine whether body size and perceived figure, both current and historical, are associated with a diagnosis of endometriosis on laparoscopy. Design: Cohort study of consecutively identified patients u...
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Objective: To determine whether body size and perceived figure, both current and historical, are associated with a diagnosis of endometriosis on laparoscopy. Design: Cohort study of consecutively identified patients undergoing laparoscopy for tubal sterilization or as a diagnostic procedure. Setting: Two university-affiliated hospitals. Patient(s): A cohort of 84 women aged 18-40 years. Endometriosis was visualized in 32 cases; 52 women (controls) had no visualized endometriosis, including 22 undergoing tubal sterilization and 30 with other gynecologic pathology. Intervention(s): None. Main Outcome Measure(s): Body mass index (BMI, kg/m2) from self-report and perception of body figure were compared for their ability to predict case status (diagnosed endometriosis), using logistic regression models. Longitudinal trends in BMI based on perceived figure at 5-year intervals from age 15 years were compared using mixed linear models. Result(s): Based on self-report, women diagnosed with endometriosis were taller, thinner, and had a significantly lower BMI. In this series, cases were more likely to be late maturers (menarche at ≥14 y) and late to initiate sexual activity (≥21 y), and they were less likely to be gravid, parous, and a current smoker. Adjusting for age (in years), being tall (height ≥68 in), and parity (yes vs. no), a higher current BMI was statistically protective for a diagnosis of endometriosis, regardless of whether BMI was determined by self-report (adjusted odds ratio AOR = 0.88, 95%confidence interval CI 0.79-0.99) or from perceived figure (AOR = 0.86, 95%CI 0.75-0.99). For every unit increase in BMI (kg/m2), there was an approximate 12%-14%decrease in the likelihood of being diagnosedwith endometriosis. In an adjusted repeated measures model, BMI was 21.3 ±0.6 kg/m2 (estimate ±SE) for women with endometriosis, compared with 23.2 ±0.4 kg/m2 for the controls, a difference over all ages of-1.9 ±0.8 kg/m2. This is a consistent difference of about 10 lb at
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