在无脊椎动物中,foraging 基因也叫 for 基因,它编码 NO-cGMP 通路下游一个很重要的效应激酶——蛋白激酶 G（PKG）。在果蝇中存在着 for 基因的两个等位基因 for 和 for,携带 for 等位基因的果蝇 PKG 的表达水平高于携带 for 等位基因...
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在无脊椎动物中,foraging 基因也叫 for 基因,它编码 NO-cGMP 通路下游一个很重要的效应激酶——蛋白激酶 G（PKG）。在果蝇中存在着 for 基因的两个等位基因 for 和 for,携带 for 等位基因的果蝇 PKG 的表达水平高于携带 for 等位基因的果蝇,这一差异导致它们采用完全不同的觅食策略。for 型的果蝇幼虫（rover）在有食物的情
Background &Aims: Liver transplant recipients infected with hepatitis C virus (HCV) develop recurrent hepatitis soon after transplantation and, in some cases, progress to fibrosis within the first 2 years. Our goa...
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Background &Aims: Liver transplant recipients infected with hepatitis C virus (HCV) develop recurrent hepatitis soon after transplantation and, in some cases, progress to fibrosis within the first 2 years. Our goals were to identify molecular processes influencing the liver disease progression and to find potential gene markers of early fibrosis. Methods: We performed gene expression profiling on serial liver biopsy specimens obtained from 13 (11 infected and 2 uninfected) transplant recipients within the first year after transplantation at 0, 3, 6, and 12 months. The data were compared with clinical observations and with a gene expression database obtained for 55 nontransplant HCV-infected and uninfected liver samples. Results: We identified several specific gene expression patterns. The first pattern was unique for the transplant recipients regardless of their infection status. The corresponding genes encoded stress response proteins and blood proteins involved in coagulation that were differentially expressed in response to posttransplantation graft recovery. The second pattern was specific to HCV-infected samples and included up-regulation of genes encoding components of the interferon-mediated antiviral response and immune system (antigen presentation, cytotoxic response). This upregulation pattern was absent or suppressed in the patients who developed early fibrosis, indicating that the disease progression might result from an impaired liver response to infection. Finally, we identified gene expression patterns that were specific for 12-month biopsy specimens in all 4 HCV-infected patients who developed early fibrosis. Conclusions: The identified gene expression patterns may prove useful for diagnostic and prognostic applications in HCV-infected patients, including predicting early progression to fibrosis.
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