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中国临床康复 2004年第30期8卷 6559-6561页

作者：宋晓菲刘彦君王维华刘垠兰倪彩虹许樟荣解放军第三○六医院内分泌科北京市100101 解放军第三○六医院妇产科北京市100101

目的:调查妊娠糖尿病患者抑郁患病情况,分析妊娠糖尿病患者抑郁相关因素及其不良后果,揭示妊娠糖尿病患者抑郁防治的重要性。方法:采用抑郁自评量表(self-ratingdepressionscale,SDS)对50例妊娠糖尿病患者及54例正常孕妇进行调查,制定... 详细信息

目的:调查妊娠糖尿病患者抑郁患病情况,分析妊娠糖尿病患者抑郁相关因素及其不良后果,揭示妊娠糖尿病患者抑郁防治的重要性。方法:采用抑郁自评量表(self-ratingdepressionscale,SDS)对50例妊娠糖尿病患者及54例正常孕妇进行调查,制定糖尿病对患者心理状态影响因素问卷调查表,并对妊娠糖尿病患者进行书面调查;同时测定妊娠糖尿病患者的血糖、血脂、尿微量白蛋白(Album/Creatinine,A/C)、超敏C-反应蛋白(superC-reactiveprotein,sCRP)、胰岛素、心率、血压,追踪其新生儿出生时状况;分析抑郁形成的相关因素及抑郁对孕妇及新生儿的影响。结果:妊娠糖尿病患者抑郁占22%,明显高于血糖正常孕妇7.4%。抑郁的妊娠糖尿病患者心率,A/C显著高于非抑郁组犤心率:(101.1±10.2)次/min比(92.4±9.3)次/min,t=4.211,P<0.001;A/C:(127.3±66.5)mg/g比(13.8±8.1)mg/g,t=2.177,P<0.05犦。服糖后1h胰岛素水平明显低于非抑郁组犤(102.1±65.2)mIU/L比(58.3±32.4)mIU/L,t=2.147,P<0.05犦。新生儿平均体质量犤(3200.4±264.5)g比(3495.5±480.7)g,t=2.321,P<0.05犦、脐带平均长犤(50.2±8.3)cm比(56.4±7.1)cm,t=2.056,P<0.05犦明显低于非抑郁的妊娠糖尿病患者。对患者心理状态产生影响的危险因素依次为血糖监测麻烦。

关键词：糖尿病妊娠/并发症抑郁障碍简明精神病状态评定量表心率白蛋白类胰岛素/代谢

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孕母慢性淋巴细胞性甲状腺炎对婴儿智能发育的影响

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浙江大学学报（医学版） 2006年第3期35卷 292-296页

作者：朱红毛华庆陈黎勤蒋优君浙江大学医学院附属儿童医院内分泌科浙江杭州310003

目的:探讨孕母患慢性淋巴细胞性甲状腺炎对婴儿的影响。方法:通过浙江省新生儿疾病筛查网络系统,从2001年7月至2003年6月对21例母亲患慢性淋巴细胞性甲状腺炎的婴儿进行随访,观察其甲状腺功能情况,并采用G esell发育量表对其智能发育进... 详细信息

目的:探讨孕母患慢性淋巴细胞性甲状腺炎对婴儿的影响。方法:通过浙江省新生儿疾病筛查网络系统,从2001年7月至2003年6月对21例母亲患慢性淋巴细胞性甲状腺炎的婴儿进行随访,观察其甲状腺功能情况,并采用G esell发育量表对其智能发育进行跟踪调查。结果:21例婴儿中甲状腺功能正常8例,高TSH血症11例,先天性甲低2例,与同期健康母亲的新生儿相比差异有显著性(P<0.01);孕母患慢性淋巴细胞性甲状腺炎的婴儿其应物能、应人能、粗动作能、细动作能发育均落后,与健康孕母的婴儿比较,差异有显著性(P<0.05)。结论:孕母患慢性淋巴细胞性甲状腺炎对婴儿甲状腺功能及智能发育有影响。

关键词：妊娠/并发症婴儿甲状腺炎,自身免疫性/并发症精神发育迟滞/病因学

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Increased prevalence of type 2 diabetes mellitus and impaired glucose tolerance in first-degree relatives of girls with a history of precocious pubarche

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CLINICAL ENDOCRINOLOGY 1999年第4期51卷 395-401页

作者： Ibáñez, L Castell, C Tresserras, R Potau, N Hosp Univ Materno Infantil Vall Hebron Hormonal Lab Barcelona 08035 Spain Univ Barcelona Hosp St Joan Deu Endocrinol Unit E-08007 Barcelona Spain Autonomous Govt Catalonia Dept Hlth & Social Secur Barcelona Spain Univ Barcelona Dept Publ Hlth E-08007 Barcelona Spain

OBJECTIVE To assess whether abnormal responses to an oral glucose load, dyslipidaemia and hyperandrogenaemia, which are commonly found in girls with a history of precocious pubarche, can also be detected in first-degree relatives of these patients. PATIENTS AND DESIGN Sixty first-degree relatives (age, 41.4 +/- 4.4 years;BMI, 26.9 +/- 3.3 kg/m(2)) of girls diagnosed with precocious pubarche were studied. The prevalence of gestational diabetes mellitus and the hirsutism score were assessed in the females. The study was performed during the early follicular phase of the menstrual cycle in females and at random in males. MEASUREMENTS All subjects underwent a standard 75 g 2-h oral glucose tolerance test (OGTT), Serum lipids and lipoproteins were measured in baseline blood samples in all subjects, while serum testosterone, sex hormone-binding globulin (SHBG) levels and the free androgen indices were determined only in females. Impaired glucose tolerance (IGT) and type 2 diabetes mellitus were diagnosed according to the criteria of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus, RESULTS Seven subjects (11.6%) had type 2 diabetes while a further 14 (23.3%) had IGT;prevalences significantly higher than those reported for the present population of the same age (type 2 diabetes, 2.5% and IGT, 7.5%;P < 0.001 and P < 0.001, respectively). BMIs were similar in patients with either normal or abnormal glucose tolerance. Abnormal levels of at least two lipid parameters were found in 40% of subjects. Four out of 10 hirsute women and six non-hirsute women reported gestational diabetes. Mean serum SHBG levels were lower in female relatives compared with population controls (P < 0.0005). CONCLUSIONS First-degree relatives of girls with precocious pubarche are at a higher risk of impaired glucose tolerance and type 2 diabetes which, in most cases, is accompanied by an unfavourable lipid profile. Hyperandrogenism and an increased prevalence of gestational

关键词：糖尿病 2型/血液糖尿病 2型/遗传学糖尿病妊娠/血液糖尿病妊娠/并发症父亲卵泡期/代谢葡糖耐受不良/血液葡糖耐受不良/遗传学葡糖耐量试验脂类/血液母亲患病率青春期早熟/血液青春期早熟/遗传学性激素结合球蛋白/分析统计学非参数成年人女(雌)性人类男(雄)性中年人妊娠

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A multiethnic study of the predictors of macrosomia

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DIABETES EDUCATOR 1999年第6期25卷 925-933页

作者： Hardy, DS [o_1]13511 Country Green Court Houston TX77059.

PURPOSE This study examined predictors of macrosomia in a multiethnic sample of 213 low-income women diagnosed with gestational diabetes mellitus (GDM) after week 24 of their pregnancy. METHODS Medical records were reviewed retrospectively. Variables examined were mother's height, weight history, educational level, age at diagnosis, weeks at diagnosis and delivery, type of diabetes, mean fasting blood glucose (FBC), and infant's weight, sex, and Apgar scores. RESULTS Fifty-one percent of babies were macrosomic. Weight gain, nonpregnant weight, weight at delivery, FBG, and Apgar scores at 1 minute were associated with macrosomia, especially in Hispanic women. Logistic regression revealed that nonpregnant weight was the strongest predictor of macrosomia. CONCLUSIONS Nonobese GDM mothers with optimal weight gain but with high FBG levels >90 mg/dL may be at risk for macrosomia. The major concerns with obese GDM mothers are nonpregnant weight and high blood glucose levels, in this order. Education for women with GDM should target these risk factors to decrease macrosomia.

关键词：非洲裔美国人/统计学和数值数据糖尿病妊娠/血液糖尿病妊娠/并发症糖尿病妊娠/人种学教育程度欧洲大陆世系人群/统计学和数值数据巨大胎儿/人种学西班牙裔美国人/统计学和数值数据生活方式 Logistic模型贫困/统计学和数值数据试验预期值回顾性研究危险因素得克萨斯女(雌)性人类妊娠

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The prevalence of polycystic ovaries in women with a history of gestational diabetes

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CLINICAL ENDOCRINOLOGY 2000年第4期53卷 501-507页

作者： Kousta, E Cela, E Lawrence, N Penny, A Millauer, B White, D Wilson, H Robinson, S Johnston, D McCarthy, M Franks, S Univ London Imperial Coll Sci Technol & Med St Marys Hosp Sch Med Dept Reprod Sci & Med London W2 1PG England Univ London Imperial Coll Sci Technol & Med St Marys Hosp Sch Med Sect Endocrinol & Metab Med London W2 1PG England

OBJECTIVE Women with a history of gestational diabetes mellitus (GDM) and women with polycystic ovary syndrome (PCOS) both demonstrate abnormalities in insulin action and secretion, and both are at increased risk of developing type 2 diabetes. To determine whether these similarities reflect a common pathophysiological basis, we examined the prevalence of ultrasound-based polycystic ovarian morphology in a large multiethnic group of women with a history of GDM and a group of women who had normal glucose tolerance during pregnancy. PATIENTS AND DESIGN We studied 91 women with previous GDM (48 European, 20 South Asian, 10 Afro-Caribbean and 13 of other or mixed ethnicity) and 73 normoglycaemic control women (56 European, one South Asian, 14 Afro-Caribbean and two of other or mixed ethnicity), a median (interquartile range) of 20 (11-36) and 29 (17-49) months postpartum, respectively. A detailed history was taken, and the prevalence of PCO morphology on ultrasound scan was assessed. Fasting lipids, insulin, glucose status, gonadotrophins and testosterone were measured. Estimates of beta-cell function (%B) and insulin sensitivity (%S) were derived using the HOMA algorithm. RESULTS Women with previous GDM had higher fasting glucose (5.4 (4.8-6.0) vs. 4.7 (4.4-5.0) mmol/l, P < 0.0001) and features reminiscent of syndrome X: higher BMI (26.4 (22.8-31.4) vs. 23.8 (21.0-27.5) kg/m(2), P = 0.002), waist/hip ratio (0.82 (0.79-0.88) vs. 0.77 (0.73-0.81), P < 0.0001), fasting insulin (165 (68-299) vs. 54 (24-156) pmol/l, P < 0.0001), triglycerides (1.1 (0.8-1.6) vs. 0.8 (0.6-1.1) mmol/l, P < 0.0001) and lower insulin sensitivity (%S) (27 (16-62) vs. 86 (34-139)%, P < 0.0001) compared to control women. The prevalence of PCO was higher in the previous GDM group than in the control subjects (47/91 (52%) vs. 20/73 (27%), chi(2) = 9.86, P = 0.002 overall, odds ratio 2.7, P = 0.007 by logistic regression allowing for ethnicity). There was no difference in any metabolic parameter betwee

关键词：血糖/代谢卡方分布糖尿病妊娠/并发症糖尿病妊娠/诊断显像糖尿病妊娠/人种学人种群卵泡刺激素/血液胰岛素/血液脂类/血液 Logistic模型促黄体激素/血液月经失调/并发症月经失调/诊断显像月经失调/人种学卵巢/诊断显像多囊卵巢综合征/并发症多囊卵巢综合征/诊断多囊卵巢综合征/人种学产后期患病率回顾性研究统计学非参数睾酮/血液超声检查女(雌)性人类妊娠

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BLOOD EOSINOPHIL RESPONSES TO ACTH IN HYPEREMESIS GRAVIDARUM

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ACTA PHYSIOLOGICA SCANDINAVICA 1954年第2-3期31卷 187-193页

作者： JARVINEN, PA UUSPAA, VJ Second Women's Clinic University of Heismki and from the Department of Pharmacology University of Helsinki Finland. Fellow Rockefeller Foundation.

***\'s test was carried out, during the first trimester of pregnancy, in ten cases of hyperemesis gravidarum and in ten control cases of normal *** the cases of hyperemesis, the average initial eosinophil count carried out before the administration of ACTH was slightly higher than in the control series. After the injection of ACTH. 70 per cent of the cases of hyperemesis showed a fall of less than 50 per cent in the number of circulating eosinophils, while in all control cases it was more than 50 per *** result seems to suggest the presence of an adaptation disturbance in hyperemesis gravidarum, with an insufficient absolute or relative output of II‐oxycorticosteroid

关键词：嗜酸细胞/药物作用白细胞计数/药物作用妊娠/并发症呕吐

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MANAGEMENT OF PRIMARY CARCINOMA OF THE RECTUM DIAGNOSED DURING PREGNANCY

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AMERICAN JOURNAL OF SURGERY 1955年第5期90卷 816-825页

作者： MCLEAN, DW ARMINSKI, TC BRADLEY, GT Detroit Michigan U.S.A.

The methods of treatment of primary carcinoma of the rectum or rectosigmoid diagnosed during pregnancy are determined by the stage of the pregnancy, the extent of the malignancy and the presence or absence of complications. Thus, the following treatments should be instituted depending upon the time of diagnosis: 1.1. Prior to the twentieth week of gestation—treat at once without regard for the pregnancy.2.2. Between the twentieth and twenty-seventh week—treat according to the extent of the malignancy, namely, (a) early or presumably curable lesions—treat by hysterotomy and resection without delay; (b) advanced malignancy—treat by Porro section after the thirtieth week followed by appropriate palliative treatment for the malignancy.3.3. After the twenty-seventh week—cesarean section at thirty to thirty-two weeks with resection of the tumor, or resection of the tumor two weeks later.4.4. After the thirty-second week—treat as in paragraph 3 without delay.5.5. At any stage of the pregnancy when the rectal malignancy is complicated by obstruction, perforation, severe hemorrhage or ulcerative colitis—treat at once without regard for the pregnancy.

关键词：妊娠/并发症

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IMPERFORATE ANUS COMPLICATING PREGNANCY

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AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY 1953年第6期66卷 1286-1289页

作者： POWELL, DV LOWDEN, RJ Department of Obstetrics and Gynecology of Western Reserve University at City Hospital Cleveland Ohio USA

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FATAL SUBARACHNOID HAEMORRHAGES IN PREGNANT WOMEN WITH INTRACRANIAL AND INTRAMEDULLARY VASCULAR MALFORMATIONS

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ACTA PSYCHIATRICA ET NEUROLOGICA SCANDINAVICA 1954年第4期29卷 441-451页

作者： CHRISTENSEN, E LARSEN, H PSYCHIATRIC LABORATORY OF THE UNIVERSITY OF COPENHAGEN (CHIEF: PROFESSOR VILLARS LUNN M.D.) AND THE UNIVERSITY INSTITUTE OF PATHOLOGICAL ANATOMY (CHIEF: PROFESSOR J. ENGELBRETHHOLM M.D.)

A report is given of 5 cases of pregnant women, with fatal subarachnoid hemorrhages in the latter part of pregnancy in 4. Three of these patients had intracranial vascular malformations with ruptured blood vessels and subarachnoid hemorrhages, which in 2 of the cases took a fatal course. One patient had an intramedullary cervical hemangioma with fatal hemorrhage. The 5th patient was a woman suffering from a tumor of the hypophysis, also with a fatal subarachnoid hemorrhage probably originating from abnormal vessels round the tumor. Attention is called to the circumstance that even uncomplicated pregnancy means a very serious complication for patients with intracranial and intraspinal, space-occupying, processes[long dash]especially vascular malformations[long dash]as towards the end of pregnancy there is an increase in the blood volume and minute volume together with a rise in the blood pressure on working.

关键词：畸形脑/血液供给妊娠/并发症蛛网膜下腔出血

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艾叶煎敷配合炉甘石洗剂及激素治疗妊娠瘙痒临床观察

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陕西中医 2014年第6期35卷 709-710页

作者：王颖张岩雪孙军华河北省民政总医院邢台054000

目的:探讨中西医结合治疗妊娠瘙痒的临床疗效。方法:对照组A采用艾叶煎服外敷,对照组B采用炉甘石洗剂以及外用皮质类固醇激素,治疗组采用上述中西医结合治疗方案。结果:治疗组的治疗效果均显著优于对照组A和对照组B,两组相比较差别具有... 详细信息

目的:探讨中西医结合治疗妊娠瘙痒的临床疗效。方法:对照组A采用艾叶煎服外敷,对照组B采用炉甘石洗剂以及外用皮质类固醇激素,治疗组采用上述中西医结合治疗方案。结果:治疗组的治疗效果均显著优于对照组A和对照组B,两组相比较差别具有统计学意义(P<0.05);治疗组的治疗时间均明显短于对照组A和对照组B,两组相比较差别具有统计学意义(P<0.05);根据满意度调查分析,治疗组患者满意率均大大高于对照组A和B,两组相比较差别具有统计学意义(P<0.05)。结论:中西医结合能有效缓解患者的瘙痒症状,增加患者的舒适度,值得临床上广泛应用。

关键词：妊娠/并发症瘙痒症/中医药疗法艾叶/治疗应用炉甘石洗剂

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