作者：
Watkins, KEGadian, DGVargha-Khadem, FMcGill Univ
Montreal Neurol Inst Cognit Neurosci Unit Montreal PQ H3A 2B4 Canada UCL
Sch Med Inst Child Hlth Radiol & Phys Unit London W1N 8AA England UCL
Sch Med Inst Child Hlth Cognit Neurosci Unit London W1N 8AA England
Examines the function of brain morphometry in developmental language disorder in London, England. Causes of developmental cognitive disorders; Implications of genetic etiology for brain structure and function; Use of ...
详细信息
Examines the function of brain morphometry in developmental language disorder in London, England. Causes of developmental cognitive disorders; Implications of genetic etiology for brain structure and function; Use of magnetic resonance imaging for cognitive disorder detection.
To investigate changes in the relation between presynaptic and postsynaptic dopaminergic functions in vivo in both nigrostriatal and mesocortical systems in Parkinson's disease (PD), 10 drug-naive early PD patient...
详细信息
To investigate changes in the relation between presynaptic and postsynaptic dopaminergic functions in vivo in both nigrostriatal and mesocortical systems in Parkinson's disease (PD), 10 drug-naive early PD patients were studied twice using positron emission tomography with [C-11]CFT (dopamine transporter probe) followed by [C-11]SCH 23390 (D1 receptor probe). Regional binding potentials (k(3)/k(4)) of [C-11]CFT and [C-11]SCH 23390 in the striatum (nigrostriatal system) and the orbitofrontal cortex (mesocortical system) were estimated by compartment analyses. Levels of [C-11]CFT k(3)/k(4) in the two projection areas were shown to be significantly lower in PD, whereas [C-11]SCH 23390 levels remained unchanged. Regression analysis showed that estimates of CFT k(3)/k(4) were positively correlated with those of SCH 23390 k(3)/k(4) in the striatum in normal control, whereas the two binding estimates were less positively correlated in the caudate and inversely correlated in the putamen in PD. No significant correlation was observed in the orbitofrontal cortex in both groups. These results indicated that dopamine transporters and D1 receptors change in parallel in the normal striatal synapses, but the association becomes asymmetrical because of reduction in presynaptic and relative elevation in postsynaptic markers in PD. Alterations in synaptic parallel regulation in the nigrostriatal system might reflect early pathophysiology in the parkinsonian brain.
暂无评论