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中华医学杂志 1984年第7期64卷 414-416+463+466页

作者：齐淑玲杨崇礼胡文伟傅津李来全中国医学科学院血液学研究所

作者观察了7例白前骨髓的超微结构,骨髓三系统血细胞均明显异常,而以巨核细胞的变化为著。并指出骨髓细胞超微结构的变化能解释白前的主要症状,骨髓三系统同时发现异常有利于白前的诊断。亦进一步证实本病为干细胞病,提出本病的名称以&q... 详细信息

作者观察了7例白前骨髓的超微结构,骨髓三系统血细胞均明显异常,而以巨核细胞的变化为著。并指出骨髓细胞超微结构的变化能解释白前的主要症状,骨髓三系统同时发现异常有利于白前的诊断。亦进一步证实本病为干细胞病,提出本病的名称以"白前"为宜。

关键词：白血病前期/病理学巨核细胞/超微结构造血干细胞/超微结构

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Platelet production in the pulmonary capillary bed -: New ultrastructural evidence for an old concept

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AMERICAN JOURNAL OF PATHOLOGY 2000年第1期157卷 69-74页

作者： Zucker-Franklin, D Philipp, CS NYU Med Ctr Dept Med New York NY 10016 USA Univ Med & Dent New Jersey Robert Wood Johnson Med Sch Dept Med Div Hematol New Brunswick NJ 08903 USA

Although there is substantial evidence indicating that platelets are released from megakaryocytes in the capillary bed of the lung, this concept has not been universally accepted because much of the evidence has been Indirect. To more definitively substantiate that platelet production takes place in the lungs, megakaryocyte and platelet production was accelerated in mice by phlebotomy or by administration of thrombopoietin, and ultrastructural analysis was performed on lung specimens. Intact megakaryocytes, megakaryocyte fragments with numerous demarcated platelet fields, dissociating intact platelets, and denuded megakaryocyte nuclei were seen in the pulmonary capillaries of mice. In addition, some megakaryocyte nuclei exhibited the morphological counterpart of apoptosis, These observations provide evidence for platelet release in the capillary bed of the lungs during stimulated as well as reactive thrombocytosis without precluding observations that some "proplatelets" form in the sinusoids of the bone marrow before transmigration of intact megakaryocytes into the circulation.

关键词：血小板/代谢血小板/超微结构毛细血管/代谢毛细血管/超微结构肺/血液供给肺/代谢肺/超微结构巨核细胞/细胞学巨核细胞/超微结构显微镜检查电子动物人类小鼠

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REED-STERNBERG-LIKE CELLS IN NODULAR LYMPHOMA INVOLVING BONE-MARROW

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AMERICAN JOURNAL OF CLINICAL PATHOLOGY 1975年第6期63卷 779-785页

作者： MCKENNA, RW BRUNNING, RD UNIV MINNESOTA HLTH SCI CTRDEPT LAB MED & PATHOLBOX 198MAYO MEM BLDGMINNEAPOLISMN 55455

McKenna, Robert W., and Brunning, Richard D. Reed-Sternberg-like cells in nodular lymphoma involving the bone marrow. Am JClin Pathol 63: 779-785, 1975. Two patients with cells indistinguishable from Reed-Sternberg cells in bone marrow lesions of nodular poorly differentiated lymphocytic lymphoma are described. Both patients had lymph node biopsies showing nodular lymphoma. Bone marrow and blood involvement with the lymphoma was demonstrated at the time of initial diagnosis. Reed-Sternberg-like cells were not demonstrated in either case until later in the course of the disease, after the patients had been treated with numerous chemotherapeutic agents. Other similarities of bone marrow involvement with nodular lymphoma to Hodgkin's disease of the bone marrow are noted. The origin of the Reed-Sternberg-like cells in nodular lymphoma is not clear, but they could result from morphologicalteration of lymphoma cells by chemotherapy. The finding of Reed-Sternberg cells in bone marrow lesions should be interpreted with caution unless diagnostic biopsy material from other sites is available for study. (Key words: Bone marrow lymphoma' nodular lymphoma; Reed-Sternberg cells).

关键词：活组织检查骨髓/超微结构骨髓细胞细胞核仁/超微结构环磷酰胺/治疗应用诊断鉴别组织细胞/超微结构霍奇金病/诊断淋巴结/病理学淋巴细胞/超微结构淋巴瘤非霍奇金/血液淋巴瘤非霍奇金/诊断淋巴瘤非霍奇金/药物疗法淋巴瘤非霍奇金/病理学巨核细胞/超微结构显微镜检查电子成年人女(雌)性人类男(雄)性中年人

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Myelodysplastic syndrome (MDS), acute myeloid leukaemia (AML) and chronic myeloproliferative disorder (CMPD) in cats

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JOURNAL OF COMPARATIVE PATHOLOGY 1999年第3期121卷 203-216页

作者： Breuer, W Hermanns, W Thiele, J Univ Munich Inst Vet Pathol D-80539 Munich Germany Univ Cologne Inst Pathol D-50931 Cologne Germany

Histological, enzyme histochemical and ultrastructural findings in three cases of feline bone marrow neoplasia are described. The following changes were observed: in myelodysplastic syndrome (MDS), a low medullary blast count, strongly atypical (micromegakaryocytic) proliferative megakaryocytopoiesis, hypoplastic erythrocytopoiesis with impairment of differentiation, multifocal extravasation and lymphoid aggregates;in acute myeloid leukaemia (AML), medullary proliferation of undifferentiated cell types;in chronic myeloproliferative disorder (CMPD), trilinear medullary proliferation with complete cellular maturation, osteomyelosclerosis and extramedullary haemopoiesis. In two cases (MDS, AML), ultrastructural demonstration of C-type virus particles (feline leukaemia virus) suggested a viral aetiology. (C) 1999 Harcourt Publishers Ltd.

关键词：急性病抗体病毒/分析骨髓/病理学骨髓/超微结构骨髓/病毒学猫疾病/病理学猫疾病/病毒学慢性病酶联免疫吸附测定 γ逆转录病毒/分离和提纯白血病髓样/病理学白血病髓样/兽医学白血病髓样/病毒学肝/病理学淋巴结/病理学巨核细胞/病理学巨核细胞/超微结构骨髓增生异常综合征/病理学骨髓增生异常综合征/兽医学骨髓增生异常综合征/病毒学骨髓增殖性疾病/病理学骨髓增殖性疾病/兽医学骨髓增殖性疾病/病毒学脾/病理学动物猫女(雌)性男(雄)性

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GROWTH OF MOUSE MEGAKARYOCYTE COLONIES INVITRO

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 1975年第5期72卷 1744-1748页

作者： METCALF, D MACDONALD, HR ODARTCHENKO, N SORDAT, B SWISS INST EXPTL CANC RES LAUSANNESWITZERLAND

Mouse bone marrow and spleen cells formed pure or mixed colonies of up to 80 megakaryocytes in agar cultures after stimulation by medium conditioned by activated mouse lymphoid cells. Megakaryocytes were identified on the basis of their morphology, polyploid mitoses and DNA content, and high cytoplasmic content of acetylcholinesterase. Megakaryocyte colony-forming cells were relatively small with a peak sedimentation velocity of 4.2 mm/hr. Spleen, lymph node, and thymus cells produced the factor stimulating megakaryocyte proliferation after culture in medium containing 2-mercaptoethanol, with or without added mitogens or allogeneic spleen cells. Peak activity in conditioning medium was associated with the small lymphocyte fractions in mouse spleen.

关键词：细胞计数离心法培养基培养技术/方法 DNA/分析淋巴细胞/细胞学巨噬细胞/分析巨核细胞/分析巨核细胞/细胞学巨核细胞/超微结构小鼠近交BALBC 显微镜检查相差脾/细胞学时间因素动物小鼠

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PLATELET MORPHOLOGY AFTER ASPIRIN

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AMERICAN JOURNAL OF CLINICAL PATHOLOGY 1975年第4期63卷 554-558页

作者： FAJARDO, LF VET ADM HOSP PALO ALTOCA STANFORD UNIV MED SCHDEPT PATHOL300 PASTEUR DRSTANFORDCA 94305

Previous studies have revealed morphologic platelet abnormalities, particularly inclusions, in patients who have acute malarial infections. To determine the possible role of aspirin (ASA) in the etiology of these abnormalities, the thrombocytes of 14 normal men were examined before and after ingestion of 2 Gm. of ASA. A significant decrease in platelet size was noticed after ASA: however, no ultrastructural alteration of these circulating platelets was found, although functional impairment was manifested in vivo (bleeding time) and in vitro (aggregation). It is concluded that inclusions and other morphologic abnormalities in thrombocytes of malaria patients are not caused by aspirin ingestion.

关键词：阿司匹林/药理学血液凝固试验血小板/药物作用血小板/生理学血小板/超微结构巨核细胞/药物作用巨核细胞/超微结构显微镜检查电子血小板聚集/药物作用时间因素成年人人类男(雄)性

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Hypersensitivity of circulating progenitor cells to megakaryocyte growth and development factor (PEG-rHu MGDF) in essential thrombocythemia

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BLOOD 2000年第10期96卷 3310-3321页

作者： Axelrad, AA Eskinazi, D Correa, PN Amato, D Univ Toronto Dept Anat & Cell Biol Toronto ON M5S 1A8 Canada Univ Toronto Dept Med Biophys Toronto ON M5S 1A8 Canada Mt Sinai Hosp Dept Med Hematol Oncol Toronto ON Canada

Hematopoietic progenitor cells in 2 myeloproliferative disorders, juvenile chronic myelomonocytic leukemia and polycythemia vera, are known to be hypersensitive to cytokines that control normal progenitor cell proliferation, differentiation, and survival in their respective granulocyte/macrophage and erythroid lineages. Because thrombopoietin controls these functions in the normal megakaryocytic lineage, we asked the question: Are megakaryocytic progenitor cells in the myeloproliferative disorder essential thrombocythemia (ET) hypersensitive to thrombopoietin? Peripheral blood mono-nuclear cells from patients with ET, or secondary (reactive) thrombocytosis (2 degreesT), or healthy volunteers were grown in strictly serum-free agarose culture containing interleukin 3 (IL-3) and all-transretinoic acid, with various concentrations of PEG-rHu megakaryocyte growth and development factor (MGDF), The concentration of cytokine at half-maximum colony number served as a measure of progenitor cell sensitivity. Hypersensitivity to PEG-rHu MGDF was found in circulating progenitors from 18 of 20 (90%) informative patients with presumptive diagnosis ET, 1 of 8 (12.5%)2 degreesT patients, and none of the 22 healthy volunteers. Median MGDF sensitivity ratio in ET patients was approximately 53 times greater than in the controls. This hypersensitivity, which was also directed to rHu thrombopoietin, was highly specific with respect to cytokine, disease, and cell lineage. We propose that, despite their single pluripotential cell origin, the different clinicopathologic phenotypes in different chronic myeloproliferative disorders are determined by lineage-restricted hypersensitivities of hematopoietic progenitor cells to endogenous cytokines, This work emphasizes the importance of stringent serum-free conditions for revealing true sensitivities to cytokines, The findings also offer a basis for evolving a positive test for ET, a diagnosis now made essentially by exclusion. (C) 2000 by The A

关键词：血液循环细胞培养技术/方法队列研究集落形成单位测定细胞因子类/药理学剂量效应关系药物药物过敏/病因学造血干细胞/药物作用巨核细胞/药物作用巨核细胞/病理学巨核细胞/超微结构聚乙烯二醇类/药理学重组蛋白质类/药理学血小板增多出血性/血液血小板增多出血性/病因学血小板生成素/药理学成年人老年人老年人 80以上女(雌)性人类男(雄)性中年人

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Megakaryocyte dense granule components are sorted in multivesicular bodies

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BLOOD 2000年第12期95卷 4004-4007页

作者： Youssefian, T Cramer, EM Hop Cochin INSERM U474 F-75014 Paris France

Recent studies suggest that multivesicular bodies are an intermediate stage in the formation of a-granules. In contrast, the kinetics and mode of appearance of dense granules during megakaryocytic maturation has remained poorly understood. Immunoelectron microscopy was used to monitor the appearance of dense granular markers (granulophysin and serotonin) on cryosections of human megakaryocytes (MKs) cultured from CD34(+) precursors. The monitoring was done on days 8 and 13 of culture. The data suggest that dense granules appear in immature MKs early during their maturation, concomitantly with a-granule formation. In MKs of intermediary maturation stage, granulophysin was mainly localized within dense granules and multivesicular bodies (MVBs), which were also labeled for serotonin. This study provides evidence that granulophysin is a dense granule marker in human MKs and that MVBs are an intermediary stage of dense granule maturation and probably constitute a sorting compartment between a-granules and dense granules. (C) 2000 by The American Society of Hematology.

关键词：抗原 CD34/分析生物学标记/分析骨髓细胞/细胞学细胞培养的细胞质颗粒/超微结构造血干细胞/细胞学巨核细胞/细胞学巨核细胞/超微结构显微镜检查免疫电子血清素/分析成年人人类

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中药抗炎6号注射液对大鼠腹腔噬细胞氧化爆发的影响

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中国病理生理杂志 1989年第4期5卷 200-203页

作者：陈汐同济医科大学

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巨核细胞性白血病的细胞化学及电镜观察

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中华内科杂志 1987年第1期26卷 24-26+62+66页

作者：颜永碧蒋鲁丽郑尊第二军医大学中心实验室

本文就少见的巨核细胞性白血病的血细胞形态作了描述, 其中大量未分化的原始及幼稚细胞, 缺乏正常巨核细胞系所具有的形态特征。我们利用透射、扫描电镜结合细胞化学方法(血小板过氧化物酶反应)作出了确切诊断。

关键词：巨核细胞/超微结构显微镜检查电子血小板增多原发性/病理学

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