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中国校医 2012年第3期26卷 207-207,209页

作者：曾嫦林祥伟黄宇泽黄江玲汕头市中心医院检验科广东汕头515031

目的探讨人类巨细胞病毒(CMV)感染与流产、死(畸)胎、肾炎、脑炎和诊断不明发热(无名热)关系,对以上643例患者和60例对照者CMV感染状态进行了调查分析。方法应用酶联免疫吸附试验(ELISA)检测CMV-IgM特异性抗体。结果 CMV-IgM抗体阳性率... 详细信息

目的探讨人类巨细胞病毒(CMV)感染与流产、死(畸)胎、肾炎、脑炎和诊断不明发热(无名热)关系,对以上643例患者和60例对照者CMV感染状态进行了调查分析。方法应用酶联免疫吸附试验(ELISA)检测CMV-IgM特异性抗体。结果 CMV-IgM抗体阳性率病人组18.2%(117/643),对照组1.7%(1/60)。两组阳性率比较,差异有统计学意义(χ2=10.735P<0.01)。结论 CMV感染与流产、死(畸)胎、肾炎、脑炎和无名热等疾病的部分患者发病有关。

关键词：巨细胞病毒感染/血液巨细胞病毒感染/流行病学免疫球蛋白M/血液

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Human cytomegalovirus glycoprotein B genotypes in immunocompetent, immunocompromised, and congenitally infected Italian populations

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ARCHIVES OF VIROLOGY 2003年第3期148卷 547-554页

作者： Arista, S De Grazia, S Giammanco, GM Di Carlo, P Iannitto, E Univ Palermo Dipartimento Igiene & Microbiol I-90127 Palermo Italy Univ Palermo Osped Bambini G Di Cristina Ist Patol Infettiva & Virol Palermo Italy Univ Palermo Div Ematol Trapianto Midollo Palermo Italy

Human cytomegalovirus (HCMV) strains, obtained from immunocompetent and immunocompromised Italian hosts, were typed with glycoprotein B (gB) gene restriction analysis. A predominant circulation of HCMV strains with gB type 2 and 3 was detected in both the immunocompetent host with a primary HCMV infection and the immunocompromised host with or without HCMV disease. No association between gB types and subjects with different risks of developing HCMV disease was found. All four gB genotypes were capable of causing congenital infection in Italian babies, with gB type 1 accounting for 50% of the strains examined in symptomatic infants and a remarkable incidence of gB type 4 viruses.

关键词：巨细胞病毒/分类巨细胞病毒/遗传学巨细胞病毒感染/先天性巨细胞病毒感染/流行病学巨细胞病毒感染/病毒学基因型 HIV感染/并发症 HIV感染/病毒学免疫活性免疫减弱宿主聚合酶链反应限制性内切酶图谱法病毒包膜蛋白质类/遗传学人类婴儿新生

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Renal allograft outcome from cytomegalovirus seronegative donor into cytomegalovirus seronegative recipient: Poor prognosis after seroconversion

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TRANSPLANTATION PROCEEDINGS 2000年第2期32卷 408-410页

作者： Besse, T Malaise, J De Meyer, M Mourad, M Squifflet, JP Clin Univ St Luc Dept Renal Transplantat B-1200 Brussels Belgium

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Screening and diagnosis of congenital cytomegalovirus infection:: A 5-y study

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SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES 2000年第2期32卷 137-142页

作者： Halwachs-Baumann, G Genser, B Danda, M Engele, H Rosegger, H Fölsch, B Maurer, U Lackner, H Truschnig-Wilders, M Karl Franzens Univ Graz Gemeinsame Einrichtung Med Chem Labordiagnost A-8036 Graz Austria Karl Franzens Univ Graz Klin Gynakol & Geburtshilfe Abt Neonatol A-8036 Graz Austria Karl Franzens Univ Graz Kinderklin Graz Austria Stadt Kliniken Dortmund Inst Blutspendewesen Dortmund Germany

Although cytomegalovirus infection is the most common infection transmitted via the placenta, there are no guidelines for routine screening to detect children congenitally infected with cytomegalovirus. From 1993 to 1997, maternal serum and cord vein blood of newborns was screened for HCMV-IgM (n = 21,183). Urine was examined for HCMV-excretion during the first postnatal week to prove HCMV infection in children who expressed HCMV-IgM in cord vein blood (n = 13) or who were born to mothers positive for HCMV-IgM in the serum (n = 234), or when both ford vein blood and maternal serum were positive for HCMV-IgM (n = 6). Congenital HCMV infection was detected in 17 newborns. To determine the incidence of congenital HCMV infection, only those mother/child pairs were selected in whom serum and cord vein blood were investigated (n=5967 mother/child pairs). In this group 13 newborns were infected. The observed incidence for congenital HCMV infection is 0.21%. It is concluded that that this screening programme will detect those children at risk for congenital HCMV infection. These children have to be examined for virus excretion in the urine. Although the observed incidence is only 0.21%, congenital HCMV infection is a problem that can no longer be neglected because of its long-term sequelae.

关键词：抗体病毒/血液抗病毒药/治疗应用奥地利/流行病学脑脊髓液/病毒学巨细胞病毒/免疫学巨细胞病毒感染/先天性巨细胞病毒感染/流行病学巨细胞病毒感染/病毒学 DNA 病毒/分析胎血/病毒学更昔洛韦/治疗应用免疫球蛋白M/血液发病率新生儿筛查尿/病毒学成年人女(雌)性人类婴儿新生

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Nephrotoxicity-free, mycophenolate mofetil-based induction/maintenance immunosuppression in elderly recipients of renal allografts from elderly cadaveric donors

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TRANSPLANTATION PROCEEDINGS 2000年第1A期32卷 9S-11S页

作者： Theodorakis, J Schneeberger, H Illner, WD Stangl, M Zanker, B Land, W Univ Munich Div Transplant Surg Dept Surg Med Ctr Grosshadern D-81377 Munich Germany

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The long-term efficacy of multivisceral transplantation

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TRANSPLANTATION PROCEEDINGS 2000年第6期32卷 1219-1220页

作者： Madariaga, JR Reyes, J Mazariegos, G Fung, JJ Starzl, TE Abu-Elmagd, K Univ Pittsburgh Med Ctr Thomas E Starzl Transplantat Inst Pittsburgh PA 15213 USA

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Cytomegalovirus infection and disease after autologous CD34-selected peripheral blood stem cell transplantation for multiple myeloma: no evidence of increased incidence based on polymerase-chain-reaction monitoring

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BLOOD 2000年第1期96卷 369-370页

作者： Peggs, KS Ings, SJ Kottaridis, PD Yong, K Williams, CD Goldstone, AH Mackinnon, S UCL Dept Haematol London England

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Report on a long-term study of maternal and congenital cytomegalovirus infection in Sweden. Review of prospective studies available in the literature

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SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES 1999年第5期31卷 443-457页

作者： Ahlfors, K Ivarsson, SA Harris, S Univ Lund Hosp Dept Logoped Phoniatr & Audiol Lund Sweden Malmo Univ Hosp Dept Paediat Malmo Sweden Malmo Univ Hosp Dept Clin Microbiol Sect Clin Virol Malmo Sweden

This report summarizes knowledge accumulated in a long-term study of congenital and maternal cytomegalovirus (CMV) infection in Sweden. Some nem finding are included. We considered diagnostic methods, sources of maternal infection (including occupational risks), roles of primary and secondary maternal infections, transmission to foetuses, incidence, symptoms and prognosis of established congenital infection and relative importance of such infection in infantile sensorineural deafness, microcephaly and type 1 diabetes mellitus. Virus isolation testing was done 1977-1985 on 16,474 newborns. 76 (0.5%) congenitally infected infants mere found, 22/76 (29%) with transient neonatal symptoms and 11/60 (18%) with neurological symptoms by the age of 7 y. Type of maternal CMV infection was serologically determined in 62/76 cases (30 primary, 32 secondary). CNS disturbances in the infants occurred after both primary (all trimesters) and secondary maternal infections. The negative potential of secondary maternal infections might be an obstacle to preventive vaccination.

关键词：出生体重巨细胞病毒/分离和提纯巨细胞病毒感染/分类巨细胞病毒感染/先天性巨细胞病毒感染/流行病学巨细胞病毒感染/传播英格兰/流行病学孕龄发病率传染性疾病传播垂直母亲年龄预后前瞻性研究回顾性研究危险因素瑞典/流行病学美国/流行病学青少年成年人女(雌)性人类婴儿新生男(雄)性

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Low incidence of transplant coronary artery disease in Chinese heart recipients

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JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 1999年第6期33卷 1573-1577页

作者： Hsu, RB Chu, SH Wang, SS Ko, WJ Chou, NK Lee, CM Chen, MF Lee, YY Natl Taiwan Univ Hosp Dept Surg Taipei 100 Taiwan Natl Taiwan Univ Hosp Dept Internal Med Taipei 100 Taiwan

OBJECTIVES This study sought to assess the incidence of transplant coronary artery Chinese heart recipients. BACKGROUND The prevalence of transplant CAD detected by angiography ar 1, 2 and 4 years after heart transplantation was 11%, 22% and 45%, respectively. The incidence of transplant CAD in Chinese heart recipients has not been reported. METHODS For those recipients surviving for more than 1 year after transplantation, coronary angiography was performed annually for surveillance of transplant CAD. The recipient characteristics, donor characteristics, rejection episodes, medication and human leukocyte antigen (HLA mismatches were recorded. RESULTS Fifty patients were included in this study. Thirteen (26%) recipients had ischemic heart disease. Two patients (4%) had active cytomegalovirus (CMV) infection after transplantation The mean number of rejection episodes in the 1st year after transplantation was 1.15. Among 47 patients with complete data of donor and recipient histocompatibility antigens, there were seven patients (14.9%) with two or fewer HLA mismatches Among 74 angiograms of 50 patients reviewed, only one patient had discrete stenosis less than 50% in the middle portion of the left anterior descending artery at 1 year after transplantation The cumulative incidence of transplant CAD was 2% at 1 year and 2% at 2 and 4 years after transplantation. CONCLUSIONS The incidence of transplant CAD was low in Chinese heart transplant recipients Low percentage of ischemic heart disease in recipients, low occurrence of active CMV infection and rejection episodes after transplantation, less racial disparity, and lower HLA mismatches maybe the important factors. (C) 1999 by the American college of Cardiology.

关键词：亚洲大陆世系人群冠心病/流行病学冠心病/人种学文化交叉比较横断面研究巨细胞病毒感染/流行病学巨细胞病毒感染/人种学随访研究移植物排斥/流行病学移植物排斥/人种学心脏移植/统计学和数值数据组织相容性试验/统计学和数值数据发病率手术后并发症/流行病学台湾/流行病学美国/流行病学青少年成年人女(雌)性人类男(雄)性中年人

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Cytomegalovirus infection in kidney transplant recipients at our center

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TRANSPLANTATION PROCEEDINGS 1999年第8期31卷 3205-3206页

作者： Moray, G Köseoglu, F Karakayali, H Demirag, A Bilgin, N Haberal, M Baskent Univ Hastanesi Maresal Fevzi Cakmak Cad Fac Med TR-06490 Ankara Turkey

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