检索结果-内蒙古大学图书馆

Increased heterogeneity of coronary perfusion in patients with early coronary atherosclerosis

AMERICAN HEART JOURNAL 2001年第4期142卷 691-697页

作者： Wieneke, H Schmermund, A Ge, J Altmann, C Haude, M von Birgelen, C Baumgart, D Dirsch, O Erbel, R Univ Clin Essen Dept Cardiol D-45122 Essen Germany Univ Essen Gesamthsch Dept Pathol Essen Germany Shanghai Inst Cardiovasc Dis Shanghai Peoples R China Zhongshan Hosp Shanghai Peoples R China

Background in patients with typical angina but angiographically normal coronary arteries, abnormal vasomotor function is assumed to be a major underlying cause. However, data on this issue are conflicting, and recent studies suggest that fluid dynamic abnormalities exist in these patients. The aim of the study was to evaluate whether early stages of atherosclerosis are characterized by alterations of baseline coronary hemodynamics and endothelium-independent vasomotion. Besides established intracoronary Doppler parameters, heterogeneity of perfusion was assessed and related to early signs of atherosclerosis as determined by electron-beam computed tomography (EBCT). Methods In 59 patients with typical angina and angiographically normal or near-normal coronary arteries, intracoronary Doppler measurements were performed in all 3 major coronary arteries. Baseline average peak velocity (bAPV) and hyperemic average peak velocity (hAPV) in response to intracoronary injection of adenosine were measured, and coronary flow velocity reserve (CFVR) was calculated. Heterogeneity was assessed as variability of bAPV, hAPV, and CFVR and was calculated as (STD/MEAN) - 100. Doppler data were analyzed according to tertiles of the EBCT-derived Agatston calcium;core (ie, score 0-1 [lowest tertile], 2-28 [medium tertile], and > 28 [highest tertile]). Results The mean EBCT-derived Agatston calcium score was 49 +/- 107. No coronary calcium was observed in 17 (29%) patients. The mean values of bAPV, hAPV, and CFVR were not different between the calcium score tertiles. However, patients in the highest tertile had a significantly increased variability index of bAPV (29.6%+/- 11.6%) compared with patients in the lowest tertile (13.4%+/-7.3%, P < .0001). Variability of CFVR was also increased in these patients (15.5%+/- 11.7% vs 10.5%+/-4.0%, P =.03). Conclusion These results indicate that early stages of atherosclerosis are characterized by microvascular abnormalities that do not uniformly aff

关键词：腺苷/诊断应用腺苷/药理学心绞痛/诊断钙冠状血管造影术/统计学和数值数据冠状动脉循环/药物作用冠状动脉循环/生理学冠状血管/药物作用冠状血管/生理学超声心动描记术多普勒/统计学和数值数据微血管性心绞痛/血液微血管性心绞痛/诊断体层摄影术 X线计算机/统计学和数值数据女(雌)性人类男(雄)性中年人

来源：评论

学校读者我要写书评

暂无评论

Enhanced exercise-induced hyperkalemia in patients with syndrome x

引用

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 1999年第4期33卷 1056-1061页

作者： Botker, HE Sonne, HS Frobert, O Andreasen, F Aarhus Univ Hosp Skejby Hosp Dept Cardiol DK-8200 Aarhus N Denmark Univ Aarhus Inst Pharmacol Dept Clin Pharmacol Aarhus Denmark

OBJECTIVES The purpose of this study was to determine whether patients with syndrome X have altered potassium metabolism. BACKGROUND Patients with syndrome X have angina pectoris and exercise induced ST segment depression on the electrocardiogram despite normal coronary angiograms. Increasing evidence suggests that myocardial ischemia is uncommon in these patients. Altered potassium metabolism causing interstitial potassium accumulation in the myocardium may be an alternative mechanism for chest pain and ST segment depression in syndrome X. METHODS We compared the magnitude of exercise-induced hyperkalemia in 16 patients with syndrome X (12 female and four male, mean +/- SD age 53 +/- 6 years) and 15 matched healthy control subjects. The participants underwent a bicycle test at a fixed load of 75 W for 10 min, and blood samples were taken for analysis of potassium, catecholamines and lactate before, during and in the recovery period after exercise. In five patients with syndrome X, the test was repeated during alpha(1) adrenoceptor blockade. RESULTS Baseline concentrations of serum potassium, plasma catecholamines and plasma lactate were similar in patients and control subjects. The rate of exercise-induced increment of serum potassium was increased in the patients (70 +/- 29 vs. 30 +/- 21 mu mol/liter/min in control subjects, p < 0.001). Six patients, who stopped before 10 min of exercise, showed very rapid increments in serum potassium concentration. Compared to the control subjects, patients also demonstrated larger increments in rate-pressure product, plasma norepinephrine and lactate concentrations during exercise. The rate of serum potassium increment correlated with the rate of plasma norepinephrine increment in the patients (r = 0.63, p < 0.02), but not in the control subjects (r = 0.01, p = 0.97). Blockade of alpha(1) adrenoceptors decreased systolic blood pressure at baseline, but did not influence the increment of serum potassium, plasma catecholamines an

关键词：运动试验高钾血症/血液高钾血症/诊断乳酸/血液微血管性心绞痛/血液微血管性心绞痛/诊断心肌/代谢去甲肾上腺素/血液钾/血液女(雌)性人类男(雄)性中年人

来源：评论

学校读者我要写书评

暂无评论

Cardiac syndrome X: An overview

引用

HOSPITAL PRACTICE 2000年第2期35卷 75-+页

作者： Kaski, JC Russo, G Univ London St Georges Hosp Sch Med Dept Cardiol Sci Coronary Artery Dis Res Unit London England

Not all patients with angina have myocardial ischemia. A sizable minority-up to 30% of angina patients studied at tertiary referral centers-have normal coronary angiograms. Such patients often undergo an expensive and extensive array of testing and treatment. Yet the prognosis is generally good, and symptomatic management may be effective.

关键词：冠状血管造影术诊断鉴别心电描记术内皮缩血管肽类/血液雌激素类/缺乏运动试验微血管性心绞痛/诊断微血管性心绞痛/病因学微血管性心绞痛/病理生理学微血管性心绞痛/治疗预后危险因素人类

来源：评论

学校读者我要写书评

暂无评论

Effects of transcendental meditation on symptoms and electrocardiographic changes in patients with cardiac syndrome X

引用

AMERICAN JOURNAL OF CARDIOLOGY 2000年第5期85卷 653-+页

作者： Cunningham, C Brown, S Kaski, JC Univ Westminster London W1R 8AL England Univ London St Georges Hosp London England

Chest pain with normal coronary angiograms is often associated with chronic sympathetic activation anxiety, and depression, and is resistant to conventional antianginal treatment. The practice of transcendental meditation, a standard relaxation method for 3 months twice daily, significantly improved exercise tolerance, angina episodes, and quality of life in 9 women;the positive findings in this study warrant further research.

关键词：心电描记术运动试验沉思微血管性心绞痛/诊断微血管性心绞痛/心理学微血管性心绞痛/治疗试点项目生活质量老年人女(雌)性人类中年人

来源：评论

学校读者我要写书评

暂无评论

Reduced vasodilator capacity in syndrome X related to structure and function of resistance arteries

引用

AMERICAN JOURNAL OF CARDIOLOGY 1999年第2期83卷 149-154页

作者： Buus, NH Bottcher, M Botker, HE Sorensen, KE Nielsen, TT Mulvany, MJ Aarhus Univ Dept Pharmacol DK-8000 Aarhus C Denmark Aarhus Univ Hosp Dept Cardiol DK-8000 Aarhus Denmark Aarhus Univ Hosp PET Ctr DK-8000 Aarhus Denmark

The combination of angina pectoris, angiographically normal epicardial coronary arteries, and a positive exercise test is referred to as syndrome X. Previous studies have demonstrated an impaired coronary flow reserve and a peripheral vascular dysfunction, suggesting that vascular abnormalities in syndrome X may not be confined to the heart. The aim of this study was to investigate whether any vascular disorder of syndrome X is due to intrinsic structural or functional disturbances in resistance arteries. We compared 16 patients with syndrome X (56.6 +/- 1.2 years, 3 men) with 15 matched control subjects. Myocardial blood flow was measured with N-13-ammonia positron emission tomography. Forearm blood flow was measured in the brachial artery with high-resolution ultrasound. Gluteal subcutaneous resistance arteries were dissected and mounted on a myograph for measurement of active tension development, lumen diameter, and media thickness. Baseline myocardial blood flow was similar in patients and controls, but dipyridamole-induced hyperemia was decreased in patients (1.67 +/- 0.13 vs 2.31 +/- 0.12 ml/min/g, p <0.01). Patients and controls had similar baseline forearm blood flow, but hyperemic flow after transient occlusion of the brachial artery was impaired in patients (198 +/- 20 vs 273 +/- 32 ml/min, p < 0.05). isolated resistance arteries showed no differences in constriction to noradrenaline, or relaxation to acetylcholine, dipyridamole, or nitroglycerin. Furthermore, the ratio between media thickness and lumen diameter were similar in syndrome X patients and controls. Our data show that when compared with a well-matched control group, syndrome X patients have a decreased coronary and peripheral vasodilator capacity. However, this is not reflected by functional abnormalities or structural changes as evaluated in subcutaneous resistance arteries. We conclude that syndrome X is not a generalized intrinsic abnormality of the resistance circulation. (C) 1999 by Excerp

关键词：动脉/药物作用动脉/病理学动脉/病理生理学病例对照研究冠状动脉循环双嘧达莫/药理学前臂/血液供给微血管性心绞痛/诊断微血管性心绞痛/病理生理学体层摄影术发射型计算机血管阻力/药物作用血管舒张血管舒张药/药理学女(雌)性人类男(雄)性中年人

来源：评论

学校读者我要写书评

暂无评论

微循环阻力指数在X综合征诊断中的价值

引用

中国医师杂志 2016年第2期18卷 191-194页

作者：徐冰何胜虎徐日新谢勇陈述刘晓东纪军廖清池沈建华程铖王松鹤苏北人民医院扬州大学附属临床医院心血管内科江苏省扬州225001 苏北人民医院扬州大学附属临床医院心功能检查科江苏省扬州225001

目的探讨微循环阻力指数（IMR）对比校正的心肌梗死溶栓（TIMI）计帧法（CTFC）在X综合征（CSX）诊断中的价值。方法入选心电图平板运动试验阳性患者28例（X综合征组），运动试验阴性组28例（正常对照组），两组利用热稀释法测得IMR值... 详细信息

目的探讨微循环阻力指数（IMR）对比校正的心肌梗死溶栓（TIMI）计帧法（CTFC）在X综合征（CSX）诊断中的价值。方法入选心电图平板运动试验阳性患者28例（X综合征组），运动试验阴性组28例（正常对照组），两组利用热稀释法测得IMR值，利用冠状动脉造影测算静息相校正的TIMI帧数（B—CTFC）、充血相校正的TIMI帧数（H—CTFC），将B—CTFC除以H—CTFC得出冠状动脉血流储备（CFRCTFC）。比较两组间IMR、CTFC、CFRCTFC的相关性。结果X综合征组高血压和糖尿病患者比例高于正常对照组（75％V846．4％，60．7％V828．6％，P〈0．05）；X综合征组IMR高于正常对照组（39．5±27．6VS16．1±5．9，P〈0．01）；X综合征组H—CTFC高于正常对照组（13．0±4．2vs9．5±2．4，P〈0．01）；X综合征组CFRCTFC低于正常对照组（2．0±0．5vs2．6±0．5，P〈0．01）；IMR与CFRcTFC之间呈负相关（r=-0．62，P〈0．01）。结论IMR与校正的TIMI计帧法测定的CFRCTFC有显著的相关性，IMR可以用于评价X综合征患者冠脉微循环功能，对X综合征的诊断有一定的应用价值。

关键词：毛细血管阻力微循环微血管性心绞痛/诊断

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：