Objective.-To assess whether migraine is associated with retinal microvascular ***.-Migraine is believed to be associated with vascular disease,but few studies have investigated the relationship between structural mic...
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Objective.-To assess whether migraine is associated with retinal microvascular ***.-Migraine is believed to be associated with vascular disease,but few studies have investigated the relationship between structural microvascular changes and ***.-Population-based cross-sectional ***.-Participants in the Blue Mountains Eye Study follow-up(1997 to 1999,n=2335,aged 54+)had retinal photographs taken.A computer-assisted method was used to measure average retinal arteriolar and venular diameters and calculate the arteriole-to-venule *** of migraine was recorded by interview using International Headache Society criteria(1988).Results.-Subjects giving a history of migraine without aura(n=128)had narrower retinal arterioles than subjects giving a history of migraine with aura(n=182)or subjects with no migraine history(n=1619).After multivariate adjustment,mean retinal arteriolar diameter was 4.3 μ m(95% confidence interval 0.5,8.1)narrower in subjects reporting migraine without aura as compared to subjects with no *** with a history of migraine without aura were more likely to have slightly narrower retinal arteriolar caliber than individuals without *** relationship was not present for migraine with *** data support the hypothesis that microvascular disease may be associated with certain types of migraine.
Background: Magnifying endoscopy is a promising modality for fine observation of minute surface structures and microvessel architecture in gastric lesions. Objective: To observe the response of microvessels to epineph...
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Background: Magnifying endoscopy is a promising modality for fine observation of minute surface structures and microvessel architecture in gastric lesions. Objective: To observe the response of microvessels to epinephrine stimulation in early gastric cancer tissues and to assess the usefulness of magnifying pharmacoendoscopy for histologic diagnosis. Design: This was a prospective pilot study. Setting: This study was conducted at an academic hospital. Patients: Twenty-nine patients with differentiated early gastric cancer were enrolled. Interventions: Microvessels in both the cancerous lesion and its adjacent non-neoplastic gastric mucosa were observed by magnifying endoscopy before and after focal spray with epinephrine solution (0.05 mg/mL).Main Outcome Measurements and Results: After epinephrine stimulation, noncancerous gastric mucosa surrounding the cancerous lesion showed a change in color from red to white; no microvessels were evident. On the other hand, all the cancerous lesions examined clearly showed enhancement of tumor microvessels. The rate of detection of tumor microvessels by magnifying pharmacoendoscopy (100%) was significantly higher than that by magnifying endoscopy alone (41.3%). Limitations: This was small pilot study. Conclusions: Magnifying pharmacoendoscopy with epinephrine is a powerful tool for assessing tumor vascularity and may contribute to the histologic diagnosis of differentiated early gastric cancers before endoscopic treatment.
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