bjective:To examine the relation b etween diameters of the retinal arterioles and 10year in cidence of ***:Population based prospective cohort ***:Beaver Dam eye ***:2451nor-motensive people aged 43to *** outcome meas...
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bjective:To examine the relation b etween diameters of the retinal arterioles and 10year in cidence of ***:Population based prospective cohort ***:Beaver Dam eye ***:2451nor-motensive people aged 43to *** outcome measures:Diameters of retinal arte rioles and venules measured from digitised photographs of the retina taken at *** summarised as the arteriole:venule ratio,with a lower ratio indi cating smaller arteriolar *** hypertension,defined as systolic blood pressure≥140mm Hg,diastolic blood pressure≥90mm Hg,or use of antihypertensive d rugs during follow ***:721participants developed hypertension over a 10year *** with lower arteriole:venule ratios had a higher cumulative incidence of hypertension(incidences of 17.4%,24.1%,31.0%,a nd 45.1%,respectively,for decreasing quarters of distribution of ar-teriole:venule ratio).After adjustment for age and sex,participants with arteriole:venul e ratios in the lowest quarter had a threefold higher risk o f hypertension(odds ratio 2.95,95%confidence interval2.77to 3.88)than those with ratios in the highest *** association remained significant after further adjustment for baseline systolic and diastolic blood pressu re and other risk factors(1.82,1.39to 2.40,for lowest versus highest ratio quarters).Conclusions:Narrowed retinal arterioles are associated with long term risk of hyp ertension,suggestingthat structural alterations of the microvasculature may be linked to the development of hyperte nsion.
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