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CA 125 and its relation to cardiac function

AMERICAN HEART JOURNAL 1999年第6期137卷 1044-1049页

作者： Nägele, H Bahlo, M Klapdor, R Schaeperkoetter, D Rödiger, W Univ Hamburg Krankenhaus Eppendorf Abt Thorax Herz & Gefasschirurg D-20246 Hamburg Germany Ctr Clin & Expt Tumor Marker Diag & Therapy Hamburg Germany

Background CA 125, known cls a marker for ovarian cancer with hypothetical but hitherto uncharacterized biologic functions, was reported to be elevated in some not-well-defined benign conditions. There are no reports on fluctuations of CA 125 related to cardiac function, especially the failing heart and neurohumoral factors such as norepinephrine or atrial natriuretic peptid/e. Methods and Results cn 125 blood levels were determined in patients with heart failure before and after heart transplantation (HTx). In 71 patients, parallel determinations of norepinephrine, atrial natriuretic peptide, pulmonary capillary wedge pressure, and right atrial filling pressure were done. CA 125 levels also were prospectively studied in patients with heart failure with stabilization (n = 25) or worsening of the clinical status (n = 9) and after HTx (n = 25), Parallel determinations of the tumor markers CEA, CA 199, CA 153, TPS, end TPA were also done. The results were grouped according to the clinical status (New York Heart Association class) of the patients, CA 125 was significantly correlated with neurohormones and filling pressures, Follow-vp investigations revealed a decrease of CA 125 levels after HTx (401 +/- 259 U/L vs 33 +/- 22 U/L, P <.001, n = 25) or stabilization (429 +/- 188 U/L vs 78 +/- 35 U/L P <.001 n = 25) and an increase during worsening of heart failure (42 +/- 25 U/L vs 89 +/- 32 U/L, P <.01, n = 9). In 4 patients after HTx, unexpected death was preceded by rising CA 125 levels. CEA, CA 199, CA 153, TPS, or TPA did not correlate with heart failure status or clinical events, Conclusions CA 125 is a marker of the clinical and hemodynamic status and the course of patients with heart failure before and after heart transplantation. The determination of CA 125 serum levels may be an additional tool in the management of these patients, In patients with cancer, these "nonspecific" changes must be considered when CA 125 levels are determined. Whether CA 125 has a specifi

关键词：心钠素/血液生物学标记/血液 CA-125抗原/血液队列研究综合疗法心脏/病理生理学心脏移植/生理学心脏移植/统计学和数值数据多元分析去甲肾上腺素/血液前瞻性研究回归分析统计学非参数时间因素人类

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Measuring effect size:: A non-parametric analogue of ω²

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BRITISH JOURNAL OF MATHEMATICAL & STATISTICAL PSYCHOLOGY 1999年第Pt 1期52卷 93-110页

作者： Wilcox, RR Muska, J Univ So Calif Dept Psychol Los Angeles CA 90089 USA

When comparing two groups of subjects, one of the many measures of effect size is omega(2). This paper suggests a non-parametric analogue of omega(2) based on the following point of view. Given an observation from one of two groups, but not knowing whether it came from the first or second group, how certain can we be that the observation came from the first group? This is in contrast to omega(2) where, given that an observation came from a specific group, say the first group, how much does this reduce our uncertainty about the dependent variable? One problem with omega(2) is that it is not robust-it is a function of the variances-so it can be misleading for reasons reviewed in the paper. Four estimators of the proposed measure of effect size are described and compared in a simulation study. Contrary to what was expected, the .632 bootstrap estimator performed best in terms of bias and mean squared error.

关键词：心脏移植/统计学和数值数据模型统计学正态分布统计学非参数成年人人类

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Asian transplant registry

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TRANSPLANTATION PROCEEDINGS 1999年第1-2期31卷 205-209页

作者： Ota, K Ota Med Res Inst Chuo Ku Tokyo 1030027 Japan

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Low incidence of transplant coronary artery disease in Chinese heart recipients

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JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 1999年第6期33卷 1573-1577页

作者： Hsu, RB Chu, SH Wang, SS Ko, WJ Chou, NK Lee, CM Chen, MF Lee, YY Natl Taiwan Univ Hosp Dept Surg Taipei 100 Taiwan Natl Taiwan Univ Hosp Dept Internal Med Taipei 100 Taiwan

OBJECTIVES This study sought to assess the incidence of transplant coronary artery Chinese heart recipients. BACKGROUND The prevalence of transplant CAD detected by angiography ar 1, 2 and 4 years after heart transplantation was 11%, 22% and 45%, respectively. The incidence of transplant CAD in Chinese heart recipients has not been reported. METHODS For those recipients surviving for more than 1 year after transplantation, coronary angiography was performed annually for surveillance of transplant CAD. The recipient characteristics, donor characteristics, rejection episodes, medication and human leukocyte antigen (HLA mismatches were recorded. RESULTS Fifty patients were included in this study. Thirteen (26%) recipients had ischemic heart disease. Two patients (4%) had active cytomegalovirus (CMV) infection after transplantation The mean number of rejection episodes in the 1st year after transplantation was 1.15. Among 47 patients with complete data of donor and recipient histocompatibility antigens, there were seven patients (14.9%) with two or fewer HLA mismatches Among 74 angiograms of 50 patients reviewed, only one patient had discrete stenosis less than 50% in the middle portion of the left anterior descending artery at 1 year after transplantation The cumulative incidence of transplant CAD was 2% at 1 year and 2% at 2 and 4 years after transplantation. CONCLUSIONS The incidence of transplant CAD was low in Chinese heart transplant recipients Low percentage of ischemic heart disease in recipients, low occurrence of active CMV infection and rejection episodes after transplantation, less racial disparity, and lower HLA mismatches maybe the important factors. (C) 1999 by the American college of Cardiology.

关键词：亚洲大陆世系人群冠心病/流行病学冠心病/人种学文化交叉比较横断面研究巨细胞病毒感染/流行病学巨细胞病毒感染/人种学随访研究移植物排斥/流行病学移植物排斥/人种学心脏移植/统计学和数值数据组织相容性试验/统计学和数值数据发病率手术后并发症/流行病学台湾/流行病学美国/流行病学青少年成年人女(雌)性人类男(雄)性中年人

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A study of the experience of Spanish heart transplant groups

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TRANSPLANTATION PROCEEDINGS 1999年第6期31卷 2531-2533页

作者： Almenar, L Arizón, JM

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The tenth report of the Latin American Transplant Registry

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TRANSPLANTATION PROCEEDINGS 1999年第7期31卷 2937-2938页

作者： Santiago-Delpín, EA García, VD Univ Puerto Rico San Juan PR 00919 USA Auxilio Mutuo Hosp San Juan PR 00919 USA

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Orthotopic cardiac transplantation technique: A survey of current practice

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ANNALS OF THORACIC SURGERY 1999年第4期68卷 1242-1246页

作者： Aziz, TM Burgess, MI El-Gamel, A Campbell, CS Rahman, AN Deiraniya, AK Yonan, NA Wythenshawe Hosp Cardiac Transplantat Unit Manchester M23 9LT Lancs England

Background. The Lower and Shumway technique has been the gold standard for orthotopic heart transplantation (OHT) for the past 35 years. In the last decade the bicaval and total techniques have been introduced but it is unclear how these alternative techniques have influenced the current surgical practice of OHT. Methods. A worldwide survey of 210 International Society of Heart and Lung Transplantation centers was conducted by questionnaire: 169 replies were received;a response rate of 80%. Results. Seventy-four centers (44%) use a combination of more than one technique with the remaining centers (n = 95 centers) employing one technique exclusively. The bicaval technique is the most frequently used technique in the majority of transplant procedures in 92 (54%) centers. In only 38 centers (22%), the standard technique was the most frequently employed technique. The total technique was the choice in 8 centers (5%). The maximum acceptable ischemic time varied from 3 to 9 hours with a median of 5.7 hours. Only 92 centers (54%) do not use cardioplegia during implantation. Conclusions. Since its introduction, the bicaval technique has become the most commonly used procedure for OHT. The long-term advantage of right atrial preservation with the bicaval technique will require further studies. (C) 1999 by The Society of Thoracic Surgeons.

关键词：文化交叉比较数据收集心脏停搏人工/方法心脏移植/方法心脏移植/统计学和数值数据器官保存/方法治疗结果人类

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Heart transplantation: Our experience in 450 cases

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TRANSPLANTATION PROCEEDINGS 1999年第6期31卷 2534-2534页

作者： Roda, JR Castedo, E Tellez, JC Burgos, R Serrano-Fiz, S Montero, CG Tellez, G Segovia, J Pulpon, LA Ugarte, J Clin Puerta de Hierro Dept Cardiol Cardiovasc & Thorac Surg Dept Madrid 28035 Spain

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