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国棉六厂心血管疾病流行病学调查报告

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青岛医药卫生 1984年第6期 62-67页

作者：于超青岛棉纺医院

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生命早期营养不良与成年期心血管功能的关系

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浙江大学学报（医学版） 2015年第3期44卷 349-353页

作者：劳林江章丽燕杜立中浙江大学医学院附属儿童医院新生儿科浙江杭州310003 福州儿童医院新生儿科福建福州350000

流行病学调查和实验研究发现成年期心血管疾病除了与遗传和生活方式相关外，还受生命早期营养环境的影响。宫内和出生后早期营养不良及相伴随的追赶生长模式均影响成年期血压、内皮功能等心血管指标。目前已建立多种出生前和（或）出生... 详细信息

流行病学调查和实验研究发现成年期心血管疾病除了与遗传和生活方式相关外，还受生命早期营养环境的影响。宫内和出生后早期营养不良及相伴随的追赶生长模式均影响成年期血压、内皮功能等心血管指标。目前已建立多种出生前和（或）出生后营养干预的动物模型研究不同干预方式对成年期心血管功能的影响。本综述结合“健康与疾病的发育起源”假说相关概念阐述成年期心血管疾病的早期营养起源，并对可能的预防措施提出设想。

关键词：心血管疾病/病因学心血管疾病/流行病学胎儿发育营养不良模型动物综述

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乌鲁木齐市汉族人群心血管危险链构成及其影响因素

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中国临床康复 2005年第31期9卷 7-9页

作者：张泳南祁燕谢自敬曾小云朱筠王薇彬新疆医科大学第一附属医院内分泌科新疆维吾尔自治区乌鲁木齐市830054

目的:调查乌鲁木齐市汉族人群代谢综合征及其相关疾病的患病状况,并探讨其影响因素。方法:①于2001-08/09采用整群抽样方法调查乌鲁木齐新市区25岁以上汉族成人2688人。排除有高血压病史、严重心、肝、肾功能不全的人群,排除资料不全者... 详细信息

目的:调查乌鲁木齐市汉族人群代谢综合征及其相关疾病的患病状况,并探讨其影响因素。方法:①于2001-08/09采用整群抽样方法调查乌鲁木齐新市区25岁以上汉族成人2688人。排除有高血压病史、严重心、肝、肾功能不全的人群,排除资料不全者,纳入2670人。按下列标准分为4组:代谢综合征组(n=243):1个个体同时存在高血糖、高血压、血脂紊乱3种成分;两种代谢紊乱组(n=701):1个个体同时存在高血糖、高血压、血脂紊乱3种成分中任意2种;一种代谢紊乱组(n=1087):即个体存在高血糖、高血压、血脂紊乱3种成分中的任意1种;无代谢紊乱组(n=639):无代谢异常。②所有调查对象均进行血压、体质量指数、腰围、血糖、血脂、胰岛素等指标的测定。比较分析不同性别及血脂紊乱状况人群的糖脂代谢紊乱、肥胖患病情况。③组间比较用方差分析,多因素分析采用Logistic回归。结果:纳入汉族成人2688人,排除资料不全者,2670人纳入结果分析并完成问卷调查。①男性糖尿病、糖耐量低减/空腹血糖受损、高血压、高三酰甘油血症、高低密度脂蛋白胆固醇血症、低高密度脂蛋白胆固醇血症、超重、肥胖、代谢综合征患病率均明显高于女性(P<0.01);高总胆固醇血症患病率明显低于女性(P<0.01)。②代谢综合征组、2种代谢紊乱组、1种代谢紊乱组、无代谢紊乱组体质量指数、腰臀比、空腹血糖、餐后2h血糖、收缩压、舒张压、总胆固醇、三酰甘油、低密度脂蛋白胆固醇呈降低趋势,且组间两两比较均有明显差异(P<0.01);高密度脂蛋白胆固醇呈上升趋势,无代谢紊乱组明显高于其余3组(P<0.01),而代谢紊乱各组间差异不明显(P>0.05)。③多因素非条件Logistic回归分析结果提示,体质量指数、腰臀比、年龄与代谢综合征高度相关(OR=2.6610,1.8710,3.7768,P<0.01)。结论:①乌鲁木齐市汉族男性成年人血糖、血脂紊乱、肥胖发生情况较女性严重。②代谢紊乱种类越多,血糖、血脂紊乱情况越严重。③代谢综合征患病与体质量指数、腰臀比、年龄有关。

关键词：新疆[维吾尔自治区] 汉族心血管疾病/流行病学危险因素

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第十次全国心血管病流行病学及人群防治学术会议纪要

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中华心血管病杂志 1991年第4期19卷 205-206页

作者：周北凡

1990年 11月 27日至 30日由中华医学会心血管病学会、全国心血管病防治办公室及中国医学科学院心血管病研究所共同组织在北京召开了全国心血管病流行病学及人群防治学术会议,与会者有来自全国25个省、市、自治区的科研及防治人员共208... 详细信息

1990年 11月 27日至 30日由中华医学会心血管病学会、全国心血管病防治办公室及中国医学科学院心血管病研究所共同组织在北京召开了全国心血管病流行病学及人群防治学术会议,与会者有来自全国25个省、市、自治区的科研及防治人员共208人。会议共收到学术论文200篇,在会上报告73篇,摘要列入汇编73篇,包括心血管病发病死亡动态的人群监测,患病情况的调查,危险因素的研究、防治措施和效果评价等较丰富的内容。

关键词：会议心血管疾病/流行病学心血管疾病/预防和控制人类

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军队老干部群体心血管危险因素现状调查

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中国临床康复 2005年第11期9卷 14-15页

作者：曹少军周书明尹秋生解放军北京军区总医院干部病房一科北京市100700

目的:通过研究心血管危险因素流行状况和变化趋势现状,进一步对其现存多重危险因素进行综合评估和干预。方法:以Framingham心脏研究中心冠心病流行病学研究为模式,采用统一自制调查表对北京军区驻京部队17个休干所和军区机关的在职、离... 详细信息

目的:通过研究心血管危险因素流行状况和变化趋势现状,进一步对其现存多重危险因素进行综合评估和干预。方法:以Framingham心脏研究中心冠心病流行病学研究为模式,采用统一自制调查表对北京军区驻京部队17个休干所和军区机关的在职、离退休师以上干部进行心血管危险因素流行病学调查,了解该自然人群健康及心血管危险因素现状,并进行综合评估。结果:1781例被调查者以男性为主,占90.85%(1618/1781),年龄主要分布在70～79岁,其次是60～69岁,共占78.77%(1403/1781)。67.76%的人有体质量异常,其中超重占49.0%861/1781),肥胖占(18.75%332/1781)。高血压占58.34%456/1781),其中32.91%(((575/1781)年最高血压异常,4.38%(78/1781)年平均血压异常,6.9%123/1781)当日血压异常。41.3%735/1781)总胆固醇高,((32.3%575/1781)三酰甘油高,7.8%139/1781)HDL-C低,血脂异((常总患病率高达68.1%。24.6%(438/1781)血糖异常,其中明确糖尿病191例(10.7%),空腹血糖异常45例(2.5%),糖耐量减低202例(11.3%)。具有心血管危险因素一重的占6.68%117/1781);二重的(占16.75%(293/1781);三重的占29.33%(523/1781);四重的占31.10%544/1781);五重以上的占15.20%266/1781)。((结论:所调查军队干部中老年人群每一个体至少存在两个危险因素。

关键词：军事人员危险因素老年人心血管疾病/流行病学

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Comparing methods to identify general internal medicine clinic patients with chronic heart failure

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AMERICAN HEART JOURNAL 2001年第6期142卷 1003-1009页

作者： Udris, EM Au, DH McDonell, MB Chen, LW Martin, DC Tierney, WM Fihn, SD Vet Affairs Puget Sound Hlth Care Syst NW Hlth Serv Res & Dev Ctr Excellence Seattle WA 98108 USA Univ Washington Dept Med Seattle WA USA Univ Rochester Dept Med Div Cardiol Rochester NY USA Richard L Roudebush Vet Affairs Med Ctr Hlth Serv Res & Dev Program Indianapolis IN USA Indiana Univ Sch Med Dept Med Div Gen Internal Med & Geriatr Indianapolis IN USA

Objectives Identification of patients with left ventricular systolic dysfunction is the first step in identifying which patients may benefit from clinical practice guidelines. The purpose of this study was to develop and validate a computerized tool using clinical information that is commonly available to identify patients with left ventricular systolic dysfunction (LVSD). Methods We performed a cross-sectional study of patients seen in a Department of Veterans Affairs General Internal Medicine Clinic who had echocardiography or radionuclide ventriculography performed as part of their clinical care. Results We identified 2246 subjects who had at least one cardiac imaging study. A total of 778 (34.6%) subjects met study criteria for LVSD. Subjects with LVSD were slightly older than subjects without LVSD (70 years vs 68 years, P = .00002) but were similar with regard to sex and race. Subjects with LVSD were more likely to have prescriptions for angiotensin-converting enzyme (ACE) inhibitors, carvedilol, digoxin, loop diuretics, hydralazine, nitrates, and angiotensin II receptor antagonists. Of the variables included in the final predictive model, ACE inhibitors, loop diuretics, and digoxin exerted the greatest predictive power. Discriminant analysis demonstrated that models containing pharmacy information were consistently more accurate (75% accurate [65% sensitivity, 81% specificity]) than those models that contained only International Classification of Diseases, 9th revision (ICD-9), codes, including ICD-9 codes for congestive heart failure (72% accurate [80% sensitivity, 68% specificity]). Conclusions We demonstrated that an automated, computer-driven algorithm identifying LVSD permits simple, rapid, and timely identification of patients with congestive heart failure by use of only routinely collected data. Future research is needed to develop accurate electronic identification of heart failure and other common chronic conditions.

关键词：心血管疾病/药物疗法心血管疾病/流行病学卡方分布共病现象计算机模拟横断面研究数据说明统计判别分析超声心动描记术内科学/统计学和数值数据病案系统计算机化/统计学和数值数据模型统计学试验预期值 ROC曲线放射性核素心室显像术敏感性与特异性美国/流行病学心室功能障碍左/诊断心室功能障碍左/流行病学老年人女(雌)性人类男(雄)性

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Alcohol, wine, and health

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AMERICAN JOURNAL OF SURGERY 2000年第5期180卷 357-361页

作者： de Lorimier, AA Univ Calif San Francisco Dept Surg San Francisco CA 94143 USA

BACKGROUND: For the past 20 years numerous epidemiological studies have correlated the consumption of alcohol and a variety of disease states: overall mortality, arteriosclerotic vascular diseases, hypertension, cancers, peptic ulcer, respiratory infections, gall stones, kidney stones, age-related macular degeneration, bone density, and cognitive function. METHODS: A review of these articles reveals that each of these studies has compared the outcome of individuals at various levels of alcohol consumption with that of abstainers. RESULTS: Each analysis has identified a U-shaped or J-shaped curve of reduced relative risk for a given disease state compared with abstainers. A clear definition of consumption in moderation becomes evident: for men it should not exceed 2 to 4 drinks per day, and for women it should not exceed 1 to 2 drinks per day. CONCLUSIONS: Alcohol by itself has favorable effects on the level of high-density lipoprotein cholesterol, and inhibition of platelet aggregation. Wine, particularly red wine, has high levels of phenolic compounds that favorably influence multiple biochemical systems, such as increased high-density lipoprotein cholesterol, antioxidant activity, decreased platelet aggregation and endothelial adhesion, suppression of cancer cell growth, and promotion of nitric oxide production. Am J Surg. 2000;180:357-361, (C) 2000 by Excerpta Medica, Inc.

关键词：年龄因素骨密度乳腺肿瘤/流行病学乳腺肿瘤/预防和控制心血管疾病/流行病学心血管疾病/预防和控制胆结石/流行病学胆结石/预防和控制队列研究胃肠肿瘤/流行病学胃肠肿瘤/预防和控制卫生肾结石/流行病学肾结石/预防和控制黄斑变性/流行病学黄斑变性/预防和控制前瞻性研究呼吸道感染/流行病学呼吸道感染/预防和控制危险因素性别因素葡萄酒成年人老年人女(雌)性人类男(雄)性中年人妊娠

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Snoring and risk of cardiovascular disease in women

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JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 2000年第2期35卷 308-313页

作者： Hu, FB Willett, WC Manson, JAE Colditz, GA Rimm, EB Speizer, FE Hennekens, CH Stampfer, MJ Harvard Univ Sch Publ Hlth Dept Nutr Boston MA 02115 USA Harvard Univ Sch Publ Hlth Dept Epidemiol Boston MA 02115 USA Brigham & Womens Hosp Dept Med Div Prevent Med Boston MA USA Harvard Univ Sch Med Boston MA USA Univ Miami Sch Med Miami FL USA

OBJECTIVES To examine prospectively the association between snoring and incidence of cardiovascular disease (CVD) in women. BACKGROUND Whether snoring increases risk of CVD remains unclear;most previous studies have been small, not prospective and limited to men. METHODS Seventy-one thousand seven hundred seventy nine female nurses 40 through 65 years of age and without previously diagnosed CVD or cancer at baseline in 1986 were followed up for eight years. Frequency of snoring was assessed using mailed questionnaires at baseline. RESULTS During eight pears of follow-up, we documented 1,042 incident cases of major CVD events (644 coronary heart disease [CHD] and 398 stroke). Compared with nonsnorers, the age-adjusted relative risks (RRs) of CVD were 1.46 (95% confidence interval 1.23 to 1.74) for occasional snorers and 2.02 (1.62 to 2.53) for regular snorers. The age-adjusted RRs of CHD were 1.43 (1.15 to 1.77) for occasional snorers and 2.18 (1.65 to 2.87) for regular snorers. The age-adjusted RRs of stroke were 1.60 (1.21 to 2.12) and 1.88 (1.29 to 2.74), respectively After further adjustment for smoking, body mass index (BMI) and other covariates, the positive association between snoring and CVD was attenuated but remained statistically significant (RRs of CVD were 1.20 [1.01 to 1.43] for occasional snorers and 1.33 [1.06-1.67] for regular snorers. CONCLUSIONS These data suggested that snoring is associated with a modest but significantly increased risk of CVD in women, independent of age, smoking, BMI and other cardiovascular risk factors. While further study is needed to elucidate the biological mechanism underlying this association, snoring may help clinicians identify individuals at higher risk for CVD. (J Am Coll Cardiol 2000;35:308-13) (C) 2000 by the American College of Cardiology.

关键词：年龄因素人体质量指数心血管疾病/流行病学心血管疾病/病因学发病率婚姻状况患病率前瞻性研究危险因素吸烟/副作用打鼾/并发症打鼾/流行病学美国/流行病学成年人老年人女(雌)性人类中年人

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CARDIOVASCULAR RISK-FACTORS AND HEARING-LOSS - STUDY OF 1000 50-YEAR-OLD MEN

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ACTA OTO-LARYNGOLOGICA 1975年第5-6期79卷 366-371页

作者： DRETTNER, B HEDSTRAND, H KLOCKHOFF, I SVEDBERG, A UNIV HOSP UPPSALA DEPT AUDIOL OTOLARNGOL & INTERN MEDS-75014 UPPSALASWEDEN

The hypothesis that cardiovascular risk factors might be of importance in the development of sensorineural hearing loss was tested in a material of 1000 fifty-year-old men. No significant correlations were found. The present study confirmed the well-known observation that the left ear usually is poorer than the right. Hearing loss in the right ear was found to be related to the smoking habits in the groups with no history of noise exposure. The explanation for this is discussed. Hearing loss was more common in social class 3 than in the other social classes. This difference was principally referable to noise exposure but also to conductive hearing loss. A prospective study of this material will further analyze the question concerning a possible relationship between cardiovascular risk factors and hearing loss.

关键词：测听法心血管疾病/流行病学聋/流行病学噪声危险吸烟社会阶级瑞典人类男(雄)性中年人

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Relation of fibrinogen to cardiovascular events is independent of preclinical cardiovascular disease: The Strong Heart Study

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AMERICAN HEART JOURNAL 2003年第3期145卷 467-474页

作者： Palmieri, V Celentano, A Roman, MJ de Simone, G Best, L Lewis, MR Robbins, DC Fabsitz, RR Howard, BV Devereux, RB Cornell Univ Weill Med Coll New York NY USA Univ Naples Federico II Naples Italy Missouri Breaks Ind Res Timber Lake SD USA Univ Vermont Coll Med Burlington VT USA Medstar Res Inst Washington DC USA Natl Heart Long Blood Inst Bethesda MD USA

Background It is unclear whether fibrinogen predicts cardiovascular events independently of echocardiographic cardiovascular abnormalities and traditional risk factors., Methods We studied 2671 American Indians who participated in the second Strong Heart Study examination (19931995) and were observed for an average of 50 - 6 months. Participants with baseline overt coronary artery disease or. a plasma creatinine level greater than or equal ***/dL were excluded. Left ventricular hypertrophy, elevated arterial stiffness, and subnormal myocardial contractility were assessed by echocardiography. Results Prevalences of echocardiographic abnormalities and cardiovascular event rates were higher with higher fibrinogen levels. Incident cardiovascular events (n = 158) and deaths (n = 64) were more frequent in participants with elevated fibrinogen levels (>400 mg/dL) than in participants with lower fibrinogen levels, as was the prevalence of echocardiographic abnormalities (both P < .01). Incident cardiovascular fatal and nonfatal events and cardiovascular deaths were 4 and 8 times higher, respectively, in participants with both elevated fibrinogen levels and echocardiographic abnormalities than in participants with neither echocardiographic abnormalities nor elevated fibrinogen levels. However, participants with fibrinogen levels >400 mg/dL had a 2 times greater relative risk of cardiovascular events or mortality, independent of both risk factors and echocardiographic abnormalities. Conclusions in a population-based sample of adults without clinical evidence of coronary artery disease at, baseline, fibrinogen levels predicted cardiovascular events independent of traditional risk factors, left ventricular hypertrophy, elevated arterial stiffness, and subnormal myocardial. systolic function.

关键词：心血管疾病/血液心血管疾病/流行病学心血管疾病/死亡率超声心动描记术/统计学和数值数据纤维蛋白原/分析心脏病/血液心脏病/流行病学心脏病/死亡率肥大左心室/血液肥大左心室/流行病学肥大左心室/死亡率印第安人北美洲纵向研究危险因素心室功能障碍左/血液心室功能障碍左/流行病学心室功能障碍左/死亡率人类

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