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Improving patient outcomes by pooling resources (The Texas heart care partnership experience)

AMERICAN JOURNAL OF CARDIOLOGY 2000年第3A期85卷 43A-51A页

作者： Hillert, B Remonte, S Rodgers, G Yancy, CW Kaul, AF Texas Med Assoc Heart Care Partnership Subcomm Cardiovasc Dis Austin TX USA Doctors Hosp Dallas TX USA Austin Heart Austin TX USA SW Med Sch Dallas TX USA Med Outcomes Management Inc Foxboro MA USA Univ Rhode Isl Coll Pharm Kingston RI 02881 USA

The morbidity and mortality associated with cardiovascular disease presents an enormous humanistic and economic burden in the United States. In Texas, cardiovascular disease has been the leading cause of death since 1950. Risk-factor modification has been targeted in the secondary prevention of cardiovascular disease, including lipid management, smoking cessation, improved control of blood pressure, physical activity, weight management, the use of a nti platelet agents/anticoagulants, angiotensin-converting enzyme (ACE) inhibitors in congestive heart failure, beta blockers after myocardial infarction, and estrogen replacement therapy. The Heart Care Partnership (HCP) is a multifaceted interactive program designed to improve risk-factor management in the secondary prevention of cardiovascular disease through physician education, participation, and consensus development in addition to practice improvement processes and patient education. Development and implementation of the Texas HCP was a joint effort of the Texas Medical Association, the Texas Affiliate of the American Heart Association, and Merck & Co. This program helps hospitals improve the quality of care and outcomes for patients with heart disease. Program resources include educational workshops, quality improvement processes, and patient educational materials. HCP workshops address the treatment gap, define optimal care, and help define institution-specific plans for treating heart disease. Quality-improvement processes provide hospitals with baseline data and tools to improve and measure outcomes over time. The HCP workshops are provided as a combination of lectures, interactive discussions, and small group planning sessions designed to encourage audience participation. Upon completing the HCP program, participants are able to (1) describe the evidence-based medicine supporting secondary prevention of cardiovascular disease;(2) identify and prioritize cardiovascular disease risk factors for secondary preven

关键词：心脏病学/组织和管理心血管药物/治疗应用心血管疾病/死亡率心血管疾病/预防和控制卫生资源/组织和管理结果评价(卫生保健)/组织和管理回顾性研究学会医学得克萨斯人类

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Predictors of outcome of medically treated patients with left main/three-vessel coronary artery disease by coronary angiography

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AMERICAN JOURNAL OF CARDIOLOGY 1999年第3期83卷 445-+页

作者： Amanullah, AM Heo, J Acio, E Narula, J Iskandrian, AE MCP Hahnemann Sch Med Dept Med Div Cardiol Sch Med Philadelphia PA 19102 USA

This study examined the prognostic value of single-photon emission computed tomography in angiographically high-risk patients with left main and/or 3-vessel coronary artery disease who were treated medically. Multivariable Cox survival analysis revealed the single-photon emission computed tomography score (based on size of perfusion abnormality, multivessel abnormality, left ventricular dilation, and lung uptake) as the only independent predictor of outcome.

关键词：腺苷/投药和剂量腺苷/诊断应用心血管药物/治疗应用冠状血管造影术/方法冠心病/药物疗法冠心病/放射摄影术冠心病/放射性核素显像心电描记术运动试验随访研究注射静脉内观察者偏差回顾性研究铊放射性同位素/投药和剂量铊放射性同位素/诊断应用体层摄影术发射型计算机单光子治疗结果血管舒张药/投药和剂量血管舒张药/诊断应用女(雌)性人类男(雄)性中年人

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Comparison of one-year outcome in women versus men with chronic congestive heart failure

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AMERICAN JOURNAL OF CARDIOLOGY 2000年第3期86卷 353-+页

作者： Opasich, C Tavazzi, L Lucci, D Gorini, M Albanese, MC Cacciatore, G Maggioni, AP Assoc Nazl Med Cardiol Osped ANMCO Res Ctr I-50121 Florence Italy Fdn Salvatore Maugeri Dept Cardiol Pavia Italy Policlin San Matteo Dept Cardiol I-27100 Pavia Italy SM Misericordia Hosp Div Cardiol Udine Italy S Giovanni Hosp Dept Cardiol Rome Italy

Using information from the Italian Network on Congestive Heart Failure, we examined whether clinical epidemiologic characteristics, drug prescription patterns, and outcome of patients with congestive heart failure dif... 详细信息

关键词：心血管药物/治疗应用死亡原因慢性病随访研究意大利/流行病学病人入院/统计学和数值数据性别因素存活率治疗结果女(雌)性人类男(雄)性

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Novel peptidomimetic hematoregulatory compounds

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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2000年第6期10卷 531-534页

作者： Heerding, DA Abruzzese, M Alberts, D Burgess, J Callahan, JF Huffman, WF King, AG LoCastro, S DeMarsh, P Pelus, LM Takata, JS Bhatnagar, PK SmithKline Beecham Pharmaceut Dept Med Chem Collegeville PA 19426 USA SmithKline Beecham Pharmaceut Dept Mol Virol & Host Def Collegeville PA 19426 USA

The activity of a novel series of peptidomimetic hematoregulatory compounds, designed based on a pharmacophore model inferred from the structure-activity relationships of a peptide SK&F 107647 (1), is reported. These compounds induce a hematopoietic synergistic factor (HSF) which in turn modulates host defense. The compounds may represent novel therapeutic agents in the area of hematoregulation. (C) 2000 Elsevier Science Ltd. All rights reserved.

关键词：氨基酸类/化学念珠菌病/药物疗法心血管药物/化学合成心血管药物/药理学心血管药物/治疗应用细胞系趋化因子CXCL1 趋化因子 CXC 趋化因子类/代谢药物设计粒细胞集落刺激因子/生物合成粒细胞巨噬细胞集落刺激因子/生物合成生长物质/代谢胞间信号肽类和蛋白质类巨噬细胞集落刺激因子/生物合成寡肽类/化学寡肽类/药理学受体药物/化学受体药物/药物作用动物小鼠

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Prevalence and treatment of heart failure in elderly long-term-care patients

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AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY 1999年第13期56卷 1334-1338页

作者： Ranz, TT Blumenschein, K Clifton, GD Heart Inst Spokane Spokane WA 99204 USA D&R Pharmacare Profess Dev Louisville KY USA Univ Kentucky Coll Pharm Div Pharm Practice & Sci Lexington KY USA Washington State Univ Dept Pharm Practice Pullman WA 99164 USA

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AMERICAN JOURNAL OF MEDICINE 2000年第6期109卷 489-492页

作者： Shah, MR Granger, CB Bart, BA McMurray, JJV Petrie, MC Michelson, EL Tudor, CE Swedberg, K Stevenson, LW Califf, RM Pfeffer, MA Duke Clin Res Inst Durham NC 27715 USA Univ Glasgow Glasgow Lanark Scotland AstraZeneca LP Wayne PA USA Sahlgrens Univ Hosp S-41345 Gothenburg Sweden Brigham & Womens Hosp Boston MA 02115 USA

An important step in understanding whether heart failure affects men and women differently is to define the clinical characteristics and patterns of treatment in women with this disease (1,2). We reviewed the Study of Patients Intolerant of Converting Enzyme inhibitors (SPICE) registry, a large registry of patients with left ventricular systolic dysfunction, to describe the clinical features and trends in medication use in women. We also sought to identify any differences between the sexes in the use of angiotensin-converting enzyme (ACE) inhibitors, diuretics, and other heart-failure *** important step in understanding whether heart failure affects men and women differently is to define the clinical characteristics and patterns of treatment in women with this disease (1,2). We reviewed the Study of Patients Intolerant of Converting Enzyme inhibitors (SPICE) registry, a large registry of patients with left ventricular systolic dysfunction, to describe the clinical features and trends in medication use in women. We also sought to identify any differences between the sexes in the use of angiotensin-converting enzyme (ACE) inhibitors, diuretics, and other heart-failure medications.

关键词：血压心血管药物/治疗应用利尿药/投药和剂量处方药物/统计学和数值数据登记疾病严重程度指数性别因素心缩期心室功能障碍左/药物疗法心室功能障碍左/病因学心室功能障碍左/病理生理学女(雌)性人类男(雄)性中年人

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An unusual cause of shock in a woman with chest pain

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HOSPITAL PRACTICE 1999年第4期34卷 155-+页

作者： Alberio, L Fiori, G Domenighetti, G Reg Hosp La Carita Multidisciplinary Intens Care Unit Locarno Switzerland

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关键词：心绞痛不稳定型/并发症心绞痛不稳定型/药物疗法心绞痛不稳定型/病因学心血管药物/治疗应用心室/药物作用心室/病理生理学肥大左心室/并发症休克心原性/化学诱导休克心原性/药物疗法室性流出道阻塞/并发症室性流出道阻塞/病因学室性流出道阻塞/病理生理学女(雌)性人类中年人

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养心氏片对冠心病血液流变学影响

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中国误诊学杂志 2005年第9期5卷 1637-1638页

作者：赵炳海薛群星沈阳机车车辆厂医院药剂科辽宁沈阳110035

2003-07～2004-06我院收诊的冠心病患者在常规治疗基础上联用养心氏片，观察其血液流变学变化，探讨养心氏对冠心病的治疗作用。

关键词：心绞痛/病理生理学血液流变学心血管药物/治疗应用血液流变学变化冠心病患者养心氏片治疗基础治疗作用

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晚期实验性失血性休克治疗中血管活性药物的应用

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中华医学杂志 1979年第11期59卷 674-676+707页

作者：苏静怡徐宁生北京医学院病理生理教研组

本文报道对家兔晚期实验性失血性休克的实验治疗,观察到在输液基础上,加用去甲肾上腺素不利于动物的恢复,而加用山莨菪碱则促进动物的恢复。其疗效的差异,可能是由于两者对微循环血管口径和血流情况的影响不同。

关键词：心血管药物/治疗应用休克出血性/药物疗法

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Endothelin in cardiovascular control: The role of endothelin antagonists

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Current Hypertension Reports 1999年第1期1.0卷 79-87页

作者： Wenzel, René R. Czyborra, Peter Lüscher, Thomas F. Philipp, Thomas Department of Nephrology and Hypertension University Hospital Essen D-45122 Essen Hufelandstrasse 45 Germany Department of Cardiology University Hospital Zürich CH-8091 Zurich Ramistrasse 100 Switzerland

Endothelin (ET) is a potent vasoconstrictor associated with various cardiovascular diseases. ET mediates its effects through ET receptors on vascular smooth muscle cells as well as on the vascular endothelium. Furthermore, a neurotransmitter role for ET has been suggested on the basis of experimental and human in vivo studies. ET antagonists are potent tools for studying the effects of ET and its receptors. They have been widely used in vitro and in experimental models of cardiovascular disease, where ET levels are elevated and reactivity to ET is altered. Promising clinical trials in hypertension, coronary artery disease, and congestive heart failure are discussed in this review. Different forms of renal failure are associated with markedly increased ET levels, and ET antagonists experimentally improve renal function in these models. Extrapolating from experimental and first clinical experience, ET antagonists could be useful in the treatment of hypertension, coronary artery disease, congestive heart failure, and renal failure, especially in combination with other drugs, ie, angiotensin converting enzyme inhibitors. The inhibition of ET-induced stimulation of nociception allows for speculation that ET antagonists might even have analgesic properties. Copyright © 1999 by Current Science Inc.

关键词：心血管药物/治疗应用心血管疾病/药物疗法心血管疾病/病理生理学内皮缩血管肽1/生理学受体内皮缩血管肽/拮抗剂和抑制剂受体内皮缩血管肽/生理学血管阻力/药物作用血管阻力/生理学动物人类大鼠

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